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Topic Review
Indoor Positioning System
The indoor positioning system (IPS) provides continuous real-time localization of objects or people within an enclosed space in different environments, using a network of transmitters and receivers. Indoor localization is more complex than outdoor localization because the indoor communication channel varies significantly with the environment and depends heavily on many factors, such as building structure, room layout, and construction materials.
  • 2.2K
  • 16 Dec 2022
Topic Review
Methodologies and Wearable Devices to Monitor Sleep Dysfunctions
Sleep is crucial for human health from metabolic, mental, emotional, and social points of view; obtaining good sleep in terms of quality and duration is fundamental for maintaining a good life quality. Several systems have been proposed in the scientific literature and on the market to derive metrics used to quantify sleep quality as well as detect sleep disturbances and disorders. In this field, wearable systems have an important role in the discreet, accurate, and long-term detection of biophysical markers useful to determine sleep quality.
  • 2.2K
  • 07 Sep 2022
Topic Review
Nanostructured Materials-Enabled Biosensors
A biosensor is an integrated receptor-transducer device, which can convert a biological response into an electrical signal.
  • 2.2K
  • 18 Mar 2021
Topic Review
Microsoft HoloLens 2 in Medical and Healthcare Context
Microsoft® HoloLens was developed and manufactured by Microsoft (MS) and can be presented as a pair of mixed reality smart glasses able to describe an environment in which real and virtual elements appear to coexist. More specifically, the Microsoft® HoloLens is a novel MR-based HMD that makes the user the protagonist of an immersive experience and allows him to interact with the surrounding environment using holograms whilst engaging their senses throughout. It is used in a variety of applications such as medical and surgical aids and systems, medical education and simulation, architecture and several engineering fields (civil, industrial and so on). The use of HoloLens 2 in a medical and healthcare context was analyzed by dividing contributions into the following sub-field applications: surgical navigation, AR-BCI (Brain-Computer Interface) systems integration and human computer interaction (HCI), gait analysis and rehabilitation, medical education and training/virtual teaching/tele-mentoring/tele-consulting and other applications.
  • 2.2K
  • 10 Nov 2022
Topic Review
Drug Resistance Mechanisms in Tuberculosis
The increased incidence of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) strains, defined as resistant to at least isoniazid and rifampin, the two highly bactericidal first-line drugs, is a major concern for tuberculosis (TB) control. The worldwide estimate of almost half a million incident cases of MDR/rifampin-resistant TB, is causing increasing concern. In this view, it is important to continuously update the knowledge on the mechanisms involved in the development of drug-resistant TB. Clinical, biological and microbiological reasons account for the generation of resistance, including: (i) nonadherence of patients to their therapy, and/or errors of physicians in therapy management, (ii) complexity and poor vascularization of granulomatous lesions, which obstruct drug distribution to some sites, resulting in resistance development, (iii) intrinsic drug resistance of tubercle bacilli, (iv) formation of non-replicating, drug-tolerant bacilli inside the granulomas, (v) development of mutations in Mtb genes, which are the most important molecular mechanisms of resistance. Here, a piece of information on the interplay of these factors is provided, to facilitate the clinical and microbiological management of drug-resistant TB at the global level, with attention also to the most recent diagnostic methods.
  • 2.2K
  • 21 Apr 2020
Topic Review
Additive Manufacturing
Additive manufacturing, which is also known as 3D printing, is an emerging and growing technology. It is providing significant innovations and improvements in many areas such as engineering, production, medicine, and more. 3D food printing is an area of great promise to provide an indulgence or entertaining experience, personalized food product, or specific nutritional needs. This entry reviews the additive manufacturing methods and materials in detail as well as their advantages and disadvantages. After a full discussion of 3D food printing, the reports on edible printed materials are briefly presented and discussed. In the end, the current and future outlook of additive manufacturing in the food industry is shown.
  • 2.1K
  • 09 Apr 2021
Topic Review
Dental Prosthetics or Implants
Dental implants or prosthetics are used to replace missing teeth and treat partially or fully damaged teeth. The dental implant success rate is more than 90% after ten years, ensuring long-term reliability. There are three primary types of dental implants: endosteal or endosseous, subperiosteal, and transosteal. Dental implants are a continuously growing market for both medical and cosmetic purposes. Modern science has allowed dentists to offer a wide variety of implants, such as crowns, screws, dental bridges, dentures, and braces. Implant reliability and proper design are essential for patient comfort and usage. The selection of suitable materials, depending on the patient’s oral health and implant objectives, is the primary criteria for proper implant design.
  • 2.1K
  • 17 Jan 2023
Topic Review
Features in Interdigitated Electrode Array
The electrical double layer (EDL) and crucial parameters such as sensitivity, selectivity, specificity, and limit of detection (LOD) are prominent to determine the interdigitated electrode array (IDEA)-based electrochemical sensor. The design of IDEA focuses on controlling the width and gap measurements between the adjacent fingers and increases the IDEA’s height are crucial because all the design measurement and parameters affected the IDEA-based electrochemical sensor functionality according to the application usage.
