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Topic Review
Friction Dissipative Beam-to-Column Connections for MRFs
The use of friction-based beam-to-column connections (BCCs) for earthquake-resistant moment-resistant frames (MRFs), aimed at eliminating damage to beam end sections due to the development of plastic hinges, has been prevalent since the early 1980s. Different technical solutions have been proposed for steel structures, and some have been designed for timber structures, while a few recent studies concern friction joints employed in reinforced concrete structures. Research aimed at characterizing the behavior of joints has focused on the evaluation of the tribological properties of the friction materials, coefficient of friction, shape and stability of the hysteresis cycles, influence of the temperature, speed of load application, effects of the application method, stability of preload, the influence of seismic excitation characteristics on the structural response, statistical characterization of amplitude, and frequency of the slip excursion during seismic excitation. Studies aimed at identifying the design parameters capable of optimizing performance have focused attention mainly on the slip threshold, device stiffness, and deformation capacity. 
  • 1.1K
  • 27 Mar 2024
Topic Review
HDAC8 in Different Diseases
Histone deacetylases (HDACs), also known as lysine deacetylases (KDACs), belong to the class of zinc (Zn2+)-dependent or nicotinamide adenine dinucleotide (NAD+)-dependent proteolytic enzymes. HDACs participate in transcriptional repression and chromatin condensation mechanisms by removing the acetyl moiety from the acetylated ε-amino group of histone lysines and other non-histone proteins. These enzymes play a pivotal role in the modulation of several cellular pathways such as cell proliferation, apoptosis, neurogenesis and epigenetic regulations. In some cases, HDACs are involved in the occurrence and progression of numerous pathophysiological conditions as well as diseases such as neurological disorders, fibrosis, cancer, metabolic dysfunctions and parasitic infections.
  • 1.1K
  • 23 Sep 2022
Topic Review
Positive and Solidarity Messages Amid the COVID-19 Pandemic
The COVID-19 outbreak has caused significant stress in daily lives, which potentially increases frustration, fear, and resentful emotions. Managing stress is complex, but helps to alleviate negative psychological effects. The COVID-19 outbreak, and its subsequent effects have increased the risk of poor mental health outcomes among the general population, which is a significant challenge for tackling the pandemic. Thus, creating a positive atmosphere in crisis communication is imperative.
  • 1.1K
  • 24 Jun 2022
Topic Review
Municipal Wastewater Treatment Plant Effluents and Microalgae Growth
Municipal wastewater (MWW) provides a promising platform for microalgae cultivation due to its rich content of essential nutrients. Research has showcased the multifaceted benefits of microalgae-based wastewater treatment, from the potent depollution capabilities of these organisms to their biomass potential for ecofriendly applications. A significant advantage lies in the ability of these systems to promote environmental sustainability without producing secondary pollutants, aligning with the circular economy model. 
  • 1.1K
  • 11 Oct 2023
Topic Review
Minimal Models
In theoretical physics, a minimal model or Virasoro minimal model is a two-dimensional conformal field theory whose spectrum is built from finitely many irreducible representations of the Virasoro algebra. Minimal models have been classified and solved, and found to obey an ADE classification. The term minimal model can also refer to a rational CFT based on an algebra that is larger than the Virasoro algebra, such as a W-algebra.
  • 1.1K
  • 07 Nov 2022
Topic Review
Natural Salicylates
Salicylic acid (SA) is a plant hormone which plays a crucial role in the plant defense against various pathogens and abiotic stresses.
  • 1.1K
  • 18 Mar 2021
Topic Review
Albumin Nanovectors
Albumin nanovectors represent one of the most promising carriers recently generated because of the cost-effectiveness of their fabrication, biocompatibility, safety, and versatility in delivering hydrophilic and hydrophobic therapeutics and diagnostic agents.
