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Topic Review
SpyCatcher-SpyTag System
The SpyCatcher-SpyTag system was developed as a method for protein ligation. It is based on a modified domain from a Streptococcus pyogenes surface protein (SpyCatcher), which recognizes a cognate 13-amino-acid peptide (SpyTag). Upon recognition, the two form a covalent isopeptide bond between the side chains of a lysine in SpyCatcher and an aspartate in SpyTag. This technology has been used, among other applications, to create covalently stabilized multi-protein complexes, for modular vaccine production, and to label proteins (e.g., for microscopy). 
  • 10.0K
  • 19 Oct 2022
Topic Review
Iranian Plateau
The Iranian Plateau or the Persian Plateau is a geological feature in Central Asia, South Asia, and Western Asia. It is the part of the Eurasian Plate wedged between the Arabian and Indian plates, situated between the Zagros Mountains to the west, the Caspian Sea and the Kopet Dag to the north, the Armenian Highlands and the Caucasus Mountains in the northwest, the Strait of Hormuz and the Persian Gulf to the south and the Indo-Gangetic Plain to the east in Indian subcontinent. As a historical region, it includes Parthia, Media, Persis, the heartlands of Iran and some of the previous territories of Greater Iran. The Zagros Mountains form the plateau's western boundary, and its eastern slopes may be included in the term. The Encyclopædia Britannica excludes "lowland Khuzestan" explicitly and characterizes Elam as spanning "the region from the Mesopotamian Plain to the Iranian Plateau". From the Caspian in the northwest to Balochistan in the south-east, the Iranian Plateau extends for close to 2,000 km. It encompasses the greater part of Iran, all of Afghanistan, and Pakistan west of the Indus River containing some 3,700,000 square kilometres (1,400,000 sq mi). In spite of being called a "plateau", it is far from flat but contains several mountain ranges, the highest peak being Damavand in the Alborz at 5610 m, and the Dasht-e Lut east of Kerman in Central Iran falling below 300 m.
  • 10.0K
  • 22 Nov 2022
Topic Review
Vitamin B6 and Diabetes
Vitamin B6 is an essential nutrient for the human health. It is involved in more that 150 metabolic reactions which regulate the metabolism of glucose, lipids, amino acids, DNA, and neurotransmitters. In addition, vitamin B6 is an antioxidant molecule able to  counteracting the formation of reactive oxygen species (ROS) and advanced glycation end-products (AGEs). Epidemiological and experimental studies indicated the reduced levels of vitamin B6 can cause diabetes. In contrast other studies show that diabetes decreases vitamin B6 levels. Thus these findings lead to envisage the existence of a vicious circle at the basis of the relationship between vitamin B6 and diabetes. This entry reports the main evidence concerning the role of vitamin B6 in diabetes and examine the underlying molecular and cellular mechanisms.  
  • 10.0K
  • 28 Oct 2020
Topic Review
Ground-Penetrating Radar in Soil Studies
Information on the spatiotemporal variability of soil properties and states within the agricultural landscape is vital to identify management zones supporting precision agriculture (PA). Ground-penetrating radar (GPR) and electromagnetic induction (EMI) techniques have been applied to assess soil properties, states, processes, and their spatiotemporal variability. 
  • 10.0K
  • 14 Jun 2023
Topic Review
Collagen
Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in the tissues of marine invertebrates. The present overview has focused on a brief history of collagen, basic structure and synthesis, nomenclature, types, and classifications, sources of collagen with the emphasis on sea cucumber collagen, and related functional properties.
  • 10.0K
  • 13 Oct 2020
Topic Review
The Heritage Foundation
The Heritage Foundation (abbreviated to Heritage) is an American conservative think tank based in Washington, D.C., primarily geared towards public policy. The foundation took a leading role in the conservative movement during the presidency of Ronald Reagan, whose policies were taken from Heritage's policy study Mandate for Leadership. Since then, The Heritage Foundation has continued to have a significant influence in U.S. public policy making, and is considered to be one of the most influential conservative public policy organizations in the United States .
  • 10.0K
  • 07 Nov 2022
Topic Review
IBIDA
A company's earnings before interest, taxes, depreciation, and amortization (commonly abbreviated EBITDA, pronounced /iːbɪtˈdɑː/, /əˈbɪtdɑː/, or /ˈɛbɪtdɑː/) is an accounting measure calculated using a company's earnings, before interest expenses, taxes, depreciation, and amortization are subtracted, as a proxy for a company's current operating profitability (i.e., how much profit it makes with its present assets and its operations on the products it produces and sells, as well as providing a proxy for cash flow). Though often shown on an income statement, it is not considered part of the Generally Accepted Accounting Principles (GAAP) by the SEC.
