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Topic Review
Economic History
Economic history is the academic study of economies or economic events of the past. Research is conducted using a combination of historical methods, statistical methods and the application of economic theory to historical situations and institutions. The field can encompass a wide variety of topics, including equality, finance, technology, labour, and business. It emphasizes historicizing the economy itself, analyzing it as a dynamic force and attempting to provide insights into the way it is structured and conceived. Using both quantitative data and qualitative sources, economic historians emphasize understanding the historical context in which major economic events take place. They often focus on the institutional dynamics of systems of production, labor, and capital, as well as the economy's impact on society, culture, and language. Scholars of the discipline may approach their analysis from the perspective of different schools of economic thought, such as mainstream economics, Marxian economics, the Chicago school of economics, and Keynesian economics. Economic history has several sub-disciplines. Historical methods are commonly applied in financial and business history, which overlap with areas of social history such as demographic and labor history. In the sub-discipline called New Economic History or cliometrics, economists use quantitative (econometric) methods. In history of capitalism, historians explain economic historical issues and processes from a historical point of view.
  • 2.9K
  • 21 Nov 2022
Topic Review Peer Reviewed
Effects of in Utero SARS-CoV-2 Exposure on Newborn Health Outcomes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 600 million people worldwide, including millions of pregnant women. While newborns exposed to other viruses in utero are sometimes at high risk for vertical transmission, a substantial body of literature since early 2020 has demonstrated that vertical transmission of SARS-CoV-2 from infected mother to neonate is rare, and that newborns who do become infected with SARS-CoV-2 generally have favorable outcomes. In this review, the authors evaluate the existing literature on vertical transmission of SARS-CoV-2 and its potential mechanisms and discuss short- and long-term health outcomes in newborns who were exposed to SARS-CoV-2 in utero. The authors conclude that vertical transmission and adverse neonatal and infant/child outcomes are unlikely, but that neonates exposed to prenatal maternal SARS-CoV-2 infection may be at slightly higher risk for preterm birth, possibly related to increased risk of severe COVID-19 disease in pregnant women, placental changes, or infection timing. Ultimately, the need for additional and longer-term follow-up data in this population is highlighted.
  • 2.9K
  • 12 Jan 2023
Topic Review
Lignans
This entry focuses on lignans, a non-flavonoid polyphenolic class found in plant foods for human nutrition, recently studied as potential modulators of the gut-brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic effects. The variability in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of parent lignans through the entire gastrointestinal tract. 
  • 2.9K
  • 06 Jan 2021
Topic Review
Soil and Food Crops Irrigated with Wastewater
Wastewater is actively used for irrigation of vegetable and forage crops in arid lands due to water scarcity and cost advantages. The objective of this review was to assess the effect of wastewater (mixture sources) reuse in irrigation on soil, crop (vegetable and forage crops), animal products, and human health. 
  • 2.9K
  • 31 Dec 2021
Topic Review
Internet Challenge
On the internet, a challenge is a genre of videos in which users record themselves performing an action and then dare others to repeat it. They play a role in internet meme culture, with many challenges spreading through such memes. Examples include the ALS Ice Bucket challenge, which went viral in mid-2014 and the TrashTag Challenge which went viral in 2019. An internet challenge is similar to the common children's dare game in which they dare each other to perform an action that one would not normally do. Some challenges/talks predate the internet; some periodically resurface in a somewhat different form. The popularity of internet challenges is explained by people's, especially teenagers', need to gain attention and be liked.
  • 2.9K
  • 21 Nov 2022
Topic Review
Smart Tourism Ecosystem
For the sustainable tourism experience, a smart tourism ecosystem is created so that personalized, context awareness, as well as real-time monitoring, can be ensured.
  • 2.9K
  • 01 Dec 2022
Topic Review
Role of Naturally Occurring Coumarins in Plants
Coumarins are secondary plant metabolites widely distributed in higher plants, bacteria, fungi, and sponges. This great structural diversity of these natural compounds and their synthesized derivatives enables their wide range of pharmacological activities, such as antioxidant; antibacterial; antifungal; anti-human immunodeficiency infection; anti-tubercular; and anti-cancer activities. There are also many reports about their effectiveness against plant pathogenic pests (phytopathogenic fungi, bacteria, nematodes, and insects). 
