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Topic Review
Covalent Inhibitors Covalently Bound to Cysteine
Covalent inhibitors are a class of small molecule compounds that can covalently bind to specific target proteins, thereby inhibiting their biological functions. Cysteine is one of the least abundant amino acids in proteins of many organisms, which plays a crucial role in catalysis, signal transduction, and redox regulation of gene expression. The thiol group of cysteine possesses the ability to perform nucleophilic and redox-active functions that are not feasible for other natural amino acids. Cysteine is the most common covalent amino acid residue and has been shown to react with a variety of warheads, especially Michael receptors.
  • 2.5K
  • 18 Nov 2022
Topic Review
Savoia-Marchetti SM.79
The Savoia-Marchetti SM.79 Sparviero (Italian for sparrowhawk) was a three-engined Italian medium bomber developed and manufactured by aviation company Savoia-Marchetti. It could be the best-known Italian aeroplane of the Second World War. The SM.79 was easily recognizable due to its distinctive fuselage dorsal "hump", and was reportedly well liked by its crews, who nicknamed it il gobbo maledetto ("damned hunchback"). The SM.79 had been originally developed during the early 1930s as a cantilever low-wing monoplane employing a combined wood-and-metal structure. It had been designed with the initial intention of producing a swift eight-passenger transport aircraft, capable of besting even the fastest of its contemporaries at that time, however, the project quickly attracted the attention of the Italian government for its potential as an armed combat aircraft. Performing its first flight on 28 September 1934; between 1937 and 1939, early examples of the type established 26 separate world records, qualifying it for some time as being the fastest medium bomber in the world. As such, the SM.79 quickly became regarded as an item of national prestige in Fascist Italy, attracting significant government support and often being deployed as an element of state propaganda. Early on, the aircraft was routinely entered into competitive fly-offs and air races, seeking to capitalise on its advantages, and often emerged victorious in such contests. The SM.79 first saw combat during the Spanish Civil War; in this theatre, it operated without fighter escorts, normally relying on its relatively high speed to evade interception instead. While some issues were identified, and in some cases resolved, the SM.79's performance during the Spanish deployment was encouraging and stimulated demand for the type, including a decision to adopt it as the backbone of Italy's bomber units. Both Yugoslavia and Romania opted to procure the type for their own air services, while large numbers were also procured for the Regia Aeronautica. Almost 600 SM.79-I and –II aircraft were in service when Italy entered the Second World War during May 1940; thereafter, these aircraft were deployed across every theatre of war in which the Italians fought. The SM.79 was operated in various different capacities during the Second World War; initially, the type was used as a transport aircraft and medium bomber. Following pioneering work by the "Special Aerotorpedoes Unit", Italy put the type to work as a torpedo bomber; in this role, the SM.79 achieved notable successes against Allied shipping, particularly in the Mediterranean theater. A specialised drone version of the aircraft, flown by remote control was also developed, although the Armistice with Italy was enacted prior to any operational deployment. It was the most numerous Italian bomber of the Second World War, around some 1,300 aircraft were constructed. The type would remain in Italian service until 1952.
  • 2.5K
  • 30 Nov 2022
Topic Review
The Role of Small Molecules Containing Fluorine Atoms
The fluorine atom possesses many intrinsic properties that can be beneficial when incorporated into small molecules. These properties include the atom’s size, electronegativity, and ability to block metabolic oxidation sites. Substituents that feature fluorine and fluorine-containing groups are currently prevalent in drugs that lower cholesterol, relieve asthma, and treat anxiety disorders, as well as improve the chemical properties of various medications and imaging agents. 
  • 2.5K
  • 27 Feb 2024
Topic Review
Children’s and Adolescents’ Happiness and Family Functioning
Researchers represents the first systematic review of the literature on the relation between happiness (i.e., subjective well-being, life satisfaction, positive affect) and family functioning in families with children aged 6-18 years. 
  • 2.5K
  • 18 Jan 2023
Topic Review
Artificial Intelligence for Hydrogen Storage Vessels Design
Hydrogen is a potential candidate to replace fossil fuels for transport applications, with three technologies considered for the onboard storage of hydrogen: storage in the form of a compressed gas, storage as a cryogenic liquid, and storage as a solid. These technologies are now competing to meet the requirements of vehicle manufacturers; each has its own unique challenges that must be understood to direct future research and development efforts. 
  • 2.5K
  • 27 Jun 2023
Topic Review
The Leafless Vanilla Species
The pantropical genus Vanilla is a member of the Orchidaceae family. It originated in America and differentiated in America, Africa, and Asia. About 132 species of Vanilla have now been accepted since the discovery of the genus. Within the Vanilla genus, leaflessness has appeared at least three independent times, in Africa, Asia, and America as an adaptation to drought conditions. The South-West Indian Ocean (SWIO) region is home to seven leafless species. Chloroplast markers failed to differentiate species within this recent SWIO clade. Morphological traits used for description are very similar between species and do not provide reliable identification. Leafless Vanilla species from the SWIO islands are thus an excellent model for understanding the evolution of orchids. For their conservation, and to confirm the identity of these leafless species, an integrated approach with classical taxonomy using a large number of samples, intense fieldwork on biology and ecology, and molecular studies using variable markers is necessary.
