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Topic Review
Chelating Ability of Plant Polyphenols
Many studies have widely examined the effects of dietary polyphenols on human health. Polyphenols are well known for their antioxidant properties and for their chelating abilities, by which they can be potentially employed in cases of pathological conditions, such as iron overload. The iron-binding abilities of dietary polyphenols can be important in inflammatory/immunomodulatory responses, especially involving macrophages and dendritic cells, and they also might contribute to reshape the gut microbiota into a healthy profile. As the axes “polyphenol–iron metabolism–inflammatory responses” and “polyphenol–iron availability–gut microbiota” have not been very well explored so far, there is the need for further investigation to exploit such a potential to prevent or counteract pathological conditions.
  • 2.3K
  • 16 Mar 2023
Topic Review
Calcium Phosphate Nanoparticles in Bone
Bone injuries and diseases constitute a burden both socially and economically, as the consequences of a lack of effective treatments affect both the patients’ quality of life and the costs on the health systems. This impended need has led to a recent focus on the development of efficacious bone tissue engineering solutions. Here, the use of biomaterial-based nanoparticles for the delivery of therapeutic factors is summrised. Among the biomaterials being considered to date, calcium phosphates have emerged as one of the most promising materials for bone repair applications due to their osteoconductivity, osteoinductivity and their ability to be resorbed in the body. Calcium phosphate nanoparticles have received particular attention as non-viral vectors for gene therapy, as factors such as plasmid DNAs, microRNAs (miRNA) and silencing RNA (siRNAs) can be easily incorporated on their surface. Calcium phosphate nanoparticles loaded with therapeutic factors have also been delivered to the site of bone injury using scaffolds and hydrogels. Here an overview of the use of calcium phosphate nanoparticles as carriers for therapeutic factors for application in bone tissue engineering is provided.
  • 2.3K
  • 30 Oct 2020
Topic Review
Microsoft HoloLens
Microsoft HoloLens, known under development as Project Baraboo, are a pair of mixed reality smartglasses developed and manufactured by Microsoft. HoloLens was the first head-mounted display running the Windows Mixed Reality platform under the Windows 10 computer operating system. The tracking technology used in HoloLens can trace its lineage to Kinect, an add-on for Microsoft's Xbox game console that was introduced in 2010. The pre-production version of HoloLens, the Development Edition, shipped on March 30, 2016, and is targeted to developers in the United States and Canada for a list price of $3000 which allowed hobbyist, professionals, and corporations to participate in the pre-production version of HoloLens. Samsung and Asus have extended an offer to Microsoft to help produce their own mixed-reality products, in collaboration with Microsoft, based around the concept and hardware on HoloLens. On October 12, 2016, Microsoft announced global expansion of HoloLens and publicized that HoloLens would be available for preorder in Australia, Ireland, France, Germany, New Zealand and the United Kingdom. There is also a Commercial Suite (similar to a pro edition of Windows), with enterprise features, such as BitLocker security. As of May 2017, The Suite sold for US$5,000. Microsoft has decided to rent the Hololens without clients making the full investment. Microsoft partners with a company called Abcomrents to give the service of Hololens rental. HoloLens 2 was announced at the Mobile World Congress (MWC) in Barcelona, Spain, on February 24, 2019, and was available on preorder at US$3,500.
