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Topic Review
Surface Water and Floods Detection with Multispectral Satellites
The use of multispectral satellite imagery for water monitoring is a fast and cost-effective method that can benefit from the growing availability of medium–high-resolution and free remote sensing data. Since the 1970s, multispectral satellite imagery has been exploited by adopting different techniques and spectral indices. The high number of available sensors and their differences in spectral and spatial characteristics led to a proliferation of outcomes that depicts a nice picture of the potential and limitations of each. 
  • 2.0K
  • 06 Dec 2022
Topic Review
Bacopa monnieri (L.) Wettst.
Bacopa monnieri has been used as a reputed drug in the Indian traditional ayurvedic system for centuries. This medicinal herb with important phytopharmaceuticals has been popularly known as “Brahmi”. In recent years, B. monnieri has been extensively studied for its bioactive constituents, constituents responsible for memory enhancing effect, and also its diverse other useful effects. It possesses many pharmacological activities such as antioxidant, gastrointestinal, endocrine, antimicrobial, anti-inflammatory etc. The plant has been also used for the treatment of neurological and neuropsychiatric diseases. Due to its multipurpose therapeutic potential, micropropagation using axillary meristems and de novo organogenesis has been extensively studied in the species and is being reviewed. High frequency direct shoot organogenesis can be induced in excised leaf and internode explants in the absence of exogenous phytohormones and the rate of induction is enhanced in the presence of exogenous cytokinins, supplements, growth regulators, etc. Using explants from tissue culture raised plants, direct shoot regeneration leading to production of more than 100 rooted plants/explant within 8–12 weeks period with 85%–100% survival in the field after acclimatization can be expected following optimized protocols. Bioreactor based micropropagation was found to increase the multiplication rate of shoot cultures for the commercial propagation of B. monnieri plants. The maximum content of bacosides has been recorded in shoot biomass using an airlift bioreactor system. Further studies for the biosynthesis of bacosides and other secondary metabolites need to be conducted in the species utilizing untransformed shoot cultures in bioreactors.
  • 2.0K
  • 28 Oct 2020
Topic Review
Microbiota and Endometriosis
Imbalances in gut and reproductive tract microbiota composition, known as dysbiosis, disrupt normal immune function, leading to the elevation of proinflammatory cytokines, compromised immunosurveillance and altered immune cell profiles, all of which may contribute to the pathogenesis of endometriosis. Over time, this immune dysregulation can progress into a chronic state of inflammation, creating an environment conducive to increased adhesion and angiogenesis, which may drive the vicious cycle of endometriosis onset and progression. Recent studies have demonstrated both the ability of endometriosis to induce microbiota changes, and the ability of antibiotics to treat endometriosis. Endometriotic microbiotas have been consistently associated with diminished Lactobacillus dominance, as well as the elevated abundance of bacterial vaginosis-related bacteria and other opportunistic pathogens. Possible explanations for the implications of dysbiosis in endometriosis include the Bacterial Contamination Theory and immune activation, cytokine-impaired gut function, altered estrogen metabolism and signaling, and aberrant progenitor and stem-cell homeostasis. 
  • 2.0K
  • 23 Jun 2021
Topic Review
Oral Semaglutide
The gastrointestinal tract secretes gut hormones in response to food consumption, and some of these stimulate insulin secretion. Glucagon-like peptide-1 (GLP-1) is an incretin peptide hormone released from the lower digestive tract that stimulates insulin secretion, suppresses glucagon secretion, and decreases hunger. GLP-1 receptor agonist (GLP-1RA) mimics the action of endogenous GLP-1, consequently reversing hyperglycemia and causing weight reduction, demonstrating its efficacy as an antidiabetic and antiobesity agent. Previously restricted to injection only, the invention of the absorption enhancer sodium N-(8-[2-hydroxybenzoyl]amino) caprylate resulted in the development of oral semaglutide, the first ingestible GLP-1RA. Oral semaglutide demonstrated its efficacy in glycemic management and body weight loss with a low risk of hypoglycemia as a monotherapy and in combination with other hypoglycemic medications in its clinical trial programs named Peptide Innovation for Early Diabetes Treatment. Consistent with other injectable GLP-1RAs, gastrointestinal side effects were often reported. Additionally, cardiovascular safety was established by demonstrating that oral semaglutide was not inferior to placebo in terms of cardiovascular outcomes. Thus, oral semaglutide represents a novel treatment option that is particularly well-suited for patients with type 2 diabetes and/or obesity.
