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Topic Review
Imaging Techniques in CKD-MBD
Standard radiological imaging is generally used for the diagnosis of fracture or pseudo-fractures, vascular calcifications and other features of CKD-MBD. However, bone fractures can also be diagnosed using computed tomography (CT) scan, magnetic resonance (MR) imaging and vertebral fracture assessment (VFA). Fracture risk can be predicted by bone densitometry using dual-energy X-ray absorptiometry (DXA), quantitative computed tomography (QTC) and peripheral quantitative computed tomography (pQTC), quantitative ultrasound (QUS) and most recently magnetic resonance micro-imaging. 
  • 1.2K
  • 18 Jun 2021
Topic Review
Magnetic Particle Imaging
Magnetic nanoparticles (MNPs) have a wide range of applications; an area of particular interest is magnetic particle imaging (MPI). MPI is an imaging modality that utilizes superparamagnetic iron oxide particles (SPIONs) as tracer particles to produce highly sensitive and specific images in a broad range of applications, including cardiovascular, neuroimaging, tumor imaging, magnetic hyperthermia and cellular tracking. 
  • 1.2K
  • 31 Aug 2021
Topic Review
Cone-Beam Breast Computed Tomography
Cone-beam breast computed tomography (CBBCT) is a revolutionary modality that will assist in overcoming the limitations of current imaging for dense breast tissue and overlapping structures. 
  • 1.2K
  • 02 Dec 2021
Topic Review
Hydrogel Spacer SpaceOAR Vue for Prostate Radiotherapy
Damage in the surrounding structures, including the rectum, due to unintended exposure to radiation is a large burden to bear for patients who undergo radiation therapy for prostate cancer. The use of injectable rectal spacers to distance the anterior rectum from the prostate is a potential strategy to reduce the dose of unintended radiation to the rectum. Hydrogel spacers are gaining increasing popularity in the treatment regimen for prostate cancer. After FDA approval of SpaceOAR, specialists are receiving an increasing number of referrals for hydrogel placements. 
  • 1.2K
  • 03 Nov 2022
Topic Review
Anatomy and General Technique of Hemorrhoidal Embolization
Hemorrhoids are blood cushions located into the anus and lower rectum, acknowledged as a common cause of bleeding, which can reduce the quality of life. The development of minimally invasive techniques such as endovascular embolization of superior rectal artery, "Emborrhoid technique", is an effective treatment, with no pain or ischemic complications, and allows quick patient recovery. 
  • 1.2K
  • 22 Nov 2022
Topic Review
Clinical Application of FAPi-PET/CT in Oncology
The tumor microenvironment (TME) surrounding tumor cells is a complex and highly dynamic system that promotes tumorigenesis. Cancer-associated fibroblasts (CAFs) are key elements in TME playing a pivotal role in cancer cells’ proliferation and metastatic spreading. Considering the high expression of the fibroblast activation protein (FAP) on the cell membrane, CAFs emerged as appealing TME targets, namely for molecular imaging, leading to a pan-tumoral approach. Therefore, FAP inhibitors (FAPis) have recently been developed for PET imaging and radioligand therapy, exploring the clinical application in different tumor sub-types.
  • 1.2K
  • 20 Apr 2022
Topic Review
Pterostilbene in Cancer Therapy
Natural polyphenols are organic chemicals which contain phenol units in their structures and possess antitumor properties. However, a key problem is their short half-life and low bioavailability under in vivo conditions. Pterostilbene (3,5-dimethoxy-4'-hydroxystilbene; PT) is a phytoalexin originally isolated from the heartwood of red sandalwood. As recently reported by our group, PT was shown to be effective in the treatment of melanoma. Counterintuitively, PT is not effective (cytotoxic) against melanoma in vitro, and only under in vivo conditions does PT display its anticancer activity. This study elucidated that PT can be effective against melanoma through the inhibition of adrenocorticotropic hormone production in the brain of a mouse, which weakens the Nrf2-dependent antioxidant defenses of melanoma and also pancreatic cancers. This results in both the inhibition of tumor growth and sensitization of the tumor to oxidative stress. Moreover, PT can promote cancer cell death via a mechanism involving lysosomal membrane permeabilization. Different grades of susceptibility were observed among the different cancer cells depending on their lysosomal heat shock protein 70 content, a known stabilizer of lysosomal membranes. In addition, the safety of PT administered i.v. has been evaluated in mice. PT was found to be pharmacologically safe because it showed no organ-specific or systemic toxicity (including tissue histopathologic examination and regular hematology and clinical chemistry data) even when administered i.v. at a high dose (30 mg/kg per day × 23 days). Moreover, new pharmacological advances are being developed to increase its bioavailability and, thereby, its bioefficacy. Therefore, although applications of PT in cancer therapy are just beginning to be explored, it represents a potential (and effective) adjuvant/sensitizing therapy which may improve the results of various oncotherapies. The aim of this review is to present and discuss the results that in our opinion best support the usefulness of PT in cancer therapy, making special emphasis on the in vivo evidence.
