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Topic Review
LINE1 Retrotransposons
LINE-1 (L1) is a class of autonomous mobile genetic elements that form somatic mosaicisms in various tissues of the organism. The activity of L1 retrotransposons is strictly controlled by many factors in somatic and germ cells at all stages of ontogenesis. Alteration of L1 activity was noted in a number of diseases: in neuropsychiatric and autoimmune diseases, as well as in various forms of cancer.
  • 2.3K
  • 20 Oct 2021
Topic Review
Effects of Environmental Changes in the Amazon Region
Environmental changes caused by human activities alter the water, energy, and carbon cycles in the Amazon region. This has resulted in biological changes across several plant species, some of which are used in both regional and global trade and represent important sources of food and income for people. Reports from local people and scientific studies point to the effects of deforestation, forest degradation, and climate change on native plant species. Indeed, people who are typically dependent on natural resources and ecosystem services are the most threatened by plant species productivity and geographical distribution changes. However, there is a lack of scientific literature concerning the effects of environmental changes on plant species and forest-dependent communities in the Amazon region.
  • 2.3K
  • 28 Mar 2022
Topic Review
Social Login
Social login is a form of single sign-on using existing information from a social networking service such as Facebook, Twitter or Google, to sign into a third party website instead of creating a new login account specifically for that website. It is designed to simplify logins for end users as well as provide more and more reliable demographic information to web developers.
  • 2.3K
  • 03 Nov 2022
Topic Review
Cannabinoid Receptor Antagonist
A cannabinoid receptor antagonist, also known simply as a cannabinoid antagonist or as an anticannabinoid, is a type of cannabinoidergic drug that binds to cannabinoid receptors (CBR) and prevents their activation by endocannabinoids. They include antagonists, inverse agonists, and antibodies of CBRs. The discovery of the endocannabinoid system led to the development of CB1 receptor antagonists. The first CBR inverse agonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of CBR antagonists. Cannabidiol (CBD), a naturally occurring cannabinoid, is a non-competitive CB1/CB2 receptor antagonist. And Δ9-tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid, modulate the effects of THC via direct blockade of cannabinoid CB1 receptors, thus behaving like first-generation CB1 receptor inverse agonists, such as rimonabant. CBD is a very low-affinity CB1 ligand, that can nevertheless affect CB1 receptor activity in vivo in an indirect manner, while THCV is a high-affinity CB1 receptor ligand and potent antagonist in vitro and yet only occasionally produces effects in vivo resulting from CB1 receptor antagonism. THCV has also high affinity for CB2 receptors and signals as a partial agonist, differing from both CBD and rimonabant.
  • 2.3K
  • 08 Nov 2022
Topic Review
PLBs organogenesis in orchid
A protocorm-like structure those are generated from the vegetative explant in vitro, are known as protocorm like body (PLB). For the mass propagation of plant, PLBs regeneration is one of the key focusing. Orchid is the largest genus of the flowering plants and they have number of commercially important genus. Orchids are difficult to propagate by seeds and vegetative propagation methods. In vitro propagation is the most efficient technique for the orchid propagation. Induction and proliferation of PLBs can accelerate their propagation by reduce the time and costs. It is possible to propagate numerous numbers of plants within short period of time with low costs from PLBs. Researchers are trying to develop efficient PLBs induction and proliferation techniques using different plant growth regulators, carbon sources, and light emitting diodes. Here, we are discussing about the progress of the PLBs organogenesis in orchids.
  • 2.3K
  • 13 Jan 2021
Topic Review
Maxillofacial Prosthodontics
A maxillofacial prosthesis, an alternative to surgery for the rehabilitation of patients with facial disabilities (congenital or acquired due to malignant disease or trauma), are meant to replace parts of the face or missing areas of bone and soft tissue and restore oral functions such as swallowing, speech and chewing, with the main goal being to improve the quality of life of the patients.
  • 2.3K
  • 20 Feb 2021
Topic Review
Magnesium Oxide in Constipation
Magnesium oxide has been widely used as an osmotic laxative for a long time especially in East Asia. 
  • 2.3K
  • 04 Mar 2021
Topic Review
Mechanical Properties of Geopolymer Concrete
Geopolymer is essentially different from the conventional concrete which consists of hydraulic cement as a binder.
  • 2.3K
  • 12 Sep 2021
Topic Review
Staphylococcus aureus in Inflammatory Diseases
Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections play an extremely important role in a variety of diseases. Staphylococcus aureus (S. aureus), a Gram-positive bacterium, is one of the most notorious human pathogens, causing illnesses ranging from mild skin and wound infections to fatal sepsis or multi-organ failure. Inflammatory cells play an important role in S. aureus infection. S. aureus infection and toxins can activate a variety of inflammatory cells, such as keratinocytes, helper T cells, innate lymphoid cells (ILCs), macrophages, dendritic cells (DCs), mast cells, neutrophils, eosinophils, and basophils, which release inflammatory factors that accumulate at the site of infection and cause an inflammatory response.
  • 2.3K
  • 22 Jul 2022
Topic Review
Mohammed Bin Rashid Space Centre
The Mohammed Bin Rashid Space Centre (MBRSC) (Arabic: مركز محمد بن راشد للفضاء), is a Dubai government organisation working on the UAE space program, which includes various space satellite projects, the Emirates Mars Mission, and the UAE astronaut programme. The centre actively works to promote space science and research in the region. The centre encompasses the Emirates Institution for Advanced Science and Technology (EIAST).
