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Topic Review
China’s New-Type Urbanisation
China’s new-type urbanisation, as a national strategy, is one of the reasons why the leap in development has been made in the last decade. Existing studies mainly focus on the status and outcomes of china’s new-type urbanisation while stressing not enough the overlooked aspects of new-type urbanisation policies that are currently in use. 
  • 2.2K
  • 27 Jun 2022
Topic Review
Mitochondria-Targeted Drug in Cardiovascular Disease
Cardiovascular disease (CVD) represents a major threat for human health. The available preventive and treatment interventions are insufficient to revert the underlying pathological processes, which underscores the urgency of alternative approaches. Mitochondria dysfunction plays a key role in the etiopathogenesis of CVD and is regarded as an intriguing target for the development of innovative therapies. Oxidative stress, mitochondrial permeability transition pore opening, and excessive fission are major noxious pathways amenable to drug therapy. Thanks to the advancements of nanotechnology research, several mitochondria-targeted drug delivery systems (DDS) have been optimized with improved pharmacokinetic and biocompatibility, and lower toxicity and antigenicity for application in the cardiovascular field.
  • 2.2K
  • 03 Dec 2020
Topic Review
Alien Insect Species for Food and Feed
While the use of alien insect species for food and feed can help to alleviate protein shortage and provide for a more sustainable feed production, their invasive potential should be considered.
  • 2.2K
  • 05 Jul 2022
Topic Review
Impact of the Pandemic and War on Energy
The COVID-19 pandemic and Russia’s war on Ukraine have impacted the global economy, including the energy sector. The pandemic caused drastic fluctuations in energy demand, oil price shocks, disruptions in energy supply chains, and hampered energy investments, while the war left the world with energy price hikes and energy security challenges. The long-term impacts of these crises on low-carbon energy transitions and mitigation of climate change are still uncertain but are slowly emerging. Both crises initially appeared as opportunities for low-carbon energy transitions: the pandemic by showing the extent of lifestyle and behavioral change in a short period and the role of science-based policy advice, and the war by highlighting the need for greater energy diversification and reliance on local, renewable energy sources. However, the early evidence suggests that policymaking worldwide is focused on short-term, seemingly quicker solutions, such as supporting the incumbent energy industry in the post-pandemic era to save the economy and looking for new fossil fuel supply routes for enhancing energy security following the war. As such, the fossil fuel industry may emerge even stronger after these energy crises creating new lock-ins. This implies that the public sentiment against dependency on fossil fuels may end as a lost opportunity to translate into actions toward climate-friendly energy transitions, without ambitious plans for phasing out such fuels altogether. 
  • 2.2K
  • 06 Sep 2022
Topic Review
Mitochondrion Structure and Function
Mitochondria are subcellular organelles involved in essential cellular functions, including cytosolic calcium regulation, cell apoptosis, and reactive oxygen species production. They are the site of important biochemical pathways, including the tricarboxylic acid cycle, parts of the ureagenesis cycle, or haem synthesis.
  • 2.2K
  • 15 Mar 2023
Topic Review
Cymbidium Orchids
Cymbidium is an economically important genus in the orchid family (Orchidaceae) that has a pronounced medicinal and ornamental value. Medicinally, the plant is employed as a tonic to treat weakness in chronic diseases, dizziness, eye problems, burns, and wounds, etc. Cymbidiums are highly prized for their graceful flowers and sweet fragrance and are among the top ten most popular cut flowers. They are one of the most important commercial orchid groups and account for 3% of cut flowers in floriculture. Some orchid species in this genus are particularly threatened by excessive harvesting, so conservation measures are needed.
  • 2.2K
  • 26 Jun 2023
Topic Review
The Role of Wnt
Alterations in the Wnt signaling pathway are associated with the advancement of cancers; however, the exact mechanisms responsible remain largely unknown. It has recently been established that heightened intratumoral Wnt signaling correlates with tumor immunomodulation and immune suppression, which likely contribute to the decreased efficacy of multiple cancer therapeutics. Here, we review available literature pertaining to connections between Wnt pathway activation in the tumor microenvironment and local immunomodulation. We focus specifically on preclinical and clinical data supporting the hypothesis that strategies targeting Wnt signaling could act as adjuncts for cancer therapy, either in combination with chemotherapy or immunotherapy, in a variety of tumor types.
  • 2.2K
  • 29 Oct 2020
Topic Review
Smart City Research Risk Evaluation
Although they offer major advantages, smart cities present unprecedented risks and challenges. There are abundant discrete studies on risks related to smart cities; however, such risks have not been thoroughly understood to date. This paper is a systematic review that aims to identify the origin, trends, and categories of risks from previous studies on smart cities. This review includes 85 related articles published between 2000 and 2019. Through a thematic analysis, smart city risks were categorized into three main themes: organizational, social, and technological. The risks within the intersections of these themes were also grouped into (1) digital transformation, (2) socio-technical, and (3) corporate social responsibility. The results revealed that risk is a comparatively new topic in smart-city research and that little focus has been given to social risks. The findings indicated that studies from countries with a long history of smart cities tend to place greater emphasis on social risks.
  • 2.2K
  • 01 Dec 2020
Topic Review
Metabolic Reprogramming
Metabolic reprogramming is now recognized as a hallmark of cancer cells and supports cancer growth. Elucidating the underlying mechanisms of metabolic reprogramming in cancer cells may help identifying cancer targets and treatment strategies.
  • 2.2K
  • 20 Jan 2021
Topic Review
ADP-ribosylation
Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-dependent post-translational modification that is found on proteins as well as on nucleic acids. Promising technological advances have enabled the development of innovative tools to detect NAD+ and NAD+/NADH (H for hydrogen) ratios as well as ADP-ribosylation. These tools have significantly enhanced our current understanding of how intracellular NAD dynamics contribute to the regulation of ADP-ribosylation as well as to how mono-ADP-ribosylation integrates into various cellular processes.
