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Topic Review
Wilson’s Disease
Wilson disease (WD) is a rare disorder caused by mutations in ATP7B, which leads to a defective biliary excretion of copper. Subsequent gradual accumulation of copper in different organs produces an extremely variable clinical picture, which comprises hepatic, neurological psychiatric, ophthalmological, and other disturbances. WD has specific treatment, so that early diagnosis is crucial in order to avoid the progression of the disease and its devastating consequences. The clinical diagnosis of WD is based on the Leipzig scale, which considers clinical, histological, biochemical and genetic data. However, even patients with an initial WD diagnosis based on a high Leipzig score result to suffer from other condition that mimics the WD’s phenotype (Wilson-like).
  • 2.0K
  • 22 Sep 2021
Topic Review
Liver Metastatic Breast Cancer
The median overall survival of patients with metastatic breast cancer is only 2–3 years, and for patients with untreated liver metastasis, it is as short as 4–8 months. Improving the survival of women with breast cancer requires more effective anti-cancer strategies, especially for metastatic disease. Nutrients can influence tumor microenvironments, and cancer metabolism can be manipulated via dietary modification to enhance anti-cancer strategies. Yet, there are no standard evidence-based recommendations for diet therapies before or during cancer treatment, and few studies provide definitive data that certain diets can mediate tumor progression or therapeutic effectiveness in human cancer. This review focuses on metastatic breast cancer, in particular liver metastatic forms, and recent studies on the impact of diets on disease progression and treatment.
  • 2.0K
  • 22 Jul 2022
Topic Review
Mechanobiology of Chondrocytes
This entry is associated with a review article, published in MDPI Applied Sciences on 23 April 2020, about the current knowledge on the mechanical stimulation of mesenchymal stem cells for cartilage regeneration. Loading stresses, physiologically experienced by chondrocytes, regulate the production of glycosaminoglycan and collagen, as well as promote and preserve cell viability. Therefore, there is a rising interest in the development of devices that impose mechanical stimuli, such as compression and shear stress, on mesenchymal stem cells. The mentioned review will analyze the dynamics within the joint, the physiological stimuli experienced by the chondrocytes, and how the biomechanical stimulation can be applied to a stem cell culture in order to induce chondrogenesis. In addition to that, paper lists some of the current applications in the field.
  • 2.0K
  • 29 Oct 2020
Topic Review
Ultraviolet Reactors for Nonsolid Food Pasteurization
UV-C is an increasingly popular option for the pasteurization of non-solid plant-based foods because it is germicidal, economical, and environmentally-friendly. It is a proven alternative to conventional thermal processes for inactivating microorganisms.UV-C irradiation in nonsolid foods can be performed in equipment that either uses batch or continuous operation modes.
  • 2.0K
  • 30 Aug 2023
Topic Review
Plants Secondary Metabolites
Plant secondary metabolites were reported to inhibit carbohydrate metabolizing enzymes, possess kinase activating capacity, thereby affecting all the metabolic pathways of carbohydrate, lipid and protein, and can intervene in the insulin-signaling pathway, inflammatory response, and oxidative stress and restore molecular aberrations leading to insulin resistance and glucose intolerance.
  • 2.0K
  • 09 Oct 2021
Topic Review
Superficial Heat Therapy
Low back pain (LBP) is an exceptionally common musculoskeletal problem and a leading cause of disability. LBP is experienced by most adults at some stage of their life, with an estimated 577 million people affected in 2017. A recent systematic literature review stated that the prevalence of LBP ranges from 1.4% to 20.0%, and the incidence from 0.024% to 7.0%. The review focused on the application and effect of mild superficial heat for musculoskeletal pain, especially back pain. The review was able to show that the application of mild heat is easily applicable and effective when indicated.
  • 2.0K
  • 20 Aug 2021
Topic Review
The Evaluation Role of the Ground-Penetrating Radar
Ground-Penetrating Radar (GPR) is a popular non-destructive technique for evaluating RC bridge elements as it can identify major subsurface defects within a short span of time.
  • 2.0K
  • 01 Apr 2022
Topic Review
Zirconolite and Murataite for the Immobilization of Actinides
Zirconolite is highly stable in nature, with isotope systems that have been closed for hundreds of million years, making it possible for age determination. Murataite is a very rare mineral, its synthetic counerpart was first discovered in the Synroc matrix from defense waste obtained by sintering. Synthetic zirconolie and murataite can be applied for nuclear waste immobilization. 
  • 2.0K
  • 14 Sep 2022
Topic Review
Mental Disorders Diagnosed in Childhood
Mental disorders diagnosed in childhood are divided into two categories: childhood disorders and learning disorders. These disorders are usually first diagnosed in infancy, childhood, or adolescence, as laid out in the DSM-IV-TR and in the ICD-10. The DSM-IV-TR includes ten subcategories of disorders including mental retardation, Learning Disorders, Motor Skills Disorders, Communication Disorders, Pervasive Developmental Disorders, Attention-Deficit and Disruptive Behavior Disorders, Feeding and Eating Disorders, Tic Disorders, Elimination Disorders, and Other Disorders of Infancy, Childhood, or Adolescence.
  • 2.0K
  • 28 Nov 2022
Topic Review
Dopamine and Related Drugs as Anti-Inflammatories and Antioxidants
Dopamine (DA), its derivatives, and dopaminergic drugs are compounds widely used in the management of diseases related to the nervous system. However, DA receptors have been identified in nonneuronal tissues, which has been related to their therapeutic potential in pathologies such as sepsis or septic shock, blood pressure, renal failure, diabetes, and obesity, among others. In addition, DA and dopaminergic drugs have shown anti-inflammatory and antioxidant properties in different kinds of cells. 