  • 2.1K
  • 08 Dec 2022
Topic Review
Pre-clinical Cerebral Perfusion MRI Techniques
Alterations to the cerebral microcirculation have been recognized to play a crucial role in the development of neurodegenerative disorders. However, the exact role of the microvascular alterations in the pathophysiological mechanisms often remains poorly understood. The early detection of changes in microcirculation and cerebral blood flow (CBF) can be used to get a better understanding of underlying disease mechanisms. This could be an important step towards the development of new treatment approaches. Animal models allow for the study of the disease mechanism at several stages of development, before the onset of clinical symptoms, and the verification with invasive imaging techniques. Specifically, pre-clinical magnetic resonance imaging (MRI) is an important tool for the development and validation of MRI sequences under clinically relevant conditions. This article reviews MRI strategies providing indirect non-invasive measurements of microvascular changes in the rodent brain that can be used for early detection and characterization of neurodegenerative disorders. The perfusion MRI techniques: Dynamic Contrast Enhanced (DCE), Dynamic Susceptibility Contrast Enhanced (DSC) and Arterial Spin Labeling (ASL), will be discussed, followed by less established imaging strategies used to analyze the cerebral microcirculation: Intravoxel Incoherent Motion (IVIM), Vascular Space Occupancy (VASO), Steady-State Susceptibility Contrast (SSC), Vessel size imaging, SAGE-based DSC, Phase Contrast Flow (PC) Quantitative Susceptibility Mapping (QSM) and quantitative Blood-Oxygenation-Level-Dependent (qBOLD). We will emphasize the advantages and limitations of each strategy, in particular on applications for high-field MRI in the rodent’s brain. 
  • 2.1K
  • 02 Jun 2021
Topic Review
Enzymatic Biofuel Cells
Enzymatic biofuel cells can be considered as a promising solution to generate electricity from biological catalytic reactions. Indeed, enzymes show very good results as biocatalysts thanks to their excellent intrinsic properties, such as specificity toward substrate, high catalytic activity with low overvoltage for substrate conversion, mild operating conditions like ambient temperature and near-neutral pH. Furthermore, enzymes present low cost, renewability and biodegradability. The wide range of applications moves from miniaturized portable electronic equipment and sensors to integrated lab-on-chip power supplies, advanced in vivo diagnostic medical devices to wearable devices. Nevertheless, enzymatic biofuel cells show great concerns in terms of long-term stability and high power output nowadays, highlighting that this particular technology is still at early stage of development. 
  • 2.0K
  • 22 Mar 2021
Topic Review
Low-Cost Doppler Radar Structural Monitoring
Low-Cost Microwave Doppler Radar Systems is an alternative noncontact solution for structural condition monitoring. In addition, by leveraging their capability of providing the target velocity information, the radar-based remote monitoring of complex rotating structures can also be accomplished. Modern radar systems are compact, able to be easily integrated in sensor networks, and can deliver high accuracy measurements.
  • 2.0K
  • 05 Jul 2021
Topic Review
Food safety and quality analysis at the point of care
Food safety remains a critical issue today. According to the World Health Organization (WHO), approximately two billion people worldwide die from food poisoning caused by bacteria, viruses and parasites annually. These incidences have led to the efforts to develop analytical devices for food safety and quality control. Conventional food safety analytical technologies, including high performance liquid chromatography (HPLC), gas chromatography (GC), quantitative real time polymerase chain reaction (qPCR) and enzyme-linked immunosorbent assay (ELISA), are not only labor intensive and time-consuming, but also high-cost. In addition, most of the diagnostic tests are performed at well-established laboratories. However, resources in central laboratories are limited in developing countries where foodborne diseases are prevalent. Therefore, there seems to be an urgent need to create cost-effective and robust analytical devices for healthcare applications. Recent technological advances have made it possible to develop point-of-care (POC) devices, including chip-based and paper-based devices to rapidly diagnose diseases for providing lifesaving treatment in a timely manner.
  • 2.0K
  • 28 Jan 2022
Topic Review
Incorporating Glycosaminoglycans in Collagen Hydrogels
Collagen, the most abundant protein in mammals, has garnered the interest of scientists for over 50 years. Its ubiquitous presence in all body tissues combined with its excellent biocompatibility has led scientists to study its potential as a biomaterial for a wide variety of biomedical applications with a high degree of success and widespread clinical approval. More recently, in order to increase their tunability and applicability, collagen hydrogels have frequently been co-polymerized with other natural and synthetic polymers. Of special significance is the use of bioactive glycosaminoglycans—the carbohydrate-rich polymers of the ECM responsible for regulating tissue homeostasis and cell signaling. This review covers the recent advances in the development of collagen-glycosaminoglycan blend hydrogels for translational biomedical research.
