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Topic Review
Rational Vaccine Design
Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. 
  • 3.0K
  • 29 Apr 2021
Topic Review
Chinese Hamster Ovary-K1 Cells
CHO cells are epithelial-like cells isolated from Chinese hamster ovary. The original CHO cells are cultured adherently, but they can be cultured in suspension in serum-free medium after acclimation. CHO cells are widely used for the expression of recombinant proteins.
  • 3.0K
  • 18 Sep 2021
Topic Review
Agricultural Electrostatic Spraying
Agricultural electrostatic spraying technology is superior to non-electrostatic spraying technology. Electrostatic droplets have better “adhesion, penetration, and encircling ability” in crops. Electrostatic spraying technology is used to charge droplets to induce an electric field on the surface of the crop leaves, thus adsorbing electrostatic droplets and achieving directional movement of the charged droplets.
  • 3.0K
  • 03 Dec 2021
Topic Review
Philosophy of Technology
The philosophy of technology is a sub-field of philosophy that studies the nature of technology and its social effects. Philosophical discussion of questions relating to technology (or its Greek ancestor techne) dates back to the very dawn of Western philosophy. The phrase "philosophy of technology" was first used in the late 19th century by German-born philosopher and geographer Ernst Kapp, who published a book titled Elements of a Philosophy of Technology (German title: Grundlinien einer Philosophie der Technik).
  • 3.0K
  • 14 Oct 2022
Topic Review
Chromothripsis
Chromothripsis has been defined as complex patterns of alternating genes copy number changes (normal, gain or loss) along the length of a chromosome or chromosome segment (International System for Human Cytogenomic Nomenclature 2020). The phenomenon of chromothripsis was discovered in 2011 and changed the concept of genome variability, mechanisms of oncogenic transformation, and hereditary diseases.
  • 3.0K
  • 27 May 2021
Topic Review
Cyclic AMP in Plants
The cyclic nucleotide cAMP (3′,5′-cyclic adenosine monophosphate) is nowadays recognised as an important signalling molecule in plants, involved in many molecular processes, including sensing and response to biotic and abiotic environmental stresses. The validation of a functional cAMP-dependent signalling system in higher plants has spurred a great scientific interest on the polyhedral role of cAMP, as it actively participates in plant adaptation to external stimuli, in addition to the regulation of physiological processes. The complex architecture of cAMP-dependent pathways is far from being fully understood, because the actors of these pathways and their downstream target proteins remain largely unidentified. Recently, a genetic strategy was effectively used to lower cAMP cytosolic levels and hence shed light on the consequences of cAMP deficiency in plant cells. This review aims to provide an integrated overview of the current state of knowledge on cAMP’s role in plant growth and response to environmental stress. Current knowledge of the molecular components and the mechanisms of cAMP signalling events is summarised.
  • 3.0K
  • 23 May 2021
Topic Review
Allium sativum (Garlic)
Garlic (Allium sativum) is an ancient civilised plant, originated from the Asian continent between the Mediterranean and China over 600 years ago. Humans use garlic as a medicinal herb in food as well as to relieve from pain and physical and emotional stress. Currently, people are looking for alternative natural medicine.
  • 3.0K
  • 08 Feb 2021
Topic Review
Sludge Treatment Reed Beds
Sludge Treatment Reed Beds (STRB) represent a state-of-the-art nature-based solution to sludge treatment and management. It is an effective, economical (i.e., of low investment, operation and maintenance cost, and low energy consumption), environmentally friendly, and technically efficient technology. In STRBs, the sludge is applied to a growing stand of reeds under controlled conditions. The method relies on the exploitation of the transpiring and aerating capabilities of the reeds, which absorb moisture and nutrients from the sludge for their growth. Additionally, the sludge is dewatered by drainage through the underlying gravel layers, and evaporation from the sludge surface. In the long run, the sludge is oxidized and its organic matter content decreases. The final solids content of the dewatered sludge can build up to and exceed 40%, depending on the sludge loading rate and the climate. STRB operational life is usually at least 30 years and is divided into two or three operational phases of 8-12 years. At the end of each operational phase, the accumulated residual sludge is removed and recycled typically in agriculture and the STRB is emptied.
  • 3.0K
  • 01 Apr 2021
Topic Review Peer Reviewed
Dental Patients’ Perspective on COVID-19: A Systematic Review
The COVID-19 epidemic has changed patients’ approach to dental treatments. While dentists worldwide have shown an excellent level of adaptability to face the new challenges presented by the unprecedented situation due to the rapid spread of COVID-19, dental patients have witnessed a sudden suspension of elective treatments and a slow resumption of dental care activities after several national lockdowns. In addition, the general climate of anxiety and fear due to the high COVID-19 risk and the high level of mortality has influenced the perception and attitudes of people towards dental activity, inducing many dental patients to avoid appointments to the dentist if not highly urgent. We present an overview of the current state of knowledge about dental patients’ perception, perspective, attitude, and expectations towards a full resumption of regular dental treatments.