  • 2.5K
  • 14 Dec 2020
Topic Review
Anthocyanin Compositions in Carrots
Anthocyanins extracted from black carrots have received increased interest as natural colorants in recent years. The reason is mainly their high content of acylated anthocyanins that stabilizes the color and thereby increases the shelf-life of products colored with black carrot anthocyanins. Still, the main type of anthocyanins synthesized in all black carrot cultivars is cyanidin limiting their use as colorants due to the narrow color variation. Additionally, in order to be competitive against synthetic colors, a higher percentage of acylated anthocyanins and an increased anthocyanin content in black carrots are needed. However, along with the increased interest in black carrots there has also been an interest in identifying the structural and regulatory genes associated with anthocyanin biosynthesis in black carrots. Thus, huge progress in the identification of genes involved in anthocyanin biosynthesis has recently been achieved. Given this information it is now possible to attempt to modulate anthocyanin compositions in black carrots through genetic modifications.
  • 2.5K
  • 23 Mar 2021
Topic Review
Apostles
In Christian theology and ecclesiology, apostles, particularly the Twelve Apostles (also known as the Twelve Disciples or simply the Twelve), were the primary disciples of Jesus according to the New Testament. In addition to Christian theology, Islamic theology also acknowledges the apostles in the Quran. During the life and ministry of Jesus in the 1st century AD, the apostles were his closest followers and became the primary teachers of the gospel message of Jesus. While Christian tradition often refers to the apostles as being twelve in number, different gospel writers give different names for the same individual, and apostles mentioned in one gospel are not mentioned in others. There is also an Eastern Christian tradition derived from the Gospel of Luke of there having been as many as 70 apostles during the time of Jesus' ministry. Paul is often referred to as an apostle, because he was directly taught and commissioned by a vision of Christ (Acts 9:4–9) during his journey to Damascus. The commissioning of the Twelve Apostles during the ministry of Jesus is recorded in the Synoptic Gospels. After his resurrection, Jesus sent eleven of them (minus Judas Iscariot, who by then had died) by the Great Commission to spread his teachings to all nations. This event has been called the Dispersion of the Apostles. In modern usage, missionaries under Pentecostal movements often refer to themselves as apostles, a practice which stems from the Latin equivalent of apostle, i.e. missio, the source of the English word missionary. For example, Saint Patrick (AD 373–463) was the "Apostle of Ireland", Saint Boniface (680–755) was the "Apostle to the Germans", Saint José de Anchieta (1534–1597) was the "Apostle of Brazil" and Saint Peter of Betancur (1626–1667) was the "Apostle of Guatemala". The period of early Christianity during the lifetimes of the apostles is called the Apostolic Age. During the 1st century AD, the apostles established churches throughout the territories of the Roman Empire and, according to tradition, through the Middle East, Africa, and India . Of the tombs of the apostles, all but two are claimed by premises of the Catholic Church, half of them located in the Diocese of Rome.
  • 2.5K
  • 20 Oct 2022
Topic Review
Hyoscine
Hyoscine, also known as scopolamine, is a medication used to treat motion sickness and postoperative nausea and vomiting. It is also sometimes used before surgery to decrease saliva. When used by injection, effects begin after about 20 minutes and last for up to 8 hours. It may also be used by mouth and via a skin patch. Common side effects include sleepiness, blurred vision, dilated pupils, and dry mouth. It is not recommended in people with angle-closure glaucoma or bowel obstruction. It is unclear if use during pregnancy is safe; however, it appears to be safe during breastfeeding. Hyoscine is in the antimuscarinic family of medications and works by blocking some of the effects of acetylcholine within the nervous system. Hyoscine was first written about in 1881 and started to be used for anesthesia around 1900. It is on the World Health Organization's List of Essential Medicines. Hyoscine is main active component produced by certain plants of the nightshade family which historically have been used as psychoactive drugs due to their hallucinogenic effects. The name "scopolamine" is derived from one type of nightshade known as Scopolia while the name "hyoscine" is derived from another type known as Hyoscyamus niger.
  • 2.5K
  • 25 Nov 2022
Topic Review
Immobilized Algae Bioremediation Technology
A green technology that immobilizes algae through a carrier to improve biosorbent’s stability and adsorption performance is immobilization technology. An environmentally friendly technology is bioremediation, which uses the metabolic potential of microorganisms to remove heavy metals through a series of physicochemical interactions which occur between the functional groups of microorganisms and the heavy metals.
