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Topic Review
A Structural Approach to Anti-Virulence
The anti-virulence strategy is designed to prevent bacterial virulence factors produced by pathogenic bacteria from initiating and sustaining an infection. 
  • 1.1K
  • 16 Dec 2021
Topic Review
The anticancer properties of Oligonucleotides
       Telomerase provides cancer cells with replicative immortality, and its overexpression serves as a near-universal marker of cancer. Oligonucleotide-based therapies that inhibit telomerase through direct or indirect modulation of its subunits, human telomerase reverse transcriptase (hTERT) and human telomerase RNA gene (hTERC), are a unique and diverse subclass of telomerase inhibitors which hold clinical promise. 
  • 1.1K
  • 25 Aug 2020
Topic Review
Desmin Intermediate Filaments
Desmin intermediate filaments (IFs) is one of cytoskeleton components of muscle cells and play an important role in maintaining their structural and functional integrity .Disturbance of their network due to desmin mutations or deficiency leads to an infringement of myofibril organization and to a deterioration of mitochondrial distribution, morphology, and functions. The nature of the interaction of desmin IFs with mitochondria is not clear. To elucidate the possibility that desmin can directly bind to mitochondria, we have undertaken the study of their interaction in vitro. Using desmin mutant Des(Y122L) that forms unit-length filaments (ULFs) but is incapable of forming long filaments and, therefore, could be effectively separated from mitochondria by centrifugation through sucrose gradient, we probed the interaction of recombinant human desmin with mitochondria isolated from rat liver. Our data show that desmin can directly bind to mitochondria, and this binding depends on its N-terminal domain. We have found that mitochondrial cysteine protease can disrupt this interaction by cleavage of desmin at its N-terminus.
  • 1.1K
  • 04 Nov 2020
Topic Review
Brain-specific angiogenesis inhibitor 1 (BAI1)
Brain-specific angiogenesis inhibitor 1 (BAI1/ADGRB1) is an adhesion G protein-coupled receptor that has been found to play key roles in phagocytosis, inflammation, synaptogenesis, the inhibition of angiogenesis, and myoblast fusion.     
  • 1.1K
  • 26 Jul 2021
Topic Review
Biological Properties of Essential Oils
Essential oils (EOs) are a mixture of natural, volatile, and aromatic compounds obtained from plants. In recent years, several studies have shown that some of their benefits can be attributed to their antimicrobial, antioxidant, anti-inflammatory, and also immunomodulatory properties. Therefore, EOs have been proposed as a natural alternative to antibiotics or for use in combination with antibiotics against multidrug-resistant bacteria in animal feed and food preservation. 
  • 1.1K
  • 29 Jul 2021
Topic Review
Mechanisms of Neutrophil Activation
Neutrophil extracellular traps (NETs) are major contributors to inflammation and autoimmunity, playing a key role in the development of thrombotic disorders. NETs, composed of DNA, histones, and numerous other proteins serve as scaffolds for thrombus formation and promote platelet activation, coagulation, and endothelial dysfunction.
  • 1.1K
  • 03 Nov 2023
Topic Review
Sources of Reactive Oxygen Species
Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the cellular anti-oxidant defense mechanisms, plays a critical role in the pathogenesis of various human diseases. ROS are either produced through cellular processes or environmental factors. Of note, oxidative stress has been described as a secondary effect within the pathology of several rare monogenic diseases and sometimes been called a common denominator. 
  • 1.1K
  • 26 Feb 2024
Topic Review
MEIS1 in Hematopoiesis and Cancer
MEIS1 is highly expressed in the bone marrow, and its predominant and better-known role is in embryonic and adult hematopoiesis. Along withPBX1 and HOXA9, MEIS1 is expressed in hematopoietic stem cells (HSCs) but downregulated during their differentiation.
  • 1.1K
  • 27 Oct 2021
Topic Review
JmjC Domain-Containing Proteins
Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells. In particular, many myeloid malignancies show evidence of epigenetic dysregulation.
  • 1.1K
  • 13 Jan 2022
Topic Review
Fruit Plants in the Management of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by a lack of insulin action and/or generation. Discrepancies in protein, carbohydrate, and lipid metabolism can emerge due to the insufficiency of insulin. Low insulin levels, insulin resistance in target tissues, insulin-receptor expression, especially in adipose tissue and skeletal muscles, and to a lesser extent in the liver, effector enzymes, and/or signal transduction system all can play vital roles in metabolic disorders. Herbal products, such as fruit, seed, bark, fruit peel, and leaf, are always considered as promising sources of bioactive phytochemicals to treat different ailments including diabetes, pain, fever, cancer, hypertension, and so on. Phytomedicines are believed to be sanctified with lesser side effect, and thus, almost 80% of drug moieties are directly plant-extracted or their modified versions. Fruits are one of the most notable natural sources which provide fiber, minerals, vitamins, and many other essential nutrients which are included in daily diets. Fruits are also rich sources of flavonoids, saponins, polyphenols, carotenoids, isothiocyanates, and several other bioactive phytochemicals. Fruits are thought to be useful in the management of diabetes, cancer, obesity, and other disease states, including cardiovascular complications. From ancient Chinese therapies to modern approaches, local fruits are heavily incorporated to treat diabetic patients. Ayurveda medicines in the Indian subcontinent, including Bangladesh, also use a wide variety of locally produced fruits. It is believed that fruits and other plant parts can exhibit antidiabetic potential through several mechanism of actions.
