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Topic Review
Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
The pathophysiological mechanisms underlying the development of Non-alcoholic fatty liver disease (NAFLD) and its progression to Non-alcoholic steatohepatitis (NASH) and cirrhosis are various and involve pro-inflammatory agents, oxidative stress, apoptosis, adipokines, c-Jun N-terminal kinase (JNK)-1 activation, increased insulin-like growth factor 1 (IGF-1) activity, immunomodulation, and alteration of the gut microbiota.
  • 650
  • 22 Feb 2023
Topic Review
Preventative Medicine Programs in Animal Welfare and Wellbeing
In animals undergoing veterinary treatment, including therapeutic, quarantine and preventative medicine, their physiology and behaviour are derailed from their normal states and the animal’s choices and comfort are de facto limited. Traditional paradigms of animal welfare do not apply perfectly to animals under veterinary care, including quarantine and preventative medicine. A paradigm separating animal wellbeing from animal welfare is proposed in order to instil much needed clarity of thought and to guide actions in regard to the welfare of animals under human care. 
  • 641
  • 10 Aug 2023
Topic Review
When Surgery is Needed for Bone Fractures
Discover when surgery is necessary for bone fractures, including key factors and treatment options for optimal recovery.
  • 635
  • 29 Nov 2024
Topic Review
Types of Breast Cancer Imaging
Cancer is an incurable disease based on unregulated cell division. Breast cancer is the most prevalent cancer in women worldwide, and early detection can lower death rates. Medical images can be used to find important information for locating and diagnosing breast cancer. The best information for identifying and diagnosing breast cancer comes from medical pictures.
  • 625
  • 09 Aug 2023
Topic Review
Genomic Classifier and Its Role in Supporting MDD
Interstitial lung diseases (ILDs) are a group of heterogeneous diseases characterized by inflammation and/or fibrosis of the lung interstitium, leading to a wide range of clinical manifestations and outcomes. Over the years, the literature has demonstrated the increased diagnostic accuracy and confidence associated with a multidisciplinary approach (MDA) in assessing diseases involving lung parenchyma. This approach was recently emphasized by the latest guidelines from the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Association for the diagnosis of ILDs.
  • 624
  • 08 Aug 2023
Topic Review
Diagnosis of Low Back Pain
Low back pain ranks as the leading cause of years lived with disability worldwide. Although best practice guidelines share a consistent diagnostic approach for the evaluation of patients with low back pain, confusion remains as to what extent patient history and physical examination findings can inform management strategies.
  • 622
  • 01 Jun 2023
Topic Review
Top Psoriasis Triggers and How to Manage Them
Identify common psoriasis triggers and learn effective management tips to reduce flare-ups and improve skin health.
  • 603
  • 29 Nov 2024
Topic Review
Impact of COVID-19 on Overeating
It is found that stress and the family environment can affect overeating, but less is known about how COVID-19 stressors and family health may affect overeating during the COVID-19 pandemic. 
  • 602
  • 31 May 2022
Topic Review
Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is one of the most-prevalent cancer types worldwide, and it poses a serious threat to public health due to its high mortality and morbidity rates. OSCC typically has a poor prognosis, significantly reducing the chances of patient survival.
  • 590
  • 20 Oct 2023
Topic Review
GP's Perspectives on Weight Loss Dietary Advice
General practitioners (GPs) play a crucial role in guiding patients’ health behaviors, including advising on weight loss. GPs have access to a variety of lifestyle, medical, and surgical approaches to weight loss to assist their patients. 
  • 582
  • 31 Jul 2023
Topic Review
Caring for Migrant Populations in Italy
The foreign population living in Italy, on 1 January 2021, was about 5.2 million, plus about 500,000 irregular foreigners, according to the ISMU Foundation. It is a “young” population, with a high rate of unaccompanied foreign minors, and the male: female ratio is about 1:1, with wide differences depending on the citizenship of origin.
