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Topic Review
ECM decellularization methods
The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of the ECM have been thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option to carry out regenerative medicine research, with multiple advantages compared to other approaches. We recently published an overview of the most common methods used to obtain the dECM from specific tissues[1]. Here we provide a summary from that report as a helpful guide for future research development.
  • 4.0K
  • 25 Aug 2020
Topic Review
Layered Double Hydroxides
Layered double hydroxides (LDHs) are anionic clays which have found applications in a wide range of fields, including medicine (especially in drug delivery and release), environment (to remediate pollution), biotechnology, as precursors for catalysts, and in electrochemical applications (electrocatalysts, sensors, oxygen evolution reaction (OER), energy storage, fuel cells, etc.). To be used in electrochemistry  they should possess electrical conductivity which can be ensured by the presence of metals able to give reversible redox reactions in a proper potential window. The metal centers can act as redox mediators to catalyze reactions for which the required overpotential is too high, and this is a key aspect for the development of processes and devices where the control of charge transfer reactions plays an important role.
  • 4.0K
  • 30 Mar 2021
Topic Review
Cybersecurity Practices for Social Media Users
Cybersecurity is a collection of technologies established to protect the cyber environment of an individual user or organization. There are many cyber threats existing within the social media platform, such as loss of productivity, cyber bullying, cyber stalking, identity theft, social information overload, inconsistent personal branding, personal reputation damage, data breach, malicious software, service interruptions, hacks, and unauthorized access to social media accounts. It is also revealed that demographic factors, for example age, gender, and education level, may not necessarily be influential factors affecting the cyber awareness of the internet users.
  • 4.0K
  • 10 Feb 2022
Topic Review
Heart Rate Variability in Irritable Bowel Syndrome
Heart Rate Variability (HRV) is a non-invasive biomarker that can measure autonomic tone. Autonomic Nervous System deregulation is considered the leading cause of Irritable Bowel Syndrome (IBS), which is associated with decreased parasympathetic tone. HRV can measure the parasympathetic tone and changes in autonomic tone caused by therapeutic intervention in IBS. Further research is needed to confirm the efficacy of using HRV to measure the effectiveness of therapeutic interventions in IBS.
  • 4.0K
  • 10 Oct 2022
Topic Review
Milk Fat Globule Membrane (MFGM)
Milk fat globule membrane (MFGM) is an important component of milk lipids that showed several biological properties (such as anticarcinogenic, antimicrobial, anti-inflammatory, and anticholesterolemic activities). In this review we analyse the latest results obtained from comparative proteomic studies regarding the variations and the similarities of MFGM proteome across species and lactation stages. Infant formula supplementation with MFGM represents an interesting opportunity to implement the bioactive properties exerted by MFGM, in order to narrow the gap between human breast milk and infant formula. 
  • 4.0K
  • 27 Sep 2020
Topic Review
3D Braiding Technology
3D braiding technologies enable the production of structures with complex geometry, which are often used for lightweight solutions, for example in automotive engineering. In addition, medical technology offers wide-ranging applications for 3D braiding technology. 3D braided structures are defined as those with yarns that intersect in all three spatial directions. 3D braiding processes allow the fiber orientation to be easily influenced, thus ensuring high strength and stiffness with reduced mass.
  • 4.0K
  • 25 Aug 2021
Topic Review
H Bridge
An H bridge is an electronic circuit that switches the polarity of a voltage applied to a load. These circuits are often used in robotics and other applications to allow DC motors to run forwards or backwards. Most DC-to-AC converters (power inverters), most AC/AC converters, the DC-to-DC push–pull converter, most motor controllers, and many other kinds of power electronics use H bridges. In particular, a bipolar stepper motor is almost invariably driven by a motor controller containing two H bridges.
  • 4.0K
  • 24 Oct 2022
Topic Review
Implant–Abutment Connections
Different implant–abutment connections have been developed to reduce mechanical and biological failure. The most frequent complications are loss of preload, screw loosening, abutment or implant fracture, deformations at the different interfaces, and bacterial microleakage.  To review the evidence indicating whether the implant–abutment connection type is significant regarding the following issues: (1) maintenance of the preload in static and dynamic in vitro studies; (2) assessment of possible deformations at the implant–abutment interfaces, after repeated application of the tightening torque; (3) evaluation of the sealing capability of different implant connections against microleakage. 
