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Topic Review
LSTM-Based Stock Prediction and Selection
A great deal of attention has been devoted to the use of neural networks in portfolio management, particularly in the prediction of stock prices. First, data from historical quotes and technical and fundamental indicators are used in the long short-term memory (LSTM) network to provide good predictions. Second, the EMN strategy allows for the funding of long-position stocks by short-sell-position stocks, thus hedging the market risk.
  • 1.1K
  • 04 Dec 2023
Topic Review
Student and Instructor Ratings in Geographic Information Systems
Geographic information system (GIS) education empowers engineering students to make informed decisions, integrate comprehensive data, and communicate effectively through maps and visualizations. In GIS education, it is common to employ problem-based learning, which can benefit from the advantages of peer assessment methods.
  • 1.1K
  • 29 Jan 2024
Topic Review
Agroecological Nutrient Management Strategy
Rice self-sufficiency is central to Indonesia’s agricultural development, but the country is increasingly challenged by population growth, climate change, and arable land scarcity. Agroecological nutrient management offers solutions though optimized fertilization, enhanced organic matter and biofertilizer utilizations, and improved farming systems and water management.
  • 1.1K
  • 31 Jan 2024
Topic Review
[M(Salen)] Complexes, Their Polymers, and Composites Based Thereon
The polymers of square–planar complexes of 3d metal (M) atoms with tetradentate N2O2 Schiff base ligands, the so-called salen complexes ([M(Salen)]), are characterized by high redox conductivity, electrochromic behavior, and selective catalytic activity in heterogeneous reactions (including electrocatalysis). An important advantage of these polymers is also their high thermal stability (up to 350 °C) compared with monomer complexes due to their conductive polymer matrix. It is also expected that the synthesis of nanocomposites based on poly-[M(Salen)] and various forms of carbon (mesoporous and activated carbon), including nanostructured ones (carbon nanotubes, graphene, and nanoglobular carbon), will lead to the development of materials with improved energetic, catalytic, and other characteristics. This quality improvement is achieved due to the uniform distribution of the polymer on the surface of the carbon component of the composite material, which has a high specific surface area, electrical conductivity, and mechanical properties (strength, elasticity).
  • 1.1K
  • 18 Feb 2024
Topic Review
Aptamer Technologies in Neuroscience
Aptamers developed using in vitro Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology are single-stranded nucleic acids 10–100 nucleotides in length. Their targets, often with specificity and high affinity, range from ions and small molecules to proteins and other biological molecules as well as larger systems, including cells, tissues, and animals. Aptamers often rival conventional antibodies with improved performance, due to aptamers’ unique biophysical and biochemical properties, including small size, synthetic accessibility, facile modification, low production cost, and low immunogenicity. Therefore, there is sustained interest in engineering and adapting aptamers for many applications, including diagnostics and therapeutics. 
  • 1.1K
  • 06 Mar 2024
Topic Review
Sturm-Liouville Theory
In mathematics and its applications, a classical Sturm–Liouville equation, named after Jacques Charles François Sturm (1803–1855) and Joseph Liouville (1809–1882), is a real second-order linear differential equation of the form where y is a function of the free variable x. Here the functions p(x) > 0 has a continuous derivative, q(x), and w(x) > 0 are specified at the outset, and in the simplest of cases are continuous on the finite closed interval [a,b]. In addition, the function y is typically required to satisfy some boundary conditions at a and b. The function w(x), which is sometimes called r(x), is called the "weight" or "density" function. The value of λ is not specified in the equation; finding the values of λ for which there exists a non-trivial solution of (1) satisfying the boundary conditions is part of the problem called the Sturm–Liouville problem (S L). Such values of λ when they exist are called the eigenvalues of the boundary value problem defined by (1) and the prescribed set of boundary conditions. The corresponding solutions (for such a λ) are the eigenfunctions of this problem. Under normal assumptions on the coefficient functions p(x), q(x), and w(x) above, they induce a Hermitian differential operator in some function space defined by boundary conditions. The resulting theory of the existence and asymptotic behavior of the eigenvalues, the corresponding qualitative theory of the eigenfunctions and their completeness in a suitable function space became known as Sturm–Liouville theory. This theory is important in applied mathematics, where S–L problems occur very commonly, particularly when dealing with linear partial differential equations that are separable.
