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Topic Review
Personalization of Therapy in High-Grade Serous Tubo-Ovarian Cancer
High-grade serous tubo-ovarian cancer (HGSTOC) is the most lethal tumor of the female genital tract. The foregoing therapy consists of cytoreduction followed by standard platinum/taxane chemotherapy; alternatively, for primary unresectable tumors, neo-adjuvant platinum/taxane chemotherapy followed by delayed interval cytoreduction. In patients with suboptimal surgery or advanced disease, different forms of targeted therapy have been accepted or tested in clinical trials. Studies on HGSTOC discovered its genetic and proteomic heterogeneity, epigenetic regulation, and the role of the tumor microenvironment. These findings turned attention to the fact that there are several distinct primary tumor subtypes of HGSTOC and the unique biology of primary, metastatic, and recurrent tumors may result in a differential drug response. This results in both chemo-refractoriness of some primary tumors and, what is significantly more frequent and destructive, secondary chemo-resistance of metastatic and recurrent HGSTOC tumors. Treatment possibilities for platinum-resistant disease include several chemotherapeutics with moderate activity and different targeted drugs with difficult tolerable effects. Therefore, the question appears as to why different subtypes of ovarian cancer are predominantly treated based on the same therapeutic schemes and not in an individualized way, adjusted to the biology of a specific tumor subtype and temporal moment of the disease.
  • 634
  • 05 Jan 2024
Topic Review
Prevention of Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) has for many years been defined as glucose intolerance with the onset or first recognition during pregnancy. Such a definition has serious limitations due to many cases of GDM representing preexisting hyperglycemia. As such, the latest definition of GDM excludes women found to have diabetes by diagnostic criteria applied outside of pregnancy. GDM is one of the most common obstetric complications, with the prevalence varying from 7.5% to 27.0% among different areas, principally depending on different races and diagnostic criteria. 
  • 632
  • 17 Jun 2022
Topic Review
Emergency Department Care Experiences
Emergency departments (EDs) are an important source of care for people with mental health (MH) concerns. It can be challenging to treat MH in EDs, and there is little research capturing both patient and provider perspectives of these experiences. 
  • 624
  • 28 Jul 2022
Topic Review
The Prognostic Importance of ctDNA in Rectal Cancer
An individualized treatment approach is necessary to improve survival and quality of life in rectal cancer. Tools to stratify patients are currently missing. Circulating tumor DNA seems to be a good candidate, but results are sparse, conflicting and characterized by lack of a uniform approach. The ctDNA status may be of importance to the long-term prognosis, but the area of research is new and is short of dedicated studies. There is an obvious need for standardization in ctDNA research, and the issue should be addressed in future research. 
  • 623
  • 25 May 2022
Topic Review
Upper Airway Changes in Diverse Orthodontic Looms
Upper airway assessment is particularly important in the daily work of orthodontists, because of its close connection with the development of craniofacial structures and with other pathologies such as Obstructive Sleep Apnea Syndrome (OSAS). Rapid maxillary expansion and surgical advancement for the correction of Class II patients are associated with significant improvement in the upper airway, whereas maxillary protraction, extraction therapy, orthognathic surgery for Class III, and the use of a functional appliance have no significant impact.
  • 622
  • 24 Feb 2022
Topic Review
Chatbots in Personalized Care in Eye Health
In modern eye care, the adoption of ophthalmology chatbots stands out as a pivotal technological progression. These digital assistants present numerous benefits, such as better access to vital information, heightened patient interaction, and streamlined triaging. 
  • 622
  • 19 Dec 2023
Topic Review
Motherhood and Schizophrenia
Being a good parent is a very difficult task, made more difficult in the context of serious psychiatric illness such as schizophrenia. The symptoms of the disorder are aggravated by the associated stigma, by poverty, social isolation, and adverse life circumstances. Mothers with schizophrenia need to make difficult decisions, which are hampered by lack of information, social isolation, and no resources. Assistance is theoretically available but is not always accessible, and may not prove effective. Care providers to this population are recommended to partner with mothers with schizophrenia, appreciate their strengths as well as their frailties, offer a wide array of family services and social supports, monitor closely, and be generous with positive feedback.
