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Topic Review
Chromosomal instability in Fanconi anemia
Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited pathogenic variants in any of 22 FANC genes, which cooperate in the FA/BRCA pathway. This pathway regulates the repair of DNA interstrand crosslinks (ICLs) through homologous recombination. In FA proper repair of ICLs is impaired and accumulation of toxic DNA double strand breaks occurs. To repair this type of DNA damage, FA cells activate alternative error-prone DNA repair pathways, which may lead to the formation of gross structural chromosome aberrations of which radial figures are the hallmark of FA, and their segregation during cell division are the origin of subsequent aberrations such as translocations, dicentrics and acentric fragments. The deficiency in DNA repair has pleiotropic consequences in the phenotype of patients with FA, including developmental alterations, bone marrow failure and an extreme risk to develop cancer.
  • 2.4K
  • 15 Jan 2021
Topic Review
Interferon Gamma
Interferon gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. It was also shown to be produced in human lymphocytes. or tuberculin-sensitized mouse peritoneal lymphocytes challenged with Mantoux test (PPD); the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed IFN-γ release assay used to test for tuberculosis. In humans, the IFN-γ protein is encoded by the IFNG gene.
  • 2.4K
  • 28 Apr 2023
Topic Review
Oxidative Stress
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflam-matory chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of lipid metabolism is closely related to alterations of the oxidant/antioxidant balance, which affect metabolism-related organelles, leading to cellular lipotoxicity, lipid peroxidation, chronic endo-plasmic reticulum (ER) stress, and mitochondrial dysfunction. Increased OxS also triggers hepatocytes stress pathways, leading to inflammation and fibrogenesis, contributing to the pro-gression of non-alcoholic steatohepatitis (NASH). The antioxidant response, regulated by the Nrf2/ARE pathway, is a key component in this process and counteracts oxidative stress-induced damage, contributing to the restoration of normal lipid metabolism. 
  • 2.4K
  • 27 Jan 2022
Topic Review
Dyspepsia in Diabetic Patients
Diabetes mellitus is a widespread disease, and represents an important public health burden worldwide. Together with cardiovascular, renal and neurological complications, many patients with diabetes present with gastrointestinal symptoms, which configure the so-called diabetic enteropathy. 
  • 2.4K
  • 11 May 2021
Topic Review
Chinese Wine Industry
After more than 40 years of development, China’s wine regulatory system has been constantly improved, from half-base wine standards to pure-juice fermented wine standards, and then to the establishment of a relatively complete and mature industry-standard system with product and manufacturing standards as the core and other relevant industry standards as accessories. This advancement supports that the Chinese wine industry has emerged from New World wine countries. Nowadays, according to statistics from the International Organization of Vine and Wine, China is one of the top grape producers, wine consumers, and importers globally.
  • 2.4K
  • 20 May 2022
Topic Review
Fused Deposition Modelling of Polymer Composite
Additive manufacturing (AM) highlights developing complex and efficient parts for various uses. Fused deposition modelling (FDM) is the most frequent fabrication procedure used to make polymer products. Although it is widely used, due to its low characteristics, such as weak mechanical properties and poor surface, the types of polymer material that may be produced are limited, affecting the structural applications of FDM. Therefore, the FDM process utilises the polymer composition to produce a better physical product. 
  • 2.4K
  • 03 Jan 2023
Topic Review
Lateral Flow Immunoassay
Abundant immunological assays currently exist for detecting pathogens and identifying infected individuals, making detection of diseases at early stages integral to preventing their spread, together with the consequent emergence of global health crises. Lateral flow immunoassay (LFIA) is a test characterized by simplicity, low cost, and quick results. Furthermore, LFIA testing does not need well-trained individuals or laboratory settings.
  • 2.4K
  • 18 Nov 2022
Topic Review
Stimuli-Responsive Drug Delivery Systems
Recent advancements in the arena of onco-targeted therapies have enabled safe and effective tumor-specific localization through stimuli-responsive drug delivery systems. Owing to their promising characteristic features, stimuli-responsive drug delivery platforms have revolutionized the chemotherapy-based treatments with added benefits of enhanced bioavailability and selective cytotoxicity of cancer cells compared to the conventional modalities. The insensitivity of stimuli-responsive drug delivery platforms when exposed to normal cells prevents the release of cytotoxic drugs into the normal cells and therefore alleviates the off-target events associated with chemotherapy. Contrastingly, they showed amplified sensitivity and triggered release of chemotherapeutic payload when internalized into the tumor microenvironment causing maximum cytotoxic responses and the induction of cancer cell necrosis.
