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Topic Review
Microsoft Jet Database Engine
The Microsoft Jet Database Engine (also Microsoft JET Engine or simply Jet) is a database engine on which several Microsoft products have been built. The first version of Jet was developed in 1992, consisting of three modules which could be used to manipulate a database. JET stands for Joint Engine Technology. Microsoft Access and Visual Basic use or have used Jet as their underlying database engine. However, it has been superseded for general use, first by Microsoft Desktop Engine (MSDE), then later by SQL Server Express. For larger database needs, Jet databases can be upgraded (or, in Microsoft parlance, "up-sized") to Microsoft's flagship SQL Server database product. A five billion record MS Jet (Red) database with compression and encryption turned on requires about one terabyte of disk storage space. It comprises typically hundreds of *.mdb files.
  • 1.8K
  • 04 Nov 2022
Topic Review
Diverticulosis
Diverticulosis is the condition of having multiple pouches (diverticula) in the colon that are not inflamed. These are outpockets of the colonic mucosa and submucosa through weaknesses of muscle layers in the colon wall, and may be due in part to low-fiber diet prompting changes in intestinal microflora with consequent low-grade inflammation. Diverticula do not cause symptoms in most people. Diverticular disease occurs when diverticula become clinically inflamed, a condition known as diverticulitis. Diverticula typically occur in the sigmoid colon, which is commonplace for increased pressure. The left side of the colon is more commonly affected in the United States while the right side is more commonly affected in Asia. Diagnosis is often during routine colonoscopy or as an incidental finding during CT scan. It is common in Western countries with about half of those over the age of 60 affected in Canada and the United States. Diverticula are uncommon before the age of 40, and increase in incidence beyond that age. Rates are lower in Africa; the reasons for this remain unclear but may involve the greater prevalence of a high fiber diet in contrast with the lower-fiber diet characteristic of many Western populations.
  • 1.8K
  • 10 Nov 2022
Topic Review
Geochemistry of Manganese in Soils
Manganese oxides are considered an essential component of natural geochemical barriers due to their redox and sorptive reactivity towards essential and potentially toxic trace elements. Despite the perception that they are in a relatively stable phase, microorganisms can actively alter the prevailing conditions in their microenvironment and initiate the dissolution of minerals, a process that is governed by various direct (enzymatic) or indirect mechanisms. Microorganisms are also capable of precipitating the bioavailable manganese ions via redox transformations into biogenic minerals, including manganese oxides (e.g., low-crystalline birnessite) or oxalates. Microbially mediated transformation influences the (bio)geochemistry of manganese and also the environmental chemistry of elements intimately associated with its oxides. Therefore, the biodeterioration of manganese-bearing phases and the subsequent biologically induced precipitation of new biogenic minerals may inevitably and severely impact the environment. 
  • 1.8K
  • 16 Jun 2023
Topic Review
The Lean Blowout Prediction Techniques
The lean blowout is the most critical issue in lean premixed gas turbine combustion. Decades of research into LBO prediction methods have yielded promising results. Predictions can be classified into five categories based on methodology: semi-empirical model, numerical simulation, hybrid, experimental, and data-driven model.
  • 1.8K
  • 30 Nov 2022
Topic Review
Acinetobacter baumannii
Acinetobacter baumannii is regarded as a life-threatening pathogen associated with community-acquired and nosocomial infections, mainly pneumonia.
  • 1.8K
  • 14 Sep 2021
Topic Review
Extracellular Matrix in Breast Cancer
The role of extracellular matrix in breast cancer progression has recently been realized. Here, the effect of various ECM properties including fiber structure, stiffness and biochemical composition are reviewed, with a special emphasis on the extracellular vesicles. 
  • 1.8K
  • 16 Oct 2020
Topic Review
Sustainable Supply Chain Initiatives
The supply chain initiatives can be described as a set of activities performed by the firms for smooth functioning of the holistic supply chain system with the socio-economic and environmental needs in a long term period. The traditional supply chain management (SCM) practices replaced in favor of the sustainable supply chain management (SSCM) initiatives in most of the Asian industries. Nowadays, the adoption of sustainable supply chain initiatives (SSCIs) is critical for the organization to mitigate risk, handle complexities, and business dynamics of the global outsourcing. For managing supply chains smoothly, it is the very important for industries to integrate supply chains through networks designed for achieving higher business volume. This synergistic linking of sustainable supply chain practices moves the organization towards the building of the competitive edge in the global market.
