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Topic Review
Procaviidae
Hyraxes (from grc ὕραξ (Script error: No such module "Ancient Greek".) 'shrewmouse'), also called dassies, are small, thickset, herbivorous mammals in the order Hyracoidea. Hyraxes are well-furred, rotund animals with short tails. Typically, they measure between 30 and 70 cm (12 and 28 in) long and weigh between 2 and 5 kg (4 and 11 lb). They are superficially similar to pikas and marmots, but are more closely related to elephants and sea cows. Hyraxes have a life span from 9 to 14 years. Five extant species are recognised: the rock hyrax (Procavia capensis) and the yellow-spotted rock hyrax (Heterohyrax brucei), which both live on rock outcrops, including cliffs in Ethiopia and isolated granite outcrops called koppies in southern Africa; the western tree hyrax (Dendrohyrax dorsalis), southern tree hyrax (D. arboreus), and eastern tree hyrax (D. validus). Their distribution is limited to Africa, except for P. capensis, which is also found in the Middle East.
  • 2.9K
  • 20 Oct 2022
Topic Review
Role of Environmental Accounting
Environmental accounting (EA) can be a way toward solving the issue of environmental degradation and shifting toward sustainable solutions. One of the significant reasons for EA is the role of industrial and commercial activities in environmental contamination.
  • 2.9K
  • 15 Jun 2022
Topic Review
WHO Critical Priority Pathogens
The rise of multidrug-resistant (MDR) pathogens has become a global health threat and an economic burden in providing adequate and effective treatment for many infections. This large-scale concern has emerged mainly due to mishandling of antibiotics (ABs) and has resulted in the rapid expansion of antimicrobial resistance (AMR). Nowadays, there is an urgent need for more potent, non-toxic and effective antimicrobial agents against MDR strains. In this regard, clinicians, pharmacists, microbiologists and the entire scientific community are encouraged to find alternative solutions in treating infectious diseases cause by these strains. In its “10 global issues to track in 2021”, the World Health Organization (WHO) has made fighting drug resistance a priority. 
  • 2.9K
  • 21 Jul 2022
Topic Review
Technology Tree
In strategy games, a technology, tech, or research tree is a hierarchical visual representation of the possible sequences of upgrades a player can take (most often through the act of research). Because these trees are technically directed and acyclic, they can more accurately be described as a technology directed acyclic graph. The diagram is tree-shaped in the sense that it branches between each 'level', allowing the player to choose one sequence or another. Each level is called a tier and is often used to describe the technological strength of a player. Typically, at the beginning of a session of a strategy game, a player will start at tier 1, and will only have a few options for technologies to research. Each technology that a player researches will open up one or more new options, but may or may not, depending on the computer game, close off the paths to other options. The tech tree is the representation of all possible paths of research a player can take, up to the culmination of said sequence. A player who is engaged in research activities is said to be "teching up", "going up the tech tree", or "moving up the tech tree". Analysis of a tech tree can lead players to memorize and use specific build orders.
  • 2.9K
  • 26 Oct 2022
Topic Review
HP Operations Manager
HP Operations Manager is a System monitoring package manufactured by Hewlett-Packard (HP). HP Operations Manager is part of HP Operations Center that includes too: On May 20, 2015 HP started the migration for HP OM users to Operations Manager i, very similar names for very different softwares architectures. On September 1, 2016 HP Enterprise announced the End of Sale of HP Operations Manager for Windows (OMW) 9.0x and HP Operations Manager for Windows Basic Suite (OMW BS) 9.0x and all customerswas migrate to HPE Operations Bridge Suite, a hybrid IT monitoring solution.
  • 2.9K
  • 14 Oct 2022
Topic Review
3D Point Cloud Classification
Three-dimensional (3D) point cloud classification methods based on deep learning have good classification performance. The 3D point cloud is mainly collected by light detection and ranging (LiDAR) scanner, red, green, blue, and depth (RGB-D) camera, and other sensor equipment or obtained by model conversion using computer software.
  • 2.9K
  • 10 Jun 2022
Topic Review
Aflatoxins in Feed
Feeding farm animals with aflatoxin-contaminated feed can cause various severe toxic effects, leading to increased susceptibility to infectious diseases and increased mortality, weight loss, poor performance and reduced reproductive capability. Following ingestion of contaminated foodstuffs, aflatoxins are metabolized and biotransformed differently in animals. 
