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Topic Review
Nutrition-focused QIPs in Cancer Care
Malnutrition in patients with cancer is a ubiquitous but neglected problem that can reduce patient survival/quality of life and increase treatment interruptions, readmission rates, and healthcare costs. Malnutrition interventions, including nutrition support through dietary counseling, diet fortification, oral nutrition supplements (ONS), and enteral and parenteral nutrition can help improve health outcomes. However, nutritional care standards and interventions for cancer are ambiguous and inconsistently applied. The lack of systematic malnutrition screening and intervention in ambulatory cancer care has especially significant consequences and thus the nutrition support of patients with cancer represents an area for quality improvement. United States healthcare payment models such as the Oncology Care Model are linked to quality of care and health outcomes. Quality improvement programs (QIPs) can advance patient-centered care, perfect care processes, and help healthcare professionals meet their quality measure performance goals. Malnutrition QIPs like the Malnutrition Quality Improvement Initiative (MQii) have been shown to be effective in identifying and treating malnutrition. However, little is known about or has been reported on nutrition or malnutrition-focused QIPs in cancer care. This paper provides information to support translational research on quality improvement and outlines the gaps and potential opportunities for QIPs in the nutrition support of patients with cancer.
  • 1.4K
  • 27 Oct 2020
Topic Review
Anti-Obesity Effects of Microalgae
Microalgae are prokaryotic or eukaryotic microscopic single-cell organisms, producing a great variety of compounds, such as photosynthetic pigments (carotenoids and chlorophylls), sterols, polyunsaturated fatty acids, vitamins, minerals, fiber, polysaccharides, enzymes, peptides, and toxins. In recent years, they have attracted great interest as a major source of bioactive medicinal products and food ingredients with anti-oxidant, anti-inflammatory, anti-cancer and anti-microbial properties. In most pre-clinical studies performed with Euglena gracilis, Phaeodactylum tricornutum, Spirulina maxima, Spirulina platensis, or Nitzschia laevis microalgae, positive anti-obesity effects have been addressed in animals submitted to an obesogenic feeding pattern. However, more research is warranted to determine which bioactive compound(s) are responsible for their anti-obesity effects, as well as to establish the mechanisms underlying those effects.
  • 1.4K
  • 14 Apr 2021
Topic Review
Last Four Decades' Viral Pandemics
The last four decades have witnessed some of the deadliest viral pandemics with far-reaching consequences. These include the Human Immunodeficiency Virus (HIV) (1981), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2002), Influenza A virus subtype H1N1 (A/H1N1) (2009), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2012), Ebola virus (2013) and the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) (2019-present). Age- and gender-based characterizations suggest that SARS-CoV-2 resembles SARS-CoV and MERS-CoV with regard to higher fatality rates in males, and in the older population with comorbidities. The invasion-mechanism of SARS-CoV-2 and SARS-CoV, involves binding of its spike protein with angiotensin-converting enzyme 2 (ACE2) receptors; MERS-CoV utilizes dipeptidyl peptidase 4 (DPP4), whereas H1N1 influenza is equipped with hemagglutinin protein.
  • 1.4K
  • 08 Jan 2021
Topic Review
Games for Diabetes Control
Finding methods to improve people’s diabetes control and management is important to prevent its complications and maintain the quality of life. The aim of this review was to assess the effect of games on the blood glucose level (glycated hemoglobin (HbA1c)). A systematic review and meta-analysis were made. Pubmed, Scopus, and CINAHL databases were consulted in July of 2020. Ten studies were selected as a final sample, most of them being clinical trials using games to improve diabetes control. Half of the studies had samples between 8 and 14.9 years old and the other half between 57 and 65 years old. The studies informed about using applications/games for mobile phones, game consoles, and board games for diabetes education and management. The meta-analysis was performed with 4 studies showing a mean difference of 0.12 (CI 95% 0.57, 0.33) of HbA1c in favor of the intervention group with p > 0.05. Games are positive for diabetes health education and promoting healthier lifestyle, but their impact on HbA1c is low.
  • 1.4K
  • 23 Apr 2021
Topic Review
Hope in Nursing Care
Hope is a central concept within the nursing literature, which is crucial towards the development of nursing knowledge. Nursing teams play a crucial role in exploring the meaning of hope and promoting hope among patients and their families. 