  • 1.1K
  • 01 Dec 2022
Topic Review
Lipid-Based mRNA Nanoparticles
Messenger RNA (mRNA) is being extensively used in gene therapy and vaccination due to its safety over DNA, in the following ways: its lack of integration risk, cytoplasmic expression, and transient expression compatible with fine regulations. However, clinical applications of mRNA are limited by its fast degradation by nucleases, and the activation of detrimental immune responses. Advances in mRNA applications, with the recent approval of COVID-19 vaccines, were fueled by optimization of the mRNA sequence and the development of mRNA delivery systems. Although delivery systems and mRNA sequence optimization have been abundantly reviewed, understanding of the intracellular processing of mRNA is mandatory to improve its applications. 
  • 1.1K
  • 12 Jul 2021
Topic Review
Molecular Cellular Level and Genetic Material of Donkeys
Lack of archaeological and whole-genome diversity data has restricted current knowledge of the evolutionary history of donkeys. With the advancement of science and technology, the discovery of archaeological evidence, the development of molecular genetics, and the improvement of whole-genome sequencing technology, the in-depth understanding of the origin and domestication of donkeys has been enhanced. The donkey is an equine animal of the order Odd-toed ungulates. Among common livestock animals, it occupies an important place in the history of human transportation. It is often used as a pack animal for long-distance transportation due to its good packability, durability, and traction, thereby greatly facilitating commerce among regions. With the advancement of modern technology, mechanization of agriculture, and rapid development of transportation, the service value of donkeys has decreased. In economically developed regions (such as Italy and America), donkeys are more often bred as ornamental pets. However, in fast-growing developing countries (such as China), donkeys are more often used as a source of meat for mass breeding because of their rich intra-muscular fat and superior taste. Donkey milk is being sold as a commodity for the treatment of infants, the sick and the elderly who are physically weak. Donkey milk is rich in nutrients and is whey-protein milk, which is the closest to human milk and can be used as a substitute for breast milk, and has various functions such as regulating immunity and promoting growth. The scale of donkey breeding and the quality of donkey breeds are also decreasing in developed areas; however, the size of donkey inventories continues to slowly increase in developing areas.
  • 1.1K
  • 05 Dec 2022
Topic Review
Pantanal Cat
The Pantanal Cat, scientifically known as Leopardus colocola braccatus, is a captivating and elusive felid species native to the diverse ecosystems of the Pantanal region in South America. This small wild cat, a subspecies of the Colocolo, possesses a distinctive and visually striking coat pattern that aids in its camouflage within the lush landscapes of the Pantanal wetlands. The Pantanal Cat's mysterious nature and adaptation to its unique habitat make it an intriguing subject for study in the realm of wildlife biology and conservation.
  • 1.1K
  • 02 Feb 2024
Topic Review
Oxygen Homeostasis
The unique biology of the intestinal epithelial barrier is linked to a low baseline oxygen pressure (pO2), characterised by a high rate of metabolites circulating through the intestinal blood and the presence of a steep oxygen gradient across the epithelial surface. These characteristics require tight regulation of oxygen homeostasis, achieved in part by hypoxia-inducible factor (HIF)-dependent signalling. Furthermore, intestinal epithelial cells (IEC) possess metabolic identities that are reflected in changes in mitochondrial function. In recent years, it has become widely accepted that oxygen metabolism is key to homeostasis at the mucosae. In addition, the gut has a vast and diverse microbial population, the microbiota. Microbiome–gut communication represents a dynamic exchange of mediators produced by bacterial and intestinal metabolism. The microbiome contributes to the maintenance of the hypoxic environment, which is critical for nutrient absorption, intestinal barrier function, and innate and/or adaptive immune responses in the gastrointestinal tract.
  • 1.1K
  • 22 Sep 2021
Topic Review
Ceramic Composites in Aeronautics and Aerospace
The quest for increased performance in the aeronautical and aerospace industries has provided the driving force and motivation for the research, investigation, and development of advanced ceramics. Special emphasis is therefore attributed to the ability of fine ceramics to fulfill an attractive, extreme, and distinguishing combination of application requirements. This research provides an extensive discussion and review of the thermal protection systems (TPS), thermal protection barriers (TBC), and dielectric barrier discharge (DBD) plasma actuators, and discusses the concept of multifunctional advanced ceramics for future engineering needs and perspectives.