  • 580
  • 06 Feb 2024
Topic Review
DiabeticSense
Diabetes mellitus is a widespread chronic metabolic disorder that requires regular blood glucose level surveillance. Current invasive techniques, such as finger-prick tests, often result in discomfort, leading to infrequent monitoring and potential health complications. Researchers was to design a novel, portable, non-invasive system for diabetes detection using breath samples, named DiabeticSense, an affordable digital health device for early detection, to encourage immediate intervention. The device employed electrochemical sensors to assess volatile organic compounds in breath samples, whose concentrations differed between diabetic and non-diabetic individuals. The system merged vital signs with sensor voltages obtained by processing breath sample data to predict diabetic conditions.
  • 564
  • 29 Dec 2023
Topic Review
Bidirectional Relationship between Gut Dysbiosis, Anxiety and Depression
Inflammatory bowel disease represents one of the most life-altering gastrointestinal pathologies, with its multifactorial nature and unclear physiopathology. The most relevant clinical forms, ulcerative colitis and Crohn’s disease, clinically manifest with mild to severe flares and remission periods that alter the patient’s social, familial and professional integration. The chronic inflammatory activity of the intestinal wall determines severe modifications of the local environment, such as dysbiosis, enteric endocrine, nervous and immune system disruptions and intestinal wall permeability changes. These features are part of the gastrointestinal ecosystem that modulates the bottom-to-top signaling to the central nervous system, leading to a neurobiologic imbalance and clinical affective and/or behavioral symptoms. The gut-brain link is a bidirectional pathway and psychological distress can also affect the central nervous system, which will alter the top-to-bottom regulation, leading to possible functional digestive symptoms and local inflammatory responses. In the middle of this neuro-gastrointestinal system, the microbiome is a key player, as its activities offer basic functional support for both relays.
  • 554
  • 14 Sep 2023
Topic Review
Novel Therapeutic Devices in Heart Failure
Heart failure (HF) constitutes a significant clinical problem and is associated with a sizeable burden for the healthcare system. Numerous novel techniques, including device interventions, are investigated to improve clinical outcome. Interventions regarding autonomic nervous system imbalance, i.e., baroreflex activation therapy; vagus, splanchnic and cardiopulmonary nerves modulation; respiratory disturbances, i.e., phrenic nerve stimulation and synchronized diaphragmatic therapy; decongestion management, i.e., the Reprieve system, transcatheter renal venous decongestion system, Doraya, preCardia, WhiteSwell and Aquapass, are presented.
  • 543
  • 24 Feb 2023
Topic Review
BoNT-A Injection for Spinal Cord Injury
Lower urinary tract symptoms (LUTS), such as urgency, urinary incontinence, and/or difficulty voiding, hamper the quality of life (QoL) of patients with spinal cord injury (SCI). If not managed adequately, urological complications, such as urinary tract infection or renal function deterioration, may further deteriorate the patient’s QoL. Botulinum toxin A (BoNT-A) injection within the detrusor muscle or urethral sphincter yields satisfactory therapeutic effects for treating urinary incontinence or facilitating efficient voiding.
  • 520
  • 23 May 2023
Topic Review
Liquorice Toxicity
Renowned since ancient times for its medical properties, liquorice is nowadays mainly used for flavoring candies or soft drinks. Continuous intake of large amounts of liquorice is a widely known cause of pseudo-hyperaldosteronism leading to hypertension and hypokalemia. These manifestations are usually mild, although in some cases may generate life-threatening complications, i.e., arrhythmias, muscle paralysis, rhabdomyolysis, and coma. 
  • 516
  • 22 Sep 2023
Topic Review
Latest Findings in Metastatic Breast Cancer Research
Explore the latest findings in metastatic breast cancer research, including new insights and advancements in treatment options and patient outcomes.
  • 516
  • 13 Nov 2024
Topic Review
Tackling Infectious Diseases
Infectious diseases (IDs) are a leading cause of death. The diversity and adaptability of microbes represent a continuing risk to health.
  • 502
  • 13 Mar 2024
Topic Review
Sleep Apnea and Hypersomnia: How Are They Related
Learn the connection between sleep apnea and hypersomnia, and how they impact sleep and health.
  • 501
  • 29 Nov 2024
Topic Review
Weight Management on the Level of Primary Healthcare
Obesity is a complex disease that, like COVID-19, has reached pandemic proportions. Consequently, it has become a rapidly growing scientific field, represented by an extensive body of research publications.
  • 488
  • 26 Dec 2023
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