  • 1.1K
  • 06 Feb 2021
Topic Review
Model for MCMV Disease
Murine cytomegalovirus (MCMV) is a natural pathogen of mice that is present in all wild mice populations and has been used extensively as an animal model for human cytomegalovirus disease. By manipulating the mouse strain, the type of virus used, the inoculation route and the addition of various chemotherapeutic treatments (e.g. immunosuppression), many human diseases can be modeled in a realistic and consistent way. This entry describes the many ways that MCMV has been used to model human disease.
  • 1.1K
  • 03 Feb 2021
Topic Review
Metal-Based Antimicrobial Agents
Due to increasing bacterial resistance to antibiotics, surface coatings of medical devices with antimicrobial agents have come to the fore. These surface coatings on medical devices were basically thin coatings that delaminated from the medical devices due to the fluid environment and the biomechanical activities associated with inservice implants. The conventional methods of manufacturing have been used to alloy metal-based antimicrobial (MBA) agents such as Cu with Ti6Al4V to enhance its antibacterial properties but failed to produce intricate shapes. Additive manufacturing technology, such as laser powder bed fusion (LPBF), could be used to produce the Ti6Al4V–xCu alloy with intricate shapes to enhance osseointegration, but have not been successful for texturing the surfaces of the Ti6Al4V–xCu samples at the nanoscale.
  • 1.1K
  • 02 Apr 2021
Topic Review
AML Diagnosis and Prognosis
The development of molecular studies to define the somatic genetic alterations has revolutionized the diagnostic and therapeutic management of acute myeloid leukemia (AML). AML is a highly heterogenous disease that includes many molecular subtypes; each subtype is heterogeneous both for the presence of variable co-mutations and complex combinations of clones and subclones, changing during disease evolution and in response to treatment. The treatment of AML is changing from standardized schemes of induction and consolidation chemotherapy to tailored approaches according to molecular and genetic profiles and to targeted therapy. Several molecularly targeted therapies have been approved for the treatment of some AML patients, including mutation-specific targeted drugs such as FLT3, IDH1 and IDH2 inhibitors, mutation-independent targeted drugs such as the Bcl2 inhibitor venetoclax, the hedgehog inhibitor glasdegib and the CD33-targeted drug gemtuzumab ozogamicin. Furthermore, recent studies have shown the feasibility of a personalized medicine approach for the treatment of AML patients, where the therapy decisions are guided by the results of genomic studies. 
  • 1.1K
  • 07 Apr 2021
Topic Review
Hepatocellular Carcinoma Heterogeneity
Tumor heterogeneity in liver cancer is a major contributor to the high lethality rate found in patients suffering from this disease. The therapeutic outcomes are drastically affected by this heterogeneity, which complicates patient stratification and response prediction. 
  • 1.1K
  • 03 Jun 2021
Topic Review
Sarcoma Metabolomics
Sarcoma metabolomics is a broadly unexplored field that can offer diverse opportunities. Deeper characterization and a sharper picture of sarcoma metabolic and microenvironment landscape may pave the way for diagnostic and staging refinement and identification of new potential therapeutic targets, resulting in benefits for patients.
  • 1.1K
  • 02 Jul 2021
Topic Review
Renal Insufficiency
Renal impairment is defined as serum creatinine (sCr) above the upper normal limit of 2 mg/dL or as an estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73 m2.
  • 1.1K
  • 25 Oct 2021
Topic Review
Fukushima Accident: Perspectives on a Severe Accident Consequences
Scientific issues that draw international attention from the public and experts during the last 10 years after the Fukushima accident are discussed. An assessment of current severe accident analysis methodology, impact on the views of nuclear reactor safety, dispute on the safety of fishery products, discharge of radioactive water to the ocean, status of decommissioning, and needs for long-term monitoring of the environment are discussed.
  • 1.1K
  • 27 Oct 2021
Topic Review
Waste Natural Polymers
 Waste natural polymers have received much attention as renewable, biodegradable, non-toxic and low-cost filler in polymer composites. In order to exploit the high potential for residual natural loading in latex composites, different types of surface modification techniques have been applied. This review discusses the preparation and characterization of the modified waste natural fillers for latex-based composites. The potency of the waste natural filler for the latex-based composites was explored with a focus on the mechanical, thermal, biodegradability and filler–latex interaction.