  • 620
  • 30 Jan 2024
Topic Review
Epidemiological Scenario of and Gastric Cancer in Chile
Helicobacter pylori (H. pylori) is a Gram-negative, microaerophilic bacterium that colonizes the gastric mucosa of more than 50% of the world’s population. In 1994, the International Agency for Research on Cancer classified it as a Group I carcinogen. Infection can be acquired in childhood and persist asymptomatically throughout life. H. pylori causes chronic gastritis. This can lead to peptic ulcers as well as premalignant lesions such as atrophic gastritis, intestinal metaplasia, and dysplasia, which can eventually trigger gastric cancer. Atrophic gastritis is the first step in the premalignant cascade and is characterized by the loss of gastric glandular cells, resulting in reduced acid production and an increase in pH levels. Intestinal metaplasia refers to the transformation of the gastric epithelium into an intestinal-type epithelium, which can be complete or incomplete, depending on the presence of goblet cells among the epithelial cells. 
  • 619
  • 07 Feb 2024
Topic Review
Magnetic Resonance Imaging Methods in Health and Disease
Magnetic Resonance Imaging (MRI) is the modality of choice for a vast range of pathologies but also a sensitive probe into human physiology and tissue function. For this reason, several methodologies have been developed and continuously evolve in order to non-invasively monitor underlying phenomena in human adipose tissue that were difficult to assess in the past through visual inspection of standard imaging modalities.
  • 618
  • 21 Dec 2023
Topic Review
Healthcare Workers’ Moral Distress during the COVID-19 Pandemic
During the COVID-19 pandemic, healthcare workers (HCWs) did not have the opportunity to provide high-quality and standard healthcare services. Research conducted during the pandemic has revealed widespread mental health problems among HCWs. Moral distress was noted as one of the critical issues that limited the performance of HCWs in providing quality care.
  • 617
  • 14 Jul 2023
Topic Review
Self-Attachment to Treat Chronic Anxiety and/or Depression
Anxiety and depression are debilitating conditions which, together with substance abuse, are considered globally to represent the most common psychological disorders; they are correlated with each other and are also common features of many severe psychological disorders. Attachment theory was introduced by John Bowlby in the 1960s and 1970s and has since developed into a main paradigm in developmental psychology with wide impact in many related areas including psychotherapy.
  • 615
  • 28 Jun 2022
Topic Review
Epigenetic Aberrations in Extranodal NK/T-Cell Lymphoma
Extranodal NK/T-cell lymphoma (ENKTL) is a rare extranodal non-Hodgkin lymphoma (NHL) that primarily occurs in the upper aerodigestive tract and has an aggressive presentation, with locoregional invasion in the nasopharynx causing necrosis, hemorrhage, and impingement on anatomic structures including the orbits.
  • 615
  • 02 Mar 2023
Topic Review
Innovative Therapies Targeting Drug Resistant in ccRCC
A thorough study of Clear Cell Renal Cell Carcinoma (ccRCC) shows that com- bining tyrosine kinase inhibitors (TKI) with immune checkpoint inhibitors (ICI) shows promising results in addressing the tumor-promoting influences of abnormal immunologi- cal and molecular biomarkers in metastatic Clear Cell Renal Cell Carcinoma (ccRCC). These abnormal biomarkers enhance drug resistance, support tumor growth, and trigger cancer- related genes. Ongoing clinical trials are testing new treatment options that appear more effective than earlier ones. However, more research is needed to confirm their long-term safety use and potential side effects. This study highlights vital molecular and immunologi- cal biomarkers associated with drug resistance in Clear Cell Renal Cell Carcinoma (ccRCC). Furthermore, this study identifies a number of promising drug candidates and biomarkers that serve as significant contributors to the enhancement of the overall survival of ccRCC patients. Consequently, this article offers pertinent insights on both recently completed and ongoing clinical trials, recommending further toxicity study for the prolonged use of this treatment strategy for patients with metastatic ccRCC, while equipping researchers with invaluable information for the progression of current treatment strategies.