  • 2.9K
  • 16 Dec 2022
Topic Review
Fibre-Reinforced Polymer at Elevated Temperatures
Fibre-reinforced polymer is a composite material that consists of a polymer matrix and fibre reinforcement. Numerous FRPs have been produced, including basalt fibre-reinforced polymers (BFRP), glass fibre-reinforced polymers (GFRP), aramid fibre-reinforced polymers (AFRP), and carbon fibre-reinforced polymers (CFRP).
  • 2.9K
  • 28 Mar 2022
Topic Review
Microsoft Azure
Microsoft Azure, often referred to as Azure (/ˈæʒər, ˈeɪʒər/ AZH-ər, AY-zhər, UK also /ˈæzjʊər, ˈeɪzjʊər/ AZ-ure, AY-zure), is a cloud computing service operated by Microsoft for application management via Microsoft-managed data centers. It provides software as a service (SaaS), platform as a service (PaaS) and infrastructure as a service (IaaS) and supports many different programming languages, tools, and frameworks, including both Microsoft-specific and third-party software and systems. Azure, announced at Microsoft's Professional Developers Conference (PDC) in October 2008, went by the internal project codename "Project Red Dog", and was formally released in February 2010 as Windows Azure, before being renamed Microsoft Azure on March 25, 2014.
  • 2.9K
  • 01 Dec 2022
Topic Review
Mabry Syndrome
Mabry syndrome is a condition characterized by intellectual disability, distinctive facial features, increased levels of an enzyme called alkaline phosphatase in the blood (hyperphosphatasia), and other signs and symptoms.
  • 2.9K
  • 23 Dec 2020
Topic Review
Humanitarian Logistics
Although logistics has been mostly utilized in commercial supply chains, it is also an important tool in disaster relief operations. Humanitarian logistics is a branch of logistics which specializes in organizing the delivery and warehousing of supplies during natural disasters or complex emergencies to the affected area and people. However, this definition focuses only on the physical flow of goods to final destinations, and in reality, humanitarian logistics is far more complicated and includes forecasting and optimizing resources, managing inventory, and exchanging information. Thus, a good broader definition of humanitarian logistics is the process of planning, implementing and controlling the efficient, cost-effective flow and storage of goods and materials, as well as related information, from the point of origin to the point of consumption for the purpose of alleviating the suffering of vulnerable people. This figure presents numerous important aspects in humanitarian logistics, including transport, inventory management, infrastructure, and communications.
  • 2.9K
  • 04 Nov 2022
Topic Review
Biofouling on Stainless Steel
In humid environments, the formation of biofilms and microfouling are known to be the detrimental processes that first occur on stainless steel surfaces. This is known as biofouling. Subsequently, the conditions created by metabolites and the activity of organisms trigger corrosion of the metal and accelerate corrosion locally, causing a deterioration in, and alterations to, the performance of devices made of stainless steel. The microorganisms which thus affect stainless steel are mainly algae and bacteria.
  • 2.9K
  • 24 Feb 2022
Topic Review
CAR-T Cells Immunotherapies for Acute Myeloid Leukemia Therapy
The CAR is composed of four regions, namely: the extracellular antigen-binding domain usually made of a single-chain variable fragment (scFv), the hinge (the spacer region), which increases flexibility and allows the CAR to be properly matched to the target antigen, the transmembrane domain, and the intracellular signaling domain. The CAR construct was modified so as to increase the efficiency and expansion of CAR-T cells in the immunosuppressive tumor microenvironment (TME). AML is a malignancy of the hematopoietic system of a heterogeneous nature. The disease is caused by mutations resulting in the proliferation of cancer cells derived from progenitor cells of the myeloid lineage.
  • 2.9K
  • 01 Jun 2023
Topic Review
Shared Residential Landscapes
This paper uses the concept of urban commons to develop a conceptual framework to inform the design and management of shared residential landscapes in the UK. The framework is founded on an exploration of the implications of applying the traditional ‘commons’ idea within the urban context. Urban spatial concepts and theories, such as informal urbanism, territory, placekeeping and partnerships, are drawn upon to build these implication into a framework that provides a new urban, spatial and place perspective on the urban commons concept. In addressing the urban implications for commons through spatial theories, four preliminary concepts are developed. These include; 1) the emergent common mindset in a complex-adaptive assemblage, 2) a spatial arrangement that reflects a shared territorial perception of ‘ours’, 3) opportunities for adaption and occupation of space as placemaking and 4) the reorientation of professional roles in delivering urban commons. The framework creates a foundation for further research on the design and long-term management of shared residential landscapes as urban commons to benefit the everyday social lives of residential communities.
