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Topic Review
FoxO1
FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis.
  • 3.6K
  • 07 Jun 2021
Topic Review
Magnitude
In astronomy, magnitude is a unitless measure of the brightness of an object in a defined passband, often in the visible or infrared spectrum, but sometimes across all wavelengths. An imprecise but systematic determination of the magnitude of objects was introduced in ancient times by Hipparchus. The scale is logarithmic and defined such that a magnitude 1 star is exactly 100 times brighter than a magnitude 6 star. Thus each step of one magnitude is [math]\displaystyle{ \sqrt{100} \approx 2.512 }[/math] times brighter than the next faintest. The brighter an object appears, the lower the value of its magnitude, with the brightest objects reaching negative values. Astronomers use two different definitions of magnitude: apparent magnitude and absolute magnitude. The apparent magnitude (m) is the brightness of an object as it appears in the night sky from Earth. Apparent magnitude depends on an object's intrinsic luminosity, its distance, and the extinction reducing its brightness. The absolute magnitude (M) describes the intrinsic luminosity emitted by an object and is defined to be equal to the apparent magnitude that the object would have if it were placed at a certain distance from Earth, 10 parsecs for stars. A more complex definition of absolute magnitude is used for planets and small Solar System bodies, based on its brightness at one astronomical unit from the observer and the Sun. The Sun has an apparent magnitude of −27 and Sirius, the brightest visible star in the night sky, −1.46. Venus at its brightest is -5. The International Space Station (ISS) sometimes reaches a magnitude of −6.
  • 3.6K
  • 28 Sep 2022
Topic Review
Canopy
In biology, the canopy is the aboveground portion of a plant cropping or crop, formed by the collection of individual plant crowns. In forest ecology, canopy also refers to the upper layer or habitat zone, formed by mature tree crowns and including other biological organisms (epiphytes, lianas, arboreal animals, etc.). The communities that inhabit the canopy layer are thought to be involved in maintaining forest diversity, resilience, and functioning. Sometimes the term canopy is used to refer to the extent of the outer layer of leaves of an individual tree or group of trees. Shade trees normally have a dense canopy that blocks light from lower growing plants.
  • 3.6K
  • 25 Nov 2022
Topic Review
List of Volcanic Eruptions on Iceland
This is a list of recorded volcanic eruptions on Iceland.
  • 3.6K
  • 01 Nov 2022
Topic Review
Yahoo! Messenger Protocol
The Yahoo! Messenger Protocol (YMSG) is the underlying network protocol used by the Yahoo! Messenger instant messaging client. Yahoo! Instant Messager supports many features beyond just messaging, including off-line messaging, file transfer, chat, conferencing, voice chat, webcams and avatars.
  • 3.6K
  • 07 Nov 2022
Topic Review
The Effects of Stevia Consumption on Gut Bacteria
Stevia, a zero-calorie sugar substitute, is recognized as safe by the Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). In vitro and in vivo studies showed that stevia has antiglycemic action and antioxidant effects in adipose tissue and the vascular wall, reduces blood pressure levels and hepatic steatosis, stabilizes the atherosclerotic plaque, and ameliorates liver and kidney damage. 
  • 3.5K
  • 19 Apr 2022
Topic Review
Glycerol
Glycerol (1,2,3-propanetriol) is a viscous odorless and colorless liquid, with a syrupy sweet flavor that may derive from both renewable and fossil sources
  • 3.5K
  • 06 Jan 2021
Topic Review
Ashtavinayaka
Ashtavinayak (Marathi: अष्टविनायक) literally means "eight Ganeshas" in Sanskrit. Ganesh is the Hinduism/Hindu deity of unity, prosperity & learning and removes obstacles. The term refers to eight Ganeshas. Ashtavinayaka yatra trip refers to a pilgrimage to the eight Hindu temples in Maharashtra state of India that house eight distinct idols of Ganesh, in a pre-ascertained sequence. The Ashtavinayak yatra or pilgrimage covers the eight ancient holy temples of Ganesh which are situated around Pune. Each of these temples has its own individual legend and history, as distinct from each other as the murtis in each temple. The form of each murti of Ganesh and His trunk are distinct from one another. However, there are other temples of eight Ganesh in various other parts of Maharashtra; the ones around Pune are more well known than the former. It is believed to be for completion of Ashtavinayak Yatra visit the first Ganpati after visiting all the eight Ganpatis again, to complete the yatra.
  • 3.5K
  • 29 Nov 2022
Topic Review
Determination of Steroids by High Performance Liquid Chromatography-Fluorescence
Steroids are compounds widely available in nature and synthesized for therapeutic and medical purposes. Although several analytical techniques are available for the quantification of steroids in clinical samples, their analysis is challenging due to their low levels and complex matrices. The efficiency and quick separation of the high performance liquid chromatography (HPLC) combined with the sensitivity, selectivity, simplicity, and cost-efficiency of fluorescence, make HPLC coupled to fluorescence detection (HPLC-FLD) an ideal tool for routine measurement and detection of steroids for clinical and medical applications.
  • 3.5K
  • 11 Apr 2022
Topic Review
Fabrication of Organ-on-Chip
Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ biomimetic systems. OOC technology brings numerous advantages in the current landscape of preclinical models, capable of recapitulating the multicellular assemblage, tissue–tissue interaction, and replicating numerous human pathologies.
  • 3.5K
  • 26 Apr 2022
Topic Review
Ontological Turn
The ontological turn broadly relates to a development in a number of philosophical and academic disciplines that led to an increased focus on being. The ontological turn in anthropology is not concerned with anthropological notions of culture, epistemology, nor world views. Instead, the ontological turn generates interest in being in the world and accepts that different world views are not simply different representations of the same world. Rather, people have different perspectives and people see the world in different ways, but the world is still the world. Therefore, the ontological turn refers to a change in perspective that suggests that difference can be understood, not in terms of a difference in world views, but a differences in worlds and all of these worlds are of equal validity.
