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Topic Review
Antibody Conjugated Polymeric Nanoparticles
Nanoparticles (NPs) are promising drug delivery systems (DDS) for identifying and treating cancer. Active targeting NPs can be generated by conjugation with ligands that bind overexpressed or mutant cell surface receptors on target cells that are poorly or not even expressed on normal cells. Receptor-mediated endocytosis of the NPs occurs and the drug is released inside the cell or in the surrounding tissue due to the bystander effect. Antibodies are the most frequently used ligands to actively target tumor cells. In this context, antibody-based therapies have been extensively used in HER2+ breast cancer.
  • 3.2K
  • 29 Oct 2020
Topic Review
Hypobaric Hypoxia and Heart
Under hypobaric hypoxia contidition, the principal impact on humans is due to the low atmospheric pressure  and the subsequent proportional decrease in partial oxygen pressure (PO2)  in the inspired air, generating a reduction in the bioavailability of oxygen in organs, tissues and cells at high altitude.
  • 3.2K
  • 27 Oct 2020
Topic Review
Construction and Demolition Waste Marketplace
Rapid population growth and urbanization have led to an increase in Construction and Demolition (C&D) waste, prompting government and industry bodies to develop better waste management practices. Waste trading has emerged as a targeted intervention to divert waste from landfill sites and create a second life for waste material. This paper examines key barriers and enablers influencing the creation of a marketplace for waste trading. A systematic literature review was undertaken to examine global efforts in creating a marketplace for C&D waste. A framework on enablers and barriers for developing a marketplace for C&D waste emerged from the review, based on market-based, operational, and governance factors. References demonstrated that markets for materials such as glass and metals have already been established, but there are increasing marketplace opportunities for other recycled materials. Technology-based market applications are emerging as targeted interventions to facilitate online trading, which will provide a more accessible and user-friendly marketplace for sellers and buyers. Further research should test the complex interactions between people and technology associated with online waste trading platforms, as well as help develop the business case for a C&D waste marketplace.
  • 3.2K
  • 10 Dec 2020
Topic Review Peer Reviewed
Fungal Metabolites in Human Health and Diseases—An Overview
Fungi produce a wide range of secondary metabolites. Some of these metabolites are toxic to humans and cause various health disorders, ranging from acute poisoning to chronic diseases. Contrary to this, some fungal metabolites are valuable sources in therapeutics, such as penicillin. Herein, researchers briefly highlight the role played by different fungal metabolites in human health and diseases and give an overview of the most common fungal genera.
  • 3.2K
  • 24 Oct 2022
Topic Review
Vitamin B12 Deficiency Anemia
Vitamin B12 deficiency anemia, of which pernicious anemia (PA) is a type, is a disease in which not enough red blood cells are produced due to a deficiency of vitamin B12. The most common initial symptom is feeling tiredness and weakness. Other symptoms may include shortness of breath, pale skin, feeling like one may pass out (lightheadedness), chest pain, rapid heartbeat, numbness in the hands and feet, poor balance, a frequent fall of blood pressure, loss of appetite, a smooth red tongue, memory problems, poor reflexes, and in severe cases even depression and confusion. Without treatment some of these problems may become permanent. Pernicious anemia refers to anemia that results from lack of vitamin B12. Lack of intrinsic factor is most commonly due to an autoimmune attack on the cells that create it in the stomach. It can also occur following the surgical removal of part of the stomach or from an inherited disorder. Other causes of low vitamin B12 include not enough dietary intake (which can be a risk in a vegan diet), celiac disease, or tapeworm infection. When suspected, diagnosis is made by blood and, occasionally, bone marrow tests. Blood tests may show fewer but larger red blood cells, low numbers of young red blood cells, low levels of vitamin B12, and antibodies to intrinsic factor. Pernicious anemia can be treated with injections of vitamin B12. If the symptoms are severe, injections are typically recommended initially. For those who have trouble swallowing pills, a nasal spray is available. Often, treatment is lifelong. Pernicious anemia due to autoimmune problems occurs in about one per 1000 people. Among those over the age of 60, about 2% have the condition. It more commonly affects people of northern European descent. Women are more commonly affected than men. With proper treatment, most people live normal lives. Due to a higher risk of stomach cancer, those with pernicious anemia should be checked regularly for this. The first clear description was by Thomas Addison in 1849. The term "pernicious" means "deadly", and this term came into use because before the availability of treatment the disease was often fatal.
