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Topic Review
Geochemical Modeling
Geochemical modeling is the practice of using chemical thermodynamics, chemical kinetics, or both, to analyze the chemical reactions that affect geologic systems, commonly with the aid of a computer. It is used in high-temperature geochemistry to simulate reactions occurring deep in the Earth's interior, in magma, for instance, or to model low-temperature reactions in aqueous solutions near the Earth's surface, the subject of this article.
  • 1.8K
  • 26 Oct 2022
Topic Review
The Synthesis Pathway of L-Theanine in Microorganisms
Theanine, a representative non-protein amino acid in tea, is one of the umami components of tea and a major factor in the formation of the unique flavor of tea leaves. In addition to its delicious taste, theanine has a variety of health functions and is used in the food supplement, pharmaceutical, nutraceutical, and cosmetic industries. 
  • 1.8K
  • 30 Jun 2023
Topic Review
Replication Protein A
Replication protein A (RPA) is a heterotrimeric protein complex and the main single-stranded DNA (ssDNA)-binding protein in eukaryotes. RPA has key functions in most of the DNA-associated metabolic pathways and DNA damage signalling. Its high affinity for ssDNA helps to stabilise ssDNA structures and protect the DNA sequence from nuclease attacks. RPA consists of multiple DNA-binding domains which are oligonucleotide/oligosaccharide-binding (OB)-folds that are responsible for DNA binding and interactions with proteins. These RPA–ssDNA and RPA–protein interactions are crucial for DNA replication, DNA repair, DNA damage signalling, and the conservation of the genetic information of cells. Proteins such as ATR use RPA to locate to regions of DNA damage for DNA damage signalling.
  • 1.8K
  • 18 Feb 2024
Topic Review
Arisaema Jacquemontii Blume
Arisaema jacquemontii Blume (Araceae) is a medicinally important plant and is used for the treatment of different diseases specially in dermatological disorders. Alkaloids, phenols, terpenes, flavonoids, glycosides, tannins have been reported from this plant. Antioxidant, antifungal, antibacterial and anticancer activities are also shown by Arisaema jacquemontii. 
  • 1.8K
  • 15 Aug 2022
Topic Review
Untargeted Human Milk Metabolomics
Human milk (HM) is considered the gold standard for infant nutrition. HM contains macro- and micronutrients, as well as a range of bioactive compounds (hormones, growth factors, cell debris, etc.). The analysis of the complex and dynamic composition of HM has been a permanent challenge for researchers. The use of novel, cutting-edge techniques involving different metabolomics platforms has permitted to expand knowledge on the variable composition of HM. Here, the state-of-the-art in untargeted metabolomic studies of HM, with emphasis on sampling, extraction and analysis steps is presented.
  • 1.8K
  • 30 May 2022
Topic Review
Diversity of Plant Cell Wall
The plant cell wall is a complex and dynamic structure composed of many different molecules, which play multiple roles in all aspects of plant life. Today, a new frontier of biotechnology has opened up, which has provided new insights into the structural and functional diversity of cell walls, and is thus serving to re-emphasize the significance of cell wall divergence in the evolutionary history of plant species. The recent availability of plant genome datasets can be used to increase the knowledge regarding the diversity of cell walls among different plant species. Since the growth and development of all types of plant cells are functions of cell wall dynamics, further understanding of the functional diversity of cell walls in relation to diverse biological events will have a significant effect on the broad field of plant sciences.
  • 1.8K
  • 18 Sep 2020
Topic Review
Recursion Predicts Covid-19 Trajectories
Modulated recurrence model predicts Covid-19 trajectory in multiple countries.  Wave action at 14-week intervals correlates with case numbers, while predicting future growth rate surges. Graphs of total Covid-19 case numbers in many countries now show long-period wave action.  Simulations using a sine modulated time-delay recurrence equation not only correlate with case data but also proves a π-commensurate wave period of 26 weeks.  When the slope of geometric growth exceeds arithmetic growth, a periodic wave launches in the population with all the dynamics of a damped oscillation.  Recursive simulation generates trajectories that predict future wave peak times and amplitudes.  Data from USA, Canada, UK, Germany, India and Australia are studied in this research.  In all cases, Covid-19 trajectories around the world show the common feature of periodic oscillations as case numbers increase.  Discovery of repeatable Covid-19 growth dynamics suggests a common invariant mechanism of virus propagation, irrespective of country.
