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Topic Review
Therapeutic Proteins
Reinventing approved therapeutic proteins for a new dose, a new formulation, a new route of administration, an improved safety profile, a new indication, or a new conjugate with a drug or a radioactive source is a creative approach to benefit from the billions spent on developing new therapeutic proteins. These new opportunities were created only recently with the arrival of Artificial Intelligence (AI)/Machine Learning (ML) tools and high throughput screening technologies. Furthermore, the complex nature of proteins offers mining opportunities that are not possible with chemical drugs; bringing in newer therapies without spending billions makes this path highly lucrative financially while serving the dire needs of humanity. 
  • 2.4K
  • 15 May 2023
Topic Review
Rotor Dynamic Scattering
Rotor dynamic scattering refers to the phenomenon that a rotating rotor-like component continuously deflects incident radar waves in the observation field to generate dynamic echoes. This scattering feature has obvious dynamic characteristics and periodic characteristics. Factors such as observation angle, radar wave frequency, polarization mode, rotor disc angle and rotor carrier attitude angle are closely related. The emergence of dynamic scattering has transformed the rotor radar cross-section (RCS) problem from static solution to dynamic analysis. Studying rotor dynamic scattering has great engineering value for designing stealth rotors from the dynamic RCS level.
  • 2.4K
  • 30 Oct 2020
Topic Review
Dolomite Phenomenon
The so-called dolomite phenomenon, also known as dolomite edaphism or dolomitophily, occurs globally and is evidenced through the appearance of an endemic flora on nutrient-poor soils with high levels of magnesium. It occurs when dolomitic rocks emerge, especially with high Mg content, and when tectonic or weathering processes generate skeletal soils, predominantly sandy or gravelly in texture. These types of habitats are associated with a specific flora, also accompanied by other tolerant species.
  • 2.4K
  • 02 Feb 2021
Topic Review
Plastic Waste Disposal in South African Townships
Twenty-first century human behaviour continues to escalate activities that result in environmental damage. This calls for environmentally friendly solutions, such as waste recycling and handling, to deal with the increased amount of waste, especially plastics. The plastic materials manufacturing sector is booming, particularly packaging; while only a fraction of its waste is recycled, another fraction is destroyed, and the larger part continues to pollute the environment. In addition to other waste disposal activities, destroying plastic or incineration (which could be for energy recovery) is usually subjected to strict legal requirements because of its effect on the environment. However plastic is destroyed or disposed of, it poses a serious challenge in both the short term and the long term to humans and their natural environment if the process is not efficiently managed.
  • 2.4K
  • 30 Jan 2022
Topic Review
Japanese Zen
Zen is the Japanese variant of Chan Buddhism, a Mahayana school that strongly emphasizes dhyana concentration-meditation. This practice, according to Zen proponents, gives insight into one's true nature, or the emptiness of inherent existence, which opens the way to a liberated way of living.
  • 2.4K
  • 04 Nov 2022
Topic Review
Dingbat
In typography, a dingbat (sometimes more formally known as a printer's ornament or printer's character) is an ornament, specifically, a glyph used in typesetting, often employed to create box frames, (similar to box-drawing characters) or as a dinkus (section divider). Some of the dingbat symbols have been used as signature marks, used in bookbinding to order sections. In the computer industry, a Dingbat font was a computer font that has symbols and shapes that reused the code points designated for alphabetical or numeric characters. This practice was necessitated by the limited number of code points available in 20th century operating systems. Most modern fonts are based on Unicode, which has unique code points for dingbat glyphs.
  • 2.4K
  • 25 Nov 2022
Topic Review
Iron-Based Shape Memory Alloys in Construction
As a promising candidate in the construction industry, iron-based shape memory alloy (Fe-SMA) has attracted lots of attention in the engineering and metallography communities because of its foreseeable benefits including corrosion resistance, shape recovery capability, excellent plastic deformability, and outstanding fatigue resistance. Pilot applications have proved the feasibility of Fe-SMA as a highly efficient functional material in the construction sector.
  • 2.4K
  • 11 Mar 2022
Topic Review
HCN-Derived Polymers
HCN-derived polymers are a heterogeneous group of complex substances synthesized from pure HCN; from its salts; from its oligomers, specifically its trimer and tetramer, aminomalononitrile (AMN) and diaminomaleonitrile (DAMN), respectively; or from its hydrolysis products, such as formamide, under a wide range of experimental conditions. The characteristics and properties of HCN-derived polymers depend directly on the synthetic conditions used for their production and, by extension, their potential applications. These puzzling systems have been known mainly in the fields of prebiotic chemistry and in studies on the origins of life and astrobiology since the first prebiotic production of adenine by Oró in the early years of the 1960s. However, the first reference regarding their possible role in prebiotic chemistry was mentioned in the 19th century by Pflüger. Currently, HCN-derived polymers are considered keys in the formation of the first and primeval protometabolic and informational systems, and they may be among the most readily formed organic macromolecules in the solar system. In addition, HCN-derived polymers have attracted a growing interest in materials science due to their potential biomedical applications as coatings and adhesives; they have also been proposed as valuable models for multifunctional materials with emergent properties such as semiconductivity, ferroelectricity, catalysis and photocatalysis, and heterogeneous organo-synthesis. However, the real structures and the formation pathways of these fascinating substances have not yet been fully elucidated. Several models based on either computational approaches or spectroscopic and analytical techniques have endeavored to shed light on their complete nature.