  • 3.5K
  • 19 Oct 2022
Topic Review
Battery Energy Storage and Management in Electric Vehicles
Electric vehicle (EV) technology has received massive attention worldwide due to its improved performance efficiency and significant contributions to addressing carbon emission problems. In line with that, EVs could play a vital role in achieving sustainable development goals (SDGs). EVs have a substantial influence on various goals of sustainable development, such as affordable and clean energy, sustainable cities and communities, industry, economic growth, and climate actions.
  • 3.5K
  • 08 Oct 2022
Topic Review
Strychnine Poisoning
Strychnine poisoning can be fatal to humans and other animals and can occur by inhalation, swallowing or absorption through eyes or mouth. It produces some of the most dramatic and painful symptoms of any known toxic reaction, making it quite noticeable and a common choice for assassinations and poison attacks. For this reason, strychnine poisoning is often portrayed in literature and film, such as the murder mysteries written by Agatha Christie. The probable lethal oral dose in humans is 1.5 to 2 mg/kg. Similarly, the median lethal dose for dogs, cats, and rats ranges from 0.5 to 2.35 mg/kg.
  • 3.5K
  • 01 Dec 2022
Topic Review
Vestigiality
Vestigiality is the retention during the process of evolution of genetically determined structures or attributes that have lost some or all of the ancestral function in a given species. Assessment of the vestigiality must generally rely on comparison with homologous features in related species. The emergence of vestigiality occurs by normal evolutionary processes, typically by loss of function of a feature that is no longer subject to positive selection pressures when it loses its value in a changing environment. The feature may be selected against more urgently when its function becomes definitively harmful, but if the lack of the feature provides no advantage, and its presence provides no disadvantage, the feature may not be phased out by natural selection and persist across species. Examples of vestigial structures (also called degenerate, atrophied, or rudimentary organs) are the loss of functional wings in island-dwelling birds; the human vomeronasal organ; and the hindlimbs of the snake and whale. The human appendix is no longer considered vestigial.
  • 3.5K
  • 24 Oct 2022
Topic Review
Myostatin Gene Polymorphisms with Strength Phenotype of Athletes
Polymorphism (rs1805086), c.458A>G, p.Lys(K)153Arg(R), (K153R) of the myostatin gene (MSTN) has been associated with a skeletal muscle phenotype (hypertrophic response in muscles due to strength training). The K153R polymorphism is significant in the development of muscle mass and strength. The rare R variant increases the inhibition of MSTN synthesis, thereby leading to an increase in skeletal muscle mass and muscle strength. The R variant is favorable for sports in which muscle strength and mass are important, such as bodybuilding, powerlifting, weightlifting, arm wrestling, kettlebell lifting, shot put, and bobsleigh. It can be assumed that the strong effect of this allele on the ability to become a successful athlete in weightlifting and speed-power sports is based on the inhibition of MSTN synthesis. 
  • 3.5K
  • 01 Feb 2023
Topic Review
Downstream Processing of Virus Filter
Virus filtration is a single-use, size-based separation process in which the contaminating virus particles are retained while the therapeutic molecules pass through the membrane pores. Virus filtration is routinely used as part of the overall virus clearance strategy. Compromised performance of virus filters due to membrane fouling, low throughput and reduced viral clearance, is of considerable industrial significance and is frequently a major challenge.
  • 3.5K
  • 24 Apr 2022
Topic Review
Peptide for Bone and Cartilage Regeneration
The healing of osteochondral defects (OCDs) that result from injury, osteochondritis, or osteoarthritis and bear lesions in the cartilage and bone, pain, and loss of joint function in middle- and old-age individuals presents challenges to clinical practitioners because of non-regenerative cartilage and the limitations of current therapies. Bioactive peptide-based osteochondral (OC) tissue regeneration is becoming more popular because it does not have the immunogenicity, misfolding, or denaturation problems associated with original proteins. 
  • 3.5K
  • 19 Mar 2024
Topic Review Peer Reviewed
Developing Emotional Intelligence
Daniel Goleman perceptively and accurately noted that emotional intelligence is critical to leadership success, claiming that emotional intelligence is far more important to leadership emergence and effectiveness than intellectual capacity. Goleman’s research later confirmed an 85% relationship between emotional intelligence and leader effectiveness. It may be the most critical area for current and aspiring leaders to develop. While leadership scholars accept the importance of emotional intelligence for leadership and the fact that emotional intelligence can be developed, there appears to be some uncertainty around how emotional intelligence can be developed. The authors shed light on that area and provide current and aspiring leaders with some proven strategies for developing the four predominant components of emotional intelligence. The importance of emotional intelligence to leadership is well documented, and leaders would be well served by working to heighten their levels of emotional intelligence and, in doing so, increase their leadership potential, efficacy, and impact.
  • 3.5K
  • 19 Mar 2024
Topic Review
3D Printing in Organ-on-a-Chip Platforms
Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system. Hence, they have been increasingly used for biomedical research, such as drug discovery and personalized healthcare. A promising strategy for their fabrication is 3D printing, a layer-by-layer fabrication process that allows the construction of complex 3D structures.
  • 3.5K
  • 21 May 2021
Topic Review
Solanum aethiopicum
Solanum aethiopicum is a very important vegetable for both rural and urban communities in Africa. The crop is rich in both macro-and micronutrients compared with other vegetables and is suitable for ensuring food and nutritional security.
  • 3.5K
  • 18 Jun 2021
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