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Topic Review
First-Price Sealed-Bid Auction
A first-price sealed-bid auction (FPSBA) is a common type of auction. It is also known as blind auction. In this type of auction, all bidders simultaneously submit sealed bids, so that no bidder knows the bid of any other participant. The highest bidder pays the price they submitted.:p2
  • 2.8K
  • 01 Dec 2022
Topic Review
Antimicrobial Resistance
The discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance of resistant strains. Here, the main antibiotic resistance mechanisms are briefly listed with some examples. 
  • 2.8K
  • 05 Nov 2020
Topic Review
Flexible Electronics
Flexible electronics is a rapidly growing technology for a multitude of applications. Wearables and flexible displays are some application examples.
  • 2.8K
  • 28 Jan 2021
Topic Review
Spare Parts with Additive Manufacturing of Aviation Industry
Additive manufacturing (AM) is a digital technology of layered fabrication by adding material where no cutting tool is required as in the case of a subtractive manufacturing process. AM is bridging the digital and physical world as a 3D computer-aided manufacturing (CAM) method. The usage of AM has made the supply chain of the aviation spare parts industry simpler, more effective, and efficient.
  • 2.8K
  • 12 May 2022
Topic Review
Lipocalin-2
Lipocalin-2 (LCN2), which is a part of the lipocalin transport protein family, is a protein formally known for its role in iron transport and in inflammatory response.
  • 2.8K
  • 27 May 2021
Topic Review
Queen Snake
The queen snake (Regina septemvittata) is a species of nonvenomous semiaquatic snake, a member of the subfamily Natricinae of the family Colubridae. The species is endemic to North America.
  • 2.8K
  • 24 Oct 2022
Topic Review
Bioluminescent System in Dinoflagellates
The mechanisms underlying the bioluminescent phenomenon have been well characterized in dinoflagellates; however, there are still some aspects that remain an enigma. Such is the case of the presence and diversity of the luciferin-binding protein (LBP), as well as the synthesis process of luciferin. We carry out a review of the literature in relation to the molecular players responsible for bioluminescence in dinoflagellates, with particular interest in P. lunula.
  • 2.8K
  • 29 Oct 2020
Topic Review
Applications of Magnesium and Alloys
Since its discovery, magnesium has played an influential role in society. In its early days, military applications and wars fueled its growth. For example, magnesium was weaponized to construct incendiary bombs, flares, and ammunitions that were subsequently deployed in World War II, and it caused massive conflagrations and widespread devastations. Post-War, magnesium’s availability and unique blend of properties were explored and were found to be highly attractive for an extensive range of applications. Today, magnesium is used for engineering applications in automotive, aerospace, and consumer electronics. In addition, it has a role in organic chemistry and pharmaceuticals and is used to construct several general-purpose applications, such as sporting goods, household products, and office equipment.
  • 2.8K
  • 09 Oct 2021
Topic Review
Artificial Intelligence and Cyber-Physical Systems
Modern society is living in an age of paradigm changes. In part, these changes have been driven by new technologies, which provide high performance computing capabilities that enable the creation of complex Artificial Intelligence systems. Those developments are allowing the emergence of new Cyber Systems where the continuously generated data is utilized to build Artificial Intelligence models used to perform specialized tasks within the system. While, on one hand, the isolated application of the cyber systems is becoming widespread, on the other hand, their synchronical integration with other cyber systems to build a concise and cognitive structure that can interact deeply and autonomously with a physical system is still a completely open question, only addressed in some works from a philosophical point of view. From this standpoint, the AI can play an enabling role to allow the existence of these cognitive CPSs.
  • 2.8K
  • 08 Oct 2021
Topic Review
Chang Bogo-Class Submarine
The Chang Bogo-class submarine (Hangul: 장보고급 잠수함, Hanja: 張保皐級潛水艦) is a variant of the Type 209 diesel-electric attack submarine initially developed by Howaldtswerke-Deutsche Werft (HDW) of Germany , intended for service with the South Korean Navy and Indonesian Navy. A Daewoo (DSME)-upgraded model of the Chang Bogo class Type 209 is being independently exported by Korea to Indonesia in 2012, after a series of heavy competitions from Russian, French, and German-Turkish consortiums including from Germany's original Type 209. The variant is being considered for possible purchase by Thailand as well, as both newly built and second-hand options. The class is named for ancient Korean maritime figure Jang Bogo.
