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Topic Review
Management of Herbaceous/Horticultural Crops
Preserving soil quality and increasing soil water availability is an important challenge to ensure food production for a growing global population. As demonstrated by several studies, conservative crop management, combined with soil cover and crop diversification, can significantly reduce soil and water losses. 
  • 2.0K
  • 07 May 2021
Topic Review
The Mobility and Agility of Subsea AUV
The observation and detection of the subsea environment urgently require large-scale and long-term observation platforms. The design and development of subsea autonomous underwater vehicles (AUVs) involve three key points: the subsea-adapted main body structure, agile motion performance that adapts to complex underwater environments, and underwater acoustic communication and positioning technology. 
  • 2.0K
  • 27 Jun 2023
Topic Review
Unmanned Aerial Vehicle Routing Problems
Unmanned aerial vehicle (UAV) routing is transitioning from an emerging topic to a growing research area as the 3D flexible utilization of airspace, promogulated by UAVs, is a potential game-changer in solving the urban air mobility challenge by allowing to reshape transportation and logistics in the future. This has revealed a need to classify different types of research and examine the general characteristics of the research area. This research aims to assist in identifying the main topics and emerging research streams and provides a published overview of the current state and contributions to the area of the UAV routing problem (UAVRP) and a general categorization of the vehicle routing problem (VRP) followed by a UAVRP classification with a graphical taxonomy based on the analysis of UAVRP current status. To achieve this, an analysis of the existing research contributions promulgated in this domain is conducted. This analysis is used to identify the current state of UAVRP and the gaps related to the UAVs’ flight dynamics and weather conditions, which significantly influence the fuel consumption of the UAV when modeling the UAVRP.
  • 2.0K
  • 14 Jul 2020
Topic Review
CRISPR FokI Dead Cas9 System
FokI–dCas9 (fdCas9) or RNA-guided FokI nuclease (RFN) is a genome editing tool engineered by fusing  the catalytic domain of the FokI endonuclease to the N-terminal catalytic inactive Cas9 protein. The fdCas9 system is active only as a heterodimer, requiring the simultaneous binding of two fdCas9/sgRNAs monomers at adjacent target sites in a PAM-out orientation, and a specific spacer distance separating the two binding sites of the two sgRNAs. The five engineered and published constructs induce significant gene editing activities and specificities, as tested on various gene targets and overcome the off-target effects associated with other genome editing tools, including ZFNs, TALENs, and CRISPR/Cas systems.
  • 2.0K
  • 30 Nov 2020
Topic Review
Ascorbate-Glutathione Pathway
The Ascorbate-Glutathione (AsA-GSH) pathway, also known as Asada–Halliwell pathway comprises of AsA, GSH, and four enzymes viz. ascorbate peroxidase, monodehydroascorbate reductase, dehydroascorbate reductase, and glutathione reductase, play a vital role in detoxifying ROS. Apart from ROS detoxification, they also interact with other defense systems in plants and protect the plants from various abiotic stress-induced damages. Several plant studies revealed that the upregulation or overexpression of AsA-GSH pathway enzymes and the enhancement of the AsA and GSH levels conferred plants better tolerance to abiotic stresses by reducing the ROS. 
  • 2.0K
  • 29 Jul 2021
Topic Review
Aggression in Dogs
Aggression as a behavior is not always desirable, often ends in abandonment and/or euthanasia. However, it is possible to prevent the occurrence of unwanted aggression in domestic dogs. Aggression is not a fully understood phenomenon. To aim to generalize the dogs’ behavior and understand their behavioral needs, ethograms have been developed. Communication of any kind, including aggression, is a natural part of a dog’s ethogram. An ethogram is a species-specific list of natural behavior. Dog ethograms include affiliate, agonistic, defensive, sedative, sexual, demonstrative, warning, stressful, playful, grooming, exploratory, related to hunting, or related to the reduction of stress.
  • 2.0K
  • 11 Mar 2022
Topic Review
Smart Biogenic Packaging
Smart biogenic packaging is an innovative, swiftly emerging concept, where sustainability and real-time monitoring of food are coupled together, ensuring safe and healthy food, alongside commercial and ecological prosperity. Smart biogenic packaging integrates active and intelligent packaging solutions to provide consumers with more reliable information about food product conditions. It also generates a shielding effect for the food by incorporating active substances such as antimicrobial agents in a biogenic polymer matrix.
