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Topic Review
Glycogen Storage Diseases
Glycogen storage diseases (GSDs) are metabolic disorders of glycogen metabolism. In aggregate, GSDs are not considered rare diseases, but every individual type are. The overall estimated GSD incidence is 1 case per 20,000-43,000 live births, and a prevalence of 1:100,000 is considered for main types (including I, II, II, V and IX). There are 19 types which are classified by enzyme deficiency and affected tissue. Most of them are inherited in an autosomal recessive manner, except for one X-linked GSDIX and Danon subtypes. Disorders related with creation, deposits and degradation of glycogen, may primarily affect the liver (hepatic GSDs), the muscles (muscle GSDs), or in a multiorganic manner (mainly Pompe). The common characteristic of all types of GSDs is the alteration of some step in glycogenolysis/glycolysis pathway, as can be seen in figures 1a and 1b.
  • 4.4K
  • 13 May 2021
Topic Review
Molecular Imprinting
Molecular imprinting is a technique for creating artificial recognition sites on polymer matrices that complement the template in terms of size, shape, and spatial arrangement of functional groups. The main advantage of Molecularly Imprinted Polymers (MIP) as the polymer for use with a molecular imprinting technique is that they have high selectivity and affinity for the target molecules used in the molding process. 
  • 4.4K
  • 30 Nov 2021
Topic Review
Cinnamon as Useful Preventive Substance
Cinnamon is widely used as a food spice, but due to its antibacterial and pharmacological properties, it can also be used in processing, medicine and agriculture. The word “Cinnamon” can refer to the plant, processed material, or an extract. It is sometimes used as a substance, and sometimes used as a mixture or as compounds or a group. This article reviews research into the effectiveness of various forms of cinnamon for the control of plant diseases and pests in crops and during storage of fruit and vegetables. Cinnamon acts on pests mainly as a repellent, although in higher doses it has a biocidal effect and prevents egg-laying. Cinnamon and its compounds effectively hinder bacterial and fungal growth, and the phytotoxic effects of cinnamon make it a possible herbicide. This article presents the wide practical use of cinnamon for various purposes, mainly in agriculture. Cinnamon is a candidate for approval as a basic substance with protective potential. In particular, it can be used in organic farming as a promising alternative to chemical pesticides for use in plant protection, especially in preventive treatments. The use of natural products is in line with the restriction of the use of chemical pesticides and the principles of the EU’s Green Deal. 
  • 4.4K
  • 22 Sep 2021
Topic Review
Augmented Humanity
Augmented humanity is a human–computer integration technology that proposes to improve capacity and productivity by changing or increasing the normal ranges of human function, through the restoration or extension of human physical, intellectual and social capabilities.
  • 4.4K
  • 07 Feb 2022
Topic Review
Tetraspanins of extracellular vesicles
Tetraspanins are transmembrane proteins with ability to interact with each other and with other non-tetraspanin partners, building up a complex called tetraspanin web. This dynamic structure participates in many cellular processes. Although currently, the tetraspanin proteins found in extracellular vesicles are mostly applied as markers, increasing evidence points to their role in extracellular vesicle biogenesis, cargo selection, cell targeting, and cell uptake under both physiological and pathological conditions.
  • 4.4K
  • 02 Nov 2020
Topic Review
Wind Turbine Blade Failures
The wind turbine is a complex structure. Although there is no single approach and there is variability in the commercial designs, a typical WTB is a thin-walled multi-cellular hollow airfoil shaped cross-section. For its manufacture, a number of materials and material systems are used for structural purposes (fibre composites and sandwich composite systems) as well as aesthetic purposes (primers, UV gel coats, paint, etc). The potential causes of wind turbine blade failures can be classified into the following four categories:1. damage from lightning;2. failures due to fatigue;3. leading edge erosion;4. damage from icing.The types of damage caused to wind turbine blades—originating from the above four different sources—along with their significance to the turbine’s performance and secure operation, are detailed in the following sub-sections.
  • 4.4K
  • 11 Oct 2021
Topic Review
Maté (Drink)
User:RMCD bot/subject notice Maté or mate (/ˈmæteɪ/), also known as chimarrão or cimarrón, is a traditional South American caffeine-rich infused drink, that was consumed by the Guaraní and Tupí peoples. It is the National Beverage in Argentina, Uruguay and Paraguay. It is also consumed in the Bolivian Chaco, Southern Chile, Southern Brazil, Syria—the largest importer in the world—and Lebanon, where it was brought from Argentina by immigrants. It is prepared by steeping dried leaves of yerba mate (Ilex paraguariensis, known in Portuguese as erva-mate) in hot water and is served with a metal straw from a shared hollow calabash gourd. The straw is called a bombilla in Spanish, a bomba in Portuguese, and a bombija or, more generally, a masassa (straw) in Arabic. The straw is traditionally made of silver. Modern, commercially available straws are typically made of nickel silver (called alpaca), stainless steel, or hollow-stemmed cane. The gourd is known as a mate or a guampa; while in Brazil, it has the specific name of cuia, or also cabaça (the name for Indigenous-influenced calabash gourds in other regions of Brazil, still used for general food and drink in remote regions). Even if the water is supplied from a modern thermos, the infusion is traditionally drunk from mates or cuias. The maté leaves are dried, chopped, and ground into a powdery mixture called yerba, "erva" in Portuguese, which means "herb". The bombilla functions as both a straw and a sieve. The submerged end is flared, with small holes or slots that allow the brewed liquid in, but block the chunky matter that makes up much of the mixture. A modern bombilla design uses a straight tube with holes, or a spring sleeve to act as a sieve. "Tea-bag" type infusions of maté (Spanish: mate cocido, Portuguese: chá mate) have been on the market in many South American countries for many years under such trade names as "Taragüi" in Argentina, "Pajarito" and "Kurupí" in Paraguay, and Matte Leão and "Mate Real" in Brazil.