  • 3.0K
  • 27 Sep 2022
Topic Review
Studies on Smart Cities
The concept of smart cities has gained significant momentum in science and policy circles over the past decade. This study aims to provide an overview of the structure and trends in the literature on smart cities. Bibliometric analysis and science mapping techniques using VOSviewer and CiteSpace are used to identify the thematic focus of over 5000 articles indexed in the Web of Science since 1991. In addition to providing insights into the thematic evolution of the field, the three-decade study period is divided into two sub-periods (1991–2015 and 2016–2021). While splitting the dataset into more sub-periods would have been desirable, we decided to only examine two sub-periods as only very few papers have been published until 2010. The annual number of publications has progressively increased since then, with a surge in the annual number of publications observable from 2015 onwards. The thematic analysis showed that the intellectual base of the field has been very limited during the first period, but has expanded significantly since 2015. Over time, some thematic evolutions, such as further attention to linkages to climate change and resilience, and more emphasis on security and privacy issues, have been made. The thematic analysis shows that existing research on smart cities is dominated by either conceptual issues or underlying technical aspects. It is, therefore, essential to do more research on the implementation of smart cities and actual and/or potential contributions of smart cities to solving societal issues. In addition to elaborating on thematic focus, the study also highlights major authors, journals, references, countries, and institutions that have contributed to the development of the smart cities literature. 
  • 3.0K
  • 07 Jul 2021
Topic Review
Bucherer–Bergs Multicomponent Synthesis of Hydantoins
The Bucherer–Bergs reaction is one of the most convenient general methods for the preparation of 5-substituted and 5,5-disubstituted hydantoins (imidazolidine-2,4-diones, 2,4-dioxoimidazolidines). Generally, in this multicomponent reaction, the aldehyde or ketone in aqueous ethanol is heated at 60–70° with potassium (or sodium) cyanide and ammonium carbonate to produce directly hydantoins 1.
  • 3.0K
  • 28 Jul 2021
Topic Review
Hyperspectral Remote Sensing and Plant
Hyperspectral remote sensing provides image data with very high spectral resolution. This high resolution allows subtle differences in plant health to be recognized. Such a multidimensional data space, generated by hyperspectral sensors, has given rise to new approaches and methods for analyzing hyperspectral data.
  • 3.0K
  • 31 Jan 2022
Topic Review
Trust (Emotion)
In a social context, trust has several connotations. Definitions of trust typically refer to a situation characterized by the following aspects: One party (trustor) is willing to rely on the actions of another party (trustee); the situation is directed to the future. In addition, the trustor (voluntarily or forcedly) abandons control over the actions performed by the trustee. As a consequence, the trustor is uncertain about the outcome of the other's actions; they can only develop and evaluate expectations. The uncertainty involves the risk of failure or harm to the trustor if the trustee will not behave as desired. Trust can be attributed to relationships between people. It can be demonstrated that humans have a natural disposition to trust and to judge trustworthiness that can be traced to the neurobiological structure and activity of a human brain. Some studies indicate that trust can be altered e.g. by the application of oxytocin. When it comes to the relationship between people and technology, the attribution of trust is a matter of dispute. The intentional stance demonstrates that trust can be validly attributed to human relationships with complex technologies. However, rational reflection leads to the rejection of an ability to trust technological artefacts. One of the key current challenges in the social sciences is to re-think how the rapid progress of technology has impacted constructs such as trust. This is specifically true for information technology that dramatically alters causation in social systems. In the social sciences, the subtleties of trust are a subject of ongoing research. In sociology and psychology the degree to which one party trusts another is a measure of belief in the honesty, fairness, or benevolence of another party. The term "confidence" is more appropriate for a belief in the competence of the other party. A failure in trust may be forgiven more easily if it is interpreted as a failure of competence rather than a lack of benevolence or honesty. In economics, trust is often conceptualized as reliability in transactions. In all cases trust is a heuristic decision rule, allowing the human to deal with complexities that would require unrealistic effort in rational reasoning. In religion, trust is the faith and hope in good God who forgives everything and gives everlasting happiness.
  • 3.0K
  • 08 Nov 2022
Topic Review
High-Performance Laser Scribing of Thin Film Solar Cells
The development of thin-film photovoltaics has emerged as a promising solution to the global energy crisis within the field of solar cell technology. However, transitioning from laboratory scale to large-area solar cells requires precise and high-quality scribes to achieve the required voltage and reduce ohmic losses. Laser scribing has shown great potential in preserving efficiency by minimizing the drop in geometrical fill factor, resistive losses, and shunt formation. However, due to the laser induced photothermal effects, various defects can initiate and impact the quality of scribed grooves and weaken the module’s efficiency. In this regard, much research has been conducted to analyze the geometrical fill factor, surface integrity, and electrical performance of the laser scribes to reach higher power conversion efficiencies.