  • 1.3K
  • 25 Oct 2023
Topic Review
Adults with Metabolic Syndrome
Metabolic syndrome (MetS), a cluster of abdominal obesity, hyperglycemia, hypertriglyceridemia, low HDL (high density lipoprotein)-cholesterol, and hypertension, is known to be a strong risk factor for type 2 diabetes and is considered one of the most important preventable risk factors for cardiovascular diseases, whose prevalence is increasing.
  • 1.3K
  • 14 Apr 2021
Topic Review
Machine&Deep Learning towards COVID-19
With many successful stories, machine learning (ML) and deep learning (DL) have been widely used in our everyday lives in a number of ways. They have also been instrumental in tackling the outbreak of Coronavirus (COVID-19), which has been happening around the world. The SARS-CoV-2 virus-induced COVID-19 epidemic has spread rapidly across the world, leading to international outbreaks. The COVID-19 fight to curb the spread of the disease involves most states, companies, and scientific research institutions. In this research, we look at the Artificial Intelligence (AI)-based ML and DL methods for COVID-19 diagnosis and treatment. Furthermore, in the battle against COVID-19, we summarize the AI-based ML and DL methods and the available datasets, tools, and performance.
  • 1.3K
  • 18 Feb 2021
Topic Review
Women Care with Delusional Disorder
Delusional disorder is a difficult-to-treat clinical condition with health needs that are often undertreated. Although individuals with delusional disorder may be high functioning in daily life, they suffer from serious health complaints that may be sex-specific.
  • 1.3K
  • 27 Jan 2021
Topic Review
Communicable Diseases in Roma Communities
The Roma are Europe's largest minority. They are also one of its most disadvantaged, with low levels of education and health, and high levels of poverty. This entry focuses on Eastern and Central Europe, and summarises the findings of a review of 19 papers that describe communicable disease burden among the Roma. Roma in Eastern and Central Europe continue to have a higher prevalence of communicable diseases than the majority populations of the countries they live in, and are at a high risk of infection.
  • 1.3K
  • 26 Nov 2020
Topic Review
Dietary Mitophagy Enhancer
Recently, nutritional interventions have received attention as promising approaches to promote human health during a lifespan. The Mediterranean and Okinawan diets have been associated with longevity and decreasing risk for age-related diseases in contrast to the Western diet. The effect might be due to several antioxidative bioactive compounds highly consumed in both diets, namely, resveratrol, hydroxytyrosol, oleuropein, curcumin, and spermidine. This review aims to address the underlying mechanisms of these compounds to enhance mental fitness throughout life with a focus on brain mitophagy. Mitophagy is the autophagic clearance of dysfunctional, redundant, and aged mitochondria. In aging and neurodegenerative disorders, mitophagy is crucial to preserve the autophagy mechanism of the whole cell, especially during oxidative stress. Growing evidence indicates that curcumin, astaxanthin, resveratrol, hydroxytyrosol, oleuropein, and spermidine might exert protective functions via antioxidative properties and as well the enhanced induction of mitophagy mediators. The compounds seem to upregulate mitophagy and thereby alleviate the clearance of dysfunctional and aged mitochondria as well as mitogenesis. Thus, the Mediterranean or Okinawan diet could represent a feasible nutritional approach to reduce the risk of developing age-related cognitive impairment and corresponding disorders via the stimulation of mitophagy and thereby ensure a balanced redox state of brain cells.
  • 1.2K
  • 20 Oct 2020
Topic Review
Physical Activity in Older Adults
Healthy aging makes the practice of physical activity (PA) a necessity. However, PA guidelines achievement in older adults is scarce. The use of behavioral theories such as Transtheoretical Model (TTM), helps in older adults PA promotion. The aim of this review was to identify the use of TTM for PA in older adults (>60 years). PubMed, SPORTdiscus, and Medline databases were used to conduct the search. All steps of the process followed the recommendations of the PRISMA flow-diagram. We identified eight studies: Six were descriptive cross-sectional studies, one prospective-cohort study and one with a quasi-experimental design. Only two papers evaluated the four behavior change dimensions within the same study, three evaluated the processes of change and the decisional balance, four evaluated the exercise self-efficacy and all assessed the stages of change for PA behavior. 
  • 1.2K
  • 24 Apr 2021
Topic Review
Fresh Umbilical Cord Blood
Umbilical cord blood (UCB) is a rich source of hematopoietic cells that can be used to replace bone marrow components. Many blood disorders and systemic illnesses are increasingly being treated with stem cells as regenerative medical therapy. Collected blood has been stored in either public or private banks for allogenic or autologous transplantation.