  • 4.4K
  • 03 Nov 2022
Topic Review
Agarwood
Agarwood, popularly known as oudh or gaharu, is a fragrant resinous wood of high commercial value, traded worldwide and primarily used for its distinctive fragrance in incense, perfumes, and medicine. This fragrant wood is created when Aquilaria trees are wounded and infected by fungi, producing resin as a defense mechanism. The depletion of natural agarwood caused by overharvesting amidst increasing demand has caused this fragrant defensive resin of endangered Aquilaria to become a rare and valuable commodity. Given that instances of natural infection are quite low, artificial induction, including biological inoculation, is being conducted to induce agarwood formation.
  • 4.4K
  • 06 Jun 2022
Topic Review
Sadhu
A sadhu (IAST: sādhu (male), sādhvī or sādhvīne (female)), also spelled saddhu, is a religious ascetic, mendicant (monk) or any holy person in Hinduism and Jainism who has renounced the worldly life. They are sometimes alternatively referred to as jogi, sannyasi or vairagi. It literally means one who practises a ″sadhana″ or keenly follows a path of spiritual discipline. Although the vast majority of sādhus are yogīs, not all yogīs are sādhus. The sādhu is solely dedicated to achieving mokṣa (liberation), the fourth and final aśrama (stage of life), through meditation and contemplation of Brahman. Sādhus often wear simple clothing, such saffron-coloured clothing in Hinduism, white or nothing in Jainism, symbolising their sannyāsa (renunciation of worldly possessions). A female mendicant in Hinduism and Jainism is often called a sadhvi, or in some texts as aryika.
  • 4.4K
  • 10 Nov 2022
Topic Review
Techniques Involved in Plantlet Generation
Ornamentals come in a variety of shapes, sizes, and colors to suit a wide range of climates, landscapes, and gardening needs. Compared to demand, a shortage of plant materials and diversity force the search for solutions for their constant acquisition and improvement to increase their commercial value, respectively. In vitro cultures are a suitable solution to meet expectations using callus culture, somatic embryogenesis, protoplast culture, and the organogenesis of protocorm-like bodies; many of these techniques are commercially practiced. Factors such as culture media, explants, carbohydrates, plant growth regulators, and light are associated with the success of in vitro propagation. Techniques, especially embryo rescue and somatic hybridization, are widely used to improve ornamentals. The development of synthetic seed allows season-independent seed production and preservation in the long term. Despite the advantages of propagation and the improvement of ornamentals, many barriers still need to be resolved. In contrast to propagation and crop developmental studies, there is also a high scope for molecular studies, especially epigenetic changes caused by plant tissue culture of ornamentals. 
  • 4.4K
  • 07 Dec 2022
Topic Review
Bryophyllum sp.
The subgenus Bryophyllum belongs to genus Kalanchoe (Crassulaceae family) and includes about 25 plant species native to Madagascar, which are widely used in traditional medicine in vast regions throughout Africa, Asia and South Africa. Different formulations from bryophyllum (this term is proposed to be the common name to collectively refer to these species) have been employed for the treatment of several ailments, including infections, gynecological disorders, and chronic diseases, such as diabetes, neurological and neoplastic diseases. Two major families of secondary metabolites have been reported as responsible for these bioactivities: phenolic compounds and bufadienolides. These compounds are found in limited amounts in plants because they are biosynthesized in response to different biotic and abiotic stresses. Therefore, novel approaches should be undertaken with the aim of achieving the phytochemical valorization of Bryophyllum sp., allowing a sustainable production that prevents from a massive exploitation of wild plant resources. This review focuses on the study of phytoconstituents reported on bryophyllum; the application of plant tissue culture methodology as a reliable tool for the valorization of bioactive compounds; and the application of machine learning technology to model and optimize the full phytochemical potential of bryophyllum. As a result, bryophyllum species can be considered as a promising source of plant bioactive compounds, with enormous antioxidant and anticancer potential, which could be used for their large-scale biotechnological exploitation in cosmetic, food, and pharmaceutical industries.