  • 2.8K
  • 28 Nov 2022
Topic Review
Timing Sequence and Mechanism of Endocrine Organs Aging
The endocrine glands are one of the most important organs in the context of aging. Failure of the endocrine glands lead to an abnormal hormonal environment, which in turn leads to many age-related diseases. The aging of endocrine glands is closely linked to oxidative stress, cellular autophagy, genetic damage, and hormone secretion. The first endocrine organ to undergo aging is the pineal gland, at around 6 years old. This is followed in order by the hypothalamus, pituitary gland, adrenal glands, gonads, pancreatic islets, and thyroid gland.
  • 2.8K
  • 26 Apr 2023
Topic Review
Urinary Biomarkers for Bladder Cancer
Blue light cystoscopy (BLC) is the most recent clinical approach in the detection and diagnosis of bladder cancer, a common type of cancer with a high rate of recurrence. Representing a significant advance over previous approaches, this photodynamic diagnostic technique uses a photosensitiser prodrug as an adjunct to white light cystoscopy to enhance the in vivo detection of malignant tissues in the bladder based on their distinctive fluorescence. Whilst it does improve detection rates, BLC remains an invasive and costly procedure. Meanwhile, a variety of noninvasive urine detection methods and related microdevices have been developed.  In the following section, we provide the current context for urinary biomarker testing, including commercially available tests and recent development involving microdevices.
  • 2.7K
  • 27 Oct 2020
Topic Review
Community-Driven Tourism Projects
Community-driven Tourism Projects (CDTPs) are initiated, operated, managed and fully controlled by the community.  The communities identify the tourism resources they have access to, and utilize them for livelihood.  The CDTPs are a platform for not just livelihood but also for poverty alleviation
  • 2.7K
  • 27 Oct 2020
Topic Review
Ion-selective Electrodes
An Ion-selective electrode (ISE) is a transducer (sensor) which converts the activity of a specific ion dissolved in a solution into an electrical potential which can be measured by a voltmeter or pH meter. The voltage is theoretically dependent on the logarithm of the ionic activity, according to the Nernst equation. The sensing part of the electrode is usually made as an ion-specific membrane, along with a reference electrode. Ion-selective electrodes are used in biochemical and biophysical research, where measurements of ionic concentration in an aqueous solution are required, usually on a real time basis.
  • 2.7K
  • 10 Oct 2022
Topic Review
CAR-T Cells in Pancreatic cancer
Pancreatic cancer has the worst prognosis and lowest survival rate among all types of cancers and thus, there exists a strong need for novel therapeutic strategies. Chimeric antigen receptor (CAR)-modified T cells present a new potential option after successful FDA-approval in hematologic malignancies, however, current CAR T cell clinical trials in pancreatic cancer failed to improve survival and were unable to demonstrate any significant response. The physical and environmental barriers created by the distinct tumor microenvironment (TME) as a result of the desmoplastic reaction in pancreatic cancer present major hurdles for CAR T cells as a viable therapeutic option in this tumor entity. Cancer cells and cancer-associated fibroblasts express extracellular matrix molecules, enzymes, and growth factors, which can attenuate CAR T cell infiltration and efficacy. Recent efforts demonstrate a niche shift where targeting the TME along CAR T cell therapy is believed or hoped to provide a substantial clinical added value to improve overall survival.
  • 2.7K
  • 16 Oct 2020
Topic Review
Electric Vehicles
E-mobility sustainability assessment is becoming more comprehensive with research integrating social aspects without focusing only on technical, economic, and/or environmental perspectives. The transportation sector is indeed one of the leading and most challenging greenhouse-gas polluters, and e-mobility is seen as one of the potential solutions; however, a social perspective must be further investigated to improve the perception of and acceptance of electric vehicles. 
