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Topic Review
School Recess: Safety Situations and Assumable Risk
Recess at school takes place during the school day to provide the children with a change from academic activities. In the field of education, rest times within the academic activities at school are necessary for the healthy development of children and as tools to promote learning, bringing health, social, cognitive, and developmental benefits.
  • 3.0K
  • 21 Apr 2022
Topic Review
T-Cell Receptor Repertoire Sequencing and Its Applications
The immune system is a dynamic feature of each individual and a footprint of our unique internal and external exposures. Indeed, the type and level of exposure to physical and biological agents shape the development and behavior of this complex and diffuse system. Many pathological conditions depend on how our immune system responds or does not respond to a pathogen or a disease or on how the regulation of immunity is altered by the disease itself. T-cells are important players in adaptive immunity and, together with B-cells, define specificity and monitor the internal and external signals that our organism perceives through its specific receptors, TCRs and BCRs, respectively. Today, high-throughput sequencing (HTS) applied to the TCR repertoire has opened a window of opportunity to disclose T-cell repertoire development and behavior down to the clonal level. Although TCR repertoire sequencing is easily accessible today, it is important to deeply understand the available technologies for choosing the best fit for the specific experimental needs and questions. Here, an updated overview of TCR repertoire sequencing strategies, providers and applications to infectious diseases and cancer to guide researchers’ choice through the multitude of available options is provided. The possibility of extending the TCR repertoire to HLA characterization will be of pivotal importance in the near future to understand how specific HLA genes shape T-cell responses in different pathological contexts and will add a level of comprehension that was unthinkable just a few years ago.
  • 3.0K
  • 24 Aug 2022
Topic Review
Law of the Land
The phrase law of the land is a legal term, equivalent to the Latin lex terrae, or legem terrae in the accusative case. It refers to all of the laws in force within a country or region, including statute law and case-made law.
  • 3.0K
  • 04 Nov 2022
Topic Review
Catholic Encyclopedia
File:Catholic Encyclopedia, volume 1.djvu The Catholic Encyclopedia: An International Work of Reference on the Constitution, Doctrine, Discipline, and History of the Catholic Church, also referred to as the Old Catholic Encyclopedia and the Original Catholic Encyclopedia, is an English-language encyclopedia published in the United States and designed to serve the Roman Catholic Church. The first volume appeared in March 1907 and the last three volumes appeared in 1912, followed by a master index volume in 1914 and later supplementary volumes. It was designed "to give its readers full and authoritative information on the entire cycle of Catholic interests, action and doctrine". The Catholic Encyclopedia was published by the Robert Appleton Company (RAC), a publishing company incorporated at New York in February 1905 for the express purpose of publishing the encyclopedia. The five members of the encyclopedia's Editorial Board also served as the directors of the company. In 1912 the company's name was changed to The Encyclopedia Press. Publication of the encyclopedia's volumes was the sole business conducted by the company during the project's lifetime.
  • 3.0K
  • 28 Nov 2022
Topic Review
Commuter Behaviour
Lack of travel demand measures to curb private vehicles in the city, leading to the problem of traffic congestion in the emerging megacities. Analysis of the problem of traffic congestion to commuter travel mode preferences in the city opens up the door for theoretical exploration of the process of traffic congestion. The study reports the analysis of the framed field experiment to investigate the behavioural responses of commuters. By involving 204 commuters, the research is aimed to investigate the behavioural response of commuters if demand-based non-technical measures are implemented as treatments in the experiment. The two central questions related to this objective are: how do commuter travel mode preferences contribute to urban traffic congestion? And, how can this be empirically analysed in terms of the effect of demand-based non-technical measures?
  • 3.0K
  • 27 Oct 2020
Topic Review
Nitrogen in Wetlands
Wetlands are viable sinks for nitrate and have also been identified as a source of nitrous oxide, a product of two microbially regulated processes: nitrification and denitrification. Anthropogenic expansion of nitrogen is a leading cause of the eutrophication of water bodies and may also contribute to the deterioration of the ozone layer in the stratosphere. Wetlands ameliorate the quality of water percolating through them, by retaining nutrients and sequestering carbon, and simultaneously enhancing the flora and fauna diversity of these landscapes. Among the many services these wetlands provide, they also alleviate nitrate pollution by attenuating reactive nitrogen from agricultural drainage and ensure the effective reclamation of the wastewater. 
