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Topic Review
Developments in FRET- and BRET-Based Biosensors
Resonance energy transfer technologies have achieved great success in the field of analysis. Particularly, fluorescence resonance energy transfer (FRET) and bioluminescence resonance energy transfer (BRET) provide strategies to design tools for sensing molecules and monitoring biological processes, which promote the development of biosensors.
  • 1.6K
  • 06 Jan 2023
Topic Review
The Association between Biofilm Formation and Antimicrobial Resistance
Biofilm has garnered a lot of interest due to concerns in various sectors such as public health, medicine, and the pharmaceutical industry. Biofilm-producing bacteria show a remarkable drug resistance capability, leading to an increase in morbidity and mortality.
  • 1.6K
  • 22 Jul 2022
Topic Review
Decellularized Colorectal Cancer Matrices as Bioactive Scaffolds
More than a physical structure providing support to tissues, the extracellular matrix (ECM) is a complex and dynamic network of macromolecules that modulates the behavior of both cancer cells and associated stromal cells of the tumor microenvironment (TME). Over the last few years, several efforts have been made to develop new models that accurately mimic the interconnections within the TME and specifically the biomechanical and biomolecular complexity of the tumor ECM. Particularly in colorectal cancer, the ECM is highly remodeled and disorganized and constitutes a key component that affects cancer hallmarks, such as cell differentiation, proliferation, angiogenesis, invasion and metastasis. Therefore, several scaffolds produced from natural and/or synthetic polymers and ceramics have been used in 3D biomimetic strategies for colorectal cancer research. Nevertheless, decellularized ECM from colorectal tumors is a unique model that offers the maintenance of native ECM architecture and molecular composition.
  • 1.6K
  • 18 Jan 2022
Topic Review
Commercial Applications of Chlorella sp. and Spirulina sp.
Microalgae are a large and polyphyletic group of O2-evolving photosynthetic microorganisms, mostly aquatic, comprising prokaryotic cyanobacteria and eukaryotic members. Estimates of the world microalgal production are around 50.000 t/year, Chlorella sp. and Spirulina sp. accounting for more than 90% of the total microalgal biomass production.  These microorganisms have been widely recognized for their nutritional and therapeutic properties; therefore, a significant growth of their market is expected, especially in the nutraceutical, food, and beverage segments.
  • 1.6K
  • 14 Aug 2023
Topic Review
Capillary-Driven Flow Device
The capillary flow device works on the principle of capillary-driven flow microfluidics and allows detection by multiple microchannels in a single microchip via smartphone imaging/portable detectors. Compared to other types of devices such as dipsticks and paper microfluidic devices, this device is fabricated with cheaper materials, coated with minute amounts of reagents and offers multiplexity on a single microchip. The sample is loaded into the microchannels via capillary force, which eliminates the requirement of external/internal fluidic mechanisms or controls. A capillary-driven flow device was developed in this study which is simple to operate and allows loading multiple samples in a single device.
  • 1.6K
  • 30 Oct 2020
Topic Review
Hibiscus, Rooibos, Yerba Mate in Glycoxidation and Neurodegeneration
The well-known food safety associated with the consumption of hibiscus, rooibos, or yerba mate, and the acceptance of these herbs linked to pleasant taste, have elicited great interest in defining their nutraceutical potential. These plants produce several bioactive metabolites, have a pleasant taste, and a long-lasting history as safe foods. These plants produce several bioactive metabolites, have a pleasant taste, and a long-lasting history as safe foods. The literature on hibiscus, rooibos, and yerba mate teas in the context of nutritional strategies for the attenuation of oxidative stress-related glycoxidation and neurodegeneration was reviewed, and, here, Alzheimer’s Disease is approached as an example. The focus is given to mechanisms of glycation inhibition, as well as neuroprotective in vitro effects, and, in animal studies, to frame interest in these plants as nutraceutical agents related to current health concerns.
  • 1.6K
  • 23 Jun 2022
Topic Review
Factors Influencing CO2 Biofixation by Microalgae
The production of microalgal biomass is highly influenced by the suitability of microalgae strains, CO2, light, pH, culture system, temperature, and nutrients. The sources of CO2 and nutrients for microalgal cultivation can be flue gas and wastewater, respectively. Therefore, many studies have investigated whether flue gas and wastewater can be integrated with microalgal cultivations, to achieve not only CO2 reduction, but also CO2 reuse for microalgal biomass conversion to produce biofuels. Flue gas and wastewater can also be treated by microalgal cultivations to obtain environmentally friendly and health-friendly effects. In the process of microalgae cultivation, one single factor does not affect the growth of microalgae; it is often the interaction of multiple factors. Therefore, keeping the performance of long-term and stable microalgal cultivation will determine the microalgal growth, especially outdoor cultivation.