  • 1.1K
  • 15 Dec 2022
Topic Review
Biological Activities of Some Species of Genus Eryngium
There are approximately 250 species of Eryngium L. distributed throughout the world, with North America and South America being centers of diversity on this continent. In the central-western region of Mexico there may be around 28 species of this genus. Some Eryngium species are cultivated as leafy vegetables, ornamental, and medicinal plants. In traditional medicine they are used to treat respiratory and gastrointestinal conditions, diabetes, and dyslipidemia, among others. 
  • 1.1K
  • 30 May 2023
Topic Review
RNA Structure and RNA–RNA Interactions
Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation. By contrast, the nature of these interactions and characteristics of their interfaces, especially those that involve partially or wholly structured RNAs, remain elusive. This entry describes different modalities of RNA–RNA interactions with an emphasis on those that depend on secondary, tertiary, or quaternary structure, and highlight a two-way relationship between RNA structure and interactions.
  • 1.1K
  • 12 Jan 2022
Topic Review
Antibody-Based Immunotherapy for Metastatic Melanoma
Melanoma is the least common form of skin cancer and is associated with the highest mortality. Where melanoma is mostly unresponsive to conventional therapies (e.g., chemotherapy), BRAF inhibitor treatment has shown improved therapeutic outcomes. Photodynamic therapy (PDT) relies on a light-activated compound to produce death-inducing amounts of reactive oxygen species (ROS). Their capacity to selectively accumulate in tumor cells has been confirmed in melanoma treatment with some encouraging results. However, this treatment approach has not reached clinical fruition for melanoma due to major limitations associated with the development of resistance and subsequent side effects. These adverse effects might be bypassed by immunotherapy in the form of antibody–drug conjugates (ADCs) relying on the ability of monoclonal antibodies (mAbs) to target specific tumor-associated antigens (TAAs) and to be used as carriers to specifically deliver cytotoxic warheads into corresponding tumor cells. Of late, the continued refinement of ADC therapeutic efficacy has given rise to photoimmunotherapy (PIT) (a light-sensitive compound conjugated to mAbs), which by virtue of requiring light activation only exerts its toxic effect on light-irradiated cells.
  • 1.1K
  • 26 Oct 2020
Topic Review
The Proteasome Activator PA200/PSME4
Proteasomes comprise a family of proteasomal complexes essential for maintaining protein homeostasis. Accordingly, proteasomes represent promising therapeutic targets in multiple human diseases. Several proteasome inhibitors are approved for treating hematological cancers. Their side effects impede their efficacy and broader therapeutic applications. Therefore, understanding the biology of the different proteasome complexes present in the cell is crucial for developing tailor-made inhibitors against specific proteasome complexes. 
  • 1.1K
  • 09 Sep 2022
Topic Review
GPCR Reconstitution and Labeling for Solution NMR
G protein-coupled receptors (GPCRs) are a large membrane protein family found in higher organisms, including the human body. GPCRs mediate cellular responses to diverse extracellular stimuli and thus control key physiological functions, which makes them important targets for drug design. Signaling by GPCRs is related to the structure and dynamics of these proteins, which are modulated by extrinsic ligands as well as by intracellular binding partners such as G proteins and arrestins. 
  • 1.1K
  • 19 Jul 2022
Topic Review
Epigenetic Regulation in the Hematopoietic System
Epigenetic regulation of gene expression controls differentiation throughout all stages of hematopoiesis, and its disruption can result in disease. In the context of acute myeloid leukemia (AML), epigenetic dysregulation promotes aberrant gene expression in hematopoietic stem and progenitor cells, resulting in defective differentiation and leukemic transformation. 
  • 1.1K
  • 14 Dec 2022
Topic Review
Synthesis of Silver Nanostructure
Silver nanoparticles are one of the commonly used metal materials for SP because of their high sensitivity to refractive index change, convenient synthesis, and high controllable degree of shape and size. Silver nanoparticles of different sizes and shapes are used in many fields. Various synthesis methods have undergone many improvements over time and technological developments in order to provide precise control over the shape and size of the synthesized silver nanoparticles. Silver nanoparticle fabrication is usually divided into two categories: top-down and bottom-up.
  • 1.1K
  • 19 Apr 2023
Topic Review
ADAR-Mediated Site-Specific RNA Editing in Immune-Related Disease
ADAR (Adenosine Deaminases Acting on RNA) proteins are a group of enzymes that play a vital role in RNA editing by converting adenosine to inosine in RNAs. This process is a frequent post-transcriptional event observed in metazoan transcripts. Recent studies indicate widespread dysregulation of ADAR-mediated RNA editing across many immune-related diseases, such as human cancer. 
  • 1.1K
  • 09 Jan 2024
Topic Review
S-adenosyl-l-homocysteine Hydrolase
S-adenosyl-l-homocysteine hydrolase (SAHase) is a major regulator of cellular methylation reactions that occur in eukaryotic and prokaryotic organisms. SAHase activity is also a significant source of l-homocysteine and adenosine, two compounds involved in numerous vital, as well as pathological processes. Therefore, apart from cellular methylation, the enzyme may also influence other processes important for the physiology of particular organisms.
  • 1.1K
  • 17 Feb 2021
Topic Review
Carbon-Based Nanomolecules Interacting with Proteins
Scientists are designing new ways to combine proteins and carbon-based nanomomecules. We review strategies of selecting proteins able to interact with proteins and typical van der Waals interactions. Proteins and carbon based nanomomecules can form ordered clusters of hybrid materials and will guide new projects for bioimaging tools and tuning of intrinsically disordered proteins.
  • 1.1K
  • 27 Oct 2020
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