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Topic Review
Role of Pyroptosis in Psoriasis and Hidradenitis Suppurativa
Inflammatory skin diseases, also called inflammatory dermatoses, are a group of immune-mediated skin diseases with a complex etiology in which both genetic and environmental (i.e., lifestyle) factors play an essential role. Psoriasis and hidradenitis suppurativa (HS) are two of the many diseases that are encompassed by this term. It has been shown that pyroptosis plays a role in the development and exacerbation of comorbidities occurring in patients suffering from psoriasis and HS. 
  • 495
  • 17 Jan 2024
Topic Review
Melanoma and Basal Cell Carcinoma
Skin cancer is a common, preventable condition of global importance. Different types of skin cancer, like melanoma, basal cell carcinoma, and squamous cell carcinoma, have various risk factors, including UV exposure and genetics. Identifying these risk factors is crucial for targeting early detection and nuanced treatment.
  • 495
  • 29 Mar 2024
Topic Review
Emerging Biomarkers in Cutaneous Melanoma
Cutaneous melanoma (CM) is an increasingly significant public health concern. Due to alarming mortality rates and escalating incidence, it is crucial to understand its etiology and identify emerging biomarkers for improved diagnosis and treatment strategies.
  • 486
  • 14 Nov 2023
Topic Review
Genetics of Pustular Psoriasis
Psoriasis is a chronic inflammatory skin disease characterized by the appearance of clearly demarcated erythematous and scaly plaques. It can be divided into various types, including plaque, nail, guttate, inverse, and pustular psoriasis. Plaque psoriasis is the most commonly occurring type, though there is another rare but severe pustular autoinflammatory skin disease called generalized pustular psoriasis (GPP), which manifests with acute episodes of pustulation and systemic symptoms.
  • 483
  • 28 Jun 2023
Topic Review
Hydrogel-Based Skin Regeneration
The skin is subject to damage from the surrounding environment. The repair of skin wounds can be very challenging due to several factors such as severe injuries, concomitant infections, or comorbidities such as diabetes. Different drugs and wound dressings have been used to treat skin wounds. Tissue engineering, a novel therapeutic approach, revolutionized the treatment and regeneration of challenging tissue damage. Among the various 3D scaffolds used in tissue engineering, hydrogel scaffolds have gained special significance due to their unique properties such as natural mimicry of the extracellular matrix (ECM), moisture retention, porosity, biocompatibility, biodegradability, and biocompatibility properties.
  • 480
  • 27 Feb 2024
Topic Review
Gut Microbiome and Microbial Dysbiosis in Dermatologic Conditions
Dermatoses are an increasingly common problem, particularly in developed countries. The causes of this phenomenon include genetic factors and environmental elements. More and more scientific reports suggest that the gut microbiome, more specifically its dysbiosis, also plays an important role in the induction and progression of diseases, including dermatological diseases. The gut microbiome is recognised as the largest endocrine organ, and has a key function in maintaining human homeostasis.
  • 480
  • 29 Feb 2024
Topic Review
Psoriatic Patients and Obesity
Psoriasis, an autoimmune chronic inflammatory skin condition, has a high incidence in the general population, reaching 2–4%. Its pathogenesis involves an interplay of genetic factors, immune disturbances, and environmental factors. Within the environmental factors that aid the appearance of this autoimmune skin disease, the Western lifestyle and overall diet play important roles in the steady growth in psoriasis prevalence. Furthermore, psoriasis is associated with comorbidities such as psoriatic arthritis, cardiovascular disease, metabolic syndrome, and obesity. Accumulating evidence suggests that obesity is an important risk factor for psoriasis. 
  • 476
  • 15 Aug 2023
Topic Review
Bitter Phytochemicals in Skin Disease Treatment
Skin diseases represent a global healthcare challenge due to their rising incidence and substantial socio-economic burden. While biological, immunological, and targeted therapies have brought a revolution in improving quality of life and survival rates for certain dermatological conditions, there remains a stringent demand for new remedies. Nature has long served as an inspiration for drug development. Recent studies have identified bitter taste receptors (TAS2Rs) in both skin cell lines and human skin. Additionally, bitter natural compounds have shown promising benefits in addressing skin aging, wound healing, inflammatory skin conditions, and even skin cancer. Thus, TAS2Rs may represent a promising target in all these processes. 
  • 459
  • 18 Feb 2024
Topic Review
Histopathological Markers for Therapies in Primary Cutaneous Lymphomas
Targeted (biological) therapies have become available also for primary cutaneous T-cell lymphomas (PCTCLs) including anti-CD30 (brentuximab vedotin) in mycosis fungoides, primary cutaneous anaplastic large T-cell lymphoma, lymphomatoid papulosis; anti-CCR4 (mogamulizumab) in Sezary syndrome; anti-CD123 (tagraxofusp) in blastic plasmocytoid cell neoplasm. Moreover, anti-PD1 (nivolumab), anti-PDL1 (pembrolizumab, atezolizumab), anti-CD52 (alemtuzumab), anti-KIR3DL2-CD158k (lacutamab), and anti-CD70 (cusatuzumab) have been tested or are under investigations in phase II trials. The expression of these epitopes on neoplastic cells in skin biopsies or blood samples plays a central role in the management of PCTCL patients.
  • 458
  • 06 Dec 2023
Topic Review
Molecular Pathology of Melanoma
Melanoma, the deadliest form of skin cancer, presents a significant clinical challenge due to its high metastatic potential and resistance to conventional therapies. It originates from melanocytes and is increasingly prevalent. Melanoma, a highly aggressive skin cancer, is characterized by rapid progression and high mortality. Recent advances in molecular pathogenesis have shed light on genetic and epigenetic changes that drive melanoma development.
  • 454
  • 14 Mar 2024
Topic Review
Deciphering Childhood Rosacea
Rosacea is a chronic inflammatory skin disease that can affect the skin and eyes. The pathogenesis of rosacea is complex and related to interactions between genetic and environmental factors, the dysregulation of innate and acquired immune systems, the dysregulation of nerves and blood vessels, and the imbalance of the skin microbiota, particularly the overgrowth of Demodex mites.
  • 426
  • 26 Feb 2024
Topic Review
Therapeutic Agents Targeting Immune Mediators in Hidradenitis Suppurativa
Hidradenitis suppurativa (HS), also known as acne inversa (AI), is a chronic, recurrent, debilitating skin disease thought to involve occlusion of the hair follicle at the pilosebaceous unit (PSU) such as axillary, inguinal, and anogenital regions. Clinically, HS manifests as painful inflammatory nodules, abscesses, and interconnected tunnels emitting malodorous discharge and results in disfiguring scarring that has a considerable impact on a patient’s quality of life. 
  • 408
  • 07 Feb 2024
Topic Review
Treatment of Cutaneous Melanoma
Cutaneous melanoma is a public health problem. Pathogenic pathways and the tumor microclimate are key to the development of therapeutic methods. Revolutionary therapies like targeted therapy and immune checkpoint inhibitors are starting to replace traditional therapeutic methods. Targeted therapy aims at a specific molecule in the pathogenic chain to block it, stopping cell growth and dissemination. The main function of immune checkpoint inhibitors is to boost cellular immunity in order to combat cancer cells.
  • 405
  • 07 Feb 2024
Topic Review
Eccrine Porocarcinoma
Eccrine porocarcinoma (EPC) constitutes a rare malignant adnexal tumor, which accounts for about 0.005–0.01% of all cutaneous malignancies. It may develop de novo or arise from an eccrine poroma, after a latency period of years or even decades.
  • 402
  • 27 Apr 2023
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