  • 2.3K
  • 29 Sep 2022
Topic Review
Benzodiazepine Use Disorder
Benzodiazepine use disorder (BUD), also called misuse or abuse, is the use of benzodiazepines without a prescription, often for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects. Benzodiazepines are one of the more common prescription drugs used recreationally. When used recreationally benzodiazepines are usually administered orally but sometimes they are taken intranasally or intravenously. Recreational use produces effects similar to alcohol intoxication. In tests in pentobarbital trained rhesus monkeys benzodiazepines produced effects similar to barbiturates. In a 1991 study, triazolam had the highest self-administration rate in cocaine trained baboons, among the five benzodiazepines examined: alprazolam, bromazepam, chlordiazepoxide, lorazepam, triazolam. A 1985 study found that triazolam and temazepam maintained higher rates of self-injection in both human and animal subjects compared to a variety of other benzodiazepines (others examined: diazepam, lorazepam, oxazepam, flurazepam, alprazolam, chlordiazepoxide, clonazepam, nitrazepam, flunitrazepam, bromazepam, and clorazepate). A 1991 study indicated that diazepam, in particular, had a greater abuse liability among people who were drug abusers than did many of the other benzodiazepines. Some of the available data also suggested that lorazepam and alprazolam are more diazepam-like in having relatively high abuse liability, while oxazepam, halazepam, and possibly chlordiazepoxide, are relatively low in this regard. A 1991–1993 British study found that the hypnotics flurazepam and temazepam were more toxic than average benzodiazepines in overdose. A 1995 study found that temazepam is more rapidly absorbed and oxazepam is more slowly absorbed than most other benzodiazepines. Benzodiazepines have been abused both orally and intravenously. Different benzodiazepines have different abuse potential; the more rapid the increase in the plasma level following ingestion, the greater the intoxicating effect and the more open to abuse the drug becomes. The speed of onset of action of a particular benzodiazepine correlates well with the 'popularity' of that drug for abuse. The two most common reasons for preference were that a benzodiazepine was 'strong' and that it gave a good 'high'. According to Dr. Chris Ford, former clinical director of Substance Misuse Management in General Practice, among drugs of abuse, benzodiazepines are often seen as the 'bad guys' by drug and alcohol workers. Illicit users of benzodiazepines have been found to take higher methadone doses, as well as showing more HIV/HCV risk-taking behavior, greater poly-drug use, higher levels of psychopathology and social dysfunction. However, there is only limited research into the adverse effects of benzodiazepines in drug misusers and further research is needed to demonstrate whether this is the result of cause or effect.
  • 2.3K
  • 18 Oct 2022
Topic Review
2020 XL5
2020 XL5 is a near-Earth asteroid and Earth trojan discovered by the Pan-STARRS 1 survey at Haleakala Observatory, Hawaii on 12 December 2020. It oscillates around the Sun–Earth L4 Lagrangian point (leading 60°), one of the dynamically stable locations where the combined gravitational force acts through the Sun's and Earth's barycenter. Analysis of 2020 XL5's trojan orbit stability suggests it will remain around Earth's L4 point for at least four thousand years until gravitational perturbations from repeated close encounters with Venus destabilize its trojan configuration. With a diameter about 1.2 km (0.75 mi), 2020 XL5 is the second Earth trojan discovered and is the largest of its kind known, after 2010 TK7.
  • 2.3K
  • 18 Oct 2022
Topic Review
A Reactive Power Compensation Method
One of the main challenges of today’s electrical power engineering is the symmetrization of grid voltages and the minimization of reactive power flows in distribution networks. There are many negative effects associated with asymmetry in power systems, such as increased losses in electric motors, harmonics transferred to DC systems, or phase currents inequality. With the reactive power compensation method, the active power flow can be reduced even in the presence of angular asymmetry between voltage vectors of the utility grid. 
  • 2.3K
  • 09 Feb 2022
Topic Review
Compounds Involved in Bitterness and Astringency of Pulses
Despite the many advantages of pulses, they are characterised by off-flavours that limit their consumption. Off-notes, bitterness and astringency contribute to negative perceptions of pulses. Several hypotheses have assumed that non-volatile compounds, including saponins, phenolic compounds, and alkaloids, are responsible for pulse bitterness and astringency.
  • 2.3K
  • 20 Apr 2023
Topic Review
African Wild Dog
The African wild dog (Lycaon pictus) is a highly social and charismatic carnivore native to sub-Saharan Africa. Recognized by its distinctive mottled coat pattern and large rounded ears, it is one of Africa's most endangered predators. Living in cohesive packs, African wild dogs exhibit complex social behaviors and cooperative hunting strategies, making them both fascinating and ecologically important species in African ecosystems.
