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Topic Review
Iron Complexation and Flavonoids
Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron.
  • 4.4K
  • 26 Jan 2021
Topic Review
Hyperfiltration
Hyperfiltration is an important underlying cause of glomerular dysfunction associated with several systemic and intrinsic glomerular conditions leading to chronic kidney disease (CKD). These include obesity, diabetes, hypertension, focal segmental glomerulosclerosis (FSGS), congenital abnormalities and reduced renal mass (low nephron number). Hyperfiltration-associated biomechanical forces directly impact the cell membrane, generating tensile and fluid flow shear stresses in multiple segments of the nephron.
  • 4.4K
  • 01 Mar 2022
Topic Review
Mercury's Magnetic Field
Mercury's magnetic field is approximately a magnetic dipole (meaning the field has only two magnetic poles) apparently global, on planet Mercury. Data from Mariner 10 led to its discovery in 1974; the spacecraft measured the field's strength as 1.1% that of Earth's magnetic field. The origin of the magnetic field can be explained by dynamo theory. The magnetic field is strong enough near the bow shock to slow the solar wind, which induces a magnetosphere.
  • 4.4K
  • 15 Nov 2022
Topic Review
Tranditional Use and Nutritional Value of Lansium domesticum
Lansium domesticum (Langsat, Meliaceae) is a tropical fruit mainly found in Southeast Asian countries, particularly in Thailand, Malaysia, Indonesia, and the Philippines.
  • 4.4K
  • 21 Apr 2022
Topic Review
Benzimidazole and Their Derivatives
Heterocyclic compounds are significant lead drug candidates based on their various structure–activity relationships (SAR), and their use in pharmaceutics is constantly developing. Benzimidazole (BnZ) is synthesized by a condensation reaction between benzene and imidazole. The BnZ structure consists of two nitrogen atoms embedded in a five-membered imide ring which is fused with a benzene ring. 
  • 4.4K
  • 23 Oct 2023
Topic Review
Certis CISCO
Coordinates: 1°19′16.88″N 103°53′30.67″E / 1.3213556°N 103.8918528°E / 1.3213556; 103.8918528 Certis CISCO Security Private Limited, formerly CISCO Security Private Limited, is one of the five commercial Auxiliary Police forces authorized to provide armed security officers to government organizations as well as private companies or individuals in Singapore. It has its roots as a department of the Singapore Police Force (SPF), which branched out as the Commercial and Industrial Security Corporation, a statutory board with a monopoly over most areas of the local private armed security industry. From 1 June 2005, the statutory board was dissolved and Cisco Security Pte Ltd was formed upon its corporatisation as a fully owned subsidiary of Temasek Holdings, and inaugurated on 5 July 2005. The abbreviation of the former statutory board, "CISCO", was retained due to its reputation in the local market. The company was renamed as Certis CISCO Security Pte Ltd on 13 September 2007. Cisco Annual Security Report on 20 January 2016 reveals a decline in defender confidence and the increased impact of industrialized attackers. As the oldest Auxiliary Police Force with a monopoly over most of the private armed security sector in Singapore for 33 years, CISCO maintains a visible presence in many key establishments, including the private residences of VVIPs. They were deployed in major events such as the Singapore 2006 IMF Meetings, the New Year Countdown at Marina Bay in 2007 and 2008, the Chingay Parade and the Thaipusam processions. They also continue to dominate some services such as the transportation of valuables, most visibly in the form of delivering cash to automated teller machines.
  • 4.4K
  • 08 Nov 2022
Topic Review
Sustainable Consumer Behavior
Sustainable Consumer Behavior, namely a new sustainable consumer model, refers to major shifts in buying and consumption habits. Nevertheless, these shifts were lagging as consumers resisted change in the comfort of old habits. This comfort was shaken up by the COVID-19 outbreak that forced us to rethink every aspect of our lives. Therefore, this crisis context seems the perfect opportunity to shift towards the sustainable consumer model.
  • 4.4K
  • 09 Jun 2021
Topic Review Peer Reviewed
Wooden Additional Floor in Finland
One of the most effective ways to cover real estate development and renovation processes by improving functionality and energy efficiency is wooden additional floor construction. The scattered information is mapped out, organized, and collated on the current state of the art and the benefits of this practice including its different stages, focusing on the case of Finland. The topic is presented in an accessible and understandable discourse for non-technical readers. By highlighting the benefits and opportunities of this sustainable application, it will contribute to increasing the awareness of wooden additional floor construction, which has many advantages, and therefore to gain more widespread use in Finland and other countries.