  • 2.8K
  • 06 Jun 2021
Topic Review
SOS Family and Ras-GEFs
The SOS family of Ras-GEFs encompasses two highly homologous and widely expressed members, SOS1 and SOS2. Despite their similar structures and expression patterns, early studies of constitutive KO mice showing that SOS1-KO mutants were embryonic lethal while SOS2-KO mice were viable led to initially viewing SOS1 as the main Ras-GEF linking external stimuli to downstream RAS signaling, while obviating the functional significance of SOS2. Subsequently, different genetic and/or pharmacological ablation tools defined more precisely the functional specificity/redundancy of the SOS1/2 GEFs.
  • 2.8K
  • 05 Jul 2021
Topic Review Peer Reviewed
Epidemiology of Poliomyelitis in the United States and Its Recognition as an Infectious Disease from the Mid-19th Century to the Early 20th Century
This study reviews the role of epidemiology in the United States in the late 19th and early 20th century, which led to recognition that poliomyelitis is an infectious disease and set the stage for subsequent developments in virology and immunology, the development of inactivated and live attenuated polio vaccines, and a dramatic worldwide decrease in poliomyelitis mortality and morbidity. Epidemiological studies in the United States were systematically reviewed from the mid-19th to early 20th centuries. Isolated cases and scattered small outbreaks of poliomyelitis in the mid-19th century led to epidemics of increasing size by the end of the century, causing public consternation, especially as the disease was considered “new” and had a predilection for young children. By the 1890s, the seasonal pattern of epidemics suggested that poliomyelitis might have an infectious etiology, but direct evidence of communicability or contagiousness was lacking, so an infectious etiology was not widely suspected until the early 20th century. Reports of bacterial isolations from spinal fluid and postmortem tissues suggested that poliomyelitis might be a bacterial disease, and simultaneous outbreaks of paralytic disease in humans and animals suggested a possible zoonotic basis. Although experimental studies showed that it was theoretically possible for flies to serve as vectors of poliovirus, and occasional cases of polio were likely caused by fly-borne transfer of poliovirus from human feces to human food, a fly abatement field trial showed convincingly that flies, whether biting or non-biting, could not explain the bulk of cases during polio epidemics. In conclusion, the early application of epidemiological evidence beginning in the late 19th century strongly suggested the infectious nature of the disease, distinct from previously identified conditions. Subsequent advances in virology and immunology from 1909 to 1954 proved that poliomyelitis was a viral disease with no natural animal host and made feasible the development of an inactivated trivalent poliovirus vaccine by Salk, and, subsequently, a live-attenuated trivalent poliovirus vaccine by Sabin.
  • 2.8K
  • 21 Aug 2025
Topic Review
Scorpion Venom
Scorpion venom may cause severe medical complications and untimely death if injected into the human body. A wide range of bioactive molecules can be found in scorpion venoms. Advances in separation, characterization, and biotechnological approaches have enabled not only the development of more effective treatments against scorpion envenomings, but have also led to the discovery of several scorpion venom peptides with interesting therapeutic properties. Thus, scorpion venom may not only be a medical threat to human health, but could prove to be a valuable source of bioactive molecules that may serve as leads for the development of new therapies against current and emerging diseases. 
  • 2.8K
  • 25 Jun 2021
Topic Review
Internet of Things (IoT)
The Internet of Things (IoT) is an extensive network of heterogeneous devices that provides an array of innovative applications and services. IoT networks enable the integration of data and services to seamlessly interconnect the cyber and physical systems.
  • 2.8K
  • 18 Feb 2022
Topic Review
General Performance of Pressure Wave Supercharger
One main direction in improving the efficiency of an internal combustion engine, together with lowering the emissions, is supercharging, i.e., creating a considerable amount of boost for the inlet combustion air. Turbochargers are the most commonly used for this task, but another advantageous alternative exploiting the energy within exhaust gases is the pressure wave supercharger (PWS).
  • 2.8K
  • 21 Apr 2022
Topic Review
List of Fictional Crocodiles and Alligators
This is a list of fictional crocodiles and alligators from literature, folklore and myth, mascots and emblems of teams and organizations, comics, films, animations and video games. This list is subsidiary to the list of fictional animals. It is restricted to notable crocodilian characters from notable works of fiction. Characters that appear in multiple media may have separate listings for each appearance, while in instances where a character has appeared in several separate works in a single medium, only the earliest will be recorded here.
  • 2.8K
  • 21 Oct 2022
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