  • 3.0K
  • 24 May 2021
Topic Review
Implications of Sphingolipid Metabolites in Kidney Diseases
Sphingolipids (SLs) are lipids with complex structures which were named after their sphinx-like structure by Thudichium in 1870. Lipids are major components of membranes in all eukaryotic cells determining the structural and functional integrity of cells. SLs are one of the important structural components of plasma membranes in all eukaryotes, but they also act as bioactive signaling molecules with numerous cellular physiological functions that include cell adhesion, cell proliferation, cell migration, inflammatory response and apoptosis. Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the levels of sphingolipids can be lethal to cells. Abnormalities in the levels of sphingolipids are associated with several human diseases including kidney diseases. Several studies demonstrate that sphingolipids play an important role in maintaining proper renal function. Sphingolipids can alter the glomerular filtration barrier by affecting the functioning of podocytes, which are key cellular components of the glomerular filtration barrier. 
  • 3.0K
  • 29 Apr 2022
Topic Review
Orthodiagonal Quadrilateral
In Euclidean geometry, an orthodiagonal quadrilateral is a quadrilateral in which the diagonals cross at right angles. In other words, it is a four-sided figure in which the line segments between non-adjacent vertices are orthogonal (perpendicular) to each other.
  • 3.0K
  • 19 Oct 2022
Topic Review
Climate Change in Vietnam
Vietnam is considered, in coming decades, to be among the most affected countries by global climate change. A large number of studies that Vietnam is experiencing climate change and will be severely negatively affected in coming decades. These negative effects include sea level rise, salinity intrusion and other hydrological problems like flood, river mouth evolution, sedimentation as well as the increasing frequency of natural hazards such as cold waves, storm surges will all exert negative effects on the country's development and economy including agriculture, aquaculture, road infrastructure, etc. Some issues, such as land subsidence (caused by excessive groundwater extraction) further worsen some of the effects climate change will bring (sea level rise) especially in areas such as the Mekong Delta. The government, NGOs, and citizens have taken various measures to mitigate and adapt to the impact.
  • 3.0K
  • 14 Nov 2022
Topic Review
Cholesterol
Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is obtained from the diet or can be de novo synthetized. Cholesterol homeostasis is mainly regulated by the liver, where cholesterol is packed in lipoproteins for transport through a tightly regulated process. Changes in circulating lipoprotein cholesterol levels lead to atherosclerosis development, which is initiated by an accumulation of modified lipoproteins in the subendothelial space; this induces significant changes in immune cell differentiation and function. In this entry, we describe the main regulatory pathways and mechanisms of cholesterol metabolism.
  • 3.0K
  • 17 Jan 2022
Topic Review
Flow Resistance Due to Vegetation
Vegetation on the riverbed, banks and flooding areas of watercourses significantly affects energy losses. Energy dissipation takes on different values depending on whether the vegetation is emergent or submerged, rigid or flexible. Many models have been proposed in the scientific literature for its evaluation.
  • 3.0K
  • 27 Jan 2021
Topic Review
Antimicrobial Blue Light
Blue light primarily exhibits antimicrobial activity through the activation of endogenous photosensitizers, which leads to the formation of reactive oxygen species that attack components of bacterial cells, such as cell wall, cell membrane and genome. Current data show that blue light is innocuous on the skin, but may inflict photo-damage to the eyes. While complete resistance to blue light has not been reported, isolated evidence suggests that bacterial tolerance to blue light may occur over time, especially through gene mutations, although at a slower rate than antibiotic resistance. Future studies can aim at characterizing the amount and type of intracellular photosensitizers across bacterial species and at assessing the oxygen-independent mechanism of blue light.
  • 3.0K
  • 11 Jan 2021
Topic Review
Pharmacological Effects of Houttuynia cordata Thunb (H. cordata)
Houttuynia cordata Thunb (H. cordata) is a rhizomatous, herbaceous, and perennial plant widely distributed in Asia. It has multiple chemical constituents, such as alkaloids, essential oils, phenolic acids, and flavonoids used against various health problems. The essential oils and flavonoids are the main components of H. cordata that play an essential role in disease treatment and traditional health care. Moreover, the leaves and stems of H. cordata have a long medicinal history in China. In addition, H. cordata is used against several health issues, such as cold, cough, fever, pneumonia, mumps, and tumors, due to its anti-inflammatory, anti-bacterial, anti-viral, anti-oxidant, and anti-tumor effects.
