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Topic Review
3D-LC
Three-dimensional liquid chromatography (3D-LC) is the consecutive combination of 3 independent LC techniques to decrease the complexity of proteome digest samples. 3D-LC systems can be performed in an online or offline manner. Ideally, each dimension in a 3D-LC system is completely orthogonal to the others.
  • 2.1K
  • 27 Oct 2020
Topic Review
Anterior Chamber Angle Assessment Techniques
This review summarizes the last findings in Anterior Chamber Angle evaluation, focusing on new instruments and their application to the clinical practice. Special attention will be given to the comparison between these new techniques and traditional slit-lamp gonioscopy.
  • 2.1K
  • 11 Dec 2020
Topic Review
Volunteers Nature Conservation Motivational Factors
Global biodiversity is under pressure from human activities, and the effort for nature conservation and restoration and the allocation of economic resources for biodiversity policies remain insufficient. In such a context, volunteers can play an important role as a resource in nature conservation projects if their recreational activities interact with the objectives of nature management. Ensuring that volunteers remain motivated and engaged is crucial for the success of conservation projects. Five motivational factors determine the engagement of the volunteers, namely social, nature value, instrumental, identification, and personal benefit.
  • 2.1K
  • 23 Aug 2021
Topic Review
Materials and Systems in Envelope Energy Retrofit
Materials, methods, and systems related to building envelope energy retrofit, these energy retrofit measures can be applied to building envelope systems and areas such as walls, roofs, windows, floors, façades, and air leakage, and they are applicable in the residential buildings sector as the dominant sector in energy-saving research studies. Three heat gain/loss mechanisms influence building envelope energy retrofit: conduction, convection, and radiation. Most retrofit methods applicable to transparent or translucent components were developed to deal with radiation by limiting the radiative heat transfers, for example, by applying window films over the existing glass.
  • 2.1K
  • 19 Jul 2022
Topic Review
Mediterranean U-boat Campaign (World War II)
The Mediterranean U-boat Campaign lasted from about 21 September 1941 to 19 September 1944 during the Second World War. Malta was an active British base strategically located near supply routes from Europe to North Africa. Axis supply convoys across the Mediterranean Sea suffered severe losses, which in turn threatened the fighting ability of the Axis armies in North Africa. The Allies were able to keep their North African armies supplied. The Kriegsmarine tried to isolate Malta but later it concentrated its U-boat operations on disrupting Allied landing operations in southern Europe.[clarification needed] Some 60 German U-boats made the hazardous passage into the Mediterranean Sea from 1941. Only one completed the journey both ways. Karl Dönitz, the Commander-in-Chief, U-boats, Befehlshaber der Unterseeboote (BdU) was always reluctant to send his boats into the Mittelmeer but he recognised that natural bottlenecks such as the Straits of Gibraltar were more likely to result in shipping being found and attacked than relying on finding it in the vast Atlantic Ocean. The U-boats were sent to assist the Italians, although many were attacked in the Strait of Gibraltar and nine were sunk while attempting the passage and ten more were damaged. The Mediterranean is a clear and calm body of water which made escape more difficult for the U-boats. The Axis failed in their objective.
  • 2.1K
  • 08 Nov 2022
Topic Review
RT-11
RT-11 (Real-time 11) is a discontinued small, low-end, single-user real-time operating system for the full line of Digital Equipment Corporation PDP-11 16-bit computers. RT-11 was first implemented in 1970. It was widely used for real-time computing systems, process control, and data acquisition across all PDP-11s. It was also used for low-cost general-use computing.
  • 2.1K
  • 22 Nov 2022
Topic Review
Bisphenol A in Related Pathological Conditions
Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. 
  • 2.1K
  • 27 Mar 2023
Topic Review
Transformer Architecture and Attention Mechanisms in Genome Data
The emergence and rapid development of deep learning, specifically transformer-based architectures and attention mechanisms, have had transformative implications across several domains, including bioinformatics and genome data analysis. The analogous nature of genome sequences to language texts has enabled the application of techniques that have exhibited success in fields ranging from natural language processing to genomic data. 
  • 2.1K
  • 26 Jul 2023
Topic Review
Eightfold Way
In physics, the eightfold way is an organizational scheme for a class of subatomic particles known as hadrons that led to the development of the quark model. American physicist Murray Gell-Mann and Israeli physicist Yuval Ne'eman both proposed the idea in 1961. The name comes from Gell-Mann's (1961) paper and is an allusion to the Noble Eightfold Path of Buddhism.