  • 1.2K
  • 26 Jul 2021
Topic Review
MRI Guided Adaptive Radiation Therapy of Glioblastoma
Magnetic resonance imaging linear accelerators (MRLINAC) technology allows clinicians to leverage imaging information gathered during radiation therapy to adapt therapy for a patient while actively undergoing treatment. There is a significant need to understand how imaging changes may correlate to outcomes during treatment for glioblastoma (GBM) as these tumors have a poor prognosis and treatment tailored to the tumor characteristics may improve outcomes. Some of the advantages of MR guided therapy include facilitating a more detailed study of tumor and normal tissue response during chemo-radiation therapy, providing a mechanism to adapt therapy based on imaging changes, identifying new imaging biomarkers for tumor response as well as normal tissue response. These avenues could provide a more tangible way to evaluate pseudoprogression and radiation necrosis with radiogenomics as a mechanism to correlate imaging findings to genomic biomarkers. 
  • 1.2K
  • 08 Nov 2022
Topic Review
FLASH Radiotherapy—Radiobiological Rationale
FLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy through better sparing of the normal tissue.
  • 1.2K
  • 13 Apr 2021
Topic Review
Multiparametric Magnetic Resonance Imaging of Penile Cancer
Primary penile cancer is an uncommon malignancy with an incidence ranging from up to 6.8 per 100,000 in Africa, Asia, and South America to less than 1 per 100,000 in North America and Europe. Accurate preoperative staging and precise outlining of a tumor’s extent are crucial for selecting the most suitable treatment approach and improving outcomes. The current clinical staging of penile cancer is still largely based on physical examination. Multiparametric magnetic resonance imaging (mpMRI) is an important imaging modality that complements physical examination and reduces uncertainties that can easily arise during this examination.
  • 1.2K
  • 21 Nov 2023
Topic Review
Cost-Effective Diagnostic Algorithm for Intraductal Papillary Mucinous Neoplasms
The increased detection of pancreatic cysts in recent years has triggered extensive diagnostic investigations to clarify their potential risk of malignancy, resulting in a large number of patients undergoing numerous imaging follow-up studies for many years. Therefore, there is a growing need for optimization of the current surveillance protocol to reduce both healthcare costs and waiting lists, while still maintaining appropriate sensibility and specificity. Imaging is an essential tool for evaluating patients with intraductal papillary mucinous neoplasms (IPMNs) since it can assess several predictors for malignancy and thus guide further management recommendations. Although contrast-enhanced magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) has been widely recommended by most international guidelines, recent results support the use of unenhanced abbreviated-MRI (A-MRI) protocols as a surveillance tool in patients with IPMN. In fact, A-MRI has shown high diagnostic performance in malignant detection, with high sensitivity and specificity as well as excellent interobserver agreement. 
  • 1.2K
  • 18 Mar 2024
Topic Review
Human Radiosensitivity, Radiosusceptibility and Radiodegeneration
The individual response to ionizing radiation may show several clinical features such as skin burns, cancers or cataracts, according the tissue type, the genetic status or the dose. To avoid any confusion with a non-univocal way of using the term “radiosensitivity”, we have proposed the following definitions :  - “Radiosensitivity is the proneness to the radiation-induced adverse tissue events generally attributable to cell death that is correlated with unrepaired DNA damage.  -“Radiosusceptibilty” is the proneness to the radiation-induced cancers generally attributable to cell transformation that is correlated with misrepaired DNA damage. -"Radiodegeneration" is the proneness to radiation-induced non-cancer effects attributable to mechanisms related to accelerated aging that is correlated with the accumulation of tolerated unrepaired DNA damage.