  • 2.9K
  • 08 Jun 2023
Topic Review
Chasing the Elusive Luciferin
In dinoflagellates, the mechanisms related to the bioluminescent phenomenon have been well studied; however, at present, some points that remain unknown still persist. That is the case of luciferin biosynthesis, which has been reported to be an intricate process with several metabolic pathways involved. In the context of this controversial scenario, various hypotheses about the biosynthesis of luciferin in dinoflagellates are presented.
  • 2.9K
  • 05 Jan 2026
Topic Review
Thermoresponsive Hydrogel Molecule
Temperature-induced, rapid changes in the viscosity and reproducible 3-D structure formation makes thermos-sensitive hydrogels an ideal delivery system to act as a cell scaffold or a drug reservoir. Moreover, the hydrogels’ minimum invasiveness, high biocompatibility, and facile elimination from the body have gathered a lot of attention from researchers.
  • 2.9K
  • 08 Aug 2022
Topic Review
Human Cytomegalovirus
Human cytomegalovirus (HCMV) expresses a variety of viral regulatory proteins that undergo close interaction with host factors including viral-cellular multiprotein complexes. The HCMV protein kinase pUL97 represents a viral CDK ortholog (vCDK) that determines the efficiency of HCMV replication via phosphorylation of viral and cellular substrates. A hierarchy of functional importance of individual pUL97-mediated phosphorylation events has been discussed, however, the most pronounced pUL97-dependent phenotype could be assigned to viral nuclear egress, as illustrated by genetic ORF-UL97 deletion or pharmacological pUL97 inhibition. Despite earlier data pointing to a cyclin-independent functionality, experimental evidence increasingly emphasized the role of pUL97-cyclin complexes. Consequently, the knowledge about pUL97 involvement in host interaction, viral nuclear egress and additional replicative steps led to the postulation of pUL97 as an antiviral target. Indeed, validation experiments in vitro and in vivo confirmed the sustainability of this approach. Consequently, current investigations of pUL97 in antiviral treatment go beyond the known pUL97-mediated ganciclovir prodrug activation and henceforward include pUL97-specific kinase inhibitors. Among a number of interesting small molecules analyzed on experimental and preclinical stages, maribavir is presently investigated in clinical studies and, in the near future, might represent a first kinase inhibitor applied in the field of antiviral therapy.
  • 2.9K
  • 29 Oct 2020
Topic Review
Low-Voltage GaN FETs in Motor Control Application
The efficiency and power density improvement of power switching converters play a crucial role in energy conversion. In the field of motor control, this requires an increase in the converter switching frequency together with a reduction in the switching legs’ dead time. This target turns out to be complex when using pure silicon switch technologies. Gallium Nitride (GaN) devices have appeared in the switching device arena in recent years and feature much more favorable static and dynamic characteristics compared to pure silicon devices. In the field of motion control, there is a growing use of GaN devices, especially in low voltage applications.
  • 2.9K
  • 29 Oct 2021
Topic Review
Sustainable Wireless Sensor Network Based Environmental Monitoring
Wireless sensor networks (WSN) are the base of the Internet of Things (IoT) that all together give rise to the smart city. These WSNs consist of several sensors, which are densely distributed to observe physical or environmental conditions, like humidity, temperature, light intensity, and gas concertation. The sensors reading data are transmitted to the network coordinator, the IP-gateway, which is at the heart of the wireless network.
  • 2.9K
  • 27 Jul 2022
Topic Review
Innovative Tools in Farm Animals’ Early Disease Diagnosis
As the importance of farming continues to grow, innovative technology and sensors play an increasingly important role. Automation and robots in agriculture have the potential to play a significant role in helping society fulfill its future demands for food supply. Wearable sensors connected to or within cows can monitor eating, rumination, pH, body temperature, laying behavior, animal activity, animal position or placement, and more.