  • 10.0K
  • 08 Oct 2022
Biography
Nikolai Aleksandrovich Kozyrev
Nikolai Alexandrovich Kozyrev (Russian: Никола́й Алекса́ндрович Ко́зырев; 2 September 1908 – 27 February 1983) was a Soviet astronomer/astrophysicist. He was born in St. Petersburg, and by 1928 he had graduated from the Leningrad State University. In 1931 he began working at the Pulkovo Observatory, located to the south of Leningrad. He was considered to be one
  • 9.9K
  • 30 Dec 2022
Topic Review
Direct and Indirect Solar Gain Systems
The energy crisis, the risk of interruptions or irregular supplies of conventional energy carriers, and the need to protect the environment stimulate the search for new solutions to improve the heat balance of buildings with the use of solar energy. Based on the criterion of the storage, distribution, and discharge time of stored heat, passive solar gain solutions can be divided into direct and indirect solar gain systems.
  • 9.9K
  • 15 Dec 2022
Topic Review
Sensor Technology in Autonomous Vehicles
With the significant advancement of sensor and communication technology and the reliable application of obstacle detection techniques and algorithms, automated driving is becoming a pivotal technology that can revolutionize the future of transportation and mobility. Sensors are fundamental to the perception of vehicle surroundings in an automated driving system, and the use and performance of multiple integrated sensors can directly determine the safety and feasibility of automated driving vehicles.
  • 9.9K
  • 31 Mar 2021
Topic Review
Bombardier Dash 8
The Bombardier Dash 8 or Q Series, previously known as the de Havilland Canada Dash 8 or DHC-8, is a series of twin-engined, medium-range, turboprop airliners. Introduced by de Havilland Canada (DHC) in 1984, they are now produced by Bombardier Aerospace. Over 1,000 Dash 8s of all models have been built. The Dash 8 was developed from the de Havilland Canada Dash 7, which featured extreme short take-off and landing (STOL) performance. With the Dash 8, DHC focused on improving cruise performance and lowering operational costs. The engine chosen was the Pratt & Whitney Canada PW100. The aircraft has been delivered in four series. The Series 100 has a maximum capacity of 39, the Series 200 has the same capacity but offers more powerful engines, the Series 300 is a stretched, 50-seat version, and the Series 400 is further stretched to 90 passengers. Models delivered after 1997 have cabin noise suppression and are designated with the prefix "Q". Production of the Series 100 ceased in 2005, followed by the 200 and 300 in 2009, leaving the Q400 as the only series still in production. Bombardier currently markets the aircraft as the Q Series, complementing the company's CRJ Series aircraft.
  • 9.9K
  • 21 Oct 2022
Topic Review
Wind Tower Houses in Dubai
Due to the similar climate conditions and proximity of the United Arab Emirates to other neighboring countries such as Iran and India, who have been familiar with the use of wind towers as cooling devices for a long time, wind towers were readily adopted in traditional buildings in the UAE. The most concentrated number of wind towers can be found in the residential neighborhood of Dubai called Alfahidi Historic Area. The number reaches around 50 wind towers in less than 0.25 km2, with an average of one wind tower per house. This neighborhood was originally designed for merchants who immigrated from Bastak in Iran. Later, wind towers were applied to various different types of buildings, such as shops and stores, as well as other residential neighborhoods of Shindagah and Deira.
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  • 19 Apr 2022
Topic Review
Performance Comparison of SQL and Graph Databases
In developing NoSQL databases, a major motivation is to achieve better efficient query performance compared with relational databases. The graph database is a NoSQL paradigm where navigation is based on links instead of joining tables. Links can be implemented as pointers, and following a pointer is a constant time operation, whereas joining tables is more complicated and slower, even in the presence of foreign keys. Therefore, link-based navigation has been seen as a more efficient query approach than using join operations on tables. Existing studies strongly support this assumption. Query complexity has received less attention. For example, in enterprise information systems, queries are usually complex so data need to be collected from several tables or by traversing paths of graph nodes of different types.