  • 2.0K
  • 15 Apr 2022
Topic Review
Steel Structural Property Correlation
The behaviour of plain carbon, as well as, structural steel is qualitatively different at different regimes of strain rates and temperature when they are subjected to hot-working and impact-loading conditions. Ambient temperature and carbon content are the leading factors governing the deformation behaviour and substructural evolution of these steels.
  • 2.0K
  • 29 Jul 2022
Topic Review
Battery-Less RFID-Based Wireless Sensors
Wireless sensors are becoming increasingly popular in the home and industrial sectors and are used for a range of applications, from temperature or humidity monitoring to food-quality inspection of products being sold on the market. One of the main reasons for using wireless technology is that it affords non-contact, non-invasive sensing. This ability eliminates the need for long cables required for information transfer and reduces the spread of germs and brings comfort to the users.
  • 2.0K
  • 27 Jul 2021
Topic Review
Generating Point Clouds from FMCW Radar
Radar sensing-based devices, particularly those using Frequency-Modulated Continuous Wave (FMCW), can obtain target information such as distance, angle, moving speed, and target size, making them superior when compared to other non-contact sensing technologies. FMCW technology provides access to a lot of crucial information at an affordable price. It is well suited for different working conditions, making it highly suitable for in-vehicle detection scenarios.
  • 2.0K
  • 04 Jan 2024
Topic Review
Benefits of Mass Vaccination Programs
Since the late 1940s, mass vaccination programs in the USA have contributed to the significantly reduced morbidity and mortality of infectious diseases. To assist the evaluation of the benefits of mass vaccination programs, the number of individuals who would have suffered death or permanent disability in the USA in 2014, had mass vaccination never been implemented, was estimated for measles, mumps, rubella, tetanus, diphtheria, pertussis, polio, Haemophilus influenzae type b (Hib), hepatitis B, varicella, and human papillomavirus (HPV). The estimates accounted for mortality and morbidity trends observed for these infections prior to mass vaccination and the impact of advances in standard of living and health care. The estimates also considered populations with and without known factors leading to an elevated risk of permanent injury from infection. Mass vaccination prevented an estimated 20 million infections and 12,000 deaths and permanent disabilities in 2014, including 10,800 deaths and permanent disabilities in persons at elevated risk. Though 9000 of the estimated prevented deaths were from liver cirrhosis and cancer, mass vaccination programs have not, at this point, shown empirical impacts on the prevalence of those conditions. Future studies can refine these estimates, assess the impact of adjusting estimation assumptions, and consider additional risk factors that lead to heightened risk of permanent harm from infection.
  • 2.0K
  • 16 Oct 2020
Topic Review
Antimicrobial Peptides in Farm Animals
Antimicrobial peptides (AMPs) are the arsenals of the innate host defense system, exhibiting evolutionarily conserved characteristics that are present in practically all forms of life. Recent years have witnessed the emergence of antibiotic-resistant bacteria compounded with a slow discovery rate for new antibiotics that have necessitated scientific efforts to search for alternatives to antibiotics. Research on the identification of AMPs has generated very encouraging evidence that they curb infectious pathologies and are also useful as novel biologics to function as immunotherapeutic agents. Being innate, they exhibit the least cytotoxicity to the host and exerts a wide spectrum of biological activity including low resistance among microbes and increased wound healing actions. Notably, in veterinary science, the constant practice of massive doses of antibiotics with inappropriate withdrawal programs led to a high risk of livestock-associated antimicrobial resistance. Therefore, the world faces tremendous pressure for designing and devising strategies to mitigate the use of antibiotics in animals and keep it safe for posterity.
  • 2.0K
  • 07 Jan 2021
Topic Review
Rumen
The rumen is the first digester in the digestive system of ruminants, which is located on the left side of the abdominal cavity. Rumen occupying almost the entire left abdominal cavity. In its front part is the rumen vestibule, which connects with the esophagus through the cardia. Rumen microbes anaerobically ferment complex lignocellulose plant materials which cannot be directly utilized by a host, into monomers which are further degraded into different microbial end-products, including volatile fatty acids, hydrogen, carbon dioxide, methane, and other fermentation products necessary for essential metabolic pathways. The complex rumen microbiome network is dominated by bacteria, archaea, protozoa, and anaerobic fungi.
  • 2.0K
  • 23 Feb 2021
Topic Review
Glutathione in the Brain
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the antioxidant defense system and the maintenance of redox homeostasis in neurons.