  • 2.0K
  • 21 Jun 2023
Topic Review
Very-High-Temperature Reactor
The very-high-temperature reactor (VHTR), or high-temperature gas-cooled reactor (HTGR), is a Generation IV reactor concept that uses a graphite-moderated nuclear reactor with a once-through uranium fuel cycle. The VHTR is a type of high-temperature reactor (HTR) that can conceptually have an outlet temperature of 1000 °C. The reactor core can be either a "prismatic block" (reminiscent of a conventional reactor core) or a "pebble-bed" core. The high temperatures enable applications such as process heat or hydrogen production via the thermochemical sulfur–iodine cycle.
  • 2.0K
  • 16 Nov 2022
Topic Review
Nanocellulose Hybrids with Magnetic Nanoparticles
Cellulose is one of the most affordable, sustainable and renewable resources, and has attracted much attention especially in the form of nanocellulose. Bacterial cellulose, cellulose nanocrystals or nanofibers may serve as a polymer support to enhance the effectiveness of metal nanoparticles. The resultant hybrids are valuable materials for biomedical applications due to the novel optical, electronic, magnetic and antibacterial properties. In particular, superparamagnetic iron oxides nanoparticles with very small size (SPIONs) are non-toxic in small concentration, biodegradable and biocompatible and display a high magnetic resonance imaging (MRI) contrast effect. However, for biomedical applications, SPIONs need to be covered by a biocompatible shell to prevent aggregation or degradation and to delay the immune response. Nanocellulose proved to be an excellent biocompatible matrix for SPIONs in MRI applications.
  • 2.0K
  • 08 Sep 2020
Topic Review
Metabolomics
Metabolomics is the latest trend in the “-omics” sciences, of which technologies are widely used today in all life sciences. Metabolomics gave impetus to the description of biochemical processes that occur in many organisms by means of measuring of low molecular compounds by high-throughout technologies, search for new biomarkers of disease, and laid the foundation for new clinical laboratory diagnostics. The purpose of this entry is to show how metabolomics is represented in the science and to demonstrate the successes and main achievements of scientists in this field.
  • 2.0K
  • 15 Feb 2021
Topic Review
Food Fraud Detection by LPAS
Economically motivated adulterations of food, in general, and spices, in particular, are an emerging threat to world health. Reliable techniques for the rapid screening of counterfeited ingredients in the supply chain need further development. Building on the experience gained with CO2 lasers, the Diagnostic and Metrology Laboratory of ENEA realized a compact and user-friendly photoacoustic laser system for food fraud detection, based on a quantum cascade laser. The sensor has been challenged with saffron adulteration. Multivariate data analysis tools indicated that the photoacoustic laser system was able to detect adulterants at mass ratios of 2% in less than two minutes.
  • 2.0K
  • 28 Jun 2021
Topic Review
Hyperacusis in Autism Spectrum Disorders
Decreased Sound Tolerance Disorders (DSTD) are routinely observed in autism spectrum disorder (ASD). The most common types of DSTD are hyperacusis and misophonia. Hyperacusis is a class of decreased sound tolerance disorders in which a negative or incongruous reaction is triggered from exposure to sounds that are not described as threatening or uncomfortable by a neurotypical individual. These reactions are in response to general sounds, rather than specific sounds (such as chewing and sniffling), as would be the case with misophonia. Hyperacusis can affect an individual at various degrees depending on the severity. It can impact one’s emotional wellbeing, sleep, concentration, and can cause anxiety.
  • 2.0K
  • 11 Nov 2021
Topic Review
Shea Butter Tree for Nutritional Value
Vitellaria paradoxa (C.F.Gaertn.) is a multi-purpose tree species distributed in a narrow band across sub-Saharan Africa. The species is integrated into cropping and agroforestry systems as a nutritional and economic resource, which provides a range of environmental services. Integration of the species into land-use systems provides an essential source of livelihoods and income for local populations. The economic potential of the shea butter tree derives from its edible products, which also serve cosmetic and pharmaceutical applications.
  • 2.0K
  • 20 Dec 2021
Topic Review
Arthrocnemum indicum (Willd.) Moq. Extracts
Aromatic medicinal plants (AMP) with multiple targets might play a role in drug discovery and development due to their potential health-promoting effects and are a source of new pharmaceutical substances.
  • 2.0K
  • 30 Jan 2022
Topic Review
Hearing Aid Application
Hearing aid application (HAA) is software which, when installed on a mobile computational platform, helps with hearing. Mobile devices may include smartphones, tablets or smart watch.
  • 2.0K
  • 08 Oct 2022
Topic Review
Health Benefits of Mentha
A poor diet, resulting in malnutrition, is a critical challenge that leads to a variety of metabolic disorders, including obesity, diabetes, and cardiovascular diseases. Mentha species are famous as therapeutic herbs and have long served as herbal medicine. Recently, the demand for its products, such as herbal drugs, medicines, and natural herbal formulations, has increased significantly.
  • 2.0K
  • 28 Oct 2022
Topic Review
ISO Image
An ISO image is a disk image of an optical disc. In other words, it is an archive file that contains everything that would be written to an optical disc, sector by sector, including the optical disc file system. ISO image files bear the .iso filename extension. The name ISO is taken from the International Organization for Standardization (ISO) ISO 9660 file system used with CD-ROM media, but what is known as an ISO image might also contain a UDF (ISO/IEC 13346) file system (commonly used by DVDs and Blu-ray Discs). ISO images can be created from optical discs by disk imaging software, or from a collection of files by optical disc authoring software, or from a different disk image file by means of conversion. Software distributed on bootable discs is often available for download in ISO image format. And like any other ISO image, it may be written to an optical disc such as CD or DVD.
  • 2.0K
  • 07 Nov 2022
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