  • 2.3K
  • 08 Mar 2024
Topic Review
Teak Allelopathy and Agroforestry
Teak (Tectona grandis L.f.) is one of the most valuable timber species, and is cultivated in agroforestry systems in many countries across the tropical and subtropical regions of the world.
  • 2.3K
  • 09 Jan 2022
Topic Review
Seaweeds as a Fermentation Substrate
The interest in marine macroalgae are increasing  as novel and functional food and feed products. Marine macroalgae show a high flexibility and applicability due to the bioactive properties of the compounds produced. In the nutraceutical sector, the development of novel food products with high nutritious value and sustainable development raises the interest in this biological group.  Indeed, seaweeds mainly need exposure to sun, aeration, artificial or naturally, and seawater rich in nutrients to grow and obtain a high amount of biomass to then develop novel functional food products that can be produced by the fermentation method, mainly performed by lactic acid bacteria. Still, this is a topic that needs to be further developed in order to improve the beneficial and organoleptic  properties of seaweeds.Here is proposed to the potential of prebiotic and probiotic fermentation and the potential of seaweed in food and feed industrial sectors.
  • 2.3K
  • 08 Nov 2021
Topic Review
Concrete Reinforced with Sisal Fibers
Concrete is a commonly used building material; however, it is subject to abrupt failure and limited energy absorption when yielding. The use of short discrete fibers has displayed a lot of potential in overcoming these issues. Sisal is a natural fiber that is renewable, inexpensive, and readily accessible. SSF is a potential reinforcement for use in concrete because of its cheap cost, low density, high specific strength and modulus, negligible health risk, easy accessibility in certain states, and renewability. 
  • 2.3K
  • 12 Aug 2022
Topic Review
Fault Tolerance Structures in Wireless Sensor Networks (WSNs)
The Industrial Revolution 4.0 (IR 4.0) has drastically impacted how the world operates. The Internet of Things (IoT), encompassed significantly by the Wireless Sensor Networks (WSNs), is an important subsection component of the IR 4.0. WSNs are a good demonstration of an ambient intelligence vision, in which the environment becomes intelligent and aware of its surroundings. WSN has unique features which create its own distinct network attributes and is deployed widely for critical real-time applications that require stringent prerequisites when dealing with faults to ensure the avoidance and tolerance management of catastrophic outcomes. Thus, the respective underlying Fault Tolerance (FT) structure is a critical requirement that needs to be considered when designing any algorithm in WSNs. Moreover, with the exponential evolution of IoT systems, substantial enhancements of current FT mechanisms will ensure that the system constantly provides high network reliability and integrity. 
  • 2.3K
  • 26 Aug 2022
Topic Review
Stacking
In chemistry, pi stacking (also called π–π stacking) refers to attractive, noncovalent interactions between aromatic rings, since they contain pi bonds. These interactions are important in nucleobase stacking within DNA and RNA molecules, protein folding, template-directed synthesis, materials science, and molecular recognition, although new research suggests that pi stacking may not be operative in some of these applications. Despite intense experimental and theoretical interest, there is no unified description of the factors that contribute to pi stacking interactions.
  • 2.3K
  • 31 Oct 2022
Topic Review
Project Alpha
Project Alpha was an effort by magician James Randi to test the quality of scientific rigor of a well-known test of paranormal phenomena. In the late 1970s, Randi contacted the newly established McDonnell Laboratory for Psychical Research ("MacLab") with suggestions on how to conduct tests for paranormal phenomena. At the same time, two teenage boys (Steve Shaw, later known as Banachek, and Mike Edwards) independently contacted the McDonnell Laboratory and volenteered as subjects for such tests from 1979 to 1982. They quickly proved to exhibit a range of paranormal abilities far and away better than the other subjects of the experiment. The lab began leaking reports of the pair's capabilities, which were in fact simple magic tricks. When rumors of the test subjects' connection to Randi reached Peter Phillips, head of the MacLab, he instituted tighter protocols for the experiments; the two subjects' results declined sharply. In 1983, Randi held a press conference to expose the deception In the wake of Project Alpha, there were a number of controversies about the ethics of interference in scientific research and the validity of paranormal research as it then existed. It remains a watershed event in the field of parapsychology.