  • 1.1K
  • 12 Nov 2021
Topic Review
Role of Partial Splenectomy in Hematologic Childhood Disorders
The spleen is a secondary lymphoid organ that belongs to the reticular-endothelial system, directly connected to blood circulation. The spleen is greatly involved in the immune response, especially against capsulated bacteria. Splenectomy plays a fundamental role in the treatment of numerous pediatric hematologic disorders. Taking into account all the possible complications (especially infections) linked to this procedure, partial splenectomy has been proposed as a treatment that allows the reduction of infectious risk. This approach has proven safe and feasible in most patients, but multicentric and prospective studies are necessary to more accurately define the indications for performing partial splenectomy.
  • 1.1K
  • 16 Nov 2021
Topic Review
Huperzine A and Its Neuroprotective Molecular Signaling
The neuroprotective effects of HupA treatment result from cholinergic signaling, which increases Wnt signaling, nonamyloidogenic processing of the amyloid precursor protein (APP), neurotrophic factor expression, synaptic activity, antagonism of the N-methyl-D-aspartate (NMDA) receptor (NMDAR), modulation of ROS, iron homeostasis and neuronal survival.
  • 1.1K
  • 24 Nov 2021
Topic Review
The Selected Rare B-Cell Lymphoproliferative Disorders
The updated 4th edition WHO classification of lymphoid malignancies and certain lymphoproliferative disorders (LPD), released in 2016, contains pivotal new terminology and information that is important for both radiologists and oncologists to understand. In spite of these updates, some LPDs included within this update have been rarely discussed in radiology literature. Many of these disorders have distinct clinical and imaging features, overlapping with more common disorders. The purpose of this entry is provide an overview for radiologists regarding certain rare LPDs.
  • 1.1K
  • 03 Dec 2021
Topic Review
Land Use for Critical Cemeteries in Central Ecuador
Cemeteries are sites for the final disposal of human bodies that constitute a source of contamination of soil and water as a result of the cadaveric decomposition generated. In addition, land use conflicts were encountered in the cemetery grounds. It is concluded that the existing cemeteries should be subjected to more detailed environmental analysis and subsequently should be treated as security landfills in the closure and post-closure stage. Also, it has been concluded that the cemeteries should not be located in urban or peri-urban areas.
  • 1.1K
  • 11 Feb 2022
Topic Review
Medicinal and Aromatic Plants against Obesity and Arthritis
Obesity is a significant health concern, as it causes a massive cascade of chronic inflammations and multiple morbidities. Rheumatoid arthritis and osteoarthritis are chronic inflammatory conditions and often manifest as comorbidities of obesity. Adipose tissues serve as a reservoir of energy as well as releasing several inflammatory cytokines (including IL-6, IFN-γ, and TNF-α) that stimulate low-grade chronic inflammatory conditions such as rheumatoid arthritis, osteoarthritis, diabetes, hypertension, cardiovascular disorders, fatty liver disease, oxidative stress, and chronic kidney diseases. Dietary intake, low physical activity, unhealthy lifestyle, smoking, alcohol consumption, and genetic and environmental factors can influence obesity and arthritis. Current arthritis management using modern medicines produces various adverse reactions. Medicinal plants have been a significant part of traditional medicine, and various plants and phytochemicals have shown effectiveness against arthritis and obesity; however, scientifically, this traditional plant-based treatment option needs validation through proper clinical trials and toxicity tests. In addition, essential oils obtained from aromatic plants are being widely used for complementary therapy (e.g., aromatherapy, smelling, spicing, and consumption with food) against arthritis and obesity; scientific evidence is necessary to support their effectiveness.
  • 1.1K
  • 08 Mar 2022
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