  • 1.8K
  • 09 Jul 2021
Topic Review
Extended Theory of Planned Behavior
First described by Ajzen in 1985, the Theory of Planned Behavior (TPB) is one of the most widely used theories to predict and explain behavioral intentions and behavior. According to the TPB, attitude, subjective norm and perceived behavioral control towards a certain behavior determine the intention to perform this behavior. In relation to our study, attitude describes the extent to which student teachers evaluate the implementation of ESD in schools as positive or negative. The subjective norm refers to the perceived social pressure that important reference people from professional or private life expect ESD implementation in their work as teachers. Perceived behavioral control describes the perceived control of actually being able to implement ESD in schools.
  • 1.8K
  • 26 Aug 2021
Topic Review
Organoids and Aging
The biology of aging is focused on the identification of novel pathways that regulate the underlying processes of aging to develop interventions aimed at delaying the onset and progression of chronic diseases to extend lifespan. However, the research on the aging field has been conducted mainly in animal models, yeast, Caenorhabditis elegans, and cell cultures. Thus, it is unclear to what extent this knowledge is transferable to humans since they might not reflect the complexity of aging in people. An organoid culture is an in vitro 3D cell-culture technology that reproduces the physiological and cellular composition of the tissues and/or organs. This technology is being used in the cancer field to predict the response of a patient-derived tumor to a certain drug or treatment serving as patient stratification and drug-guidance approaches. Modeling aging with patient-derived organoids has a tremendous potential as a preclinical model tool to discover new biomarkers of aging, to predict adverse outcomes during aging, and to design personalized approaches for the prevention and treatment of aging-related diseases and geriatric syndromes. This could represent a novel approach to study chronological and/or biological aging, paving the way to personalized interventions targeting the biology of aging.
  • 1.8K
  • 19 Oct 2021
Topic Review
Cytokine Release Syndrome
Cytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs. It refers to cytokine storm syndromes (CSS) and occurs when large numbers of white blood cells are activated and release inflammatory cytokines, which in turn activate yet more white blood cells. CRS is also an adverse effect of some monoclonal antibody medications, as well as adoptive T-cell therapies. When occurring as a result of a medication, it is also known as an infusion reaction. The term cytokine storm is often used interchangeably with CRS but, despite the fact that they have similar clinical phenotype, their characteristics are different. When occurring as a result of a therapy, CRS symptoms may be delayed until days or weeks after treatment. Immediate-onset CRS is a cytokine storm, although severe cases of CRS have also been called cytokine storms.
  • 1.8K
  • 29 Nov 2022
Topic Review
Status of Health Estimation Methods
As the backup power supply of power plants and substations, Valve Regulated Lead Acid (VRLA) batteries are the last safety guarantee for the safe and reliable operation of power systems, and the batteries status of health（SOH）directly affects the stability and safety of power system equipment. In recent years, due to the aging and failure of VRLA batteries, some serious safety accidents have been caused, so it is very necessary to accurately evaluate the health of batteries.
  • 1.8K
  • 21 Mar 2023
Topic Review
The Extracellular Matrix in Cancer
As the core component of all organs, the extracellular matrix (ECM) is an interlocking macromolecular meshwork of proteins, glycoproteins, and proteoglycans that provides mechanical support to cells and tissues. In cancer, the ECM can be remodelled in response to environmental cues, and it controls a plethora of cellular functions, including metabolism, cell polarity, migration, and proliferation, to sustain and support oncogenesis. The biophysical and biochemical properties of the ECM, such as its structural arrangement and being a reservoir for bioactive molecules, control several intra- and intercellular signalling pathways and induce cytoskeletal changes that alter cell shapes, behaviour, and viability.
  • 1.8K
  • 18 Apr 2023
Topic Review
Telocytes
Telocytes/CD34+ stromal cells in the normal and pathological peripheral nervous system (PNS). We consider the following aspects: (A) general characteristics of telocytes; (B) the presence, characteristics and arrangement of telocytes in the normal PNS, including i) nerve epi-perineurium and endoneurium (e.g., telopodes extending into the endoneurial space); ii) sensory nerve endings (e.g., Meissner and Pacinian corpuscles, and neuromuscular spindles); iii) ganglia; and iv) the intestinal autonomic nervous system; (C) the telocytes in the pathologic PNS, encompassing (i) hyperplastic neurogenic processes (neurogenic hyperplasia of the appendix and gallbladder), highly demonstrative of telocyte characteristics and relations, (ii) PNS tumours, such as neurofibroma, schwannoma and granular cell tumour. 
  • 1.8K
  • 26 Oct 2020
Topic Review
Product/Service System Family Design
Product/service system (PSS) family design is a kind of designing a group of PSSs in order to provide the PSSs efficiently to a defined set of multiple customer segments, and was conceptualized with analogy to product family design. PSS is widely considered as a promising design object with the potential to enhance environmental sustainability of industrial solutions. PSS family design is potentially powerful to PSS customization and thereby expected to contribute to the competitiveness of PSS providers.
