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Topic Review
Gender Dysphoria in Children
Gender dysphoria in children (GD), also known as gender incongruence of childhood, is a formal diagnosis for children who experience significant discontent (gender dysphoria) due to a mismatch between their assigned sex and gender identity. The diagnostic label gender identity disorder in children (GIDC) was used by the Diagnostic and Statistical Manual of Mental Disorders (DSM) until it was renamed gender dysphoria in children in 2013 with the release of the DSM-5. The diagnosis was renamed to remove the stigma associated with the term disorder. Gender dysphoria in preadolescent children is more heavily linked to adult homosexuality than to an adult transgender identity, especially with regard to boys. According to prospective studies, the majority of children diagnosed with gender dysphoria cease to desire to be the other sex by puberty, with most growing up to identify as gay, lesbian, or bisexual, with or without therapeutic intervention. If the dysphoria persists during puberty, it is very likely permanent. Controversy surrounding the pathologization and treatment of a transgender identity and associated behaviors, particularly in children, has been evident in the literature since the 1980s. Proponents of the GD diagnoses argue that therapeutic intervention helps children be more comfortable in their bodies, have better peer relations and therefore better self-esteem, that research indicates there exist forms of distress associated directly with children's gender variance, and that treatment can prevent adult GD. Opponents have compared therapeutic interventions that aim to alter a child's gender identity to conversion (or reparative) therapy for gay men and lesbians. The World Professional Association for Transgender Health (WPATH) states that treatment aimed at trying to change a person's gender identity and gender expression to become more congruent with sex assigned at birth "is no longer considered ethical." Critics also argue that therapeutic interventions that aim to alter a child's gender identity rely on the assumption that an adult transgender identity is undesirable, challenging this assumption along with the lack of clinical data to support outcomes and efficacy. Other therapeutic interventions do not seek to change a child's gender identity, but are instead focused on creating a supportive and safe environment for the child to explore their gender identity and gender expression.
  • 2.2K
  • 14 Oct 2022
Topic Review
Chemical Properties of Calcium Phosphate
 Calcium phosphate (CaP)-based biomaterials have superior properties and have been widely used for bone defect repair, due to their similarities to the inorganic components of human bones. The biological performance of CaPs, as a determining factor for their applications, are dependent on their physicochemical properties. Hydroxyapatite (HAP) as the most thermally stable crystalline phase of CaP is mostly used in the form of ceramics or composites scaffolds with polymers. Nanostructured CaPs with large surface areas are suitable for drug/gene delivery systems. CaP is not only a family of natural minerals, but also includes biominerals in humans, which are the main inorganic component of hard tissue (bone and teeth).
  • 2.2K
  • 27 Oct 2022
Topic Review
Commercial Applications of Duckweed
Commercial applications of duckweeds include wastewater recycling and freshwater reclamation through removal of nitrogen- and phosphate-based fertilizer run-off and other waste-products, serving as feedstock for biofuels production (from starch or lipid), and production of food with superior nutritional quality (for humans and livestock), while requiring minimal space, light, and fertilizer.
  • 2.2K
  • 09 Oct 2023
Topic Review
Endowment
Endowment is a concept in philosophy that refers to human capacities and abilities which can be naturally or socially acquired. Natural endowment is biologically analysed. It is examined through individual genes or inborn abilities. Social endowment is explored through the culture and ethics of human lives in their communities. Natural and social endowment can be used to explain the behaviour of individuals. This natural and social distinction exemplifies individuals' positions within communities. The differences in human capacities enables diverse perceptions towards a similar situation. This includes Stephen Covey's human endowments which are self-awareness, imagination, will power, abundance mentality, courage, creativity, and self-renewal. The philosophical studies of human nature or endowment is outlined in the theories of medieval philosophers on human evolution such as; Jean-Jacques Rousseau, Aristotle, and Baruch Spinoza.
  • 2.2K
  • 22 Nov 2022
Topic Review
Cytopathic Effect
Cytopathic effect or cytopathogenic effect (abbreviated CPE) refers to structural changes in host cells that are caused by viral invasion. The infecting virus causes lysis of the host cell or when the cell dies without lysis due to an inability to reproduce. Both of these effects occur due to CPEs. If a virus causes these morphological changes in the host cell, it is said to be cytopathogenic. Common examples of CPE include rounding of the infected cell, fusion with adjacent cells to form syncytia, and the appearance of nuclear or cytoplasmic inclusion bodies. CPEs and other changes in cell morphology are only a few of the many effects by cytocidal viruses. When a cytocidal virus infects a permissive cell, the viruses kill the host cell through changes in cell morphology, in cell physiology, and the biosynthetic events that follow. These changes are necessary for efficient virus replication but at the expense of the host cell.