  • 3.2K
  • 27 Oct 2022
Topic Review
Wild Edible Plants in India
Despite significant evidence base on quantifying ecosystem services, the role of biodiversity in supporting such services in diversified landscapes, and how indigenous communities exploit, utilize and manage plant resources in a biocultural regime, remains understudied.  A sum total of 172 WEPs comprising 60 vegetables, 70 fruits, seeds and nuts, 23 underground tubers and 19 mushrooms were collected, consumed, and surplus were marketed by the communities. On average, the number of wild edibles collected annually by households were in the following quantities: 40–240 kg leafy vegetables, 125–386 kg flowers, 120–250 kg fruits, 12–125 kg legumes, 24–120 kg tubers, 5–35 kg mushrooms. Among ethnic groups, the Baiga primitive community utilized 70–90% followed by Gonds (58–81%), Kols (52–78%), Oraons (43–79%), and other communities (38–68%) in different zones. WEPs have contributed to 5–24% (Rs 3559- 12,710) of household income, which was highest in the core zone and lowest in the transition zone. It was observed that WEPs were complemented the diets rather than being a substitute for staple foods. They supplied only 3.7–8.3% of energy and 1.1–4.9% protein requirements; however, they significantly supplemented ascorbic acid, thiamine, calcium, and iron by 38.1–73%, 13.7–35.4%, 17.2–29.1%, 2.6–13.5%, respectively. Significantly higher quantities of nutrients were supplemented in the core zone compared to other zones. WEPs were currently underutilized (less intake) especially in buffer and transition zones, complementing the staple foods and partially supplementing the essential macro- and micro-nutrients. However, these have the potential to fulfill the dietary needs and ensure balanced nutrition, if consumed in recommended portions and sizes.
  • 3.2K
  • 14 Jan 2022
Topic Review
Mechanism of Action of Carnosine
Carnosine is a natural endogenous molecule that has been extensively studied during the last years due to its promising beneficial effects for human health. It presents multimodal mechanisms of action, being able to exert antioxidant, anti-inflammatory and anti-aggregate activities, among others.
  • 3.2K
  • 11 May 2022
Topic Review
Marker-Controlled Watershed for Segmentation of Images
Watershed is a widely used image segmentation algorithm. A grayscale image is considered as topographic relief, which is flooded from initial basins. However, frequently they are not aware of the options of the algorithm and the peculiarities of its realizations. There are many watershed implementations in software packages and products. Even if these packages are based on the identical algorithm–watershed by flooding, their outcomes, processing speed, and consumed memory, vary greatly.
  • 3.2K
  • 07 Jul 2022
Topic Review
Use of Glucagon-Like Peptide-1
Glucagon-like peptide-1 (GLP-1) is a human incretin hormone derived from the proglucagon molecule. GLP-1 receptor agonists are frequently used to treat type 2 diabetes mellitus and obesity. However, the hormone affects the liver, pancreas, brain, fat cells, heart, and gastrointestinal tract. The results showed that GLP-1 agonists can benefit defined off-medication motor scores in Parkinson’s Disease and improve emotional well-being. In Alzheimer’s disease, GLP-1 analogs can improve the brain’s glucose metabolism by improving glucose transport across the blood–brain barrier. In depression, the analogs can improve quality of life and depression scales. GLP-1 analogs can also have a role in treating chemical dependency, inhibiting dopaminergic release in the brain’s reward centers, decreasing withdrawal effects and relapses. These medications can also improve lipotoxicity by reducing visceral adiposity and decreasing liver fat deposition, reducing insulin resistance and the development of non-alcoholic fatty liver diseases. The adverse effects are primarily gastrointestinal. Therefore, GLP-1 analogs can benefit other conditions besides traditional diabetes and obesity uses.
  • 3.2K
  • 10 Jul 2022
Topic Review
Adipose Tissue Development
Despite developing prenatally, the adipose tissue is unique in its ability to undergo drastic growth even after reaching its mature size. Proper adipose tissue development relies on tightly regulated processes that require careful coordination and cooperation between many different cell types and their matrix cues.
  • 3.2K
  • 25 Oct 2022
Topic Review Peer Reviewed
Positioning Theory in Education
Positioning theory is a social theorization that aims to capture the dynamic analysis of conversations and discourses taking place in a social setting. Conversations as part of language assume interlocutors. As one engages in the interactive speech acts in the social setting, there comes the importance of interlocutors involved in these speech acts in creating a social reality, as language forms the knowledge of reality. Certain types of rights and duties can be observed in interactions between speakers and hearers in a social communicative context of interlocutors. The cluster of rights and duties, recognized in a certain social setting, can be termed as a position. One of the critical aspects is that positions are not always intentional or even conscious. Therefore, positioning theory has been redefined as a method of analysis with a focus on storylines. Storylines reveal implicit ascriptions and resistances of rights and duties through the performance of a variety of actions in a social setting where appropriateness of social acts are established and recognized by the participants engaged within the social situation. The education setting presents a dynamic situation where a variety of moral orders come into actions that set possibilities for different actors to engage in shifting positioning to accomplish certain educational actions. This entry presents the use of positioning theory in an educational setting.