  • 2.4K
  • 29 Apr 2021
Topic Review
WirelessHART
The industrialization has led to a huge demand for a network control system to monitor and control multi-loop processes with high effectiveness. WirelessHART is a wireless sensor networking technology based on the existing conventional wired Highway Addressable Remote Transducer (HART) protocol. The protocol utilizes a time-synchronized, self-organizing, and self-healing mesh architecture. This is the first wireless communication protocol that adopts over 2.4 GHz radio-frequency channel in the IEEE 802.15.4 for industrial process control applications.
  • 2.4K
  • 26 Jul 2021
Biography
Ajahn Brahm
Phra Visuddhisamvarathera AM, known as Ajahn Brahmavaṃso, or simply Ajahn Brahm (born Peter Betts[1] on 7 August 1951), is a British-Australian Theravada Buddhist monk. Currently Ajahn Brahm is the Abbot of Bodhinyana Monastery, in Serpentine, Western Australia, Spiritual Adviser to the Buddhist Society of Victoria, Spiritual Adviser to the Buddhist Society of South Australia, Spiritual Patron
  • 2.4K
  • 14 Nov 2022
Topic Review
Prostate-Specific Membrane Antigen
Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is overexpressed in prostate cancer and correlates with the aggressiveness of the disease. PSMA is a promising target for positron emission tomography (PET) imaging and theranostics in prostate cancer patients validated in recent prospective trials. Several clinical trials are currently ongoing to define the role of PSMA targeting radioligands in different settings and to evaluate the potential of other PSMA-based therapeutic modalities in prostate cancer.
  • 2.4K
  • 11 May 2021
Topic Review
China’s Macro Control Policy
Macro control refers to the adjustment and control of the whole social economy in order to promote the development of the market and standardize the operation of the market. Output growth and technological progress show the performance of economic growth in gross and efficiency, respectively, which is the external performance and internal driving force of economic growth. To achieve long-term sustainable economic development, it is necessary to consider both the aggregate problem and technological progress. In this context, we attempts to explore the effectiveness of China’s macroeconomic regulation and control policy on output growth and technological progress under the economic policy uncertainty. Specifically, this paper analyzes the effectiveness of macroeconomic regulation and control policy on China’s output growth and technological progress in an uncertain environment, and then makes an empirical study by constructing a time-varying parameter vector autoregression model (TVP-VAR). Furthermore, the simulation test of the relevant results is carried out using the counter-fact analysis method.
  • 2.4K
  • 01 Jul 2021
Topic Review
Crop Yield Prediction Approaches
Crop yield prediction is becoming more important because of the growing concern about food security. Early crop yield prediction plays an important role in reducing famine by estimating the food availability for the growing world population. Deep learning has emerged as a potential tool for crop yield prediction, allowing the model to automatically extract features and learn from the datasets. Meanwhile, smart farming technology enables the farmers to achieve maximum crop yield by extracting essential parameters of crop growth.
  • 2.4K
  • 12 May 2022
Topic Review
Venus (Planet)
Venus is the second-closest planet to the Sun, orbiting it every 224.7 Earth days. After Earth's Moon, it is the brightest object in the night sky, reaching an apparent magnitude of −4.6. As an inferior planet from Earth it never appears to venture far from the Sun, and its elongation reaches a maximum of 47.8°. Venus reaches its maximum brightness shortly before sunrise or shortly after sunset, and is often referred to as the Morning Star or as the Evening Star. A terrestrial planet, it is sometimes called Earth's "sister planet", as the two are similar in size and bulk composition. The planet is covered with an opaque layer of highly reflective clouds and its surface cannot be seen from space in visible light, making it a subject of great speculation until some of its secrets were revealed by planetary science in the 20th century. Venus has the densest atmosphere of the terrestrial planets, consisting mostly of carbon dioxide, and the atmospheric pressure at the planet's surface is 90 times that of the Earth. Venus' surface has been mapped in detail only in the last 20 years. It shows evidence of extensive volcanism, and some of its volcanoes may still be active today. In contrast to the constant crustal movement seen on Earth, Venus is thought to undergo periodic episodes of plate tectonics, in which the crust is subducted rapidly within a few million years separated by stable periods of a few hundred million years. The planet is named after Venus, the Roman goddess of love, and most of its surface features are named after famous and mythological women. The adjective Venusian is commonly used for items related to Venus, though the Latin adjective is the rarely used Venereal; the now-archaic Cytherean is still occasionally encountered.
