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Topic Review
Dexibuprofen
S-(+) enantiomer of ibuprofen (IBU) dexibuprofen (DXI) is known to be more potent than its R-(−) form and exhibits many advantages over the racemic mixture of IBU such as lower toxicity, greater clinical efficacy, and lesser variability in therapeutic effects. Moreover, DXI potential has been recently advocated to reduce cancer development and prevent the development of neurodegenerative diseases in addition to its anti-inflammatory properties. 
  • 3.9K
  • 23 Jun 2021
Topic Review
Biological Functions of Nitric Oxide
Nitric oxide (nitrogen monoxide) is a molecule and chemical compound with chemical formula of NO. In mammals including humans, nitric oxide is a signaling molecule involved in several physiological and pathological processes. It is a powerful vasodilator with a half-life of a few seconds in the blood. Standard pharmaceuticals such as nitroglycerine and amyl nitrite are precursors to nitric oxide. Low levels of nitric oxide production are typically due to ischemic damage in the liver. As a consequence of its importance in neuroscience, physiology, and immunology, nitric oxide was proclaimed "Molecule of the Year" in 1992. Research into its function led to the 1998 Nobel Prize for elucidating the role of nitric oxide as a cardiovascular signalling molecule.
  • 3.9K
  • 04 Nov 2022
Topic Review
Milk Fat Globule Membrane (MFGM)
Milk fat globule membrane (MFGM) is an important component of milk lipids that showed several biological properties (such as anticarcinogenic, antimicrobial, anti-inflammatory, and anticholesterolemic activities). In this review we analyse the latest results obtained from comparative proteomic studies regarding the variations and the similarities of MFGM proteome across species and lactation stages. Infant formula supplementation with MFGM represents an interesting opportunity to implement the bioactive properties exerted by MFGM, in order to narrow the gap between human breast milk and infant formula. 
  • 3.9K
  • 27 Sep 2020
Topic Review
HBase Storage Architecture
HBase is the top option for storing huge data. HBase has been selected for several purposes, including its scalability, efficiency, strong consistency support, and the capacity to support a broad range of data models.
  • 3.9K
  • 21 Feb 2021
Topic Review
Sol-gel Technology for Commercial Coatings
The commercial availability of inorganic/organic precursors for sol-gel formulation is very high and increase day by day. By using the sol-gel technology, it is possible to provide materials with functional/multi-functional characteristics including flame retardant, anti-mosquito, water-repellent oil-repellent, anti-bacterial, anti-wrinkle, ultraviolet (UV) protection, self-cleaning and other properties. Some of these properties are discussed here, describing basic chemistry, factors affecting the sol-gel process, as well as progress and parameters controlling sol-gel technology for thin coatings.
  • 3.9K
  • 29 Apr 2021
Topic Review
Eco-efficiency
The term eco-efficiency was first proposed in 1990 by Schaltegger and Sturm. However, it was in 1991 that the World Business Council for Sustainable Development (WBCSD) was responsible for introducing one of the main concepts of eco-efficiency to the world. The term was defined as the delivery of economically competitive goods and services that meet the needs of society in terms of quality of life and that the entire process of manufacturing and availability for consumption, that is, throughout its life cycle, should have the least possible impact on the environment.
  • 3.9K
  • 13 Dec 2021
Topic Review
Magnetoelectric Sensors
Multiferroic magnetoelectric (ME) materials with the capability of coupling magnetization and electric polarization have been providing diverse routes towards functional devices and thus attracting ever-increasing attention. The typical device applications include sensors, energy harvesters, magnetoelectric random access memories, tunable microwave devices and ME antennas etc. Among those application scenarios, ME sensors are specifically focused in this review article. We begin with an introduction of materials development and then recent advances in ME sensors are overviewed. Engineering applications of ME sensors are followed and typical scenarios are presented. Finally, several remaining challenges and future directions from the perspective of sensor designs and real applications are included.