  • 2.0K
  • 13 Oct 2021
Topic Review
Essential Oils Effect on Cucumber Powdery Mildew
Essential oils of lemongrass, lemon, thyme, peppermint, abundance blend, purification blend, and thieves blend were tested in vitro and under greenhouse conditions in two separate experiments. The effects of essential oils were tested against powdery mildew disease at concentrations of 1.0–2.5 mL/L, and the consequent impact of the oils on plant growth was evaluated. Powdery mildew fungus, Podosphaera xanthii, was identified using sequencing of the ITS region. The essential oils significantly reduced disease incidence up to 77.3% compared with the positive control (p < 0.5). 
  • 2.0K
  • 07 Dec 2021
Topic Review
Traditional Visual Simultaneous Localization and Mapping
Simultaneous Localization and Mapping (SLAM) was first applied in the field of robotics. Its goal is to build a real-time map of the surrounding environment based on sensor data without any prior knowledge, and at the same time predict its own location based on the map. SLAM has attracted extensive attention from many researchers since it was first proposed in 1986 and is now a necessary capability for autonomous mobile robots.
  • 2.0K
  • 04 Jul 2022
Topic Review
FreedomWorks
FreedomWorks is a conservative and libertarian advocacy group based in Washington D.C., United States . FreedomWorks trains volunteers, assists in campaigns, and encourages them to mobilize, interacting with both fellow citizens and their political representatives. It is widely associated with the Tea Party movement.
  • 2.0K
  • 10 Oct 2022
Topic Review
Life Support System
A life support system is the combination of equipment that allows survival in an environment or situation that would not support that life in its absence. It is generally applied to systems supporting human life in situations where the outside environment is hostile, like in space or underwater, or medical situations where the health of the person is compromised to the extent that the risk of death would be high without the function of the equipment. In human spaceflight, a life support system is a group of devices that allow a human being to survive in space. US government space agency NASA, and private spaceflight companies use the term environmental control and life support system or the acronym ECLSS when describing these systems. The life support system may supply air, water and food. It must also maintain the correct body temperature, an acceptable pressure on the body and deal with the body's waste products. Shielding against harmful external influences such as radiation and micro-meteorites may also be necessary. Components of the life support system are life-critical, and are designed and constructed using safety engineering techniques. In underwater diving, the breathing apparatus is considered to be life support equipment, and a saturation diving system is considered a life support system – the personnel who are responsible for operating it are called life support technicians. The concept can also be extended to submarines, crewed submersibles and atmospheric diving suits, where the breathing gas requires treatment to remain respirable, and the occupants are isolated from the outside ambient pressure and temperature. Medical life support systems include heart-lung machines, medical ventilators and dialysis equipment.
  • 2.0K
  • 18 Oct 2022
Topic Review
Constructed Wetlands as a Sustainable Sanitation Solution
The application of nature-based solutions (NBSs) in treating wastewater are treatment wetlands or constructed wetlands (CW). CWs are natural treatment technologies that efficiently treat many different types of wastewater (domestic wastewater, agricultural wastewater, coal drainage wastewater, petroleum refinery wastewater, compost and landfill leachates, fish-pond discharges, industrial wastewater from pulp and paper mills, textile mills, seafood processing). CWs can effectively treat raw wastewater to different levels of treatments and can be used as a primary, secondary, or tertiary treatment. CWs are engineered systems designed to optimize and copy processes found in natural environments thus they are considered as sustainable, environmentally friendly options for wastewater treatment. CWs have low operational and maintenance requirements and have a stable performance with less vulnerability to inflow variation. CWs have proved their ability to treat several types of wastewaters. Several benefits and facts, such as the low construction and operational costs of CWs, low-energy, and less operational requirements, have raised the interests in CWs as a treatment technology. The sustainability of CWs as a sanitation solution (technical, financial, environmental sustainability) is described with a focus on integrating climate change resilience and a circular economic approach to the technical and financial sustainability.
