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Topic Review
Lymphangiogenesis Induction to Accelerate Wound Healing
As the role of lymphangiogenesis in wound healing becomes more and more evident, the question of its induction in the case of chronic wounds in order to increase healing may also arise. Despite the importance of lymphangiogenesis as a therapeutic target, there are still few experimental models to trace and study this process in vivo. An example, however, are the different lines of transgenic mice used for the fluorescent visualization of the recently reported lymphatic vessels. All these lines are based on BAC transgenic constructs targeted to the gene to express GFP, mOrange, or Tomato, fluorescent proteins under the transcriptional control of Prox-1, using VEGFR-3 as a lymphatic marker. The application of pharmacological concentrations of purified polypeptide growth factors, cytokines, and matrix molecules has resulted in the acceleration of normal repair in a wide variety of skin wound models. It would be interesting to consider the use of drugs that can modulate lymphangiogenesis. At the moment, there are both drugs capable of inhibiting lymphangiogenesis, mainly used for the treatment of neoplasms, and drugs capable of increasing this phenomenon on the market. Below is a short list of these drugs, divided into inhibitors and inducers of lymphangiogenesis. Thus far, different drugs have shown effects.
  • 568
  • 06 Mar 2023
Topic Review
Real-Time Medical Diagnostic Equipment of Triboelectric Nanogenerators
The vast majority of diseases cause a gradual deterioration in the patient over time, and the rapid detection and treatment of diseases in their early stages can not only greatly reduce the investment in medical treatment required for patients, but also effectively reduce the severity of sequelae. TENG-based real-time medical monitoring equipment can provide a variety of physiological data measurements of the human body over a long time. And the equipment has different outputs with different raw materials and testing positions. Through terminal data analysis and processing, diseases can be quickly diagnosed, and personalized treatment plans can be provided for patients, effectively improving the use of medical resources.
  • 567
  • 23 Dec 2022
Topic Review
Imaging Techniques Used in Fish Bioimages
Detecting skeletal or bone-related deformities in model and aquaculture fish is vital for numerous biomedical studies. In biomedical research, model fish with bone-related disorders are potential indicators of various chemically induced toxins in their environment or poor dietary conditions. In aquaculture, skeletal deformities are affecting fish health, and economic losses are incurred by fish farmers. 
  • 567
  • 09 Jan 2024
Topic Review
Effects of PACAP on Schwann Cells
Schwann cells, the most abundant glial cells of the peripheral nervous system, represent the key players able to supply extracellular microenvironment for axonal regrowth and restoration of myelin sheaths on regenerating axons. Following nerve injury, Schwann cells respond adaptively to damage by acquiring a new phenotype. In particular, some of them localize in the distal stump to form the Bungner band, a regeneration track in the distal site of the injured nerve, whereas others produce cytokines involved in recruitment of macrophages infiltrating into the nerve damaged area for axonal and myelin debris clearance. Several neurotrophic factors, including pituitary adenylyl cyclase-activating peptide (PACAP), promote survival and axonal elongation of injured neurons. 
  • 564
  • 08 Mar 2024
Topic Review
Precision Vaccinology Approaches for Adjuvanted Vaccines
Infection persists as one of the leading global causes of morbidity and mortality, with particular burden at the extremes of age and in populations who are immunocompromised or suffer chronic co-morbid diseases. By focusing discovery and innovation efforts to better understand the phenotypic and mechanistic differences in the immune systems of diverse vulnerable populations, emerging research in precision vaccine discovery and development has explored how to optimize immunizations across the lifespan. 
  • 541
  • 07 Oct 2023
Topic Review
Fluorescence Confocal Microscopy in Urological Malignancies
Fluorescence confocal microscopy (FCM) represents a novel diagnostic technique able to provide real-time histological images from non-fixed specimens. As a consequence of its recent developments, FCM is gaining growing popularity in urological practice. 
  • 483
  • 17 Jan 2024
Topic Review
Epigenetics of BC and the Role of miR-125
Breast Cancer (BC) is one of the most common cancer types worldwide, and it is characterized by a complex etiopathogenesis, resulting in an equally complex classification of subtypes. MicroRNA (miRNA or miR) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to tumor development and angiogenesis in different types of cancer. miR-125 is a highly conserved family of microRNAs whose members have also been found in nematodes (named lin-4 in 1993, the first miR described ever).
  • 422
  • 28 Feb 2024
Topic Review
The Mystery of Anterior ST-Segment Elevation
To report a rare case of acute coronary syndrome (ACS) with triple-vessel disease, in which the electrocardiographic (ECG) presentation was complicated by multivessel involvement and collateral circulation(CC). This report aims to elucidate the unique underlying pathophysiology—the "collateral steal" phenomenon—and highlight the diagnostic challenges in such complex presentations. A 59-year-old male presented with acute chest pain lasting 5.5 hours. The ECG demonstrated anterior ST-segment elevation (V1-V5) with inferior pathological Q waves, suggestive of acute anterior ST-segment elevation myocardial infarction (STEMI) and a prior inferior infarction. Coronary angiography confirmed triple-vessel disease: severe stenosis in the left anterior descending (LAD) and left circumflex arteries, along with a subtotal occlusive thrombus in the mid segment of the right coronary artery (RCA) (TIMI flow grade 1).CC from the LAD to the RCA territory was observed. Primary percutaneous coronary intervention (PCI) was performed on the RCA. Symptoms were promptly relieved following balloon angioplasty, accompanied by reversal of the collateral flow. Subsequent stenting of both the RCA and LAD was successfully completed. Follow-up ECG showed complete resolution of the ST-segment elevation with evolving T-wave changes. This case illustrates a rare manifestation where acute RCA occlusion, in the setting of multivessel disease, precipitated acute severe anterior wall ischemia via a "collateral steal" mechanism. The absence of acute ST-segment elevation in the territory of the old inferior infarction, likely due to myocardial scar and collateral protection, underscores the complexity of ECG interpretation in multivessel acute coronary events and carries significant implications for clinical diagnosis.
  • 7
  • 08 Apr 2026
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