  • 2.9K
  • 16 Mar 2023
Topic Review
Molecular Mechanisms and Signaling Pathways in Gastric Cancer
Gastric cancer (GC) is common but often diagnosed late. Advances in chemotherapy, targeted therapy, and immunotherapy offer promising treatments. Perioperative chemotherapy is now the standard for resectable gastric cancer. Progress has also been made in treating metastatic disease using targeted immunotherapies. Molecular biomarkers such as programmed cell death protein ligand 1 (PD-L1), microsatellite instability (MSI), and human epidermal growth factor receptor 2 (HER2) guide personalized treatment approaches. 
  • 2.9K
  • 03 Nov 2023
Topic Review
Resveratrol Production in Yeast Hosts
Resveratrol is a plant secondary metabolite known for its therapeutic applications as an antioxidant, anti-cancer, anti-inflammatory, anti-aging, cardio-protective, and neuroprotective agent. Topical formulas of resveratrol are also used for skin disease management and in cosmetic industries. Due to its importance, high resveratrol production is urgently required. Yeasts were proven to be excellent host candidates for resveratrol production.
  • 2.9K
  • 30 Jul 2021
Topic Review
Geoheritage
“Geoheritage” is a new term that assumes complete perception of Man for nature and the environment. As stated by McBriar “Geological-geomorphological heritage is the collection of geotopes, deposits, forms, and processes that comprise the geological history of each region, and the concept of preserving geological-geomorphological heritage is a cultural concept”.
  • 2.9K
  • 23 Sep 2021
Topic Review
Germanium Ion Implantation and Annealing
Germanium (Ge) ion implantation into silicon waveguides will induce lattice defects in the silicon, which can eventually change the crystal silicon into amorphous silicon and increase the refractive index from 3.48 to 3.96. A subsequent annealing process, either by using an external laser or integrated thermal heaters can partially or completely remove those lattice defects and gradually change the amorphous silicon back into the crystalline form and, therefore, reduce the material’s refractive index.  In addition, Ge ion implantation and annealing are also demonstrated to enable post-fabrication trimming of ring resonators and Mach–Zehnder interferometers and to implement nonvolatile programmable photonic circuits. 
  • 2.9K
  • 01 Mar 2022
Topic Review
Remote Sensing Methods for Flood Prediction
Floods are a major cause of loss of lives, destruction of infrastructure, and massive damage to a country’s economy. Floods, being natural disasters, cannot be prevented completely; therefore, precautionary measures must be taken by the government, concerned organizations such as the United Nations Office for Disaster Risk Reduction and Office for the coordination of Human Affairs, and the community to control its disastrous effects. Floods are uncertain depending on several climatic and environmental factors, and therefore are difficult to predict. A classification framework is presented which classifies the remote sensing technologies being used for flood prediction into three types, which are: multispectral, radar, and light detection and ranging (LIDAR). 
  • 2.9K
  • 21 Mar 2022
Topic Review
Apple By-Product Valorisation
About 30% of the total production of apples is processed, being juice and cider the main resulting products. Regarding this procedure, a large quantity of apple by-product is generated, which tends to be undervalued, and commonly remains underutilised, landfilled, or incinerated. However, apple by-product is a proven source of bioactive compounds, namely dietary fibre, fatty acids, triterpenes, or polyphenols. Therefore, the application of green technologies should be considered in order to improve the functionality of apple by-product while promoting its use as the raw material of a novel product line. 
  • 2.9K
  • 03 Nov 2022
Topic Review
Underwater Sensing Technologies and Applications
Currently, a variety of sensing methods based on optics, acoustics, and electromagnetics are widely applied for ocean observation and exploration. Acoustic sensing contains various sonar devices for seafloor mapping, submersible navigation, and underwater object. Optical sensing technologies applied to ocean exploration include underwater imaging for objects inspection, spectrophotometry, and fluorophotometry for environmental parameters monitoring. Technologies of electromagnetics are used for underwater metal detection such as mines and mineral resources, and for underwater inspections of cables and pipelines.
  • 2.9K
  • 13 Dec 2021
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