  • 2.4K
  • 10 Mar 2021
Topic Review
Inspiratory Muscle Training in Patients with Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a complex and heterogeneous disease, with pulmonary and extrapulmonary manifestations, which leads to the need to personalize the assessment and treatment of these patients. The latest updates of national and international guidelines for the management of COPD reveal the importance of respiratory rehabilitation (RR) and its role in improving symptoms, quality of life, and psychosocial sphere of patients. Within RR, the inspiratory muscle training (IMT) has received special interest, showing benefits in maximum inspiratory pressure, perception of well-being, and health status in patients with chronic heart disease, respiratory diseases, and dyspnea during exercise. 
  • 2.4K
  • 20 May 2022
Topic Review
Allicin on Cardiovascular Diseases
Allicin, a sulfur compound naturally derived from garlic, has shown beneficial effects on several cardiovascular risk factors through the modulation of cellular mechanisms and signaling pathways. Garlic is especially rich in sulfur-containing compounds; thus, many of these compounds can be responsible for its therapeutic effects. Recent studies have shown that allicin, a garlic-derived sulfur compound, has beneficial effects on different cell types that could be useful for the management of CVD or its risk factors. 
  • 2.4K
  • 19 Aug 2022
Topic Review
Selection of OCV–SOC Model for Battery Management Systems
A battery management system (BMS) plays a crucial role to ensure the safety, efficiency, and reliability of a rechargeable Li-ion battery pack. State of charge (SOC) estimation is an important operation within a BMS. Estimated SOC is required in several BMS operations, such as remaining power and mileage estimation, battery capacity estimation, charge termination, and cell balancing. The open circuit voltage (OCV) model needs to be stored within the battery management system for real-time SOC estimation. The selection, storage, and processing of OCV models involve several design constraints.
  • 2.4K
  • 28 Sep 2022
Topic Review
Hydrotalcite as CO2 Sinks for Climate Change Mitigation
Hydrotalcites are known in the bibliography as LDHs (Layered double hydroxides). Hydrotalcites, as such, are not good CO2 absorbents due to poor basic properties and presence of entities that hinder CO2 adsorption and are therefore subjected to thermal treatment (around 500 °C) to obtain nearly amorphous metastable mixed solid solutions known as calcined layered double hydroxides (CLDHs). There are several parameters that can make hydrotalcites suitable for use as CO2 sinks. 
  • 2.4K
  • 11 Jul 2022
Topic Review
Cyber-Physical System
Cyber-Physical System (CPS) is a symbol of the fourth industrial revolution (4IR) by integrating physical and computational processes which can associate with humans in various ways. In short, the relationship between Cyber networks and the physical component is known as CPS, which is assisting to incorporate the world and influencing our ordinary life significantly. In terms of practical utilization of CPS interacting abundant difficulties. CPS is involved in modern society very vastly with many uptrend perspectives. All the new technologies by using CPS are accelerating our journey of innovation. Researchers have explained the research areas of 14 important domains of Cyber-Physical Systems (CPS) including aircraft transportation systems, battlefield surveillance, chemical production, energy, agriculture (food supply), healthcare, education, industrial automation, manufacturing, mobile devices, robotics, transportation, and vehicular. 
  • 2.4K
  • 11 May 2023
Topic Review
AI and General movements (GMs)
       General movements (GMs) are spontaneous movements of infants up to five months post-term involving the whole body varying in sequence, speed, and amplitude. The assessment of GMs has shown its importance for identifying infants at risk for neuromotor deficits, especially for the detection of cerebral palsy. As the assessment is based on videos of the infant that are rated by trained professionals, the method is time-consuming and expensive. Therefore, approaches based on Artificial Intelligence have gained significantly increased attention in the last years.
