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Topic Review
Radix Polygoni Multiflori
Radix Polygoni Multiflori (RPM), the dry root of Polygonum multiflorum Thunb. (Fam. Polygonaceae), has been used as a tonic and an anti-aging remedy for centuries. However, its safe and effective application in clinical practice could be hindered by its liver injury potential and lack of investigations on its hepatotoxicity mechanism.
  • 3.9K
  • 07 Dec 2020
Topic Review
Lipid and Polymeric Nanoparticles for Brain Drug Delivery
Intranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous for central nervous system disorders, such as depression and anxiety. Nanoparticles have been studied as possible alternatives to conventional formulations, with the objective of improving drug bioavailability.
  • 3.8K
  • 15 Dec 2022
Topic Review
Histamine H1 Receptor Antagonists
Histamine H1 receptor (H1 receptor) antagonists are widely prescribed medications to treat allergic diseases, while recently it has emerged that they show significant promise as anti-SARS-CoV-2 agents.
  • 3.8K
  • 03 Jun 2021
Topic Review
Thiophene-Based Compounds
Thiophene derivatives provide useful intermediaries in various areas of science and industry, with a wide range of applications, and therapeutic properties. Thiophene derivatives attract both great academic interest, and interest from the agrochemical, pharmaceutical, and dye industries, as well. As to their biological and pharmacological applications, thiophene derivatives possess remarkable properties as antipsychotic, antianxiety, antifungal, antimicrobial, antioxidant, anticancer, and anti-inflammatory agents. The present work provides an update on the role of thiophene-based derivatives in inflammation processes.
  • 3.8K
  • 09 Oct 2021
Topic Review
Treating Delusional Disorder with Antipsychotics
Delusional disorder (DD) has been considered a treatment-resistant disorder, with antipsychotics acknowledged as the best. It is possible that the discovery of the right drug could turn treatment resistance into treatment response.
  • 3.8K
  • 29 Dec 2022
Topic Review
Dexibuprofen
S-(+) enantiomer of ibuprofen (IBU) dexibuprofen (DXI) is known to be more potent than its R-(−) form and exhibits many advantages over the racemic mixture of IBU such as lower toxicity, greater clinical efficacy, and lesser variability in therapeutic effects. Moreover, DXI potential has been recently advocated to reduce cancer development and prevent the development of neurodegenerative diseases in addition to its anti-inflammatory properties. 
  • 3.8K
  • 23 Jun 2021
Topic Review
Inflammatory Pain Study in Animal-Models
Pain is an easily recognized sensation that is experienced by humans and animals alike. However, the process behind the production of the pain experience is a complex pathway that requires parallel integration of both the emotional and sensory experiences together with noxious perceptual information registered by multiple layers of our brain structure with the purpose of defending our body from harm’s way. Here, the complete protocol that is being adapted for inflammatory pain study in animals induced by different phlogogenic agents and different assessment methods were elaborated along with the underlying mechanism of actions. This provides a concise idea and improves our scientists’ understanding of inflammatory pain management in future research.
  • 3.8K
  • 05 Nov 2020
Topic Review
Causes and Risk Factors of Alzheimer’s Disease
Alzheimer’s disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline in thinking and independence in personal daily activities. AD is considered a multifactorial disease: two main hypotheses were proposed as a cause for AD, cholinergic and amyloid hypotheses. Additionally, several risk factors such as increasing age, genetic factors, head injuries, vascular diseases, infections, and environmental factors play a role in the disease.
  • 3.7K
  • 29 Feb 2024
Topic Review
Quinolones
Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become essential tools in the armoury of clinical treatments. FQs target the bacterial enzymes DNA gyrase and DNA topoisomerase IV, where they stabilise a covalent enzyme-DNA complex in which the DNA is cleaved in both strands. This leads to cell death and turns out to be a very effective way of killing bacteria. However, resistance to FQs is increasingly problematic, and alternative compounds are urgently needed.
  • 3.5K
  • 25 Dec 2020
Topic Review
Arsenic metabolism, excretion, and toxicity
       Arsenic is a global, naturally present pollutant found in drinking water that is consumed by millions of people throughout the world. Humans have evolved an arsenic methyltransferase present in high levels in the liver to expedite its excretion from the body. Most organisms have this enzyme. The enzyme generates monomethyl (MMA) and dimethyl arsenic (DMA). These methylated species are considered more toxic than arsenite, but they bind less tightly to proteins and thereby are excreted more rapidly from the body. Individuals who have been chronically exposed to arsenite were found to possess advantageous genotypes to metabolize arsenites. However, higher expression of AS3MT was found to yield more toxic MMA but lower amounts were still capable of metabolizing arsenite to DMA. This likely reflects the complex metabolic processes involving not only AS3MT, but antioxidants and upstream regulators of AS3MT, potentially transcription factor NRF2. This article discusses arsenic metabolism, excretion, toxicity, and the evolution of this enzyme across various species. The fact that so many organisms have evolved to possess this arsenite metabolizing enzyme is indicative of the widespread and ancient pollution of our drinking water by arsenite.
  • 3.5K
  • 09 Oct 2020
Topic Review
Honey and Propolis in Ocular Disease Treatment
Honey and propolis have recently become the key target of attention for treating certain diseases and promoting overall health and well-being. A high content of flavonoids and phenolic acids found in both honey and propolis contributes to the antioxidant properties to scavenge free radicals. Honey and propolis also exhibited antibacterial effects where they act in two ways, namely the production of hydrogen peroxide (H2O2) and gluconic acids following the enzymatic activities of glucose oxidase, which exerts oxidative damage on the bacteria. Additionally, the anti-inflammatory effects of honey and propolis are mainly by reducing proinflammatory factors such as interleukins and tumor necrosis factor alpha (TNF-α). Their effects on pain were discovered through modulation at a peripheral nociceptive neuron or binding to an opioid receptor in the higher center. The aforementioned properties of honey have been reported to possess potential therapeutic topical application on the exterior parts of the eyes, particularly in treating conjunctivitis, keratitis, blepharitis, and corneal injury. In contrast, most of the medicinal values of propolis are beneficial in the internal ocular area, such as the retina, optic nerve, and uvea. 