  • 9.9K
  • 15 Jul 2022
Topic Review
Schizoid Personality Disorder
Schizoid personality disorder (/ˈskɪtsɔɪd, ˈskɪdzɔɪd/, often abbreviated as SPD or SzPD) is a personality disorder characterized by a lack of interest in social relationships, a tendency toward a solitary or sheltered lifestyle, secretiveness, emotional coldness, detachment and apathy. Affected individuals may be unable to form intimate attachments to others and simultaneously possess a rich and elaborate but exclusively internal fantasy world. Other associated features include stilted speech, a lack of deriving enjoyment from most activities, feeling as though one is an "observer" rather than a participant in life, an inability to tolerate emotional expectations of others, apparent indifference when praised or criticized, a degree of asexuality, and idiosyncratic moral or political beliefs. Symptoms typically start in late childhood or adolescence. The cause of SPD is uncertain, but there is some evidence of links and shared genetic risk between SPD, other cluster A personality disorders (such as schizotypal personality disorder) and schizophrenia. Thus, SPD is considered to be a "schizophrenia-like personality disorder". It is diagnosed by clinical observation, and it can be very difficult to distinguish SPD from other mental disorders (such as autism spectrum disorder, with which it may sometimes overlap). The effectiveness of psychotherapeutic and pharmacological treatments for the disorder has yet to be empirically and systematically investigated. This is largely because people with SPD rarely seek treatment for their condition. Originally, low doses of atypical antipsychotics were also used to treat some symptoms of SPD, but their use is no longer recommended. The substituted amphetamine bupropion may be used to treat associated anhedonia. However, it is not general practice to treat SPD with medications, other than for the short-term treatment of acute co-occurring disorders (e.g. depression). Talk therapies such as cognitive behavioral therapy (CBT) may not be effective, because people with SPD may have a hard time forming a good working relationship with a therapist. SPD is a poorly studied disorder, and there is little clinical data on SPD because it is rarely encountered in clinical settings. Studies have generally reported a prevalence of less than 1% It is more common in males than in females. SPD is linked to negative outcomes, including a significantly compromised quality of life, reduced overall functioning even after 15 years and one of the lowest levels of "life success" of all personality disorders (measured as "status, wealth and successful relationships"). Bullying is particularly common towards schizoid individuals. Suicide may be a running mental theme for schizoid individuals, though they are not likely to actually attempt it. Some symptoms of SPD (e.g. solitary lifestyle and emotional detachment), however, have been stated as general risk factors for serious suicidal behaviour.
  • 9.9K
  • 20 Oct 2022
Topic Review
Shopping Hours
Customs and regulations for shopping hours for sunday (times that shops are open) vary from countries to cities.
  • 9.9K
  • 01 Dec 2022
Topic Review
Methods of Residual Stress Measurement
This entry introduces several commonly used residual stress measurement methods.
  • 9.9K
  • 01 Nov 2020
Topic Review Video
Ecological Stoichiometry
Ecological stoichiometry considers how nutritional needs of organisms for basic body-building molecules shape their ecology. It asks how nutritional demands of organisms and supply of nutrients in their environments affects organisms growth, their interactions with the biotic and abiotic worlds and nutrient cycling in whole ecosystem.
  • 9.9K
  • 04 Nov 2020
Topic Review
Biopolymers for Medical Applications
Biopolymers are the organic substances present in natural sources. The term biopolymer originates from the Greek words bio and polymer, representing nature and living organisms. Large macromolecules made up of numerous repeating units are known as biopolymers. As per the IUPAC definition, a macromolecule defines a single molecule. The biopolymers are found to be biocompatible and biodegradable, making them useful in different applications, such as edible films, emulsions, packaging materials in the food industry, and as drug transport materials, medical implants like medical implants organs, wound healing, tissue scaffolds, and dressing materials in pharmaceutical industries. 
  • 9.9K
  • 18 Mar 2022
Topic Review
Angle-Resolved Photoemission Spectroscopy (ARPES)
Angle-resolved photoemission spectroscopy (ARPES) is a vital technique in which spectra are collected from both the energy and momentum of photoemitted electrons and is indispensable for investigating the electronic band structure of solids. 
  • 9.9K
  • 08 Dec 2020
Topic Review
Nutritional Deficiencies Associated with Obesity
Obesity is a critical medical condition worldwide that is increasingly involved with nutritional derangements associated with micronutrient deficiencies, including iron, zinc, calcium, magnesium, selenium, and vitamins A, C, D, and E. Nutritional deficiencies in obesity are mainly caused by poor-quality diets, higher nutrient requirements, alterations in micronutrient metabolism, and invasive obesity treatments. The current conventional agricultural system is designed for intensive food production, focusing on food quantity rather than food quality, consuming excessive agricultural inputs, and producing nutrient-deficient foods, thus generating severe health and environmental problems; agricultural food products may worsen obesity-related malnutrition. Therefore, modern agriculture is adopting new biofortification technologies to combat micronutrient deficiencies and improve agricultural productivity and sustainability.
  • 9.8K
  • 01 Jan 2023
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