  • 1.8K
  • 17 Dec 2020
Topic Review
3D Printing for Periodontal Regeneration
The three-dimensional printing of scaffolds is an interesting alternative to the traditional techniques of periodontal regeneration. This technique uses computer assisted design and manufacturing after CT scan. After 3D modelling, individualized scaffolds are printed by extrusion, selective laser sintering, stereolithography, or powder bed inkjet printing. These scaffolds can be made of one or several materials such as natural polymers, synthetic polymers, or bioceramics.
  • 1.8K
  • 14 Apr 2021
Topic Review
Lactose Intolerance and Personalized Nutrition
Recent discoveries in the “omics” field and the growing focus on preventive health have opened new avenues for personalized nutrition (PN), which is becoming an important theme in the strategic plans of organizations that are active in healthcare, food, and nutrition research. PN holds great potential for individual health optimization, disease management, public health interventions, and product innovation. However, there are still multiple challenges to overcome before PN can be truly embraced by the public and healthcare stakeholders. The diagnosis and management of lactose intolerance (LI), a common condition with a strong inter-individual component, is explored as an interesting example for the potential role of these technologies and the challenges of PN. From the development of genetic and metabolomic LI diagnostic tests that can be carried out in the home, to advances in the understanding of LI pathology and individualized treatment optimization, PN in LI care has shown substantial progress. However, there are still many research gaps to address, including the understanding of epigenetic regulation of lactase expression and how lactose is metabolized by the gut microbiota, in order to achieve better LI detection and effective therapeutic interventions to reverse the potential health consequences of LI.
  • 1.8K
  • 20 May 2021
Topic Review
Ergot Alkaloids Mycotoxins in Cereals
Mycotoxins are secondary metabolites synthesized by an array of fungal genera, usually Fusarium, Penicillium and Aspergillus.
  • 1.8K
  • 24 May 2021
Topic Review
Fluorinated Greenhouse Gases
Fluorinated greenhouse gases (F-gases) are used for various applications, such as in refrigeration and air conditioning, as substitutes of the ozone-depleting substances. Their utilization has increased drastically over the last few decades, with serious consequences for global warming. The Kigali Amendment to the Montreal Protocol and several national and international legislations, such as the 2014 EU F-gas Regulation, aim to control the utilization and emissions of these gases. In the EU, the phase-down of hydrofluorocarbons (HFCs) is underway, with successive reductions in quotas up to 2050. Under this scenario, efficient strategies for managing the produced and already existing F-gases are of vital importance to guarantee that their effect on the environment is mitigated. Up to now, most of the F-gases recovered from end-of-life equipment or when retrofitting systems are either released into the atmosphere or destroyed. However, in order to put forward a cost-efficient adaptation to the F-gas phase-down, increasing separation and recycling efforts must be made.
  • 1.8K
  • 24 May 2021
Topic Review
Essential Oils for Food Packaging
Essential oils (EOs) are concentrated liquid mixtures of volatile compounds with antioxidant and antibacterial properties that can be used as natural, eco-friendly, renewable, and cost-effective additives. The use of combinations of different EOs and their components is a promising strategy to increase the synergistic and additive effects of EOs in foods.
  • 1.8K
  • 27 Sep 2021
Topic Review
Phorbas Sponges
Porifera, commonly referred to as marine sponges, are acknowledged as major producers of marine natural products (MNPs). Sponges of the genus Phorbas have attracted much attention over the years. They are widespread in all continents, and several structurally unique bioactive compounds have been identified from this species. 
  • 1.8K
  • 30 Nov 2021
Topic Review
Aromatic Plants and Bioactive Compounds
Natural compounds obtained from different medicinal and aromatic plants have gained respect as alternative treatments to synthetic drugs, as well as raw materials for different applications (cosmetic, food and feed industries, environment protection, and many others). Based on a literature survey on dedicated databases, the content includes a critical discussion of aspects regarding classical extraction versus modern extraction techniques; possibilities to scale up (advantages and disadvantages of different extraction methods usually applied and the influence of extraction parameters); and different medicinal and aromatic plants’ different applications (medical and industrial applications, as well as the potential use in nanotechnology).