  • 1.2K
  • 05 Sep 2023
Topic Review
Pulse Oximetry
Finger pulse oximeters are widely used to monitor physiological responses to high-altitude exposure, the progress of acclimatization, and/or the potential development of high-altitude related diseases. 
  • 1.2K
  • 24 Feb 2021
Topic Review
Conditions Determining Male Infertility
The lack of knowledge of the causes of impaired reproductive potential results in an inability to implement specific treatment, which is associated with the lack of positive outcomes (pregnancy). This review will make relevant environmental comparisons. It will allow an understanding of the importance of environmental factors in shaping the body's defense and capabilities in the field of reproductive condition. The results can be used in enhancing diagnosis and deciding on appropriate infertility treatment.
  • 1.2K
  • 23 Mar 2021
Topic Review
Propolis in Periodontal Disease
Propolis is a natural substance produced by bees which has proven useful for treating periodontal disease. 
  • 1.2K
  • 25 Feb 2021
Topic Review
Primary Healthcare
Total health expenditure in China has grown considerably since a new round of health system reform was enacted in 2009. Researchers have shown that strengthening primary healthcare may be an option for countries to solve the rapid expansion of their medical expenditures. This study was designed to explore the association between the strength of primary healthcare and medical expenditures, in the context of the hospital-oriented healthcare system in China. A longitudinal ecological study was conducted using a 5-year panel dataset of 27 provinces in mainland China. The linear mixed effects regression model was used to assess the effects of primary healthcare-related metrics on medical expenditures, controlling for the provincial level specialty care physician supply and socio-economic parameters. All of the three primary healthcare-related metrics showed negative associations with the two medical expenditure parameters. Primary care physicians per 10,000 population was significantly associated with the per capita hospital medical expenditures (p < 0.05), and the percentage of public health expenditure in total health expenditure was significantly associated with both per capita total medical expenditure and per capita hospital medical expenditures (p < 0.01 for both). Our study found negative associations between the primary healthcare capacity and medical expenditure in the context of hospital-oriented healthcare systems in China, adding to the previous evidence that primary healthcare may play a positive role in reducing medical expenditure. Policies on increasing the primary care physician supply and the public share of total health expenditure should be conducted to strengthen the primary healthcare system. With the gradual advance of medical reform and the policy inclination to primary healthcare, this will play a more important role in controlling the rapid growth of medical expenditure.
  • 1.2K
  • 19 Jan 2021
Topic Review
SARS-CoV-2 Genomics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great threat to public health, being a causative pathogen of a deadly coronavirus disease (COVID-19). It has spread to more than 200 countries and infected millions of individuals globally. Although SARS-CoV-2 has structural/genomic similarities with the previously reported SARS-CoV and MERS-CoV, the specific mutations in its genome make it a novel virus. Available therapeutic strategies failed to control this virus. Despite strict standard operating procedures (SOPs), SARS-CoV-2 has spread globally and it is mutating gradually as well.
  • 1.2K
  • 02 Mar 2021
Topic Review
COVID-19 Vaccine Hesitancy Worldwide
Utility of vaccine campaigns to control coronavirus 2019 disease (COVID-19) is not merely de-pendent on vaccine efficacy and safety. Vaccine acceptance among the general public and healthcare workers appears to have a decisive role in the successful control of the pandemic.
  • 1.2K
  • 01 Mar 2021
Topic Review
Aging of BM-MSCs
Aging of bone marrow is a complex process that is involved in the development of many diseases, including hematologic cancers. The results obtained in this field of research, year after year, underline the important role of cross-talk between hematopoietic stem cells and their close environment. In bone marrow, mesenchymal stromal cells (MSCs) are a major player in cell-to-cell communication, presenting a wide range of functionalities, sometimes opposite, depending on the environmental conditions. Although these cells are actively studied for their therapeutic properties, their role in tumor progression remains unclear. One of the reasons for this is that the aging of MSCs has a direct impact on their behavior and on hematopoiesis. In addition, tumor progression is accompanied by dynamic remodeling of the bone marrow niche that may interfere with MSC functions.
  • 1.2K
  • 06 May 2021
Topic Review
Sexuality and Mental Health in Heterosexual Adolescents
During puberty and emerging sexuality, adolescents experience important physical, mental, and social transformations. In the process of dealing with these changes, adolescents can become potentially vulnerable to mental health problems. 
  • 1.1K
  • 22 Apr 2022
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