  • 3.9K
  • 07 Jun 2021
Topic Review
Roof Plate in Neural Development
The roof plate is the most dorsal region of the neural tube. The Roof plate serves as an organizing center that controls proliferation and differentiation of dorsal interneurons. In addition, this region is involved in development of neural crest cells, which are the source of migratory neural crest cells. During early development of the spinal cord, roof plate cells secrete signaling molecules, such as Wnt and BMP family proteins, which regulate development of neural crest cells and dorsal spinal cord. After the dorso-ventral pattern is established, spinal cord dynamically changes its morphology. With this morphological transformation, the lumen of the spinal cord gradually shrinks to form the central canal. Accompanied by formation of the central canal, roof plate cells dramatically stretch along the dorso-ventral axis. During this stretching process, the tips of roof plate cells maintain contact with cells surrounding the shrinking lumen of the spinal cord, eventually exposed to the inner surface of the central canal. In this late stage of the spinal cord development, Wnt secreted by stretched roof plate cells regulates transformation of roof plate cells themselves and promotes proliferation of ependymal cells surrounding the central canal, including neural progenitor cells, in the spinal cord.
  • 3.9K
  • 05 Aug 2021
Topic Review
Visual Basic
User:RMCD bot/subject notice Visual Basic (also referred to as Classic Visual Basic) is a third-generation event-driven programming language from Microsoft known for its Component Object Model (COM) programming model first released in 1991 and declared legacy during 2008. Microsoft intended Visual Basic to be relatively easy to learn and use. Visual Basic was derived from BASIC and enables the rapid application development (RAD) of graphical user interface (GUI) applications, access to databases using Data Access Objects, Remote Data Objects, or ActiveX Data Objects, and creation of ActiveX controls and objects. A programmer can create an application using the components provided by the Visual Basic program itself. Over time the community of programmers developed third-party components. Programs written in Visual Basic can also make use of the Windows API, which requires external functions declarations. The final release was version 6 in 1998 (now known simply as Visual Basic). On April 8, 2008, Microsoft stopped supporting Visual Basic 6.0 IDE. The Microsoft Visual Basic team still maintains compatibility for Visual Basic 6.0 applications through its "It Just Works" program on supported Windows operating systems. In 2014, some software developers still preferred Visual Basic 6.0 over its successor, Visual Basic .NET. In 2014 some developers lobbied for a new version of the VB6 programming environment. In 2016, Visual Basic 6.0 won the technical impact award at The 19th Annual D.I.C.E. Awards. Visual Basic 6.0 was selected as the most dreaded programming language by respondents of Stack Overflow's annual developer survey in 2016, 2017, and 2018. A dialect of Visual Basic, Visual Basic for Applications (VBA), is used as a macro or scripting language within several Microsoft and ISV applications, including Microsoft Office.
  • 3.9K
  • 17 Nov 2022
Topic Review
Penguin Visual System
Penguins require vision that is adequate for both subaerial and submarine environments under a wide range of illumination. Amphibious vision is facilitated by a relatively flat cornea, the power in air varying from 10.2 dioptres (D) to 41.3 D depending on the species, and there is good evidence for emmetropia both above and below water. All penguins are trichromats with loss of rhodopsin 2, a nocturnal feature, but only deeper diving penguins have been noted to have pale oil droplets and a preponderance of rods. Conversely, the diurnal, shallow-diving little penguin has a higher ganglion cell density (28,867 cells/mm2) and f-number (3.5) than those that operate in dimmer light. In most species studied, there is some binocular overlap, but this reduces upon submergence.
  • 3.9K
  • 09 Feb 2023
Topic Review
Liposomes for Drug Delivery and Their Production Methods
Liposomes are well-known nanoparticles with a non-toxic nature and the ability to incorporate both hydrophilic and hydrophobic drugs simultaneously. As modern drug delivery formulations are produced by emerging technologies, numerous advantages of liposomal drug delivery systems over conventional liposomes or free drug treatment of cancer have been reported.
  • 3.9K
  • 17 Nov 2022
Topic Review
Digital Tourism
"Digital travel" refers to how we use digital tools to organize, manage and even enjoy travel experiences. So "digital tourism" harnesses all the tools of digital transformation to change the way we travel and how the industry itself operates. Nowadays tourism experience integrates augmented reality, virtual reality and even mixed realities, enabling in real time different kinds of interaction - online and off line - thus creating immersive unique experiences that combine digital and real heritage.