  • 2.1K
  • 17 Oct 2022
Topic Review
Transplacental Gene Delivery
Transplacental gene delivery (TPGD) is a technique for delivering nucleic acids to fetal tissues via tail-vein injections in pregnant mice. After transplacental transport, administered nucleic acids enter fetal circulation and are distributed among fetal tissues. In 1995, TPGD was established by Tsukamoto et al., and its mechanisms, and potential applications have been further characterized since. In 2019, Nakamura et al. demonstrated that intravenous injection of plasmid DNA containing genome editing component (CRISPR/Cas9 system) produced indels in fetal myocardial cells. In the future, this unique technique will allow manipulation of fetal cell functions in basic studies of fetal gene therapy.
  • 2.1K
  • 31 Jul 2020
Topic Review
Genomic Aberrations
Multiple Myeloma is a genetically heterogeneous disease, arising and progressing through the appearance and accumulation of a tangle of genomic aberrations. In the last decade, cheap and wide applicable sequencing technologies allowed significant advantages in its biological knowledge. Here author focus on genomic events that drive plasma cell disorders. 
  • 2.1K
  • 21 Dec 2020
Topic Review
Miracle Berry
Miracle berry (MB) (Synsepalum dulcificum) is an indigenous fruit whose small, ellipsoid, and bright red berries have been described to transform a sour taste into a sweet one. MB is rich in terpenoids, phenolic compounds, and flavonoids, which are responsible for their described antioxidant activities. Moreover, MB has been reported to ameliorate insulin resistance and inhibit cancer cell proliferation and malignant transformation in vitro. Herein, we briefly summarize the current knowledge of MB to provide a scientific basis for its potential use as a supplement in the management of chronic diseases related to altered metabolism, including obesity and insulin resistance, which are well-known risk factors in cancer. First, we introduce cancer as a metabolic disease, highlighting the impact of systemic metabolic alterations, such as obesity and insulin resistance, in cancer initiation and progression. Next, as oxidative stress is closely associated with metabolic stress, we also evaluate the effect of phytochemicals in managing oxidative stress and its relationship with cancer. Finally, we summarize the main biological activities described for MB-derived extracts with a special focus on the ability of miraculin to transform a sour taste into a sweet one through its interaction with the sweet taste receptors. The identification of sweet taste receptors at the gastrointestinal level, with effects on the secretion of enterohormones, may provide an additional tool for managing chronic diseases, including cancer.
  • 2.1K
  • 21 Feb 2021
Topic Review
Enzymatic Biofuel Cells
Enzymatic biofuel cells can be considered as a promising solution to generate electricity from biological catalytic reactions. Indeed, enzymes show very good results as biocatalysts thanks to their excellent intrinsic properties, such as specificity toward substrate, high catalytic activity with low overvoltage for substrate conversion, mild operating conditions like ambient temperature and near-neutral pH. Furthermore, enzymes present low cost, renewability and biodegradability. The wide range of applications moves from miniaturized portable electronic equipment and sensors to integrated lab-on-chip power supplies, advanced in vivo diagnostic medical devices to wearable devices. Nevertheless, enzymatic biofuel cells show great concerns in terms of long-term stability and high power output nowadays, highlighting that this particular technology is still at early stage of development. 
  • 2.1K
  • 22 Mar 2021
Topic Review
Aerobic Granular Sludge–Membrane BioReactor (AGS–MBR)
Membrane-fouling represents a major drawback hampering the wider application of membrane bioreactor (MBR) technology. Fouling can be mitigated by applying aerobic granular sludge technology, a novel kind of biofilm technology characterized by high settleability, strong microbial structure, high resilience to toxic/recalcitrant compounds of industrial wastewater, and the possibility to simultaneously remove organic matter and nutrients. Different schemes can be foreseen for the AGS–MBR process. However, an updated literature review reveals that in the AGS–MBR process, granule breakage represents a critical problem in all configurations, which often causes an increase of pore-blocking.
