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Topic Review
3D Interaction
In computing, 3D interaction is a form of human-machine interaction where users are able to move and perform interaction in 3D space. Both human and machine process information where the physical position of elements in the 3D space is relevant. The 3D space used for interaction can be the real physical space, a virtual space representation simulated in the computer, or a combination of both. When the real space is used for data input, humans perform actions or give commands to the machine using an input device that detects the 3D position of the human action. When it is used for data output, the simulated 3D virtual scene is projected onto the real environment through one output device or a combination of them.
  • 1.8K
  • 29 Nov 2022
Topic Review
Speech Features for Schizophrenia
It is known that speech and language provide unique and essential information about human thought. Speech in subjects with schizophrenia is perceived as a negative symptom because it is mainly reflected in a lack of emotion (blunted affect) and poor speech (alogia). Other speech symptoms in schizophrenia include slow speech, reduced pitch variability, more pauses, and less synchronization in syllable variability. Speech production in patients with schizophrenia is usually stimulated via clinical interviews, free speech activities, image description or reading. Free speech can be compromised in people with a diagnosis of schizophrenia. Therefore, techniques such as asking patients to report activities or plans for the future, tasks done the previous day, and dreams can be implemented. Narrative of Emotions Tasks can also be used during medical consultation.
  • 1.8K
  • 09 May 2023
Topic Review
Medical Applications of Senescence-Associated β-Galactosidase Assay
β-galactosidase is a lysosomal hydrolase, which cleaves terminal β-d-galactose residues. Senescence-associated β-galactosidase (SA-β-gal) assay found its place in the routine work of thousands of biological laboratories. There is a bulk of evidence that supports the future implementation of β-galactosidase detection as a prognostic marker in medical practice as well.
  • 1.8K
  • 11 Oct 2022
Topic Review
Dietary Iron
Iron (Fe) is a biochemical microelement important for the health of the population and Fe is necessary for the fetus and all stages of growth individuals. Fe is an essential mineral necessary for delivering oxygen to tissue throughout the body as well as serving important roles in metabolism, respiration, and immune function.  Due to the importance of maintaining Fe stores, even Fe intake meets the recommended daily allowance (RDA), Fe supplementation may be justified, in states of Fe deficiency, with or without anemia, female in particular. The recommended oral Fe supplements are the first line of treatment, however, the bioavailability oral galenic forms is very low and have side effects that reduce tolerance and adherence to treatment.  Thus, a pharmaceutics strategy is to improve the bioavailability of Fe with a bioavailability enhancer.  Some studies indicate that the concomitant use of vitamin C (ascorbic acid), vitamin A, vitamin E, vitamin B9 (folic acid), vitamin B12 (cobalamin) and vitamin D3 (cholecalciferol) increases the bioavailability and absorption of Fe in the intestinal tract.
  • 1.8K
  • 10 Nov 2020
Topic Review
Salts Hydrates and Composites
Salt hydrates are alloys of salts and water. Salt hydrates display high theoretical energy densities, which are promising materials in thermal energy storage (TES).
  • 1.8K
  • 25 Jan 2022
Topic Review
Impacts of COVID-19 on Fisheries and Aquaculture Sector
Fish is a major source of food and nutritional security for subsistence communities in developing countries, it also has linkages with the economic and supply-chain dimensions of these countries. It is revealed that COVID-19 has posed numerous challenges to fish supply chain actors, including a shortage of inputs, a lack of technical assistance, an inability to sell the product, a lack of transportation for the fish supply, export restrictions on fish and fisheries products, and a low fish price. These challenges lead to inadequate production, unanticipated stock retention, and a loss in returns. COVID-19 has also resulted in food insecurity for many small-scale fish growers. Fish farmers are becoming less motivated to raise fish and related products as a result of these cumulative consequences. Because of COVID-19’s different restriction measures, the demand and supply sides of the fish food chain have been disrupted, resulting in reduced livelihoods and economic vulnerability.