  • 1.8K
  • 23 Sep 2022
Topic Review
Health Star Rating System
The Health Star Rating System (HSR) is an Australian Government initiative that assigns health ratings to packaged foods and beverages. The Health Star Rating System was established in 2014 as a preventative measure in slowing or reversing the rate of overweight Australians. According to the Australian Bureau of Statistics, over 63% of Australian adults were classified either overweight or obese at that time. The purpose for the Health Star Rating is to provide a visual comparison of like for like products, to assist consumers into distinguishing and choosing the healthier options. It was designed to target time-deprived working adults as well as parents and children who were less likely to check how healthy each individual product was, through examination of the nutritional facts label on the back of products. Ratings scale by half star increments between half a star up to five stars, with the higher the rating, the healthier the product. These scores are determined through the use of the Health Star Rating Calculator, which was created by the federal and state governments in collaboration with leading health industry consumer groups and expert nutritionists. The calculator uses nutritional information such as total sugar, sodium, energy and other variants to obtain a rating for the product. Points are added for "healthy" nutrients such as fibres, proteins and vegetable matter whilst points are deducted for "unhealthy" nutrients; nutrients that have been scientifically linked to chronic health disease, such as fats and sugars. There are two types of HSR logos that companies can add to their packaging, one which simply displays the rating and another which depicts the rating along with some of the key nutritional categories. The Health Star Rating has received criticism over the effectiveness of the calculator and how some companies have potentially manipulated its use. The system has undergone consistent internal monitoring including a two-year review and is currently undertaking a five-year review. An early preview of the five year report was made available for public viewing from February 2019. The Australian Government has stated that it has closely followed external input and advice from independent journals and papers to continually improve on the system and resolve problems as they arise.
  • 1.8K
  • 20 Oct 2022
Topic Review
Harbour
Harbour is a modern computer programming language, primarily used to create database/business programs. It is a modernized, open sourced and cross-platform version of the older Clipper system, which in turn developed from the dBase database market of the 1980s and 90s. Harbour code using the same databases can be compiled under a wide variety of platforms, including Microsoft Windows, Linux, Unix variants, several BSD descendants, Mac OS X, MINIX 3, Windows CE, Pocket PC, Symbian, iOS, Android, QNX, VxWorks, OS/2/eComStation, BeOS/Haiku, AIX and MS-DOS.
  • 1.8K
  • 04 Nov 2022
Topic Review
Photocatalytic Degradation of Antibiotics
Various methods, including carbon filtration, ozonation, catalytic membranes, Fenton-like catalysis, sorption, and biodegradation have been employed to eliminate such enduring antibiotic substances. As a result, wastewater accumulates effluents from corporations, clinics, and farmland. Sewage treatment is typically regarded as the preferred method for treating these antibiotics. Photocatalysis has gained a lot of interest as an effective method for eliminating antibiotic contaminants since it is inexpensive, effective, and environmentally benign as it eliminates antibiotics in sunlight and under ambient conditions. The reactions endured by a semiconductor and the potential to absorb photons with energies higher than its energy band gap is called “photocatalytic degradation”.
  • 1.8K
  • 02 Mar 2023
Topic Review
Polyhydroxyalkanoates (PHAs) as Biomaterials in Tissue Engineering
Polyhydroxyalkanoates (PHAs) are biodegradable and biocompatible biopolymers. These biomaterials have grown in importance in the fields of tissue engineering and tissue reconstruction for structural applications where tissue morphology is critical, such as bone, cartilage, blood vessels, and skin, among others. Furthermore, they can be used to accelerate the regeneration in combination with drugs, as drug delivery systems, thus reducing microbial infections. When cells are cultured under stress conditions, a wide variety of microorganisms produce them as a store of intracellular energy in the form of homo- and copolymers of [R]—hydroxyalkanoic acids, depending on the carbon source used for microorganism growth. 
  • 1.8K
  • 03 Mar 2022
Topic Review
Salicylic Acid and Systemic Immunity in Plants
Systemic acquired resistance (SAR) occurs when primary infected leaves produce several SAR-inducing chemical or mobile signals that are transported to uninfected distal parts via apoplastic or symplastic compartments and activate systemic immunity. The transport route of many chemicals associated with SAR is unknown.
  • 1.8K
  • 09 Mar 2023
Topic Review
Isolation and Purification of EVs
Extracellular vesicles are sacs that are secreted by almost all types of cells and are responsible for intracellular communication. They inherit their content and characteristics from their donor cells. Pathological and physiological characteristics of donor cells are reflected in the appearance of specific nucleotide and proteins (on the EV surface or in their content).
  • 1.8K
  • 11 Jan 2022
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