  • 4.4K
  • 14 Apr 2022
Topic Review
List of Intel Core I7 Microprocessors
The following is a list of Intel Core i7 brand microprocessors. Introduced in 2008, the Core i7 line of microprocessors are intended to be used by high-end users.
  • 4.4K
  • 24 Nov 2022
Topic Review
World View
A world view or worldview is the fundamental cognitive orientation of an individual or society encompassing the whole of the individual's or society's knowledge and point of view. A world view can include natural philosophy; fundamental, existential, and normative postulates; or themes, values, emotions, and ethics. The term is a calque of the German word Weltanschauung [ˈvɛltʔanˌʃaʊ.ʊŋ] (listen), composed of Welt ('world') and Anschauung ('view' or 'outlook'). The German word is also used in English. It is a concept fundamental to German philosophy and epistemology and refers to a wide world perception. Additionally, it refers to the framework of ideas and beliefs forming a global description through which an individual, group or culture watches and interprets the world and interacts with it. Worldview remains a confused and confusing concept in English, used very differently by linguists and sociologists. It is for this reason that James W. Underhill suggests five subcategories: world-perceiving, world-conceiving, cultural mindset, personal world, and perspective. Worldviews are often taken to operate at a conscious level, directly accessible to articulation and discussion, as opposed to existing at a deeper, pre-conscious level, such as the idea of "ground" in Gestalt psychology and media analysis. However, core worldview beliefs are often deeply rooted, and so are only rarely reflected on by individuals, and are brought to the surface only in moments of crises of faith.
  • 4.4K
  • 26 Oct 2022
Topic Review
Tudor Rose
The Tudor rose (sometimes called the Union rose) is the traditional floral heraldic emblem of England and takes its name and origins from the House of Tudor, which united the House of Lancaster and the House of York. The Tudor rose consists of five white inner petals, representing the House of York, and five red outer petals to represent the House of Lancaster.
  • 4.4K
  • 16 Nov 2022
Topic Review
Essential Oil Standards for Lavandula angustifolia
Lavender is in the research spotlight due to its increasing economic importance, while market demand is expected to continue to grow. Among the hundreds of essential-oil-bearing plants, Lavandula angustifolia Mill. remains one of the most valuable. Due to the increasing market demand as well as the expanding use of essential oils, the development of regulations, guidelines and standards aiming to maintain a high level of quality and safety remains a priority. Exigence is necessary for ensuring that buyers are receiving what they paid for, and in addition, depending on the destination of use and industry, for ensuring the derived product quality is not adversely affected.
  • 4.4K
  • 13 Mar 2023
Topic Review
Biological Production of Vanillin
Vanillin (4-hydroxy-3-methoxybenzaldehyde), the primary ingredient in vanilla bean or pod extracts, possesses a rich, creamy, and distinctive vanilla smell, which is also one of the most significant aromas in the world. Vanillin can serve as a flavoring agent in the food industry (about 60%), a pharmaceutical intermediate in the pharmaceutical industry (about 7%), and a scent ingredient in the cosmetics sector (about 33%).
  • 4.4K
  • 08 May 2023
Topic Review
Four Effects of High-Entropy Alloys
As a new type of alloy with high hardness, high heat resistance, strong corrosion resistance, high wear resistance and fatigue resistance, high-entropy alloys are different from any existing traditional alloy. As a new alloy system, high-entropy alloys have important research value and broad application prospects. Therefore, the design, preparation and application of high-entropy alloys have become an important direction for the development of new materials.
  • 4.4K
  • 17 Nov 2023
Topic Review
Essential-thrombocythemia and Acquired von-Willebrand Syndrome
Over the past decade, new insights have emerged on the pathophysiology of essential thrombocythemia (ET), its clinical management, and associated thrombohemostatic disturbances. Here, we review the latest diagnostic and risk stratification modalities of ET and its therapeutics. Moreover, we discuss the clinical evidence-based benefits, deriving from major clinical trials, of using cytoreductive therapy and antiplatelet agents to lower the risk of fatal vascular events. Also, we focus on the condition of extreme thrombocytosis (>1000 × 109/L) and bleeding risk, the development and pathogenesis of acquired von Willebrand syndrome, and the clinical approach to this paradoxical scenario in ET.