  • 1.8K
  • 09 Feb 2022
Topic Review
Participatory Budgeting
Participatory budgeting (PB) is a process of democratic deliberation and decision-making, in which ordinary people decide how to allocate part of a municipal or public budget. Participatory budgeting allows citizens to identify, discuss, and prioritize public spending projects, and gives them the power to make real decisions about how money is spent. PB processes are typically designed to involve those left out of traditional methods of public engagement, such as low-income residents, non-citizens, and youth. A comprehensive case study of eight municipalities in Brazil analyzing the successes and failures of participatory budgeting has suggested that it often results in more equitable public spending, greater government transparency and accountability, increased levels of public participation (especially by marginalized or poorer residents), and democratic and citizenship learning. The frameworks of PB differentiate variously throughout the globe in terms of scale, procedure, and objective. PB, in its conception, is often contextualized to suit a region's particular conditions and needs. Thus, the magnitudes of PB vary depending on whether it is carried out at a municipal, regional, or provincial level. In many cases, PB has been legally enforced and regulated; however, some are internally arranged and promoted. Since the original invention in Porto Alegre, Brazil, in 1988, PB has manifested itself in a myriad of designs, with variations in methodology, form, and technology. PB stands as one of several democratic innovations such as British Columbia's Citizens' Assembly, encompassing the ideals of a participatory democracy. Today, PB has been implemented in nearly 1,500 municipalities and institutions around the world.
  • 1.8K
  • 09 Oct 2022
Topic Review
Crown Colony-Class Cruiser
The Crown Colony-class cruisers were a class of light cruisers of the Royal Navy named after Crown Colony of the British Empire. The first eight are known as the Fiji class, while the last three to be built are commonly referred to as the Ceylon class and were built to a slightly modified design.
  • 1.8K
  • 24 Oct 2022
Topic Review
Democracy 2.1
Janeček Method (D21) is an electoral system created by Czech mathematician Karel Janeček. Janeček Method (D21) is a modern voting and electoral method. Its main advantage is an effect of multiple votes which enables casting multiple plus votes, and in certain cases, also a minus vote. Multiple votes enable us to express a wider scope of preferences, thereby reflecting the complexities of social choice more accurately. The system was developed ostensibly in response to corruption within the Czech political system. Though it has not yet been used in any general elections, D21 has found use in several participatory budgeting programs conducted by cities and countries around the world, including the New York City. The game Prezident 21 was introduced in 2016 in order to help familiarize people with the D21 system.
  • 1.8K
  • 31 Oct 2022
Biography
B. A. Chopade
Professor B. A. Chopade is a distinguish scientist, innovator and academician of international repute. His research area includes microbiology, biotechnology and nanotechnology. He is research mentor, institution builder, great visionary and innovative administrator. Currently he is working as Vice-Chancellor as well as advisor to the Pro- Chancellor at AKS University, Satna, Madhya Pradesh, Ind
  • 1.8K
  • 22 Feb 2023
Topic Review
Complexity in Interim Payment of Construction Projects
An increasing trend in late payment and nonpayment of construction projects would hinder the sustainable development of projects by impeding progress or causing disputes.  
  • 1.8K
  • 12 May 2023
Topic Review
Electrochemical Biosensors for Monitoring the Water Quality
Electrochemical biosensors are advantageous analytical devices or tools that convert a bio-signal by biorecognition elements into a significant electrical response. Biosensors have many advantages over the conventional lab-based method, including low costs, portability, fast response time, less usage of reagents, and the capability to continuous monitor the complex wastewater. Such sensors significantly benefit from sensing the minimum level in polluted water, such as wastewater.
  • 1.8K
  • 14 Jul 2023
Topic Review
PiRNAs in Environmentally-Induced Transgenerational Epigenetic Inheritance
The piRNAs correspond to a class of small non-coding RNAs interacting with the PIWI proteins (Piwi, Aub, and Ago3 in Drosophila), belonging to the AGO subfamily proteins, mainly active in animal gonads to protect genome integrity against transposable elements (TEs).
  • 1.8K
  • 07 Feb 2022
Topic Review
Endoglin
Endoglin is a class I, single-membrane spanning receptor with an apparent molecular weight of 95 kDa containing a short cytoplasmic and a modular extracellular domain. This domain contains attachment sites for N- and O-dependent glycosylation and ligand binding residues.
