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Topic Review
Aspergillus
Aspergilli have been widely used in the production of organic acids, enzymes, and secondary metabolites for almost a century. Today, several GRAS (generally recognized as safe) Aspergillus species hold a central role in the field of industrial biotechnology with multiple profitable applications. Since the 1990s, research has focused on the use of Aspergillus species in the development of cell factories for the production of recombinant proteins mainly due to their natively high secretion capacity. Advances in the Aspergillus-specific molecular toolkit and combination of several engineering strategies (e.g., protease-deficient strains and fusions to carrier proteins) resulted in strains able to generate high titers of recombinant fungal proteins
  • 1.9K
  • 09 Oct 2020
Topic Review
Cutaneous Melanoma
Cutaneous Melanoma (CM), arising from pigment-producing melanocytes in the skin, is an aggressive cancer with high metastatic potential. While cutaneous melanoma represents only a fraction of all skin cancers (<5%), it accounts for most skin-cancer-related deaths worldwide. Immune checkpoint inhibition has been the first therapeutic approach to significantly benefit patient survival after treatment. Nevertheless, the immunosuppressive tumor microenvironment and the intrinsic and acquired treatment resistance of melanoma remain crucial challenges. Combining local and systemic treatment offers the potential to augment therapeutic response and overcome resistance, although, complex drug combinations can harbor an increased risk of immune-related adverse events.
  • 1.9K
  • 22 Sep 2021
Topic Review
FAAH and Major Depressive Disorder
Altered activity of fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system, has been implicated in several neuropsychiatric disorders, including major depressive disorder (MDD). It is speculated that increased brain FAAH expression is correlated with increased depressive symptoms.
  • 1.9K
  • 02 Jun 2021
Topic Review
Biomass Increment of Melia dubia
Farmland tree cultivation is considered an important option for enhancing wood production. In South India, the native leaf-deciduous tree species Melia dubia is popular for short-rotation plantations. Exploration of key controls of biomass accumulation in tree is very much essential to guide farmers and update agricultural landscape carbon budget. Further, resource conservation and allocation for components of agroforestry. M. dubia growths depends on water availability and how water it requires for its aggressive carbon consumption strategy has yet to be explored.
  • 1.9K
  • 16 Jan 2022
Topic Review
Lincos (Artificial Language)
Lincos (an abbreviation of the Latin phrase lingua cosmica) is a constructed language first described in 1960 by Dr. Hans Freudenthal in his book Lincos: Design of a Language for Cosmic Intercourse, Part 1. It is a language designed to be understandable by any possible intelligent extraterrestrial life form, for use in interstellar radio transmissions. Freudenthal considered that such a language should be easily understood by beings not acquainted with any Earthling syntax or language. Lincos was designed to be capable of encapsulating "the whole bulk of our knowledge."
  • 1.9K
  • 09 Oct 2022
Biography
Douglas Mawson
Sir Douglas Mawson OBE FRS[1] FAA (5 May 1882 – 14 October 1958) was an Australian geologist, Antarctic explorer, and academic. Along with Roald Amundsen, Robert Falcon Scott, and Sir Ernest Shackleton, he was a key expedition leader during the Heroic Age of Antarctic Exploration. Mawson was born in England and came to Australia as an infant. He completed degrees in mining engineering and geo
  • 1.9K
  • 30 Nov 2022
Topic Review
Mycotoxins Associated with Meat and Meat Products Contamination
Food sustainability and safety have been heavily prioritized by consumers, producers, and government entities alike. In this regard, filamentous fungi have always been a health hazard due to their contamination of the food substrate with mycotoxins. Additionally, mycotoxins are proven resilient to technological processing. Mycotoxins are considered an increasing health hazard, causing internal organ disorders, immunosuppression, or even death. Some mycotoxins, such as aflatoxins, ochratoxins, and fumonisins, have additional genotoxic effects and can be associated with certain types of cancer, as recognised by the International Agency for Research on Cancer (IARC).
  • 1.9K
  • 08 Dec 2022
Topic Review
Big Five Personality Traits and Romantic Relationship Formation
This entry discusses whether personality traits from the Big Five model predict romantic relationship formation, especially in the context of professional matchmaking. Based on empirical evidence, it explores the limited role of traits like Extraversion or Agreeableness in actual partner selection and investigates why personality may be less predictive than expected in real-life settings.
  • 1.9K
  • 29 Apr 2025
Topic Review
Nitrogen Compounds Prediction
The prediction of nitrogen not only assists in monitoring the nitrogen concentration in streams but also helps in optimizing the usage of fertilizers in agricultural fields. A precise prediction model guarantees the delivering of better-quality water for human use, as the operations of various water treatment plants depend on the concentration of nitrogen in streams
  • 1.9K
  • 27 Oct 2020
Topic Review
Neuro-Monitoring in Intravenous Anaesthesia
The monitoring of hypnosis depth by means of electroencephalogram-based (EEG-based) systems is emerging in paediatric anaesthesia common practice. This monitor system measures specific EEG signs which derive from anaesthetic-induced changes in neuronal firing.