  • 4.4K
  • 05 Jan 2021
Topic Review
Hydrochar
Recently, due to the escalating usage of non-renewable fossil fuels such as coal, natural gas and petroleum coke in electricity and power generation, and associated issues with pollution and global warming, more attention is being paid to finding alternative renewable fuel sources. Thermochemical and hydrothermal conversion processes have been used to produce biochar and hydrochar, respectively, from waste renewable biomass. Char produced from the thermochemical and hydrothermal decomposition of biomass is considered an environmentally friendly replacement for solid hydrocarbon materials such as coal and petroleum coke. Unlike thermochemically derived biochar, hydrochar has received little attention due to the lack of literature on its production technologies, physicochemical characterization, and applications.
  • 4.4K
  • 23 Aug 2021
Topic Review
Draco
Draco, Latin for "the dragon," is a large and distinctive constellation in the northern celestial hemisphere. It is renowned for its winding shape, resembling a serpentine dragon winding around the celestial pole, and is home to several notable deep-sky objects, including the Cat's Eye Nebula and the Draco Dwarf Galaxy.
  • 4.4K
  • 08 Mar 2024
Topic Review
Social Closure
Social closure refers to the process by which groups or social categories seek to establish and maintain boundaries to protect their privileged position and restrict access to resources, opportunities, or social status. This phenomenon involves mechanisms such as exclusion, discrimination, or credentialism, aimed at preserving the advantages of certain groups while limiting the mobility and opportunities of others. Social closure can manifest in various domains, including education, employment, and social institutions, contributing to social stratification and inequality within societies.
  • 4.4K
  • 08 Feb 2024
Topic Review
Corporate Social Responsibility Reporting
Corporate Social Responsibility (CSR) Reporting is an essential mechanism for ensuring the transparency and accountability of companies towards sustainability performance. To further promote that sustainable development agenda, CSR-related regulations and policies have emerged worldwide.
  • 4.4K
  • 22 Oct 2021
Topic Review
Plant Cell Culture
The large-scale production of plant-derived secondary metabolites (PDSM) in bioreactors to meet the increasing demand for bioactive compounds for the treatment and prevention of degenerative diseases is nowadays considered an engineering challenge. Plant cell culture (PCC) is nowadays recognized as a promising, renewable, sustainable, and environmentally friendly alternative to obtain PDSM out of wild plants. PCC accounts for the virtues of whole-plant cultivation systems and offers significant advantages, such as controlled manufacture due to standardized environmental conditions, i.e., it is not seasonal dependent, makes use of low amounts of water, and pesticides and herbicides are not required, achieving better quality in the desired product.
  • 4.4K
  • 29 Dec 2021
Topic Review
Life Cycle Assessment of State-of-the-Art Steel Production Routes
Using the life cycle assessment (LCA) methodology, the impacts of the primary steel production via the blast furnace route and the scrap-based secondary steel production via the electric arc furance (EAF) route are assessed. Methodological as well as technical differences are analysed and their impacts on the results.
  • 4.4K
  • 08 Nov 2022
Topic Review
Power
In physics, power is the amount of energy transferred or converted per unit time. In the International System of Units, the unit of power is the watt, equal to one joule per second. In older works, power is sometimes called activity. Power is a scalar quantity. Power is related to other quantities; for example, the power involved in moving a ground vehicle is the product of the traction force on the wheels and the velocity of the vehicle. The output power of a motor is the product of the torque that the motor generates and the angular velocity of its output shaft. Likewise, the power dissipated in an electrical element of a circuit is the product of the current flowing through the element and of the voltage across the element.
  • 4.4K
  • 31 Oct 2022
Topic Review
Modular Multilevel Converter Submodules
Voltage-source converter (VSC) HVDC systems based on modular multilevel converters (MMCs) combine the system advantages of fast and independent active and reactive power control, passive network supply, black start capabilities, frequency support and power oscillation damping with power electronics benefits such as scalable design, increased reliability, lower conversion losses and reduced filtering requirements, thus offering a commercially competitive solution. The structure of the SM is an important element of the MMC. This has been the case, where substantial SM topologies have been presented, specifically aimed at extending the functionalities of the MMC, in many cases aligned with niche applications of the converter rather than generic use as a VSC converter.
  • 4.4K
  • 18 Mar 2022
Topic Review Peer Reviewed
Organizational Justice: Typology, Antecedents and Consequences
Organizational Justice is an individual’s perception that events, actions, or decisions within an organization adhere to a standard of fairness. Justice researchers have categorized justice into four types, differentiated by how fairness is evaluated by employees: distributive, procedural, interpersonal, and informational justice. Organizational justice perceptions have consequences for the employee and the organization: increasing job satisfaction, commitment, and trust; and decreasing turnover, counterproductive work behaviors, and even workplace violence. Contemporary organizational justice research seeks to understand how to restore justice after an injustice has occurred. 
  • 4.4K
  • 08 Jul 2022
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