  • 4.0K
  • 08 Dec 2020
Topic Review
Philosophy of Baruch Spinoza
Baruch Spinoza's philosophy encompasses nearly every area of philosophical discourse, including metaphysics, epistemology, political philosophy, ethics, philosophy of mind, and philosophy of science. It earned Spinoza an enduring reputation as one of the most important and original thinkers of the seventeenth century. Samuel Shirley, who translated Spinoza's complete works into English, summed up the significance of Spinoza's philosophy as follows: Spinoza's philosophy is largely contained in two books: the Theologico-Political Treatise, and the Ethics. The former was published during his lifetime, but the latter, which contains the entirety of his philosophical system in its most rigorous form, was not published until after his death in 1677. The rest of the writings we have from Spinoza are either earlier, or incomplete, works expressing thoughts that were crystallized in the two aforementioned books (e.g., the Short Treatise and the Treatise on the Emendation of the Intellect), or else they are not directly concerned with Spinoza's own philosophy (e.g., The Principles of Cartesian Philosophy and The Hebrew Grammar). He also left behind many letters that help to illuminate his ideas and provide some insight into what may have been motivating his views.
  • 4.0K
  • 24 Nov 2022
Topic Review
Reductive Aminations with Metal Catalysts
Recently, N-substituted anilines have been the object of increasing research interest in the field of organic chemistry due to their role as key intermediates for the synthesis of important compounds such as polymers, dyes, drugs, agrochemicals and pharmaceutical products. Among the various methods reported in literature for the formation of C–N bonds to access secondary anilines, the one-pot reductive amination of aldehydes with nitroarenes is the most interesting procedure, because it allows to obtain diverse N-substituted aryl amines by simple reduction of nitro compounds followed by condensation with aldehydes and subsequent reduction of the imine intermediates. These kinds of tandem reactions are generally catalyzed by transition metal-based catalysts, mainly potentially reusable metal nanoparticles. 
  • 4.0K
  • 21 Apr 2021
Topic Review
Ischemic Stroke Pathophysiology and Preclinical Models
Ischemic stroke is a leading cause of death worldwide, mainly in western countries. So far, approved therapies rely mainly on reperfusion of the affected brain area, by intravenous thrombolysis or mechanical thrombectomy. The combination of pharmacological brain-protective strategies with reperfusion is the future of stroke therapy, aiming to reduce brain cell death and decrease patients’ disabilities. The success of new therapies relies on bringing preclinical studies and clinical practice close together. Recent upgrades of in vitro and in vivo stroke models for accurate and effective evaluation of therapeutic strategies are described.
  • 4.0K
  • 20 Oct 2022
Topic Review
Lipid and Polymeric Nanoparticles for Brain Drug Delivery
Intranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous for central nervous system disorders, such as depression and anxiety. Nanoparticles have been studied as possible alternatives to conventional formulations, with the objective of improving drug bioavailability.
  • 4.0K
  • 15 Dec 2022
Topic Review
Electrode Passivation
The main reason for electrode passivation is adsorption/deposition of a passivating compound on working electrode surface. The most pronounced consequences are the decrease of the rate of electrode reaction resulting in the shift of half-wave or peak potential to more negative (in the case of cathodic reaction) or to more positive (in the case of anodic reaction) potentials and in the decrease of peak current, which is especially in the case of pulsed technique influenced by this rate. 
  • 4.0K
  • 22 Feb 2021
Topic Review
Bladder Cancer Biomarkers
The high occurrence of bladder cancer and its tendency to recur combined with lifelong surveillance make the treatment of superficial bladder cancer one of the most expensive and time-consuming. Moreover, carcinoma in situ often leads to muscle invasion with an unfavourable prognosis. Currently, invasive methods including cystoscopy and cytology remain a gold standard. The aim is to find biomarkers with the best specificity and sensitivity, allowing the treatment plan to optimise and have potential applications in clinical practice. Such non-invasive methods can be measure in human body fluids, for example, urine or serum: Cytokeratin fragments (CYFRA 21.1), Excision Repair Cross-Complementation 1 (ERCC1), Tumour Protein p53 (Tp53), Fibroblast Growth Factor Receptor 3 (FGFR3), Tumor-Associated Trypsin Inhibitor (TATI).
  • 4.0K
  • 29 Mar 2022
Topic Review
Chital
The chital (/tʃiːtəl/; Axis axis), also known as spotted deer, chital deer, and axis deer, is a species of deer that is native to the Indian subcontinent. It was first described by German naturalist Johann Christian Polycarp Erxleben in 1777. A moderate-sized deer, male chital reach nearly 90 cm (35 in) and females 70 cm (28 in) at the shoulder. While males weigh 30–75 kg (66–165 lb), the lighter females weigh 25–45 kg (55–99 lb). It is sexually dimorphic; males are larger than females, and antlers are present only on males. The upper parts are golden to rufous, completely covered in white spots. The abdomen, rump, throat, insides of legs, ears, and tail are all white. The antlers, three-pronged, are nearly 1 m (3.3 ft) long.