  • 3.0K
  • 26 May 2023
Topic Review
N,N-Dimethylacrylamide-Based Hydrogels
N,N-dimethylacrylamide produces hydrogel when polymerized with cross-linkers. Moreover, poly(N,N-dimethylacrylamide) has gotten a lot of attention as it is commonly used as the hydrophilic side of copolymers due to its unique properties and high water solubility. In addition, van der Waals interactions between N,N-dimethylacrylamide and dye molecules even more increase the applicability of DMAA hydrogels.
  • 3.0K
  • 03 Dec 2021
Topic Review
Women's Studies
Women's studies is an academic field that draws on feminist and interdisciplinary methods in order to place women’s lives and experiences at the center of study, while examining social and cultural constructs of gender; systems of privilege and oppression; and the relationships between power and gender as they intersect with other identities and social locations such as race, sexual orientation, socio-economic class, and disability. Popular theories within the field of women's studies include feminist theory, standpoint theory, intersectionality, multiculturalism, transnational feminism, social justice, affect studies, agency, biopolitics, materialisms, and embodiment. Research practices and methodologies associated with women's studies include ethnography, autoethnography, focus groups, surveys, community-based research, discourse analysis, and reading practices associated with critical theory, post-structuralism, and queer theory. The field researches and critiques societal norms of gender, race, class, sexuality, and other social inequalities. Women's studies is closely related to the fields of gender studies, feminist studies, and sexuality studies, and more broadly related to the fields of cultural studies, ethnic studies, and African-American studies. Women's studies courses are offered in over seven hundred institutions in the United States, and globally in more than forty countries.
  • 3.0K
  • 05 Nov 2022
Topic Review
Fission
Fission, in biology, is the division of a single entity into two or more parts and the regeneration of those parts to separate entities resembling the original. The object experiencing fission is usually a cell, but the term may also refer to how organisms, bodies, populations, or species split into discrete parts. The fission may be binary fission, in which a single organism produces two parts, or multiple fission, in which a single entity produces multiple parts.
  • 3.0K
  • 21 Nov 2022
Topic Review
Winkler Index
The Winkler Index, sometimes known as the Winkler Scale or Winkler Regions, is a technique for classifying the climate of wine growing regions based on heat summation or growing degree-days. In the system, geographical areas are divided into five climate regions based on temperature converted to growing degree-days, and is commonly known as Regions I–V (see below). The system was developed at the University of California, Davis by A. J. Winkler and Maynard Amerine.
  • 3.0K
  • 27 Sep 2022
Topic Review
Viroids
Viroids are a group of infectious plant lncRNAs that are composed of RNA genomes and replicate by using the host enzymatic activities.
  • 3.0K
  • 30 Oct 2020
Topic Review
Premna odorata Blanco
In-depth botanical characterization was performed on Premna odorata Blanco (Lamiaceae) different organs for the first time. The leaves are opposite, hairy and green in color. Flowers possess fragrant aromatic odors and exist in inflorescences of 4–15 cm long corymbose cyme-type. In-depth morphological and anatomical characterization revealed the great resemblance to plants of the genus Premna and of the family Lamiaceae, such as the presence of glandular peltate trichomes and diacytic stomata. Additionally, most examined organs are characterized by non-glandular multicellular covering trichomes, acicular, and rhombic calcium oxalate crystals. P. odorata leaves n-hexane fraction revealed substantial anti-tuberculous potential versus Mycobacterium tuberculosis, showing a minimum inhibition concentration (MIC) of 100 μg/mL. Metabolic profiling of the n-hexane fraction using gas-chromatography coupled to mass spectrometry (GC/MS) analysis revealed 10 major compounds accounting for 93.01%, with trans-phytol constituting the major compound (24.06%). The virtual screening revealed that trans-phytol highly inhibited MTB C171Q receptor as M. tuberculosis KasA (β-ketoacyl synthases) with a high fitting score (∆G = −15.57 kcal/mol) approaching that of isoniazid and exceeding that of thiolactomycin, the co-crystallized ligand. Absorption, distribution, metabolism, excretion and toxicity predictions (ADME/TOPKAT) revealed that trans-phytol shows lower solubility and absorption levels when compared to thiolactomycin and isoniazid. Still, it is safer, causing no mutagenic or carcinogenic effects with higher lethal dose, which causes the death of 50% (LD50). Thus, it can be concluded that P. odorata can act as a source of lead entities to treat tuberculosis.
  • 3.0K
  • 12 Oct 2021
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