  • 4.4K
  • 20 Oct 2020
Topic Review
Burn Pathophysiology
Burns are a widespread global public health traumatic injury affecting many people worldwide. Non-fatal burn injuries are a leading cause of morbidity, resulting in prolonged hospitalization, disfigurement, and disability, often with resulting stigma and rejection. The treatment of burns is aimed at controlling pain, removing dead tissue, preventing infection, reducing scarring risk, and tissue regeneration. 
  • 4.4K
  • 26 May 2023
Topic Review
Power Generation in Sewage-Water Treatment Plants
Sewage-water treatment comprehends primary, secondary, and tertiary steps to produce reusable water after removing sewage contaminants. However, a sewage-water treatment plant is typically a power and energy consumer and produces high volumes of sewage sludge mainly generated in the primary and secondary steps. The use of more efficient anaerobic digestion of sewage water with sewage sludge can produce reasonable flowrates of biogas, which is shown to be a consolidated strategy towards the energy self-sufficiency and economic feasibility of sewage-water treatment plants. Anaerobic digestion can also reduce the carbon footprint of energy sources since the biogas produced can replace fossil fuels for electricity generation. 
  • 4.4K
  • 05 May 2022
Topic Review
OX40-OX40L Inhibition for the Treatment of Atopic Dermatitis
OX40 and OX40L are two checkpoint molecules that bind to potentiate pro-inflammatory T-cell responses that are pivotal to atopic dermatitis pathogenesis. Two OX40-OX40L inhibitors, rocatinlimab and amlitelimab, are being developed for the treatment of atopic dermatitis. Rocatinlimab, an anti-OX40 antibody, was evaluated in phase 2b, a randomized, placebo-controlled clinical trial. At week 16, rocatinlimab groups achieved a greater reduction in the EASI percentage change from the baseline (−48.3% to −61.1%) against the placebo (−15.0%; p < 0.001), and clinical response was maintained 20 weeks after the treatment had ceased. Amlitelimab, an anti-OX40L antibody, was studied in a 12-week treatment phase 2a clinical trial, with a significant efficacy response observed within 2 weeks. At week 16, amlitelimab groups reached the EASI mean percentage change from the baseline of −69.9% and −80.1% versus the placebo (−49.4%; p = 0.072 and p = 0.009). Among the responders, 68% of amlitelimab patients were sustained 24 weeks following the last dose. Both treatments were shown to be safe and well tolerated. The evidence points to OX40-OX40L inhibitors as future options for atopic dermatitis treatment with potential disease-modifying effects.
  • 4.4K
  • 17 Feb 2023
Topic Review
Panel Van
A panel van (or panelvan) is a form of solid (rigid-bodied, non-articulated) van, smaller than a lorry or truck, without rear side windows. In the UK this body style is referred to as a "car-derived van" and in North American as a "sedan delivery" (while the term "panel van" or "cargo van" generally refers to larger, truck-based vans such as the Ford E-Series and Chevrolet Express). In Australia panel vans were a development of the Australian "ute" (utility), a variety of pickup, based on a car chassis, these often utilizing the floorpan of the station wagon model. In North America a two-door station wagon base was used with only front seats and steel sheet-metal panels in place of the rear and side windows. Panel vans are widely used in many parts of the world for transporting cargo. In some national usages it is distinct from a purpose-designed van in that it is based on the chassis of a family car design. In places where they are distinct from a "van", they have less cargo space but better agility and maneuverability, making them particularly suited for cities with narrow streets or heavy traffic.
  • 4.4K
  • 11 Nov 2022
Topic Review
Sponge City Practices in China
In recent years, China has been committed to strengthening environmental governance and trying to build a sustainable society in which humans and nature develop in harmony. As a new urban construction concept, sponge city uses natural and ecological methods to retain rainwater, alleviate flooding problems, reduce the damage to the water environment, and gradually restore the hydrological balance of the construction area.
  • 4.4K
  • 17 May 2022
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