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Topic Review
In Vivo Calcium Imaging under General Anesthesia
General anesthesia has been widely utilized since the 1840s, but its underlying neural circuits remain to be completely understood. Calcium ions are popular targets used to detect neuronal activities that link circuit dynamics to behaviors in modern neuroscience research.
  • 1.1K
  • 15 Jul 2022
Topic Review
Clustering Based Optimal Cluster Head Selection
The goal of today’s technological era is to make every item smart. Internet of Things (IoT) is a model shift that gives a whole new dimension to the common items and things. Wireless sensor networks, particularly Low-Power and Lossy Networks (LLNs), are essential components of IoT that has a significant influence on daily living. Routing Protocol for Low Power and Lossy Networks (RPL) has become the standard protocol for IoT and LLNs. It is not only used widely but also researched by various groups of people. The extensive use of RPL and its customization has led to demanding research and improvements. There are certain issues in the current RPL mechanism, such as an energy hole, which is a huge issue in the context of IoT.
  • 1.1K
  • 15 Jul 2022
Topic Review
Verbot
The Verbot (Verbal-Robot) was a popular chatterbot program and Artificial Intelligence Software Development Kit (SDK) for the Windows platform and for the web.
  • 1.1K
  • 26 Oct 2022
Topic Review
Button Pusher
A button pusher (Ukrainian: кнопкодав, Knopkodav) is a term in Ukrainian politics and society related to a member of the Verkhovna Rada of Ukraine (the parliament of Ukraine) who votes on a motion by using own identity card as well as ones belonging to other deputies. This voting is done either with or without the consent of the absent deputies. On 2 March 2021 sensor technologies were installed in the Ukrainian parliament that were designed to make it impossible for MP's to vote on behalf of absent colleagues (since they need now to use both their hands for a single vote).
  • 1.1K
  • 30 Nov 2022
Topic Review
Photobiomodulation in Alzheimer’s Disease
Alzheimer’s disease (AD), as a neurodegenerative disorder, usually develops slowly but gradually worsens. Transcranial photobiomodulation (PBM) has emerged as a potential clinical treatment and cognitive enhancement method for various neurodegenerative pathologies by delivering red and near-infrared light to the frontal and midbrain areas, which could also help increasing the potential of pharmacological therapies.
  • 1.1K
  • 16 Mar 2023
Topic Review
Wetland Water-Level Prediction
Wetlands are simply areas that are fully or partially saturated with water. Wetlands have numerous hydrological, ecological, and social values. They play an important role in interactions among soil, water, plants, and animals. The rich biodiversity in the vicinity of wetlands makes them invaluable. Many anthropogenic activities damage wetlands. Climate change has adversely impacted wetlands and their biodiversity. The shrinking of wetland areas and reducing wetland water levels can therefore be frequently seen. However, the opposite can be seen during stormy seasons. Since wetlands have permissible water levels, the prediction of wetland water levels is important.
  • 1.1K
  • 09 May 2023
Topic Review
Crossiella in Caves
The genus Crossiella contains two species, C. equi, causing nocardioform placentitis in horses, and C. cryophila, an environmental bacterium.
  • 1.1K
  • 19 Jun 2023
Topic Review
Classification of Lymphoblastic Leukemias and Lymphomas
The diagnosis and treatment of lymphoid neoplasms have undergone a progressively positive change in the past, with accelerated progress in the previous decade due to the advent of genomics in cancer diagnosis. Significantly, there has been an increasing emphasis on integrating molecular genetics with clinical, morphologic, immunophenotypic, and cytogenetic evaluation for diagnosis. 
  • 1.1K
  • 29 Jun 2023
Topic Review
Cenobamate and Drug-Resistant Epilepsy
Cenobamate (CNB), ([(R)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl], is a novel tetrazole alkyl carbamate derivative. In November 2019, the Food and Drug Administration approved Xcopri®, marketed by SK Life Science Inc., (Paramus, NJ, USA) for adult focal seizures. The European Medicines Agency approved Ontozry® by Arvelle Therapeutics Netherlands B.V.(Amsterdam, The Neatherlands) in March 2021. Cenobamate is a medication that could potentially change the perspectives regarding the management and prognosis of refractory epilepsy.
  • 1.1K
  • 02 Aug 2023
Topic Review
Grape Ripe Rot Caused by the Colletotrichum Complex
Grape ripe rot, which is predominantly caused by the Colletotrichum species, presents a growing threat to global grape cultivation. This threat is amplified by the increasing populations of the Colletotrichum species in response to warmer climates.