  • 2.0K
  • 22 Nov 2022
Topic Review
Gravitational Two-Body Problem
The gravitational two-body problem concerns the motion of two point particles that interact only with each other, due to gravity. This means that influences from any third body are neglected. For approximate results that is often suitable. It also means that the two bodies stay clear of each other, that is, the two do not collide, and one body does not pass through the other's atmosphere. Even if they do, the theory still holds for the part of the orbit where they don't. Apart from these considerations a spherically symmetric body can be approximated by a point mass. Common examples include the parts of a spaceflight where the spacecraft is not undergoing propulsion and atmospheric effects are negligible, and a single celestial body overwhelmingly dominates the gravitational influence. Other common examples are the orbit of a moon around a planet, and of a planet around a star, and two stars orbiting each other (a binary star).
  • 2.0K
  • 25 Nov 2022
Topic Review
Logic Gates and Molecular Logic Gates
Logic gates are devices used to perform binary arithmetic and logical operations and thus constitute the basis of modern computers. They perform Boolean logic operations on one or more inputs to produce an output. Molecular switches convert input stimulations into output signals. Therefore, the principles of binary logic can be applied to the signal transduction operated by molecular switches. The presence of various ions, neutral species, pH, temperature, and viscosity, among many others, result in color or emission changes due to the complex interplay of many excited state processes and environmental parameters. In this entry, basic logic gates are defined, and their types are given, while examples of molecular logic gates are also presented.
  • 2.0K
  • 29 Mar 2024
Topic Review
Structural Health Monitoring Damage Classification and System Models
Structural health monitoring (SHM) is a field of science that focuses its efforts on evaluating and monitoring the integrity of a structure of interest.
  • 2.0K
  • 07 Nov 2022
Topic Review
Technological Uses of Thioketal in Drug Delivery Systems
To take advantage of ROS-specific cleavage, different technological uses of Thioketal (TK) functional group have been proposed in the design of selective and improved “smart” nanosystems, including as linker to connect a drug on the surface of nanoparticles, form prodrugs, as a core component of the Drug Delivery System (DDS) to directly control its structure, to control the opening of drug-releasing gates or to change the conformation of the nano-systems. This allows to overcome the major limitations of conventional DDS counterparts, including uncontrolled drug release and off-target effects, by controlling the degradation kinetics, drug release kinetics, or even increasing potential administration routes. 
  • 2.0K
  • 01 Mar 2022
Topic Review
Dickeya dadantii
Dickeya dadantii is a gram-negative bacillus that belongs to the family Enterobacteriaceae. It was formerly known as Erwinia chrysanthemi but was reassigned as Dickeya dadantii in 2005. Members of this family are facultative anaerobes, able to ferment sugars to lactic acid, have nitrate reductase, but lack oxidases. Even though many clinical pathogens are part of the Enterobacteriaceae family, most members of this family are plant pathogens. D. dadantii is a motile, nonsporing, straight rod-shaped cell with rounded ends. Cells range in size from 0.8 to 3.2 μm by 0.5 to 0.8 μm and are surrounded by numerous flagella (peritrichous). In the natural plant environment, D. dadantii causes plant maladies such as necrosis, blight and “soft rot,” which is a progressive tissue maceration. D. dadantii contains many pectinases that are able to macerate and break down the plant cell wall material. This exposed part of the plant releases nutrients that can facilitate bacterial growth. Commonly infected plants include potato tubers, bulbs of vegetables, and ornamental crops.
  • 2.0K
  • 11 Oct 2022
Topic Review
Forensic Podiatry
Forensic Podiatry is a subdiscipline of forensic science in which specialized podiatric knowledge including foot and lower limb anatomy, musculoskeletal function, deformities and diseases of the foot, ankle, lower extremities, and at times, the entire human body is used in the examination of foot-related evidence in the context of a criminal investigation. Forensic Podiatry has been defined as: The application of sound and researched podiatry knowledge and experience in forensic investigations, to show the association of an individual with a scene of crime, or to answer any other legal question concerned with the foot or footwear that requires knowledge of the functioning foot. Those who specialize in this field need to have gained knowledge and experience in podiatry and also in forensic science and practice. Forensic Podiatry is usually used to assist in the process of human identification, but can also be employed to help address issues relating to questions that have arisen within the context of forensic enquiry. Such questions could include whether or not a shoe could have had multiple wearers, what the effects of a shoe not fitting correctly could have been, whether or not someone could have placed their foot into a shoe that was too small for the postulated wearer's foot and other matters involving the podiatric interpretation of relevant evidential materials.