  • 2.3K
  • 25 Oct 2022
Topic Review
Logical Syntax of Language
Rudolf Carnap (/ˈkɑːrnæp/; German: [ˈkaʁnaːp]; 18 May 1891 – 14 September 1970) was a German-language philosopher who was active in Europe before 1935 and in the United States thereafter. He was a major member of the Vienna Circle and an advocate of logical positivism. He is considered "one of the giants among twentieth-century philosophers."
  • 2.3K
  • 17 Nov 2022
Topic Review
Quadjet
A quadjet or four-engine jet is a jet aircraft powered by four engines. The presence of four engines offers increased power output and redundancy, allowing quadjets to be used as civilian airliners, freighters and military aircraft. Many of the first purpose-built jetliners were quadjets, among which stands the De Havilland Comet, the world's first commercial jetliner. In the past two decades, the use of quadjet airliners has gradually begun to decline due to a variety of factors, including the approval of twinjets to fly further from diversion airports and an increased emphasis on fuel efficiency.
  • 2.3K
  • 24 Nov 2022
Topic Review
Desalination in China
In recent decades, the ever-growing demands for clean water in households and industries have urged researchers to take every possible step to deal with the global water crisis. Seawater desalination has turned out to be the most promising and efficient way to provide clean water. Owing to the advancement of synthetic chemistries and technologies, great success has been achieved in the desalination and utilization of seawater worldwide. China, with the world’s largest population, has pushed the development of desalination and multipurpose utilization of seawater further in respect of materials, technologies and services, etc. 
  • 2.3K
  • 30 Mar 2021
Topic Review
Hyponatremia
Hyponatremia, usually defined as serum sodium concentration < 135 mEq/L, is the most common electrolyte abnormality encountered both in hospitalized patients and in the general population and is associated with increased morbidity and mortality.
  • 2.3K
  • 29 Jan 2022
Topic Review
Circadian System and Light Govern Rhythmic Brain Function
Life on earth has evolved under the influence of rhythmic changes in the environment, such as the 24 h light/dark cycle. Living organisms have developed internal circadian clocks, which allow them to anticipate these rhythmic changes and adapt their behavior and physiology accordingly. 
  • 2.3K
  • 17 Mar 2022
Topic Review
Glial Cells in Physiological and Pathological States
Glial cells are the most abundant and widely distributed cells that maintain cerebral homeostasis in the central nervous system. They mainly include microglia, astrocytes, and the oligodendrocyte lineage cells. Moreover, glial cells may induce pathological changes, such as inflammatory responses, demyelination, and disruption of the blood–brain barrier, to regulate the occurrence and development of neurological diseases through various molecular mechanisms.
  • 2.3K
  • 29 Aug 2022
Topic Review
Temperament
In psychology, temperament broadly refers to consistent individual differences in behavior that are biologically based and are relatively independent of learning, system of values and attitudes. Some researchers point to association of temperament with formal dynamical features of behavior, such as energetic aspects, plasticity, sensitivity to specific reinforcers and emotionality. Temperament traits (such as Neuroticism, Sociability, Impulsivity, etc.) remain its distinct patterns in behavior throughout adulthood but they are most noticeable and most studied in children. Babies are typically described by temperament, but longitudinal research in the 1920s began to establish temperament as something which is stable across the lifespan. Although a broad definition of temperament is agreed upon, many classification schemes for temperament have been developed, and there is no consensus. Historically, the concept of temperament (originally "temperamentums" in Latin means "mixtures") was a part of the theory of the four humors, with their corresponding four temperaments. This historical concept was explored by philosophers, psychologists, psychiatrists and psycho-physiologists from very early times of psychological science, with theories proposed by Immanuel Kant, Hermann Lotze, Ivan Pavlov, Carl Jung, Gerardus Heymans among others. More recently, scientists seeking evidence of a biological basis of personality have further examined the relationship between temperament and neurotransmitter systems and character (defined in this context as developmental aspects of personality). However, biological correlations have proven hard to confirm.
  • 2.3K
  • 06 Dec 2022
Topic Review
CPC with a Tubular Absorber
The compound parabolic concentrator (CPC) is a highly interesting solar collector technology for different low-concentration applications due to no tracking requirement. The CPC with a tubular absorber is the most common type of CPC. 
  • 2.3K
  • 27 Sep 2021
Topic Review
Interventions to Built Heritage
The expression of genius loci in architecture implies the reflection of memory and symbols, which serve to root the society that can be traced on the cultural heritage and the language of architecture. This property of architecture is essential for human beings to associate themselves with the place since it contributes to culture and cultural sustainability. As stated by Abusafieh, there is a significant link between culture and sustainability, and the rules, values, beliefs, and norms of the culture transfer the sustainability of vitality of the communities.
  • 2.3K
  • 23 May 2022
Topic Review
Metallurgical Technologies to Treat E-Waste
e-waste is any broken/unwanted electrical and electronic equipment (EEE) that has reached the end of its lifecycle or economic life span. E-waste has been traditionally treated with metallurgical technologies such as mechanical separations, pyro-metallurgical, and hydrometallurgical methods. The technologies such as the pyro-metallurgical process to treat e-waste has been studied and linked with environmental challenges such as the generation of large quantities of harmful by-products, the formation of brominated and chlorinated di-benzo furans, and dioxins from halogens present in the plastic part of e-waste during the burning process. The pyro-metallurgical process requires high-energy to treat e-waste and is inefficient in the recovery of precious metals. Hydrometallurgical technology has also been explored, mostly involving chemical reagents such as strong acids (sulphuric acid, nitric acid, hydrochloric acid) and complex chemical reagents such as cyanide and thiosulfate to leach base, rare earth, and precious metals. 
  • 2.3K
  • 28 Sep 2022
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