  • 3.9K
  • 21 Mar 2022
Topic Review
Different Definitions of Dyslexia
Defining dyslexia has still not reached a consensus. This uncertainty may explain why only one of the seven definitions proved satisfactory according to the four-level model. Today, dyslexia is a term that is commonly known and denotes an innate disposition leading to reading and/or writing difficulties. Medicine, linguistics, psychology, pedagogics, social sciences have been involved in assessing dyslexia from different angles.
  • 3.9K
  • 09 Nov 2022
Topic Review
ECM decellularization methods
The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of the ECM have been thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option to carry out regenerative medicine research, with multiple advantages compared to other approaches. We recently published an overview of the most common methods used to obtain the dECM from specific tissues[1]. Here we provide a summary from that report as a helpful guide for future research development.
  • 3.9K
  • 25 Aug 2020
Topic Review
Molecular Dynamics Simulations
Molecular dynamics (MD) is a simulation technique that aims at deriving statements about the structural, dynamical, and thermodynamical properties of a molecular system. MD simulations have become increasingly useful in the modern drug development process. For example, in the lead discovery and lead optimization phases, MD facilitates the evaluation of the binding energetics and kinetics of the ligand-receptor interactions, therefore guiding the choice of the best candidate molecules for further development. in the future, the role of MD simulations in facilitating the drug development process is likely to grow substantially with the increasing computer power and advancements in the development of force fields and enhanced MD methodologies.
  • 3.9K
  • 20 Jan 2021
Topic Review
Legendary Salamander in Popular Culture
References to the legendary salamander in popular culture—in fiction (especially fantasy fiction), games, animation, and so on—can be categorized in three ways: as a fantastic (sometimes magical) beast with an affinity with fire, as a true fire elemental, and allusions to the salamander's fiery nature.
  • 3.9K
  • 28 Nov 2022
Topic Review
β-Glucan
β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties. 
  • 3.9K
  • 07 Feb 2021
Topic Review
Bladder Cancer Biomarkers
The high occurrence of bladder cancer and its tendency to recur combined with lifelong surveillance make the treatment of superficial bladder cancer one of the most expensive and time-consuming. Moreover, carcinoma in situ often leads to muscle invasion with an unfavourable prognosis. Currently, invasive methods including cystoscopy and cytology remain a gold standard. The aim is to find biomarkers with the best specificity and sensitivity, allowing the treatment plan to optimise and have potential applications in clinical practice. Such non-invasive methods can be measure in human body fluids, for example, urine or serum: Cytokeratin fragments (CYFRA 21.1), Excision Repair Cross-Complementation 1 (ERCC1), Tumour Protein p53 (Tp53), Fibroblast Growth Factor Receptor 3 (FGFR3), Tumor-Associated Trypsin Inhibitor (TATI).
  • 3.9K
  • 29 Mar 2022
Topic Review
Classification of Solid Oxide Fuel Cells
Solid oxide fuel cells (SOFC) are promising, environmentally friendly energy sources. Many works are devoted to the study of materials, individual aspects of SOFC operation, and the development of devices based on them. This entry attempts to cover and structure the entire spectrum of SOFC concepts and designs that currently exist.
  • 3.9K
  • 13 Apr 2022
Topic Review
Monotremata
Monotremes (/ˈmɒnətriːmz/) are prototherian mammals of the order Monotremata. They are one of the three groups of living mammals, along with placentals (Eutheria) and marsupials (Metatheria). Monotremes are typified by structural differences in their brains, jaws, digestive tract, reproductive tract, and other body parts compared to the more common mammalian types. In addition, they lay eggs rather than bearing live young, but, like all mammals, the female monotremes nurse their young with milk. Monotremes have been considered members of Australosphenida, a clade which contains extinct mammals from the Jurassic and Cretaceous of Madagascar, South America and Australia, though this is disputed. The only surviving examples of monotremes are all indigenous to Australia and New Guinea although there is evidence that they were once more widespread, as Monotrematum is known from the Paleocene of South America. The extant monotreme species are the platypus and four species of echidnas. There is currently some debate regarding monotreme taxonomy. The name monotreme derives from the Greek words μονός (monós 'single') and τρῆμα (trêma 'hole'), referring to the cloaca.
  • 3.9K
  • 19 Oct 2022
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