  • 3.0K
  • 07 Sep 2022
Topic Review
Distributed Element Circuit
Distributed element circuits are electrical circuits composed of lengths of transmission lines or other distributed components. These circuits perform the same functions as conventional circuits composed of passive components such as capacitors, inductors, and transformers. They are used mostly at microwave frequencies where conventional components are difficult or impossible to implement. A major advantage of distributed element circuits is that they can be produced cheaply as a printed circuit board for consumer products such as satellite television. They are also made in coaxial and waveguide formats for applications such as radar, satellite communication, and microwave links. A phenomenon that is much used in distributed element circuits is that a length of transmission line can be made to behave as a resonator. Distributed element components that do this include stubs, coupled lines, and cascaded lines. Circuits built from these components include filters, power dividers, directional couplers, and circulators. Distributed element circuits were investigated in the 1920s and 1930s but did not become important until World War II when they were used in radar. After the war their use was at first limited to military, space, and broadcasting infrastructure use but improvements in materials science in the field soon led to wider applications.
  • 3.0K
  • 17 Oct 2022
Topic Review
List of Wartime Cross-Dressers
Many people have engaged in cross-dressing during wartime under various circumstances and for various motives. This has been especially true of women, whether while serving as a soldier in otherwise all-male armies, while protecting themselves or disguising their identity in dangerous circumstances, or for other purposes. Conversely, men would dress as women to avoid being drafted, the mythological precedent for this being Achilles hiding at the court of Lycomedes dressed as a girl to avoid participation in the Trojan War.
  • 3.0K
  • 08 Nov 2022
Topic Review Peer Reviewed
Artificial Intelligence in Special Education
This entry examines the growing role of artificial intelligence (AI) in special education. The authors discuss applications of AI in the field, including its uses for personalized learning, adaptive technologies, teacher support, and AI’s potential to address issues related to student accessibility and engagement. The entry draws on recent syntheses of literature, highlighting studies that reveal AI’s capacity to improve educational outcomes for students with disabilities, mitigate teacher workload, and foster inclusion. Despite these promising developments, the authors address ethical considerations, potential biases, and privacy concerns surrounding the use of AI, as well as the need for high-quality research that validates AI’s effectiveness in special education. The authors conclude that while AI can offer substantial support, it should be integrated thoughtfully, guided by empirical research, and accompanied by skilled professional oversight to ensure that it truly benefits students with disabilities.
  • 3.0K
  • 15 Jan 2025
Topic Review
Bacterial Nanocellulose
Bacterial nanocellulose (BNC) is a biomaterial with a growing interest in the field of nanocomposites and sustainable materials. It is produced through fermentative processes by several species of bacteria as extracellular secretion. BNC looks like a highly pure and flexible 3D porous network suitable for various applications including biodegradable materials, reinforcing agents, packaging films, transpiring membranes, and medical devices. Among the many applications, the use of BNC functionalized with organic and inorganic groups has found wide use as a catalyst in chemical transformations.
  • 3.0K
  • 25 Jan 2021
Topic Review
Biomass Feedstocks Thermochemical Conversion Processes
An effective analytical technique for biomass characterisation is inevitable for biomass utilisation in energy production. To improve biomass processing, various thermal conversion methods such as torrefaction, pyrolysis, combustion, hydrothermal liquefaction, and gasification have been widely used to improve biomass processing. Thermogravimetric analysers (TG) and gas chromatography (GC) are among the most fundamental analytical techniques utilised in biomass thermal analysis. Thus, GC and TG, in combination with MS, FTIR, or two-dimensional analysis, were used to examine the key parameters of biomass feedstock and increase the productivity of energy crops. We can also determine the optimal ratio for combining two separate biomass or coals during co-pyrolysis and co-gasification to achieve the best synergetic relationship. 
  • 3.0K
  • 18 Sep 2021
Topic Review
Pheomelanin
Pheomelanin is a natural yellow-reddish sulfur-containing pigment derived from tyrosinase-catalyzed oxidation of tyrosine in presence of cysteine. It is one of the existing forms of the natural pigment melanin, which is present in the skin in two forms: eumelanin and pheomelanin. Generally, the formation of melanin pigments is a protective response against the damaging effects of UV radiation in skin.
  • 3.0K
  • 20 Jan 2022
Topic Review
Metamaterials
Metamaterials are amongst the advanced materials made up initially with metal structures. However, there is a huge ongoing work on dielectric metasurfaces and metamaterials with the aim of replacing metal structures with dielectric ones in order to reduce the electromagnetic losses.
  • 3.0K
  • 31 Mar 2022
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