  • 2.2K
  • 30 Nov 2022
Topic Review
Sensorial Perception of Astringency
Astringency has Latin origin from the word ad stringere, which means “to bind”. It is commonly referred to as the dry mouthfeel, although it is a very complex sensation with various definitions proposed over time. It is as a complex phenomenon that provokes a range of sensations, triggered by different types of substances, and explained by diverse mechanisms. The American Society for Testing and Materials (ASTM) defines it as "the complex of sensations due to shrinking, drawing or puckering of the epithelium as a result of exposure to substances such as alums or tannins". The astringency perception arises from the interaction of astringents with the oral cavity, e.g., tissues, cell membrane proteins, epithelial cells, mechano, and chemo-receptors. Consequently, many mechanisms, beyond simple lubrication, drive this mouthfeel. 
  • 2.2K
  • 27 Oct 2020
Topic Review
Nanotechnology for Eye Topical Drug Delivery
Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are the most prevalent drug form because they are convenient and easy to apply by patients. However, conventional drug formulations are usually characterized by short retention time in the tear film, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Not more than 5% of the total drug dose administered in eye drops reaches the interior ocular tissues. Drug-loaded nanoparticles/hydrogels do not enter cells via diffusion. The endocytosis pathway is related to the penetration of drug-loaded nanoparticles/hydrogels into the cell. The interactions between the nanoparticles and the cell membrane generate forces of different origins and lead to the membrane wrapping of the nanoparticles followed by cellular uptake.
  • 2.2K
  • 24 Dec 2021
Topic Review
3DP Medicines and Medical Devices
Novel additive manufacturing (AM) techniques and particularly 3D printing (3DP) have achieved a decade of success in pharmaceutical and biomedical fields. Highly innovative personalized therapeutical solutions may be designed and manufactured through a layer-by-layer approach starting from a digital model realized according to the needs of a specific patient or a patient group. The combination of patient-tailored drug dose, dosage, or diagnostic form (shape and size) and drug release adjustment has the potential to ensure the optimal patient therapy. This document provides an overview on different 3DP techniques to produce personalized medicines and medical devices, highlighting, for each method, the critical printing process parameters, the main starting materials, as well as advantages and limitations.
  • 2.2K
  • 17 May 2022
Topic Review
Bio-energy with Carbon Capture and Storage
Bio-energy with carbon capture and storage (BECCS) is a potential greenhouse gas mitigation technology which produces negative carbon dioxide emissions by combining bioenergy (energy from biomass) use with geologic carbon capture and storage. The concept of BECCS is drawn from the integration of trees and crops, which extract carbon dioxide (CO2) from the atmosphere as they grow, the use of this biomass in processing industries or power plants, and the application of carbon capture and storage via CO2 injection into geological formations. There are other non-BECCS forms of carbon dioxide removal and storage that include technologies such as biochar, carbon dioxide air capture and biomass burial and enhanced weathering. According to a recent Biorecro report, there is 550 000 tonnes CO2/year in total BECCS capacity currently operating, divided between three different facilities (as of January 2012). In the IPCC Fourth Assessment Report by the Intergovernmental Panel on Climate Change (IPCC), BECCS was indicated as a key technology for reaching low carbon dioxide atmospheric concentration targets. The negative emissions that can be produced by BECCS has been estimated by the Royal Society to be equivalent to a 50 to 150 ppm decrease in global atmospheric carbon dioxide concentrations and according to the International Energy Agency, the BLUE map climate change mitigation scenario calls for more than 2 gigatonnes of negative CO2 emissions per year with BECCS in 2050. According to Stanford University, 10 gigatonnes is achievable by this date. The Imperial College London, the UK Met Office Hadley Centre for Climate Prediction and Research, the Tyndall Centre for Climate Change Research, the Walker Institute for Climate System Research, and the Grantham Institute for Climate Change issued a joint report on carbon dioxide removal technologies as part of the AVOID: Avoiding dangerous climate change research program, stating that "Overall, of the technologies studied in this report, BECCS has the greatest maturity and there are no major practical barriers to its introduction into today’s energy system. The presence of a primary product will support early deployment." According to the OECD, "Achieving lower concentration targets (450 ppm) depends significantly on the use of BECCS".
  • 2.2K
  • 25 Oct 2022
Topic Review
Detroit Diesel 60
The Detroit Diesel Series 60 is an inline-six 4 stroke diesel engine produced since 1987. At that time, it differed from most on-highway engines by using an overhead camshaft and "drive by wire" electronic control. In 1993, it was popular on many USA buses in the 11.1 L (677 cu in) displacement.
  • 2.2K
  • 07 Nov 2022
Topic Review
Infrared and Visible Image Fusion
Infrared and visible image fusion technologies make full use of different image features obtained by different sensors, retain complementary information of the source images during the fusion process, and use redundant information to improve the credibility of the fusion image.