  • 2.5K
  • 27 Mar 2023
Topic Review
Golden Jackal
The Golden Jackal (Canis aureus) stands as a fascinating and adaptable canid species, widely distributed across a diverse range of habitats in Europe, Asia, and parts of Africa. Known for its striking golden or tawny fur and remarkable adaptability, the Golden Jackal embodies a complex ecological role within its ecosystems.
  • 2.5K
  • 08 Feb 2024
Topic Review
Global Open-Data Remote-Sensing Satellite Missions
The application of global open data remote sensing satellite missions is in the state of rapid growth, ensuring an observation with high spatial and spectral resolution over large areas. Multispectral (Landsat, Sentinel-2, and MODIS), radar (Sentinel-1), and digital elevation model missions (SRTM, ASTER) were analyzed, as the most often used global open data satellite missions, according to the number of scientific research articles published in Web of Science database. Processing methods of these missions’ data consisting of image preprocessing, spectral indices, image classification methods, and modelling of terrain topographic parameters were analyzed and demonstrated. Possibilities of their application in land cover, land suitability, vegetation monitoring, and natural disaster management were evaluated, having high potential in broad use worldwide. Availability of free and complementary satellite missions, as well as the open-source software, ensures the basis of effective and sustainable land use management, with the prerequisite of the more extensive knowledge and expertise gathering at a global scale.
  • 2.5K
  • 12 Nov 2020
Topic Review
CRISPR/Cas9 System
CRISPR/Cas9 is an endonuclease of DNA that splits the invading phage DNA into pieces and then incorporates it into the CRISPR set as a spacer. It was implemented efficiently in plants in 2013, and in five original research articles, the CRISPR/Cas9 scheme in rice was efficiently recorded.
  • 2.5K
  • 25 Apr 2022
Topic Review
Non-Intrusive Load Monitoring and Network
Non-intrusive load monitoring (NILM), also known as energy disaggregation, tries to decompose aggregated energy consumption data and estimate each appliance’s contribution. 
  • 2.5K
  • 05 Aug 2022
Topic Review
Novel Foods in Madagascar
In Madagascar, the percentage of stunted children under 5 is extremely high. Furthermore, the COVID-19 pandemic is expected to increase the risk of all forms of malnutrition, especially in low-income countries, including Madagascar, with serious intergenerational repercussions.  Efforts to promote native, traditional foods as Moringa oleifera, an indigenous plant in Asia and Africa including Madagascar, rich in protein and micronutrients, as well as edible insects, alternative sustainable source of protein, lipids, iron, and zinc, would provide not only nutritional but also cultural and economic benefits. The potential synergies between food traditions and agroecology have the potential to impact health addressing larger issues of sustainability and food security.
  • 2.5K
  • 25 May 2021
Topic Review
Autonomous Driving of Electric Vehicles
An autonomous driving system consists of perception, planning, decision, and control, which is illustrated in. The perception subsystem is the basis for other subsystems. It takes data captured from different sensors as input to obtain vehicle’s position and location, also including the size and direction of surrounding objects.
  • 2.5K
  • 17 Sep 2021
Topic Review
Gelidium in Circular Economy Framework
Gelidium corneum (Giant Gelidium or Atlantic agar) is a well-known red seaweed harvested for its high-quality agar content. Agar is a mixture of the polysaccharides used in the food industry as a gelling, thickener, clarifying, and stabilizer agent. The best agar quality is also used in the laboratory as bacteriological agar.
  • 2.5K
  • 06 Jul 2022
Topic Review
Latin Letters Used in Mathematics
Many letters of the Latin alphabet, both capital and small, are used in mathematics, science, and engineering to denote by convention specific or abstracted constants, variables of a certain type, units, multipliers, or physical entities. Certain letters, when combined with special formatting, take on special meaning. Below is an alphabetical list of the letters of the alphabet with some of their uses. The field in which the convention applies is mathematics unless otherwise noted.
  • 2.5K
  • 15 Nov 2022
Topic Review
Granite Dust as a Sustainable Additive
The increase in infrastructure requirement drives people to use all types of soils, including poor soils. These poor soils, which are weak at construction, must be improved using different techniques. The extinction of natural resources and the increase in cost of available materials require us to think of alternate resources. The usage of industry by-products and related methods for improving the properties of different soils has been studied for several years. Granite dust is an industrial by-product originating from the primary crushing of aggregates. The production of huge quantities of granite dust in the industry causes severe problems from the handling to the disposal stage. Accordingly, in the civil engineering field, the massive utilization of granite dust has been proposed for various applications to resolve these issues. 
  • 2.5K
  • 21 Dec 2021
Topic Review
Colloidal Silica and Geotechnical Properties of Liquefiable Soils
Colloidal silica (CS) is a kind of nanomaterial used in soil/rock grouting techniques in different branches of civil engineering. CS grout is chemically and biologically inert and, when injected into a subsoil, it can form a silica gel and stabilize the desired soil layer, thus representing an attractive, environmentally friendly alternative to standard chemical grouting techniques.
  • 2.5K
  • 23 Dec 2021
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