  • 1.1K
  • 02 Feb 2023
Topic Review
Pol θ as a Central Player in TMEJ
DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break (DSB) repair and DNA translesion synthesis. During Pol θ-mediated end joining (TMEJ), Pol θ aligns resected 3′-single-stranded DNA ends based on microhomology, fills DNA gaps and generates repair products with deletions of nonhomologous sequences flanking the DSB site.
  • 1.1K
  • 22 Feb 2023
Topic Review
Probiotics in Metabolic Syndrome
The aim of this systematic review is to evaluate whether the use of probiotics has any effect on the components of metabolic syndrome (MetS) before patients develop type 2 diabetes. A qualitative systematic review, following the Cochrane methodology, and a comprehensive literature search of randomized controlled trials (RCTs) were conducted in PubMed and Scopus from inception until 4 July 2019. According to our inclusion criteria, nine clinical studies were finally analyzed, corresponding to six RCTs. Probiotics intake in patients with MetS resulted in improvements in body mass index, blood pressure, glucose metabolism, and lipid profile in some studies. Regarding inflammatory biomarkers, probiotics also positively affected the soluble vascular cell adhesion molecule 1 (sVCAM-1), interleukine-6 (IL-6), tumor necrosis factor α (TNF-α), vascular endothelial growth factor (VEGF), and thrombomodulin. Despite the diversity of the published studies, the intake of probiotics for patients with MetS may offer a discrete improvement in some of the clinical characteristics of the MetS and a decrease in inflammatory biomarkers. Nevertheless, these beneficial effects seem to be marginal compared to drug therapy and a healthy lifestyle and clinically non-relevant.
  • 1.1K
  • 30 Oct 2020
Topic Review
15q24 Microdeletion
15q24 microdeletion is a chromosomal change in which a small piece of chromosome 15 is deleted in each cell. The deletion occurs on the long (q) arm of the chromosome at a position designated q24.
  • 1.1K
  • 26 Aug 2021
Topic Review
MC1R Gene
Melanocortin 1 receptor
  • 1.1K
  • 23 Dec 2020
Topic Review
Mesoporous Silica-Based Hybrid Materials
Hybrid organic-inorganic catalysts have been extensively investigated by several research groups in the last decades, as they allow combining the structural robust-ness of inorganic solids with the versatility of organic chemistry. Within the field of hybrid catalysts, synthetic strategies based on silica are among the most exploitable, due to the convenience of sol-gel chemistry, to the array of silylderivative precursors that can be synthesized and to the number of post-synthetic functionalization strategies available, amongst others. Exemplificative studies involving mono- and multi-functional silica-based hybrid catalysts featuring different types of active sites (acid, base, redox) have been studied. Materials obtained through different approaches are described and their properties, as well as their catalytic performances, are compared in the literature.
  • 1.1K
  • 25 Feb 2021
Topic Review
Anesthesiology
Anesthesia literally means without sensation. There are a number of different types of anesthesia. They allow for safe and comfortable conscious or unconscious experiences during a surgical procedure.
  • 1.1K
  • 10 May 2021
Topic Review
Gap-Juntions in the Oocyte
Connexins are proteins that form membrane channels and gap-junctions, and more precisely, these proteins enable the exchange of some ions and molecules, and therefore they do play a fundamental role in the communication between the oocyte and accompanying cells.
  • 1.1K
  • 11 Jun 2021
Topic Review
Virtual Reality Therapy for Depression
Virtual reality (VR) describes a family of technologies which immerse users in sensorily-stimulating virtual environments. Such technologies have increasingly found applications in the treatment of neurological and mental health disorders. Depression, anxiety, and other mood abnormalities are of concern in the growing older population—especially those who reside in long-term care facilities (LTCFs).
  • 1.1K
  • 11 Jun 2021
Topic Review
Entomopathogenic Microorganisms in Animals Protection
The control of ectoparasites requests the development of novel strategies and, among them, the use of entomopathogenic microorganisms appears as a promising tool to achieve an eco-friendly approach. 
  • 1.1K
  • 29 Jun 2021
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