  • 2.0K
  • 13 May 2021
Topic Review
Piezo Channels in Bone
Mechanotransduction is an important process for living cells and tissues by which they experience and respond to mechanical stimuli. Cellular mechanotransduction is crucial for bone development and physiology, and abnormal cellular mechanotransduction leads to various bone diseases, including osteoporosis (OP) and osteoarthritis (OA). Piezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. The Piezo channels play crucial roles in numerous physiological and pathological process by functioning as cellular mechanotransducers. Under mechanical stimuli, Piezo channels are opened to make cationic ions cross membrane, which promotes cellular mechanotransduction to adapt to the microenvironment.
  • 2.0K
  • 01 Jul 2021
Topic Review
Anti-inflammatory potential of Sesquiterpene Lactones
Inflammation is a crucial and complex process that reestablishes the physiological state after a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to chronic inflammation and causing tissue damage. Sesquiterpene lactones (SLs) are composed of a large and diverse group of highly bioactive plant secondary metabolites, characterized by a 15-carbon backbone structure. In recent years, the interest in SLs has risen due to their vast array of biological activities beneficial for human health. The anti-inflammatory potential of these compounds results from their ability to target and inhibit various key pro-inflammatory molecules enrolled in diverse inflammatory pathways, and prevent or reduce the inflammatory damage on tissues. Research on the anti-inflammatory mechanisms of SLs has thrived over the last years, and numerous compounds from diverse plants have been studied, using in silico, in vitro, and in vivo assays. Besides their anti-inflammatory potential, their cytotoxicity, structure–activity relationships, and pharmacokinetics have been investigated.
  • 2.0K
  • 14 Jul 2021
Topic Review
Marginal Oil Resources
The term “marginal oil resource” refers to an oil reservoir that has hydrocarbon resource preservation but cannot meet the criteria of resources under the U.S Securities and Exchange Commission (SEC) standards. When oilfields step into their late life, most of their economic petroleum reserves have been well developed, and their focuses need to be switched to their intact marginal resources.
  • 2.0K
  • 14 Mar 2022
Topic Review
Transposable Elements
Transposable elements (TEs) are mobile DNA sequences that can jump from one genomic locus to another and that have colonized the genomes of all living organisms. While TE mobilization is an important source of genomic innovations that greatly contribute to the host species evolution, it is also a major threat to genome integrity that can lead to pathologies.
  • 2.0K
  • 26 May 2022
Topic Review
Magic Number
In nuclear physics, a magic number is a number of nucleons (either protons or neutrons, separately) such that they are arranged into complete shells within the atomic nucleus. As a result, atomic nuclei with a 'magic' number of protons or neutrons are much more stable than other nuclei. The seven most widely recognized magic numbers as of 2019 are 2, 8, 20, 28, 50, 82, and 126 (sequence A018226 in the OEIS). For protons, this corresponds to the elements helium, oxygen, calcium, nickel, tin, lead and the hypothetical unbihexium, although 126 is so far only known to be a magic number for neutrons. Atomic nuclei consisting of such a magic number of nucleons have a higher average binding energy per nucleon than one would expect based upon predictions such as the semi-empirical mass formula and are hence more stable against nuclear decay. The unusual stability of isotopes having magic numbers means that transuranium elements could theoretically be created with extremely large nuclei and yet not be subject to the extremely rapid radioactive decay normally associated with high atomic numbers. Large isotopes with magic numbers of nucleons are said to exist in an island of stability. Unlike the magic numbers 2–126, which are realized in spherical nuclei, theoretical calculations predict that nuclei in the island of stability are deformed. Before this was realized, higher magic numbers, such as 184, 258, 350, and 462 (sequence A033547 in the OEIS), were predicted based on simple calculations that assumed spherical shapes: these are generated by the formula [math]\displaystyle{ 2(\tbinom n1+ \tbinom n2+\tbinom n3) }[/math] (see Binomial coefficient). It is now believed that the sequence of spherical magic numbers cannot be extended in this way. Further predicted magic numbers are 114, 122, 124, and 164 for protons as well as 184, 196, 236, and 318 for neutrons. However, more modern calculations predict 228 and 308 for neutrons, along with 184 and 196.
  • 2.0K
  • 03 Nov 2022
Topic Review
Empowerment Framework
The empowerment framework (EF) is a tool for capturing children’s involvement in their play environment and with their peers. It exposes what they are interested in and how they are learning through that process. The EF was designed as a conceptual framework, developed through PhD research with seven case-study children and families.
  • 2.0K
  • 07 Sep 2022
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