  • 2.3K
  • 28 Nov 2022
Topic Review
Integration of AI and the IoT in Education
The emulation of human intelligence processes by computer systems is known as artificial intelligence (AI). The development of intelligent machines that function and respond much like people is the focus of this area of computer science. Machine learning, computer vision, and natural language processing are all examples of AI technology. These tools may be used to build systems with intelligence that can reason, analyze, and gain knowledge from data. On the other hand, the Internet of Things (IoT) is a network of real physical items, such as gadgets and appliances, that are integrated with sensors, software, and connections to allow for data collection and exchange. The integration of AI and the IoT in education has the potential to revolutionize the way we learn. Personalized learning, real-time feedback and support, and immersive learning experiences are some of the benefits that AI and the IoT can bring to the education system.
  • 2.3K
  • 22 Nov 2023
Topic Review
Magneto-Fluorescent Nanosystems for Biomodal Imaging
The various imaging techniques used in clinic have advantages and disadvantages. The advent of nanotechnology offers the possibility to combine several imaging agents within the same nano-object. This will allow to perform multi-imaging and thus obtain additional information during the same clinical procedure. Here, the focus are made on the potentialities of biomodal agents labeled for MRI and optical imaging. The three main associations for obtaining magneto-fluorescent objects will be presented: (1) association by covalent bonding; (2) encapsulation in matrices; (3) dispersion in nanoassemblies.
  • 2.3K
  • 13 Oct 2021
Topic Review
Automatic Wheelchairs
Automatic wheelchairs refers to devices equipped with wheelchairs, which can move automatically. Automatic wheelchairs have evolved in terms of instrumentation and control, improving the mobility of people with physical disabilities. The different wheelchair control techniques are divided into two categories: sensor technology non-invasively placed on the user and wheelchair instrumentation.
  • 2.3K
  • 26 Nov 2020
Topic Review
Developmental Origins of Health and Disease (DOHaD) Hypothesis
The “developmental origins of health and disease” (DOHaD) hypothesis refers to the influence of early developmental exposures and fetal growth on the risk of chronic diseases in later periods. 
  • 2.3K
  • 11 Feb 2022
Topic Review
The Human Gut Microbiome in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder characterized by decreased verbal and social interactions, limited interests and activities, and repetitive behaviors. Along with these significant conditions, ASD regularly co-occurs with other clinical symptoms, including gastrointestinal disturbances (up to 70%), motor deficits (79%), sleep problems (50–80%), and intellectual disability (45%). The high prevalence of gastrointestinal (GI) disorders among autism spectrum disorder (ASD) patients has prompted scientists to look into the gut microbiota as a putative trigger in ASD pathogenesis.
  • 2.3K
  • 02 Mar 2022
Topic Review
Load Following of Small Modular Reactors
Small modular reactors (SMRs) are generally defined as nuclear reactors with power outputs between 10 megawatts electric (MWe) and 300 MWe. In order to solve such a problem, a load-following operation that adjusts the output of the existing large-capacity thermal power plant or nuclear power plant according to the increase or decrease in the load is required. While this is not technically impossible, it is technically and economically undesirable. The next alternative that comes to mind is a small modular reactor (SMR). This is because, by operating multiple SMRs of less than 300 MW together, as much as necessary, it is easy to carry out a load-following operation, and the safety of an SMR is much higher than that of existing large scale nuclear power plants.
  • 2.3K
  • 07 Sep 2022
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