  • 1.8K
  • 16 Apr 2021
Topic Review
GRKs
G protein-coupled receptor (GPCR) kinases (GRKs) play an important role in the regulation of signaling of GPCRs that bind neurotransmitters. The canonical model of GPCR desensitization posits that GRKs phosphorylate ligand-activated GPCRs, and this phosphorylation prepares receptors for the high-affinity binding of arrestin proteins. Arrestin binding prevents further G protein coupling, promotes receptor internalization, and initiates and/or facilitates specific branches of signaling. Existing data suggest that the role of GPCR phosphorylation by GRKs is distinct in different receptors. The relationship between G protein- and arrestin-mediated signaling on the one hand, and therapeutic and side effects of drugs on the other, is more complex than is widely believed. Also, the relationship between rapid (minutes to hours) GRK/arrestin-mediated regulation and long-term (days to weeks) neural plasticity remains to be elucidated. 
  • 1.8K
  • 19 Jan 2021
Topic Review
Hibernation
Torpor and hibernation are natural physiological processes. Torpor refers to a pe-riod of metabolic suppression with a duration from a few hours to several weeks. The state of torpor is probably older in evolutionary terms and was likely a survival strate-gy of protomammals. Hibernation is a more elaborate behavior, structured in many long bouts of torpor separated by brief interbouts of arousal.
  • 1.8K
  • 23 Feb 2021
Topic Review
Catheter-Associated Urinary Tract Infections
Catheter-associated urinary tract infections (CAUTIs) are among the leading nosocomial infections in the world and have led to the extensive study of various strategies to prevent infection. However, despite an abundance of anti-infection materials having been studied over the last forty-five years, only a few types have come into clinical use, providing an insignificant reduction in CAUTIs. Marine resources have emerged as an unexplored area of opportunity offering huge potential in discovering novel bioactive materials to combat human diseases. To date, some marine microbial-derived materials have exhibited potent antimicrobial, antiadhesive and antibiofilm activity against a broad spectrum of uropathogens (including multidrug-resistant pathogens) that could be potentially used in urinary catheters to eradicate CAUTIs.
  • 1.8K
  • 14 May 2021
Topic Review
HER2-Positive Breast Cancer
Up to one-third of all breast cancers are classified as the aggressive HER2-positive subtype, which is associated with a higher risk of recurrence compared to HER2-negative breast cancers. The HER2 hyperactivity associated with this subtype drives tumor growth by up-regulation of mTOR pathways and metabolic adaptation. Combination therapies that simultaneously target HER2 and mTOR improve clinical outcomes compared with HER2 inhibition alone. Drugs that mimic glucose deprivation in HER2-positive breast cancer patients have not been evaluated; however, preclinical studies have shown that the growth of HER2-positive breast tumors is reduced in response to combining the glycolytic inhibitor 2-DG with mTOR inhibitors.
  • 1.8K
  • 02 Jul 2021
Topic Review
Reduction (Complexity)
In computability theory and computational complexity theory, a reduction is an algorithm for transforming one problem into another problem. A reduction from one problem to another may be used to show that the second problem is at least as difficult as the first. Intuitively, problem A is reducible to problem B if an algorithm for solving problem B efficiently (if it existed) could also be used as a subroutine to solve problem A efficiently. When this is true, solving A cannot be harder than solving B. "Harder" means having a higher estimate of the required computational resources in a given context (e.g., higher time complexity, greater memory requirement, expensive need for extra hardware processor cores for a parallel solution compared to a single-threaded solution, etc.). We write A ≤m B, usually with a subscript on the ≤ to indicate the type of reduction being used (m : mapping reduction, p : polynomial reduction). The mathematical structure generated on a set of problems by the reductions of a particular type generally forms a preorder, whose equivalence classes may be used to define degrees of unsolvability and complexity classes.
  • 1.8K
  • 30 Sep 2022
Topic Review
Assessment in Higher Education
Assessment is a systemic process in higher education that uses empirical data on student learning to refine programs and improve student learning. As a continuous process, assessment establishes measurable and clear student learning outcomes for learning, provisioning a sufficient amount of learning opportunities to achieve these outcomes, implementing a systematic way of gathering, analyzing and interpreting evidence to determine how well student learning matches expectations, and using the collected information to inform improvement in student learning. Assessment functions as part of a continuous process whereby the parts of the cycle are revised and monitored. The term “assessment” is defined broadly in that any outcome or goal in any activity or discipline can be a part of this process.
  • 1.8K
  • 28 Oct 2022
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