  • 2.2K
  • 23 Jun 2021
Topic Review
Hydrogen Adsorption in Metal–Organic Frameworks
The development of hydrogen technologies and a wider use of hydrogen fuel cell systems require new materials that can store large amounts of hydrogen at relatively low pressures with small volume, low weight, and fast kinetics for recharging. Among the most challenging materials for hydrogen storage are porous coordination polymers, also called metal–organic frameworks (MOFs). MOFs are two- or three-dimensional porous crystalline materials with infinite lattices. As a result of their ultra-high surface area values (more than 2500 m2·g–1 measured by the Brunauer–Emmett–Teller (BET) approach), they were found to be promising gas adsorbers for small gaseous molecules, including CH4, CHCl3, CCl4, C6H6, C6H12, CO2, Ar, N2, and H2. The main benefit of MOFs is their reversible and high-rate hydrogen adsorption process. A reasonable number of H2 molecules inside the body of MOFs may only be obtained at very low temperatures. To date, MOFs have shown significant progress in applications of gas separation, catalysis, and coordination chemistry.
  • 2.2K
  • 09 Aug 2021
Topic Review
List of Statistical Packages
Statistical software are specialized computer programs for analysis in statistics and econometrics.
  • 2.2K
  • 29 Sep 2022
Topic Review
Curing
Curing is a chemical process employed in polymer chemistry and process engineering that produces the toughening or hardening of a polymer material by cross-linking of polymer chains. Even if it is strongly associated with the production of thermosetting polymers, the term "curing" can be used for all the processes where a solid product is obtained from a liquid solution, such as will PVC plastisols.
  • 2.2K
  • 26 Oct 2022
Topic Review
Sugarcane Biomass as Biofuel for Internal Combustion Engines
Sugarcane is one of the main agricultural crops in the world.  A deep overview of liquid biofuels produced from sugarcane bagasse is provided.
  • 2.2K
  • 01 Dec 2022
Biography
T Mayu Bogollagama
T. Mayu Bogollagama is a published poet.  He was the 1990 Virginia High School outdoor track and field 3200m state champion, which earned him a spot on the prestigious Washington Post's All-Metropolitan Team.  Subsequently, Georgetown University recruited him to attend as a scholarship student-athlete.  While an undergraduate at Georgetown University, Bogollagama volunteered as a literacy tut
  • 2.2K
  • 18 Apr 2023
Topic Review
Biopolymer-Based Food Packaging Materials
Biopolymer-based packaging materials have become of greater interest to the world due to their biodegradability, renewability, and biocompatibility. Numerous biopolymers—such as starch, chitosan, carrageenan, polylactic acid, etc.—have been investigated for their potential application in food packaging. Reinforcement agents such as nanofillers and active agents improve the properties of the biopolymers, making them suitable for active and intelligent packaging.
  • 2.2K
  • 28 Jun 2023
Topic Review
Lipids of Sulfolobus spp.
Archaea, and thereby, Sulfolobus spp. exhibit a unique lipid composition of ether lipids, which are altered in regard to the ratio of diether to tetraether lipids, number of cyclopentane rings and type of head groups, as a coping mechanism against environmental changes. Sulfolobales mainly consist of C40-40 tetraether lipids (caldarchaeol) and partly of C20-20 diether lipids (archaeol). A variant of caldarchaeol called glycerol dialkylnonitol tetraether (GDNT) has only been found in Sulfolobus and other members of the Creanarchaeota phylum so far. Altering the numbers of incorporated cyclopentane rings or the the diether to tetraether ratio results in more tightly packed membranes or vice versa.
  • 2.2K
  • 26 Oct 2020
Topic Review
Water Scarcity
Water scarcity, defined as long-term water imbalances occurring when the level of water demand exceeds natural water availability and supply capacity, is expected to pose high risks to both societies and economies in the next decade.
  • 2.2K
  • 03 Feb 2022
Topic Review
Natural and Synthetic Halogenated Amino Acids
The 3D structure and surface characteristics of proteins and peptides are crucial for interactions with receptors or ligands and can be modified to some extent to modulate their biological roles and pharmacological activities. The introduction of halogen atoms on the side-chains of amino acids is a powerful tool for effecting this type of tuning, influencing both the physico-chemical and structural properties of the modified polypeptides, helping to first dissect and then rationally modify features that affect their mode of action.
  • 2.2K
  • 16 Dec 2021
Topic Review
Circulating Tumor DNA in Early Lung Cancer Detection
Advancements in the clinical practice of non-small cell lung cancer (NSCLC) are shifting treatment paradigms towards increasingly personalized approaches. Liquid biopsies using various circulating analytes provide minimally invasive methods of sampling the molecular content within tumor cells. Plasma-derived circulating tumor DNA (ctDNA), the tumor-derived component of cell-free DNA (cfDNA), is the most extensively studied analyte and has a growing list of applications in the clinical management of NSCLC. As an alternative to tumor genotyping, the assessment of oncogenic driver alterations by ctDNA has become an accepted companion diagnostic via both single-gene polymerase chain reactions (PCR) and next-generation sequencing (NGS) for advanced NSCLC. ctDNA technologies have also shown the ability to detect the emerging mechanisms of acquired resistance that evolve after targeted therapy. Furthermore, the detection of minimal residual disease (MRD) by ctDNA for patients with NSCLC after curative-intent treatment may serve as a prognostic and potentially predictive biomarker for recurrence and response to therapy, respectively. Finally, ctDNA analysis via mutational, methylation, and/or fragmentation multi-omic profiling offers the potential for improving early lung cancer detection.
  • 2.2K
  • 20 Sep 2022
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