  • 1.9K
  • 30 Jun 2021
Topic Review
Dietary (Phyto)Nutrients for Glutathione Support
Glutathione is a tripeptide that plays a pivotal role in critical physiological processes resulting in effects relevant to diverse disease pathophysiology such as maintenance of redox balance, reduction of oxidative stress, enhancement of metabolic detoxification, and regulation of immune system function. The diverse roles of glutathione in physiology are relevant to a considerable body of evidence suggesting that glutathione status may be an important biomarker and treatment target in various chronic, age-related diseases. 
  • 1.9K
  • 26 Aug 2022
Topic Review
Substituted Azobenzene Molecules with Antimicrobial Properties
Azo molecules, characterized by the presence of a -N=N- double bond, are widely used in various fields due to their sensitivity to external stimuli, ch as light. The emergence of bacterial resistance has pushed research towards designing new antimicrobial molecules that are more efficient than those currently in use. Many authors have attempted to exploit the antimicrobial activity of azobenzene and to utilize their photoisomerization for selective control of the bioactivities of antimicrobial molecules, which is necessary for antibacterial therapy.
  • 1.9K
  • 14 Sep 2022
Topic Review
Techniques for Ventricular Tachycardia Functional Substrate Mapping
Conventional mapping techniques used to define the critical isthmus, such as activation mapping and entrainment, are limited by the non-inducibility of the clinical tachycardia or its poor hemodynamic tolerance. To overcome these limitations, a voltage mapping strategy based on bipolar electrograms peak to peak analysis was developed, but a low specificity (30%) for VT isthmus has been described with this approach. Functional mapping strategy relies on the analysis of the characteristics of the electrograms but also their propagation patterns and their response to extra-stimulus or alternative pacing wavefronts to define the targets for ablation.
  • 1.9K
  • 19 Sep 2022
Topic Review
Timeline of Women's Suffrage in California
This timeline provides an overview of the political movement for women's suffrage in California. Women's suffrage became legal with the passage of Proposition 4 in 1911 yet not all women were enfranchised as a result of this legislation.
  • 1.9K
  • 17 Oct 2022
Topic Review
GM A Platform (1936)
The GM A platform (1936) (commonly called A-body) was a rear wheel drive automobile platform designation used by General Motors from at least 1936 until 1959, and again from 1964 to 1981. In 1982, GM introduced a new front wheel drive A platform, and existing intermediate rear wheel drive products were redesignated as G-bodies.
  • 1.9K
  • 21 Oct 2022
Biography
Dr Arul Thomos Selvanathan
Dr. Arul Thomas Selvanathan is an Indian singer , songwriter and spiritual song writer. He was born in 1970 in Madurai, a small town in Tamil Nadu , South India. He was born into a Roman Catholic family. He has five brothers and two sisters. By the grace of God, he was saved in his childhood and had a personal encounter with the Lord Jesus Christ and was instantly baptized with the Holy Spirit.
  • 1.9K
  • 03 Jan 2023
Topic Review
Education in Tourism
Learning and gaining knowledge by traveling have been present in human history for centuries. Education does so well in tourism because it is accompanied by human curiosity about the world. Tourism can teach natural, social, and historical sciences. It is an important tool for learning about the past that influences the present and the future, especially if it is a difficult past such as the memory of the Holocaust. Tourism can help to draw conclusions about the past as long as it contributes to the acquisition of specific knowledge.
  • 1.9K
  • 08 Feb 2024
Topic Review
Mobile-Applications for Assessing Human Posture
Postural assessment corresponds to a stage of the physical examination that aims to identify possible misalignment of the body that may be caused by changes in the spine or other body segments. To assist in this evaluation procedure, several methods and resources are used by health professionals, including software solutions such as desktop and mobile systems.
  • 1.9K
  • 18 Aug 2020
Topic Review
Phenylketonuria
Phenylketonuria (commonly known as PKU) is an inherited disorder that increases the levels of a substance called phenylalanine in the blood. Phenylalanine is a building block of proteins (an amino acid) that is obtained through the diet. It is found in all proteins and in some artificial sweeteners. If PKU is not treated, phenylalanine can build up to harmful levels in the body, causing intellectual disability and other serious health problems.
  • 1.9K
  • 24 Dec 2020
Topic Review
Ring-Fused Benzimidazoles and Imidazobenzimidazoles
The entry covers the synthesis and biological activity of ring-fused benzimidazoles, imidazo[4,5-f]benzimidazoles and imidazo[5,4-f]benzimidazoles. Compounds are bioreductive antitumor agents when the fused benzene part is a quinone or iminoquinone. Reactions are categorized according to the cyclization reaction, and include oxidative cyclizations using the t-amino effect. Other cyclizations are onto the 1- and 2-positions of benzimidazoles using cross-dehydrogenative coupling and homolytic aromatic substitution. Many syntheses are transition metal mediated, but others are metal-free using thermal, electrochemical and photochemical conditions.
  • 1.9K
  • 11 May 2021
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