  • 3.5K
  • 02 Feb 2023
Topic Review
Medicinal Value of Chicory
Cichorium intybus L., commonly named chicory, is a perennial herbal plant of the dandelion family Asteraceae, mainly seen with bright blue flowers, and seldom pink or white. Generally distributed in Asia and Europe, all the plants’ parts were traditionally used in medicinal preparations due to their considerable contents of antioxidant phytochemicals thought to have a beneficial impact in preventing and treating various illnesses such as fever, diarrhea, jaundice, and gallstones. Different chicory types are grown for their salad leaves, chicons, or roots, and regularly used for inulin extraction, for preparing coffee substitutes, or for feeding livestock. This entry is based on a literature review and highlights the beneficial and therapeutic action of chicory extracts and their confirmed or hypothesized mechanism of action in diabetes, hepatic disorders, and cardiovascular disease, as indicated by the results of in vivo and in vitro studies, on cell lines, human and animal models.
  • 3.4K
  • 10 May 2021
Topic Review
Mangiferin
Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases. It possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity.
  • 3.3K
  • 10 Jan 2022
Topic Review
The Bioactivity and Health Benefits of Alpha-Phellandrene
Aromatic essential oils play a significant role in pharmaceuticals, food additives, cosmetics, and perfumery. Essential oils mostly comprise aliphatic hydrocarbons, monoterpenoids, sesquiterpenoids and diterpenes. Plant extracts comprise a complex mixture of terpenes, terpenoids, aliphatic and phenol-derived aromatic components. Terpenes are a significant class of hydrocarbons with numerous health benefits. Monoterpenes are the most important constituents of essential oils. α-phellandrene (α-PHE) is a cyclic monoterpene with two double bonds in a heterocyclic ring (endocyclic).
  • 3.3K
  • 20 Oct 2022
Topic Review
Euphorbia neriifolia Linn.
Medicinal plants have considerable potential as antimicrobial agents due to the presence of secondary metabolites. Researchers aim to summarize the classification, morphology, and ethnobotanical uses of Euphorbia neriifolia L. and its derived phytochemicals with the recent updates on the pharmacological properties against emerging infectious diseases, mainly focusing on bacterial, viral, fungal, and parasitic infections. 
  • 3.3K
  • 14 Jul 2022
Topic Review
Natural Compounds as Ferroptosis Inducers
Ferroptosis is classified as a non-canonical cell death mechanism. To date, several natural compounds have been discovered to induce ferroptosis in different cancer models.
  • 3.3K
  • 25 Feb 2021
Topic Review
Sodium Benzoate in Therapies for Nervous System Disorders
One of the compounds known as a preservative with a high safety profile is sodium benzoate. While some studies show that it can be used to treat conditions such as depression, pain, schizophrenia, autism spectrum disorders, and neurodegenerative diseases, others report its harmfulness. For example, it was found to cause mutagenic effects, generate oxidative stress, disrupt hormones, and reduce fertility. 
  • 3.2K
  • 29 Jun 2022
Topic Review
Recent Advances in Pterostilbene
Pterostilbene is a natural 3,5-dimethoxy analog of resveratrol. This stilbene compound has a strong bioactivity and exists widely in Dalbergia and Vaccinium spp. Besides natural extraction, pterostilbene can be obtained by biosynthesis. Pterostilbene has become popular because of its remarkable pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammation, and neuroprotection. Pterostilbene can be rapidly absorbed and is widely distributed in tissues, but it does not seriously accumulate in the body. Pterostilbene can easily pass through the blood-brain barrier because of its low molecular weight and good liposolubility. In this review, the studies performed in the last three years on resources, synthesis, bioactivity, and pharmacokinetics of pterostilbene are summarized.
  • 3.1K
  • 19 Nov 2020
Topic Review
Chromium
Chromium (Cr) is a common element in the Earth’s crust. It may exist in different oxidation states, Cr(0), Cr(III) and Cr(VI), with Cr(III) and Cr(VI) being relatively stable and largely predominant. Chromium’s peculiarity is that its behavior relies on its valence state. Cr(III) is a trace element in humans and plays a major role in glucose and fat metabolism. The beneficial effects of Cr(III) in obesity and types 2 diabetes are known. It has been long considered an essential element, but now it has been reclassified as a nutritional supplement. On the other hand, Cr(VI) is a human carcinogen and exposure to it occurs both in occupational and environmental contexts. It induces also epigenetic effects on DNA, histone tails and microRNA; its toxicity seems to be related to its higher mobility in soil and swifter penetration through cell membranes than Cr(III). The microorganisms Acinetobacter sp. Cr1 and Pseudomonas sp. Cr13 have been suggested as a promising agent for bioremediation of Cr(VI).
  • 3.1K
  • 22 Feb 2021
Topic Review
Thin-Layer Chromatography Bioautography
Thin-layer chromatography (TLC) bioautography is a methodological technique that integrates the separation and analysis technology of TLC with biological activity detection technology, which is used to isolate, locate and evaluate the active constituents of natural creatures based on the guidance of activity.
  • 3.1K
  • 06 Aug 2021
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