  • 1.8K
  • 28 Oct 2020
Topic Review
Alpha-Synuclein in Neurons
Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous inclusions represents the key histophathological hallmark of a spectrum of neurodegenerative disorders, referred to by the umbrella term a-synucleinopathies. Even though alpha-synuclein is expressed predominantly in neurons, pathological aggregates of the protein are also found in the glial cells of the brain. In Parkinson’s disease and dementia with Lewy bodies, alpha-synuclein accumulates mainly in neurons forming the Lewy bodies and Lewy neurites, whereas in multiple system atrophy, the protein aggregates mostly in the glial cytoplasmic inclusions within oligodendrocytes. In addition, astrogliosis and microgliosis are found in the synucleinopathy brains, whereas both astrocytes and microglia internalize alpha-synuclein and contribute to the spread of pathology. The mechanisms underlying the pathological accumulation of alpha-synuclein in glial cells that under physiological conditions express low to non-detectable levels of the protein are an area of intense research. Undoubtedly, the presence of aggregated alpha-synuclein can disrupt glial function in general and can contribute to neurodegeneration through numerous pathways. 
  • 1.8K
  • 17 Jun 2021
Topic Review
Engineered Bacteriophages
Engineered bacteriophages (phages) are bacteriophages that have been genetically or chemically altered in some way to create or improve a property for an application, although it would be equally valid to use this term for phages altered for research.   Application-directed properties can include: enhanced bacterial killing to improve phage therapy; insertion of reporter genes to facilitate biosensor-mediated detection; insertion of targeting peptides to a virion surface protein to enhance binding properties to bacteria or other types of cells; attachment of non-protein molecules (e.g. antibiotics or nanoparticles) to phage capsid surface proteins to facilitate phage-mediated delivery; anchoring of phages to a surface to improve target capture.  It is also possible to combine modifications to develop, for example, a phage-based cancer treatment that has binding peptides for cancer cell targeting and is conjugated to either a radioisotope nanoparticle or chemotherapy drug to improve delivery.
  • 1.8K
  • 14 Jul 2021
Topic Review
Târnave Vineyard
Located at the intersection of the geographical coordinates of 46°–47° Northern latitude and 23°–24° Eastern longitude, Târnave vineyards are part of the viticultural zone 1 of Romania. They are situated on the Transylvanian Plateau. The most significant viticultural area of Transylvania, the prestigious Târnave vineyard, named so because most of the vineyards are located on the slopes that delineate the valleys of the rivers Târnava Mare and Târnava Mică, is known and appreciated for its quality wines with a specific flavor and a good sugar/acidity balance.
  • 1.8K
  • 11 Aug 2021
Topic Review
Microtubule Poisons
Microtubule poisons, as is the case with other antitumor drugs, routinely promote autophagy in tumor cells. However, the nature and function of the autophagy, in terms of whether it is cytoprotective, cytotoxic or nonprotective, cannot be predicted; this likely depends on both the type of drug studied as well as the tumor cell under investigation. The microtubule poisons continue to play a central role in the clinical treatment of both solid tumors or hematologic malignancies. However, tumor cells can develop resistance by a number of mechanisms such as altered microtubule binding and efflux via the multidrug resistance pump family of transporters.
  • 1.8K
  • 14 Jul 2022
Topic Review
Glossary of Patent Law Terms
This is a list of legal terms relating to patents. A patent is not a right to practice or use the invention, but a territorial right to exclude others from commercially exploiting the invention, granted to an inventor or his successor in rights in exchange to a public disclosure of the invention.
  • 1.8K
  • 11 Nov 2022
Topic Review
Sensory Memory
During every moment of an organism's life, sensory information is being taken in by sensory receptors and processed by the nervous system. Sensory information is stored in sensory memory just long enough to be transferred to short-term memory. Humans have five traditional senses: sight, hearing, taste, smell, touch. Sensory memory (SM) allows individuals to retain impressions of sensory information after the original stimulus has ceased. A common demonstration of SM is a child's ability to write letters and make circles by twirling a sparkler at night. When the sparkler is spun fast enough, it appears to leave a trail which forms a continuous image. This "light trail" is the image that is represented in the visual sensory store known as iconic memory. The other two types of SM that have been most extensively studied are echoic memory, and haptic memory; however, it is reasonable to assume that each physiological sense has a corresponding memory store. Children for example have been shown to remember specific "sweet" tastes during incidental learning trials but the nature of this gustatory store is still unclear. However, sensory memories might be related to a region of the thalamus, which serves as a source of signals encoding past experiences in the neocortex.
  • 1.8K
  • 30 Nov 2022
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