  • 1.1K
  • 21 Aug 2023
Topic Review
Nonsteroidal Anti-Inflammatory Drugs in Prostate Cancer
Prostate cancer (PC) is the second most common type of cancer and the leading cause of death among men worldwide. Preventing the progression of cancer after treatments such as radical prostatectomy, radiation therapy, and hormone therapy is a major concern faced by prostate cancer patients. Inflammation, which can be caused by various factors such as infections, the microbiome, obesity and a high-fat diet, is considered to be the main cause of PC. Inflammatory cells are believed to play a crucial role in tumor progression. Therefore, nonsteroidal anti-inflammatory drugs (NSAIDs) along with their effects on the treatment of inflammation-related diseases, can prevent cancer and its progression by suppressing various inflammatory pathways. Evidence shows that nonsteroidal anti-inflammatory drugs are effective in the prevention and treatment of prostate cancer.
  • 1.1K
  • 13 Dec 2023
Topic Review
Effects of Astaxanthin on Cognitive Function in Humans
Astaxanthin is a potent antioxidant, which has been outlined to be beneficial for cognitive function both in vitro and in vivo. Astaxanthin has been researched in relation to various facets of cognitive function in humans, including episodic memory (visual and verbal stimuli), working memory/short-term memory, processing speed, response inhibition, cognitive shifting, and attention.
  • 1.1K
  • 27 Mar 2024
Topic Review
Propolis and Its Polyphenolic Compounds against Cancer
Propolis (bee glue) is a resinous mixture collected by honeybees from leaf buds and tree sap. It is used by honeybees for sealing holes in honeycombs, and to smooth out the inside walls, reinforcing the structural stability of the hive and protecting the hive entrance from intruders. 
  • 1.1K
  • 20 Sep 2022
Topic Review
Chalcones with Anticancer Activity
Chalcones of natural origin present a pattern of phenolic hydroxyls that originate from the biosynthetic reactions of flavonoids. 
  • 1.1K
  • 17 May 2023
Topic Review
American Black Bear
The American black bear (Ursus americanus) stands as an iconic and widely distributed bear species native to North America. Known for its adaptable nature and diverse habitats, this bear species exhibits a range of coat colors, including black, brown, cinnamon, and even blonde. With a complex social structure and omnivorous diet, the American black bear plays a vital ecological role in the diverse ecosystems it inhabits.
  • 1.1K
  • 04 Feb 2024
Topic Review
Mesenchymal Stem Cell-Derived Extracellular Vesicle and Osteoporosis
Osteoporosis, a metabolic skeletal disorder that results from the imbalance between bone formation and bone resorption, generally occurs in postmenopausal women and older people. The process of bone remodeling is participated by mainly osteoclasts and osteoblasts, together with other cells including osteocytes, bone lining cells, monocytes, chondrocytes, hematopoietic stem cells, and mesenchymal stem cells (MSCs).
  • 1.1K
  • 14 Dec 2021
Topic Review
Flavonoids in Breast Cancer
Breast cancer (BC) remains the second most common cause of cancer-related deaths in women in the US, despite advances in detection and treatment. In addition, breast cancer survivors often struggle with long-term treatment related comorbidities. Identifying novel therapies that are effective while minimizing toxicity is critical in curtailing this disease. Flavonoids, a subclass of plant polyphenols, are emerging as promising treatment options for the prevention and treatment of breast cancer. Recent evidence suggests that in addition to anti-oxidant properties, flavonoids can directly interact with proteins, making them ideal small molecules for the modulation of enzymes, transcription factors and cell surface receptors. Of particular interest is the ability of flavonoids to modulate the tumor associated macrophage function. However, clinical applications of flavonoids in cancer trials are limited. Epidemiological and smaller clinical studies have been largely hypothesis generating. Future research should aim at addressing known challenges with a broader use of preclinical models and investigating enhanced dose-delivery systems that can overcome limited bioavailability of dietary flavonoids. 
  • 1.1K
  • 03 Sep 2021
Topic Review
Treatment of Cisplatin/Platinum-Ineligible Metastatic Urothelial Carcinoma
Metastatic urothelial cancer (mUC) is an aggressive malignancy with limited treatment options. Cisplatin-based chemotherapy has been the standard of care in metastatic urothelial cancer (mUC). However, many patients with comorbidities cannot receive cisplatin or its alternative, carboplatin. ‘Cisplatin-ineligible’ and ‘platinum-ineligible’ patients lacked effective therapy options. However, the combination of enfortumab vedotin (EV), an antibody–drug conjugate targeting Nectin-4, with pembrolizumab (P), an antibody targeting the programmed death-1 (PD-1) immune checkpoint, is changing the status quo of frontline mUC treatment, with potential synergy seen in the EV-103 and EV-302 clinical trials.
  • 1.1K
  • 22 Mar 2024
Topic Review
THAP1 Gene
THAP domain containing 1: The THAP1 gene provides instructions for making a protein that is a transcription factor, which means that it attaches (binds) to specific regions of DNA and regulates the activity of other genes.
  • 1.1K
  • 25 Dec 2020
Topic Review
Smith-Lemli-Opitz Syndrome
Smith-Lemli-Opitz syndrome is a developmental disorder that affects many parts of the body.
  • 1.1K
  • 25 Dec 2020
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