  • 614
  • 20 Jan 2025
Topic Review
Aortic Stenosis and Cardiac Amyloidosis
The association between aortic stenosis (AS) and cardiac amyloidosis (CA) is more frequent than expected. Albeit rare, CA, particularly the transthyretin (ATTR) form, is commonly found in elderly people. ATTR-CA is also the most prevalent form in patients with AS. These conditions share pathophysiological, clinical and imaging findings, making the diagnostic process very challenging.
  • 611
  • 16 Aug 2022
Topic Review
OTFT Monitoring in Complex Body Fluid Environments
People are becoming more concerned about their physical health and putting forward higher requirements for an early and painless diagnosis of diseases. Traditional methods, such as surface plasmon resonance (SPR), enzyme-linked immunosorbent assay (ELISA), surface-enhanced raman spectroscopy (SERS), and colorimetric methods have been used for the detection of biomarkers with high selectivity and sensitivity; however, these methods still need to be further improved for immediate and rapid diagnosis. Herein, organic thin-film transistors (OTFTs)-based biosensors offer the advantages of good flexibility, low-cost fabrication, reasonable sensitivity, and great biocompatibility for efficient determination of biomarkers in complex samples, including saliva, sweat, urine, and blood, respectively, exhibiting great potential in early disease diagnosis and clinical treatment.
  • 611
  • 11 Apr 2023
Topic Review
Lifestyle and Pain following Cancer
Cancer Survivor (CS), the most widely used definition is: “being a CS, starts on the day of diagnosis and continues until the end of life. Three cancer survivorship phases can be distinguished: “acute survivorship” (i.e., early-stage or time during curative treatment), “permanent survivorship” (i.e., living with cancer or also called the palliative stage), and “extended survivorship” (i.e., cured but not free of suffering). Chronic pain is one of these and occurs in 40% of CSs. Chronic pain is defined by the International Association for the Study of Pain (IASP) as pain that persists or recurs for longer than three month. Unrelieved pain can have considerable adverse consequences on a CSs’ quality of life.
  • 610
  • 07 Jan 2022
Topic Review
Primary Amenorrhea in Adolescents
Primary amenorrhea (PA) describes the complete absence of menses by the age of 15 years. It is a devastating diagnosis that can affect the adolescent’s view of her femininity, sexuality, fertility and self-image. A normal menstrual cycle can occur only in the presence of: a properly functioning hypothalamus–pituitary axis, well-developed and active ovaries, outflow tract without abnormalities. Any dysfunction in any of these players can result in amenorrhea.
  • 609
  • 05 Sep 2023
Topic Review
Forest Therapy Programs for Stress Reduction
Forest therapy programs were effective at relieving stress, particularly on a psychological level. Forest therapy programs could be used as a part of stress reduction projects. 
  • 608
  • 23 Oct 2023
Topic Review
Development of Vibrio cholerae Candidate Vaccine Strain
Approximately 1/6 of humanity is at high risk of experiencing cholera epidemics. Therefore, сholera epidemics and outbreaks represent one of the global health threats. Vaccination is an effective global health measure to prevent cholera epidemics. There is a need for the development of more effective, stable, and safe vaccines against cholera. We describe a strategy to genetically engineer a nontoxigenic natural Vibrio cholerae strain to develop a genetically stable and relatively safe candidate vaccine strain. Our approach is applicable for developing vaccine strains against cholera and other important human pathogens.
  • 607
  • 22 Mar 2022
Topic Review
Regulation and Secretion of Glucagon in Nutrient Composition
Glucagon was initially regarded as a hyperglycemic substance; however, research has revealed its broader role in metabolism, encompassing effects on glucose, amino acids (AAs), and lipid metabolism. Notably, the interplay of glucagon with nutrient intake, particularly of AAs, and non-nutrient components is central to its secretion. Fasting and postprandial hyperglucagonemia have long been linked to the development and progression of type 2 diabetes (T2DM). However, studies have brought to light the positive impact of glucagon agonists on lipid metabolism and energy homeostasis. 
  • 606
  • 20 Nov 2023
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