  • 2.4K
  • 01 Nov 2022
Topic Review
Life Table
In actuarial science and demography, a life table (also called a mortality table or actuarial table) is a table which shows, for each age, what the probability is that a person of that age will die before their next birthday ("probability of death"). In other words, it represents the survivorship of people from a certain population. They can also be explained as a long-term mathematical way to measure a population's longevity. Tables have been created by demographers including Graunt, Reed and Merrell, Keyfitz, and Greville. There are two types of life tables used in actuarial science. The period life table represents mortality rates during a specific time period of a certain population. A cohort life table, often referred to as a generation life table, is used to represent the overall mortality rates of a certain population's entire lifetime. They must have had to be born during the same specific time interval. A cohort life table is more frequently used because it is able to make a prediction of any expected changes in mortality rates of a population in the future. This type of table also analyzes patterns in mortality rates that can be observed over time. Both of these types of life tables are created based on an actual population from the present, as well as an educated prediction of the experience of a population in the near future. In order to find the true life expectancy average, 100 years would need to pass and by then finding that data would be of no use as healthcare is continually advancing. Other life tables in historical demography may be based on historical records, although these often undercount infants and understate infant mortality, on comparison with other regions with better records, and on mathematical adjustments for varying mortality levels and life expectancies at birth. From this starting point, a number of inferences can be derived. Life tables are also used extensively in biology and epidemiology. An area that uses this tool is Social Security. It examines the mortality rates of all the people who have Social Security to decide which actions to take. The concept is also of importance in product life cycle management. All mortality tables are specific to environmental and life circumstances, and are used to probabilistically determine expected maximum age within those environmental conditions.
  • 2.4K
  • 02 Nov 2022
Topic Review
Cappadocia (Roman Province)
Template:Infobox Former Subdivision Cappadocia was a province of the Roman Empire in Anatolia (modern central-eastern Turkey), with its capital at Caesarea. It was established in 17 AD by the Emperor Tiberius (ruled 14-37 AD), following the death of Cappadocia's last king, Archelaus. Cappadocia was an imperial province, meaning that its governor (legatus Augusti) was directly appointed by the emperor. During the latter 1st century, the province also incorporated the regions of Pontus and Armenia Minor.
  • 2.4K
  • 08 Nov 2022
Topic Review
Roles of the CXCL8-CXCR1/2 Axis in Cancer
In humans, Interleukin-8 (IL-8 or CXCL8) is a granulocytic chemokine with multiple roles within the tumor microenvironment (TME), such as recruiting immunosuppressive cells to the tumor, increasing tumor angiogenesis, and promoting epithelial-to-mesenchymal transition (EMT). 
  • 2.4K
  • 29 Mar 2022
Topic Review
Lignocellulosic Biofuels: A Renewable Bioenergy
Biofuel consists of non-fossil fuel derived from the organic biomass of renewable resources, including plants, animals, microorganisms, and waste. Energy derived from biofuel is known as bioenergy. The reserve of fossil fuels is now limited and continuing to decrease, while at the same time demand for energy is increasing. In order to overcome this scarcity, it is vital for human beings to transfer their dependency on fossil fuels to alternative types of fuel, including biofuels, which are effective methods of fulfilling present and future demands. The conversion of lignocellulosic feedstock is an important step during biofuel production. It is, however, important to note that, as a result of various technical restrictions, biofuel production is not presently cost efficient, thus leading to the need for improvement in the methods employed. 
  • 2.4K
  • 26 Apr 2022
Topic Review
Pathophysiology of Diabetic Foot Ulcers
One of the most significant challenges of diabetes health care is diabetic foot ulcers (DFU). DFUs are more challenging to cure, and this is particularly true for people who already have a compromised immune system. Pathogenic bacteria and fungi are becoming more resistant to antibiotics, so they may be unable to fight microbial infections at the wound site with the antibiotics.
  • 2.4K
  • 28 Jul 2022
Topic Review
Sustainable Total Productive Maintenance
Sustainable Total Productive Maintenance (STPM) arose in 2021 as a promising, new concept to fill the lack of sustainability in Total Productive Maintenance (TPM) and allow companies to overcome its implementation barriers. It revolves around increasing the understanding of the systems approach and contributing to setting contemporary companies’ sustainable ideology by supporting orientation toward sustainability from a sustainable maintenance perspective. However, STPM is still in its infancy and is viewed as a complement to the traditional TPM approach and is based on its pillars. 
  • 2.4K
  • 18 Sep 2023
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