  • 3.2K
  • 05 Sep 2023
Topic Review
SOCH: The Mental Colonization Of India
India is a land of immense plurality, rich cultural heritage, and multiple forms of colonization since centuries. Though the physical colonization by the British ended in 1947, the mental colonization persists through several socio-economic and cultural mechanisms. This article discusses the concept of mental colonization in India, termed as "SOCH" (Spirit of Colonial Hangover), its historical roots, contemporary manifestations, and its struggle to seek and acquire indigenous identities and histories.
  • 3.2K
  • 31 Oct 2024
Topic Review
Cutting Movement Assessment Score (CMAS)
The Cutting Movement Assessment Score (CMAS) is a recently validated field-based qualitative screening tool to identify athletes that display high-risk postures associated with increased non-contact ACL injury risk during side-step cutting. Side-step cutting is an action associated with non-contact anterior cruciate ligament (ACL) injury with a plethora of negative economical, health, and psychological implications. Although ACL injury risk factors are multifactorial, biomechanical and neuromuscular deficits which contribute to “high-risk” and aberrant movement patterns are linked to ACL injury risk due to increasing knee joint loads and potential ACL loading. Importantly, biomechanical and neuromuscular deficits are modifiable; thus, being able to profile and classify athletes as potentially “high-risk” of injury is a crucial process in ACL injury mitigation. 
  • 3.2K
  • 05 May 2021
Topic Review Peer Reviewed
Social Housing Customization in Brazil
Social housing customization in Brazil refers to the current processes of development and evolution of government-funded neighborhoods for the lowest-income population. The mass production of small housing units that do not satisfy family needs instigates a self-design and self-construction process post-occupancy to customize the units. Ultimately, these changes to the units bring unintended negative consequences for the families and the city. In this context, mass customization is seen as an alternative to address some of the problems related to unit design. 
  • 3.2K
  • 13 Apr 2022
Topic Review
The Role of Phytoplankton in Carbon Dioxide Fixation
Marine phytoplankton account for more than half of the carbon dioxide fixation of Earth. The export of carbon is highest at the photic zone of the ocean, which is dominated by phytoplankton. The term phytoplankton comes from the Greek words phyto (plants) and plankton (wanderers or drifters). Plankton can also be zooplanktons that feed on phytoplankton and release fecal pellets that are made of dissolved carbon particles.
  • 3.2K
  • 13 Apr 2022
Topic Review
Proto-Norse Language
Proto-Norse (also called Proto-Scandinavian, Proto-Nordic, Ancient Scandinavian, Proto-North Germanic and a variety of other names) was an Indo-European language spoken in Scandinavia that is thought to have evolved as a northern dialect of Proto-Germanic in the first centuries CE. It is the earliest stage of a characteristically North Germanic language, and the language attested in the oldest Scandinavian Elder Futhark inscriptions, spoken from around the 2nd to the 8th centuries CE (corresponding to the late Roman Iron Age and the Germanic Iron Age). It evolved into the dialects of Old Norse at the beginning of the Viking Age around 800 CE, which later themselves evolved into the modern North Germanic languages (Faroese, Icelandic, the three Continental Scandinavian languages, and their dialects).
  • 3.2K
  • 28 Oct 2022
Topic Review
Enzyme Immobilization Techniques
Researchers have explored the technique of enzyme immobilization as a means to overcome limitations that free enzymes encounter, including reduced performance, high costs, and impracticality for large-scale applications. Enzymatic treatment offers a sustainable and eco-friendly alternative to conventional physicochemical treatment methods, such as adsorption, coagulation, and advanced oxidation processes. Free enzymes are biodegradable, highly efficient, and selective biological catalysts that can operate under mild conditions, thus reducing energy consumption and minimizing the generation of harmful byproducts.
  • 3.2K
  • 07 Sep 2023
Topic Review
Ice Crystal
Most of the aquatic products are caught from distant seas which make them prone to deterioration and quality losses. One of the main strategies that can be used to increase shelf life and maintain product quality is freezing. During freezing, however, the ice crystals formed may considerably impact the cellular integrity, resulting in loss and degradation of food quality.
  • 3.2K
  • 07 Feb 2021
Topic Review
Music and Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a severe psychiatric disorder, which can be associated with music-related symptoms. Music may also be used as an adjunct treatment for OCD. Patients with OCD might benefit from music therapy, which includes listening to music.
  • 3.2K
  • 22 Nov 2021
Topic Review
JASS
JASS and JASS2 (sometimes said to stand for Just Another Scripting Syntax) is a scripting language provided with an event-driven API created by Blizzard Entertainment. It is used extensively by their games Warcraft III (JASS2) and StarCraft (JASS) for scripting events in the game world. Map creators can use it in the Warcraft III World Editor and the Starcraft Editor to create scripts for triggers and AI (artificial intelligence) in custom maps and campaigns. Blizzard Entertainment has replaced JASS with Galaxy in Starcraft II.
  • 3.2K
  • 25 Nov 2022
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