  • 2.1K
  • 07 Apr 2021
Topic Review
Nanoparticles Migration from Food Packaging
Packaging containing nanoparticles (NPs) can increase the shelf life of products, but the presence of NPs may hazards human life. Nanomaterials that enter the body in a variety of ways can be distributed throughout the body and damage human cells by altering mitochondrial function, producing reactive oxygen, and increasing membrane permeability, leading to toxic effects and chronic disease. The diffusion and migration of nanoparticles can be analyzed by analytical techniques including atomic absorption, inductively coupled plasma mass spectrometry, inductively coupled plasma atomic emission, and inductively coupled plasma optical emission spectroscopy, as well as X-ray diffraction, spectroscopy, migration, and titration. Inductively coupled plasma-based techniques demonstrated the best results.
  • 2.1K
  • 05 May 2021
Topic Review
Silk Fibroin as Contact Lenses
Fibroin is a fibrous protein that can be conveniently isolated from the silk cocoons produced by the larvae of Bombyx mori silk moth. In its form as a hydrogel, Bombyx mori silk fibroin (BMSF) has been employed in a variety of biomedical applications. When used as substrates for biomaterial-cells constructs in tissue engineering, the oxygen transport characteristics of the BMSF membranes have proved so far to be adequate. However, over the past three decades the BMSF hydrogels have been proposed episodically as materials for the manufacture of contact lenses, an application that depends on substantially elevated oxygen permeability.
  • 2.1K
  • 26 May 2021
Topic Review
Single Ventricle
In this paper, the author enumerates cardiac defects with a functionally single ventricle, summarizes single ventricle physiology, presents a summary of management strategies to address the single ventricle defects, goes over the steps of staged total cavo-pulmonary connection, cites the prevalence of inter-stage mortality, names the causes of inter-stage mortality, discusses strategies to address the inter-stage mortality, reviews post-Fontan issues, and introduces alternative approaches to Fontan circulation. 
  • 2.1K
  • 10 Jun 2021
Topic Review
Driving Cycles for Estimating Vehicle Emission Levels
Standard driving cycles (DCs) and real driving emissions (RDE) legislation developed by the European Commission contains significant gaps with regard to quantifying local area vehicle emission levels and fuel consumption (FC). The aim of this paper was to review local DCs for estimating emission levels and FC under laboratory and real-world conditions. This review article has three sections.
  • 2.1K
  • 12 Nov 2021
Topic Review
Hung Jury
A hung jury or deadlocked jury is a judicial jury that cannot agree upon a verdict after extended deliberation and is unable to reach the required unanimity or supermajority. This situation can occur only in common law legal systems, because civil law systems either do not use juries at all or provide that the defendant is automatically acquitted if the majority or supermajority required for conviction is not reached during a single, solemn vote.
  • 2.1K
  • 20 Oct 2022
Topic Review
Boot Camp
Boot Camp Assistant is a multi boot utility included with Apple Inc.'s macOS (previously Mac OS X / OS X) that assists users in installing Microsoft Windows operating systems on Intel-based Macintosh computers. The utility guides users through non-destructive disk partitioning (including resizing of an existing HFS+ or APFS partition, if necessary) of their hard disk drive or solid-state drive and installation of Windows device drivers for the Apple hardware. The utility also installs a Windows Control Panel applet for selecting the default boot operating system. Initially introduced as an unsupported beta for Mac OS X 10.4 Tiger, the utility was first introduced with Mac OS X 10.5 Leopard and has been included in subsequent versions of the operating system ever since. Previous versions of Boot Camp supported Windows XP and Windows Vista. Boot Camp 4.0 for Mac OS X 10.6 Snow Leopard version 10.6.6 up to Mac OS X 10.8 Mountain Lion version 10.8.2 only supported Windows 7. However, with the release of Boot Camp 5.0 for Mac OS X 10.8 Mountain Lion in version 10.8.3, only 64-bit versions of Windows 7 and Windows 8 are officially supported. Boot Camp 6.0 added support for 64-bit versions of Windows 10. Boot Camp 6.1, available on macOS 10.12 Sierra and later, will only accept new installations of Windows 7 and later; this requirement was upgraded to requiring Windows 10 for macOS 10.14 Mojave. Boot Camp is currently not available on Apple silicon Macs. Via virtualization, it is possible to run ARM-based Windows 10 and 11 (only Windows Insider builds, as they are the only publicly available ARM builds of Windows) through the QEMU emulator and Parallels Desktop virtualization software, which also allows Linux).
  • 2.1K
  • 15 Nov 2022
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