  • 1.1K
  • 28 Jul 2021
Topic Review
Radiological Diagnostic Approach and Spinal Cord Tumor
Differentiating neoplastic from non-neoplastic spinal cord pathologies may be challenging due to overlapping clinical and radiological features. Spinal cord tumors, which comprise only 2–4% of central nervous system tumors, are rarer than non-tumoral myelopathies of inflammatory, vascular, or infectious origins. The risk of neurological deterioration and the high rate of false negatives or misdiagnoses associated with spinal cord biopsies require a cautious approach.
  • 1.1K
  • 08 Mar 2024
Topic Review
MRI for Evaluating DKD Noninvasively
Renal magnetic resonance techniques provide noninvasive information on renal volume, function, metabolism, perfusion, oxygenation, and microstructural alterations, without the need for exogenous contrast media.
  • 1.1K
  • 10 Jun 2021
Topic Review
Imaging in Portal Vein Thrombosis
The term portal vein thrombosis (PVT) refers to the complete or partial obstruction of blood flow in the portal vein, due to the presence of a thrombus in the vasal lumen. The underlying etiology of PVT remains unclear in up to 50% of children and adults. PVT, either primary or secondary to an underlying chronic liver disease, is the most common cause of prehepatic portal hypertension. On the one hand, primary PVT can be idiopathic, iatrogenic (neonatal umbilical vein catheterization), or related to an altered coagulation status. On the other hand, the progression of most chronic liver diseases leads to fibrosis, which increases sinusoid resistance and determines an abnormal elevation of portal venous pressure. The spontaneous development of a collateral circulation to divert the flow to the systemic circulation is the first observed anomaly, which itself contributes to PVT. 
  • 1.1K
  • 11 Nov 2022
Topic Review
Abnormal Microenvironment Responsive MRI Nanoprobe
Magnetic resonance imaging (MRI) is often used to diagnose diseases due to its high spatial, temporal and soft tissue resolution. Environment-responsive or smart MRI nanoprobes can specifically target cells based on differences in the cellular environment and improve the contrast between diseased tissues and normal tissues.
  • 1.1K
  • 21 May 2021
Topic Review
Differentiated Thyroid Cancer
Differentiated thyroid cancer (DTC) is the most common endocrine malignancy with a high incidence rate in females. 
  • 1.1K
  • 03 Jun 2021
Topic Review
Organ-Preserving Radiation Therapy in Gastric Marginal Zone Lymphoma
Gastric marginal zone lymphoma (MZL) of the stomach is a rare cancer type, often primarily treated with oral proton pump inhibitors, especially in Helicobacter pylori (Hp)-positive cases. However, the prevalence of Hp-unrelated gastric MZL has increased over the last two decades and 70-80% of Hp-negative gastric MZL are antibiotic-unresponsive. Radiation treatment can provide excellent local control in localized antibiotic-refractory gastric MZL.
  • 1.1K
  • 21 Feb 2022
Topic Review
Engineered Polymer Nanoparticle
Engineering polymeric nanoparticles for their shape, size, surface chemistry, and functionalization using various targeting molecules has shown improved biomedical applications for nanoparticles. Polymeric nanoparticles have created tremendous therapeutic platforms, particularly applications related to chemo- and immunotherapies in cancer.
  • 1.1K
  • 08 Sep 2021
Topic Review
Ultrasound in Telemedicine
The term telemedicine was to describe the practice of delivering health care services through the use of information and communications technology, whereby geographic distance is not as constraining, as in the case of traditional medical practice. Telemedicine is not only used to exchange valid information for the diagnosis, treatment, and prevention of disease and injuries and research and evaluation, but also for the continuing the education of healthcare providers to advance individual and community health.
  • 1.1K
  • 10 Feb 2022
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