  • 2.2K
  • 08 Jan 2021
Topic Review
Features in Interdigitated Electrode Array
The electrical double layer (EDL) and crucial parameters such as sensitivity, selectivity, specificity, and limit of detection (LOD) are prominent to determine the interdigitated electrode array (IDEA)-based electrochemical sensor. The design of IDEA focuses on controlling the width and gap measurements between the adjacent fingers and increases the IDEA’s height are crucial because all the design measurement and parameters affected the IDEA-based electrochemical sensor functionality according to the application usage.
  • 2.2K
  • 08 Dec 2022
Topic Review
Post-Traumatic Growth and Post-Traumatic Stress after Infidelity
Two important, while relatively uncommon, outcomes of trauma include experiences of post-traumatic growth (PTG) and symptoms of post-traumatic stress (PTS). PTG is characterized by increased personal strength, a renewed sense of life purpose and meaning, and better interpersonal relationships. Infidelity within an intimate relationship is typically described as an interpersonal betrayal. However, its lasting effects can resemble those experienced by individuals with PTSD in response to other traumas. Understanding the pathways from infidelity to PTG and PTS are important; one pathway includes determining that the event is central to one's identity or experiences.
  • 2.2K
  • 20 Oct 2023
Topic Review
Breast Milk Immunoglobulinome
Breast milk components contribute to the infant’s immune development and protection, and among other immune factors, immunoglobulins (Igs) are the most studied. The presence of IgA in milk has been known for a long time; however, less information is available about the presence of other Igs such as IgM, IgG, and their subtypes (IgG1, IgG2, IgG3, and IgG4) or even IgE or IgD.
  • 2.2K
  • 03 Jun 2021
Topic Review
Intelligent Unmanned Mining
Intelligent unmanned mining is the application of new generation of communication technology, Internet of Things (IoT), cloud computing, big data, artificial intelligence and other advanced technologies, intelligent mining and transportation equipment are taked such as coal mining machine, hydraulic support, scraper conveyor, loader, crusher, belt conveyor with autonomous perception, autonomous decision-making and autonomous control execution ability, the comprehensive intelligent control system as the core, and uses visual remote monitoring or adaptive intelligent planning mining as a means, the safe and efficient comprehensive intelligent coal mining method can realize the intelligent operation process of working face mining, support, coal transportation (working condition adaptive and process collaborative control) or one-click start-stop operation mode (including unmanned follow-up operation and safe patrol).
  • 2.2K
  • 19 Feb 2022
Topic Review
Wearable Optical Sensor
Miniaturization advances have led to several wearable sensors that are now being employed in a variety of biomedical applications. Some of these have been ingrained in people’s daily lives. Smart bands and smartwatches with pulse monitors, pulse oximeters, accelerometers, gyroscopes, and other sensors are one example.
  • 2.2K
  • 28 Jan 2022
Topic Review
Bilateral Asymmetry in Sports Performance
Asymmetry is ubiquitous in nature and humans have well-established bilateral asymmetries in their structures and functions. It is prevalent across several sports regardless of age, gender, or competitive level, and can be verified even in apparently symmetric actions (e.g., running and rowing). Assessments of bilateral asymmetries are highly task-, metric-, individual-, and sport-specific; fluctuate significantly in time (in magnitude and, more importantly, in direction); and tend to be poorly correlated among themselves, as well as with general performance measures. Most studies assessing bilateral asymmetries do not actually assess the occurrence of injuries. While injuries tend to accentuate bilateral asymmetries, there is no evidence that pre-existing asymmetries increase injury risk. While training programs reduce certain bilateral asymmetries, there is no evidence that such reductions result in increased sport-specific performance or reduced injury risk. 
  • 2.2K
  • 13 Oct 2022
Topic Review
Explainable Artificial Intelligence for Smart Cities
The emergence of Explainable Artificial Intelligence (XAI) has enhanced the lives of humans and envisioned the concept of smart cities using informed actions, enhanced user interpretations and explanations, and firm decision-making processes. The XAI systems can unbox the potential of black-box AI models and describe them explicitly.
  • 2.2K
  • 19 Apr 2023
Topic Review
Advanced Flame Spray Pyrolysis for Engineering Multifunctional Nanostructures
Flame spray pyrolysis (FSP) is an industrially scalable technology that enables the engineering of a wide range of metal-based nanomaterials with tailored properties nanoparticles.
  • 2.2K
  • 28 Nov 2023
Topic Review
Social Capital
Social capital refers to the inherent value embedded in social relationships and networks. It encompasses the trust, reciprocity, and shared norms that facilitate cooperation and collaboration within a community or society. This concept underscores the importance of social connections in fostering collective well-being, economic development, and the overall functioning of human societies.
  • 2.2K
  • 26 Jan 2024
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