  • 2.4K
  • 18 Feb 2021
Topic Review
Cerebrospinal Fluid Leak
A cerebrospinal fluid leak (CSF leak or CSFL) is a medical condition where the cerebrospinal fluid (CSF) surrounding the brain or spinal cord leaks out of one or more holes or tears in the dura mater. A cerebrospinal fluid leak can be either cranial or spinal, and these are two different disorders. A spinal CSF leak can be caused by one or more meningeal diverticula or CSF-venous fistulas not associated with an epidural leak. A CSF leak is either caused by trauma including that arising from medical interventions or spontaneously sometimes in those with predisposing conditions (known as a spontaneous cerebrospinal fluid leak or sCSF leak). Traumatic causes include a lumbar puncture noted by a post-dural-puncture headache, or a fall or other accident. Spontaneous CSF leaks are associated with heritable connective tissue disorders including Marfan syndrome and Ehlers–Danlos syndromes. A loss of CSF greater than its rate of production leads to a decreased volume inside the skull known as intracranial hypotension. Any CSF leak is most often characterized by orthostatic headaches, which worsen when standing, and improve when lying down. Other symptoms can include neck pain or stiffness, nausea, vomiting, dizziness, fatigue, and a metallic taste in the mouth. A CT myelography scan can identify the site of a cerebrospinal fluid leakage. Once identified, the leak can often be repaired by an epidural blood patch, an injection of the patient's own blood at the site of the leak, a fibrin glue injection, or surgery. The set of symptoms associated with a sCSF leak is referred to as a spontaneous cerebrospinal fluid leak syndrome (SCSFLS). A sCSF leak is uncommon but not rare, affecting at least one in 20,000 people and many more who go undiagnosed every year. On average, the condition develops at age 42, and women are twice as likely to be affected. Some people with a sCSF leak have a chronic leak of cerebrospinal fluid despite repeated patching attempts, leading to long-term disability due to pain and being unable to be upright, and surgery is often needed. SCSFLS was first described by German neurologist Georg Schaltenbrand in 1938 and by American neurologist Henry Woltman of the Mayo Clinic in the 1950s.
  • 2.4K
  • 11 Oct 2022
Topic Review
Trends in Bioenergy Production
A wide range of studies have been performed in the field of the usage of biomass for energy production, in order to contribute to the green transition from fossil fuels to renewable energies. Over the past 20 years (from 2000 to 2019), approximately 10,000 articles have been published in the “Agricultural and Biological Sciences” field on this theme, covering all stages of production—from the harvesting of crops to the particular type of energy produced. Articles were obtained from the SCOPUS database and examined with a text mining tool in order to analyze publication trends over the last two decades. Publications per year in the bioenergy theme have grown from 91 in 2000 to 773 in 2019. In particular the analyses showed how environmental aspects have increased their importance (from 7.3% to 11.8%), along with studies related to crop conditions (from 10.4% to 18.6%). Regarding the use of energy produced, growing trends were recognized for the impact of biofuels (mentions moved from 0.14 times per article in 2000 to 0.38 in 2019) and biogases (from 0.14 to 0.42 mentions).
  • 2.4K
  • 28 Aug 2020
Topic Review
Durability Performance of Geopolymer Concrete
Geopolymer concrete is produced from the geopolymerization process, in which molecules known as oligomers integrate to form geopolymer networks with covalent bonding. Its production expends less thermal energy and results in a smaller carbon footprint compared to Ordinary Portland Cement (OPC) concrete. It requires only an alkaline activator to catalyze its aluminosilicate sources such as metakaolin and fly ash, to yield geopolymer binder for the geopolymerization to take place. Because of its eco-friendly technology and practical application, current research interest is mainly concentrated on the endurance of geopolymer concrete to resist heat and chemical aggressions. 
  • 2.4K
  • 07 Mar 2022
Topic Review
Electro-Osmosis
Electroosmotic flow (or electro-osmotic flow, often abbreviated EOF; synonymous with electroosmosis or electroendosmosis) is the motion of liquid induced by an applied potential across a porous material, capillary tube, membrane, microchannel, or any other fluid conduit. Because electroosmotic velocities are independent of conduit size, as long as the electrical double layer is much smaller than the characteristic length scale of the channel, electroosmotic flow will have little effect. Electroosmotic flow is most significant when in small channels. Electroosmotic flow is an essential component in chemical separation techniques, notably capillary electrophoresis. Electroosmotic flow can occur in natural unfiltered water, as well as buffered solutions.
  • 2.4K
  • 29 Nov 2022
Topic Review
Long-Term Space Nutrition
Nutrition has many important functions in space travel, from providing enough nutrients and meeting the metabolic needs of a healthy body to enhancing an individual’s emotional well-being. Nutrition also plays a key role in offsetting many negative effects of space travel, such as radiation exposure, immune deficiency, oxidative stress, and bone and muscle loss.
  • 2.4K
  • 30 Jan 2022
Topic Review
Marine Nepheloid Layer
Marine nepheloid layer is a turbid layer containing significantly more suspended particles than the adjacent layers in oceans. The suspended particles may collide and form large falling particle aggregates known as marine snow. Although the nepheloid layer continually changes with time and space, it shows certain temporal and spatial stability. A marine nepheloid layer could last a few days to years, with a thickness ranging from meters to kilometers.
  • 2.4K
  • 16 Mar 2022
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