  • 2.0K
  • 16 Dec 2020
Topic Review
Methanotrophic Bacteria in Wastewater Treatment
Wastewater treatment plants and other remediation facilities serve important roles, both in public health, but also as dynamic research platforms for acquiring useful resources and biomolecules for various applications. An example of this is methanotrophic bacteria within anaerobic digestion processes in wastewater treatment plants. These bacteria are an important microbial source of many products including ectoine, polyhydroxyalkanoates, and methanobactins, which are invaluable to the fields of biotechnology and biomedicine.
  • 2.0K
  • 10 Sep 2021
Topic Review
Rigenera® Micrografts in Oral Regeneration
Biomaterials derive either from nature or synthesized in the laboratory using chemical approaches utilizing metallic components, polymers, ceramics, or composite materials. They are often used and adapted for medical applications. A biomaterial is also defined as autograft, allograft, or xenograft used as a transplant material. In the last decade also tissue engineering and stem cells were deeply studied trying to make better autologous biomaterials ready to be used in regenerative procedures. Micrografts are a new concept of biomaterial, they are enriched of progenitor cells that are a particular type of stem cell excellent in enhancing the regenerative potential. Moreover, another advantage is the easy handling and tissue availability.
  • 2.0K
  • 29 Oct 2020
Topic Review
Pineapple Leaf Fiber
Evidence-based research had shown that elevated alkali treatment of pineapple leaf fiber(PALF) compromised the mechanical properties of the fiber. In this work, PALF was subjected todifferential alkali concentrations: 1, 3, 6, and 9% wt/wt to study the influence on the mechanicaland crystal properties of the fiber. The crystalline and mechanical properties of untreated and alkali-treatedPALF samples were investigated by X-ray diffractometry (XRD), Fourier transforms infraredspectroscopy (FTIR), and tensile testing analysis. The XRD results indicated that crystal propertiesof the fibers were modified with 6% wt/wt alkali-treated PALF recording the highest crystallinityand crystallite size of 76% and 24 nm, respectively. The FTIR spectra suggested that all alkali-treatedPALF samples underwent lignin and hemicellulose removal to varying degrees. An increase in thecrystalline properties improved the mechanical properties of the PALF treated with alkali at 6%wt/wt, which has the highest tensile strength (1620 MPa). Although the elevated alkali treatmentresulted in decreased mechanical properties of PALF, crystallinity generally increased. The findingsrevealed that the mechanical properties of PALF not only improve with increasing crystallinity andcrystallite size but are also dependent on the intermediate bond between adjacent cellulose chains.
  • 2.0K
  • 20 Aug 2021
Topic Review
Rhizopus oryzae Lipase
Lipases are biocatalysts with a significant potential to enable a shift from current pollutant manufacturing processes to environmentally sustainable approaches. The main reason of this prospect is their catalytic versatility as they carry out several industrially relevant reactions as hydrolysis of fats in water/lipid interface and synthesis reactions in solvent-free or non-aqueous media such as transesterification, interesterification and esterification. Because of the outstanding traits of Rhizopus oryzae lipase (ROL), 1,3-specificity, high enantioselectivity and stability in organic media, its application in energy, food and pharmaceutical industrial sector has been widely studied. Significant advances have been made in the biochemical characterisation of ROL particularly in how its activity and stability are affected by the presence of its prosequence. In addition, native and heterologous production of ROL, the latter in cell factories like Escherichia coli, Saccharomyces cerevisiae and Komagataella phaffii (Pichia pastoris), have been thoroughly described. Therefore, in this review, we summarise the current knowledge about R. oryzae lipase (i) biochemical characteristics, (ii) production strategies and (iii) potential industrial applications.
  • 2.0K
  • 10 Dec 2020
Topic Review
Thermosensitive Polymers
Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites.
  • 2.0K
  • 09 Mar 2022
Topic Review
β-Ti Alloys for Orthopedic and Dental Applications
Ti and Ti alloys have charming comprehensive properties (high specific strength, strong corrosion resistance, and excellent biocompatibility) that make them the ideal choice in orthopedic and dental applications, especially in the particular fabrication of orthopedic and dental implants. However, these alloys present some shortcomings, specifically elastic modulus, wear, corrosion, and biological performance. Beta-titanium (β-Ti) alloys have been studied as low elastic modulus and low toxic or non-toxic elements.
  • 2.0K
  • 28 Mar 2022
Topic Review
Fetal Acidosis
Fetal acidosis or intrauterine hypoxia refers to a condition of deprived short supply of oxygen below the physiologic level of normal blood, which is defined as pH ≤ 7.25.
  • 2.0K
  • 18 Feb 2022
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