  • 2.0K
  • 01 Dec 2022
Topic Review
Digital Twin in the Maritime Domain
In the present world, simulation has become an integral part of system development for every engineering discipline. Starting from solving design problems using numerical algorithms in the 1960s, simulation has taken us to the digital era where simulation is integrated into the life cycle of the particular product including design, testing, manufacturing, commissioning, operating, and decommissioning. This process of evolution has opened the pathway to DT which is more versatile and dynamic than the physical twin concept. Ever since, the concept of Digital Twin (DT) has become a reality expanding its outreach to various disciplines around the world including the maritime domain. The novel concept of the DT was first proposed in the year 2002 by Dr Michael Grieves, a leading scientist in the field of advanced manufacturing at the Florida Institute of Technology at a manufacturing engineers conference in Troy, Michigan. His idea was based on constructing digital information on the physical model on his own. This digital information is a replica of the data embedded in the physical system which will be connected with the physical system in the complete life cycle of a particular system/component.
  • 2.0K
  • 24 May 2023
Topic Review
Cannabinoid Receptors
Spermatogenesis is a highly coordinated process that begins with division of spermatogonia, followed by meiosis to produce haploid spermatids, and finally the differentiation of haploid spermatids into mature spermatozoa. Several stages of male germ cell development are regulated by epigenetic mechanisms that are important for correct gamete development and functions.  The use of  Cannabis sativa has been demonstrated to induce spermatogenesis dysfunctions. Cannabis sativa (Marijuana) exerts its effect by binding to and activating  cannabinoid receptors CB1 and CB2 . In males, both the receptors CB1 and CB2, are involved in male germ cell development.  Here we will discuss on the importance of cannabinoid receptors signaling in the regulation of several stages of male germ cell development and their role in mediating epigenetic modifications that may be transmitted to the next generation by sperm.
  • 2.0K
  • 31 Jul 2020
Topic Review
Extreme Microorganisms in the Context of Biogeochemical Nitrogen Cycle
Extreme microorganisms (extremophile) are organisms that inhabit environments characterized by inhospitable parameters for most live beings (extreme temperatures and pH values, high or low ionic strength, pressure, or scarcity of nutrients). To grow optimally under these conditions, extremophiles have evolved molecular adaptations affecting their physiology, metabolism, cell signaling, etc. Due to their peculiarities in terms of physiology and metabolism, they have become good models for (i) understanding the limits of life on Earth, (ii) exploring the possible existence of extraterrestrial life (Astrobiology), or (iii) to look for potential applications in biotechnology. Recent research has revealed that extremophilic microbes play key roles in all biogeochemical cycles on Earth. Nitrogen cycle (N-cycle) is one of the most important biogeochemical cycles in nature; thanks to it, nitrogen is converted into multiple chemical forms, which circulate among atmospheric, terrestrial and aquatic ecosystems. This review summarizes recent knowledge on the role of extreme microorganisms in the N-cycle in extremophilic ecosystems, with special emphasis on members of the Archaea domain. Potential implications of these microbes in global warming and nitrogen balance, as well as their biotechnological applications are also discussed.
  • 2.0K
  • 17 Jun 2020
Topic Review
Modular CAR T Platforms
The engineering of T cells through expression of chimeric antigen receptors (CARs) against tumor-associated antigens (TAAs) has shown significant potential for use as an anti-cancer therapeutic. The development of strategies for flexible and modular CAR T systems is accelerating, allowing for multiple antigen targeting, precise programming, and adaptable solutions in the field of cellular immunotherapy. Moving beyond the fixed antigen specificity of traditional CAR T systems, the modular CAR T technology splits the T cell signaling domains and the targeting elements through use of a switch molecule. The activity of CAR T cells depends on the presence of the switch, offering dose-titratable response and precise control over CAR T cells.
  • 2.0K
  • 25 Feb 2021
Topic Review
Nutraceuticals for Peripheral Vestibular Pathology
The term “nutraceuticals” is the object of continuous debate, and to date they are described as “a food or part of a food, such as a dietary supplement, that has a medical or health benefit, including the prevention and treatment of disease”.
  • 2.0K
  • 28 Jan 2022
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