  • 4.0K
  • 29 Sep 2022
Topic Review
Social Media
Social media is a computer-based technology that facilitates the sharing of ideas, thoughts, and information through the building of virtual networks and communities.
  • 4.0K
  • 14 Oct 2021
Topic Review
Problem-Based Learning
Problem-based learning (PBL) is a student-centered pedagogy in which students learn about a subject through the experience of solving an open-ended problem found in trigger material. The PBL process does not focus on problem solving with a defined solution, but it allows for the development of other desirable skills and attributes. This includes knowledge acquisition, enhanced group collaboration and communication. The PBL process was developed for medical education and has since been broadened in applications for other programs of learning. The process allows for learners to develop skills used for their future practice. It enhances critical appraisal, literature retrieval and encourages ongoing learning within a team environment. The PBL tutorial process involves working in small groups of learners. Each student takes on a role within the group that may be formal or informal and the role often alternates. It is focused on the student's reflection and reasoning to construct their own learning. The Maastricht seven-jump process involves clarifying terms, defining problem(s), brainstorming, structuring and hypothesis, learning objectives, independent study and synthesis. In short, it is identifying what they already know, what they need to know, and how and where to access new information that may lead to the resolution of the problem. The role of the tutor is to facilitate learning by supporting, guiding, and monitoring the learning process. The tutor aims to build students' confidence when addressing problems, while also expanding their understanding. This process is based on constructivism. PBL represents a paradigm shift from traditional teaching and learning philosophy, which is more often lecture-based. The constructs for teaching PBL are very different from traditional classroom or lecture teaching and often require more preparation time and resources to support small group learning. PBL can facilitate students to learn and understand complex concepts and theories such as STEM, engineering design problems, etc.
  • 4.0K
  • 10 Nov 2022
Topic Review
Health Impact of Drying Aral Sea: One Health
Once one of the largest saline lakes, the Aral Sea, was recognized as a significant environmental disaster as the water level decreased dramatically. Water level decrease increases water salinity, affecting biodiversity. Exposed lake beds become the source for fine dust picked up by the dust storms and spread across a long distance, affecting people’s health in surrounding areas. 
  • 4.0K
  • 13 Apr 2022
Topic Review
Various Protein Kinase Inhibitors as Anticancer Agents
Protein kinases (PTKs) are enzymes that regulate the biological activity of proteins by phosphorylation of certain amino acid residues. This reaction causes a conformational change from an inactive to an active form of the protein, which is one of the most important regulatory mechanisms of the cell cycle and transduction of external signals. Dysregulation of protein kinases activity is implicated in the processes of carcinogenesis and the progression of various solid cancers. Therefore, protein kinases are prime targets for the development of selective anticancer drugs.
  • 4.0K
  • 22 Apr 2022
Topic Review
Energiewende in Germany
The Energiewende (German for energy transition) is the planned transition by Germany to a low carbon, environmentally sound, reliable, and affordable energy supply. The term Energiewende is regularly used in English language publications without being translated (a loanword).:4 The new system will rely heavily on renewable energy (particularly wind, photovoltaics, and hydroelectricity), energy efficiency, and energy demand management. Most if not all existing coal-fired generation will need to be retired. The phase-out of Germany's fleet of nuclear reactors, to be complete by 2022, is a key part of the program. Legislative support for the Energiewende was passed in late 2010 and includes greenhouse gas (GHG) reductions of 80–95% by 2050 (relative to 1990) and a renewable energy target of 60% by 2050. These targets are ambitious. The Berlin-based policy institute Agora Energiewende noted that "while the German approach is not unique worldwide, the speed and scope of the Energiewende are exceptional". The Energiewende also seeks a greater transparency in relation to national energy policy formation. Germany has made significant progress on its GHG emissions reduction target, achieving a 27% decrease between 1990 and 2014. However the country will need to maintain an average GHG emissions abatement rate of 3.5% per year to reach its Energiewende goal, equal to the maximum historical value thus far. As of 2013, Germany spends €1.5 billion per year on energy research in an effort to solve the technical and social issues raised by the transition. This includes a number of computer studies that have confirmed the feasibility and a similar cost (relative to business-as-usual and given that carbon is adequately priced) of the Energiewende.
  • 4.0K
  • 09 Oct 2022
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