  • 2.7K
  • 04 Feb 2021
Topic Review
Nickel(II) Precatalysts
Nickel(II) precatalysts are a type of catalyst used in organic reactions. Many transformations are catalyzed by nickel in organometallic chemistry and in organic synthesis. Many of these transformations invoke a low valent (generally Ni(0)) species as the active catalyst. Unfortunately, unlike its counterpart, Pd(0), Ni(0) catalysts are predominantly confined to the glovebox due to their high instability to air and water, with the most common Ni(0) catalyst being Ni(cod)2. Additionally, Ni(cod)2 is more expensive than many Ni(II) salts and the quality varies significantly amongst suppliers. To make nickel catalysis more accessible and amenable to synthesis and industrial purposes, the use of air-stable Ni(II) precursors has emerged as an important development in this area of research. This page describes the more commonly employed nickel(II) precatalysts, their synthesis for those not commercially available, and the methods for their reduction to Ni(0) complexes.
  • 2.7K
  • 08 Nov 2022
Topic Review
Equatorial Coordinate System
The equatorial coordinate system is a celestial coordinate system widely used to specify the positions of celestial objects. It may be implemented in spherical or rectangular coordinates, both defined by an origin at the centre of Earth, a fundamental plane consisting of the projection of Earth's equator onto the celestial sphere (forming the celestial equator), a primary direction towards the vernal equinox, and a right-handed convention. The origin at the centre of Earth means the coordinates are geocentric, that is, as seen from the centre of Earth as if it were transparent. The fundamental plane and the primary direction mean that the coordinate system, while aligned with Earth's equator and pole, does not rotate with the Earth, but remains relatively fixed against the background stars. A right-handed convention means that coordinates increase northward from and eastward around the fundamental plane.
  • 2.7K
  • 16 Nov 2022
Topic Review
Apocalypse
Apocalypse (from grc ἀποκάλυψις (apokálupsis) 'revelation, disclosure') is a literary genre in which a supernatural being reveals cosmic mysteries or the future to a human intermediary. The means of mediation include dreams, visions and heavenly journeys, and they typically feature symbolic imagery drawn from the Hebrew Bible, cosmological and (pessimistic) historical surveys, the division of time into periods, esoteric numerology, and claims of ecstasy and inspiration. Almost all are written under pseudonyms (false names), claiming as author a venerated hero from previous centuries, as with Book of Daniel, composed during the 2nd century BCE but bearing the name of the legendary Daniel. Eschatology, from Greek eschatos, last, concerns expectations of the end of the present age, and apocalyptic eschatology is the application of the apocalyptic world-view to the end of the world, when God will punish the wicked and reward the faithful. An apocalypse will often contain much eschatological material, but need not: the baptism of Jesus in Matthew's gospel, for example, can be considered apocalyptic in that the heavens open for the presence of a divine mediator (the dove representing the spirit of God) and a voice communicates supernatural information, but there is no eschatological element. Scholars have identified examples of the genre ranging from the mid-2nd century BCE to the 2nd century CE, and examples are to be found in Persian and Greco-Roman literature as well as Jewish and Christian. The sole clear case in the Jewish Bible (Old Testament) is chapters 7-12 of the Book of Daniel, but there are many examples from non-canonical Jewish works; the Book of Revelation is the only apocalypse in the New Testament, but passages reflecting the genre are to be found in the gospels and in nearly all the genuine Pauline epistles.Lua error: not enough memory.Lua error: not enough memory.
  • 2.7K
  • 24 Nov 2022
Topic Review
Scientific Opinion on Climate Change
Scientific opinion on climate change is a judgment of scientists regarding the degree to which global warming is occurring, its likely causes, and its probable consequences. A related—but not identical—term, "scientific consensus on climate change," is the prevailing view on climate change within the scientific community. The consensus is that:
  • 2.7K
  • 29 Nov 2022
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