  • 1.6K
  • 10 Jan 2022
Topic Review
Syndecans and Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because pa-tients rarely express symptoms in initial stages, which prevents early detection and diagnosis. Syndecans, a subfamily of proteoglycans, are involved in many physiological processes includ-ing cell proliferation, adhesion, and migration. Syndecans are physiologically found in many cell types and their interactions with other macromolecules enhance many pathways. In particu-lar, extracellular matrix components, growth factors, and integrins collect the majority of syndecans associations acting as biochemical, physical, and mechanical transducers. Syndecans are transmembrane glycoproteins, but occasionally their extracellular domain can be released from the cell surface by the action of matrix metalloproteinases, converting them into soluble molecules that are capable of binding distant molecules such as extracellular matrix (ECM) components, growth factor receptors, and integrins from other cells.
  • 1.6K
  • 02 Mar 2021
Topic Review
Fungal Cell Factories for Proteins
Filamentous fungi are a large and diverse taxonomically group of microorganisms found in all habitats worldwide. They grow as a network of cells called hyphae. Since filamentous fungi live in very diverse habitats, they produce different enzymes to degrade material for their living, for example hydrolytic enzymes to degrade various kinds of biomasses. Moreover, they produce defense proteins (antimicrobial peptides) and proteins for attaching surfaces (hydrophobins). Many of them are easy to cultivate in different known setups (submerged fermentation and solid-state fermentation) and their secretion of proteins and enzymes are often much larger than what is seen from yeast and bacteria. Therefore, filamentous fungi are in many industries the preferred production hosts of different proteins and enzymes. Edible fungi have traditionally been used as food, such as mushrooms or in fermented foods. New trends are to use edible fungi to produce myco-protein enriched foods. 
  • 1.6K
  • 12 Jul 2022
Topic Review
Microbial Electrolysis Cell
Carbon constraints, as well as the growing hazard of greenhouse gas emissions, have accelerated research into all possible renewable energy and fuel sources. Microbial electrolysis cells (MECs), a novel technology able to convert soluble organic matter into energy such as hydrogen gas, represent the most recent breakthrough. 
  • 1.6K
  • 09 Aug 2021
Topic Review
Functions of Microbial Pigments
Microbial pigments play multiple roles in the ecosystem construction, survival, and fitness of all kinds of organisms. Considerably, microbial (bacteria, fungi, yeast, and microalgae) pigments offer a wide array of food, drug, colorants, dyes, and imaging applications.
  • 1.6K
  • 10 Oct 2023
Topic Review
Mitochondrial Transplantation
Mitochondria are the major source of intercellular bioenergy in the form of ATP. They are necessary for cell survival and play many essential roles such as maintaining calcium homeostasis, body temperature, regulation of metabolism and apoptosis.
  • 1.6K
  • 26 May 2021
Topic Review
Green Cerium Oxide Nanoparticles
Green synthesized cerium oxide nanoparticles (GS-CeO2 NPs) have a unique size, shape, and biofunctional properties and are decorated with potential biocompatible agents to perform various therapeutic actions, such as antimicrobial, anticancer, antidiabetic, and antioxidant effects and drug delivery, by acquiring various mechanistic approaches at the molecular level.
  • 1.6K
  • 02 Mar 2023
Topic Review
Two-Phase Fermentation Systems for Microbial Production of Terpenes
Microbial cell factories, renowned for their economic and environmental benefits, have emerged as a key trend in academic and industrial areas, particularly in the fermentation of natural compounds. Among these, plant-derived terpenes stand out as a significant class of bioactive natural products. The large-scale production of such terpenes, exemplified by artemisinic acid—a crucial precursor to artemisinin—is now feasible through microbial cell factories. In the fermentation of terpenes, two-phase fermentation technology has been widely applied due to its unique advantages. It facilitates in situ product extraction or adsorption, effectively mitigating the detrimental impact of product accumulation on microbial cells, thereby significantly bolstering the efficiency of microbial production of plant-derived terpenes. 
  • 1.6K
  • 02 Apr 2024
Topic Review
Bioproducts from the Microalgae-Bacteria Interaction
In nature, interactions between bacteria and microalgae play an indispensable role in maintaining the integrity of the aquatic ecosystem through networks of interactions such as competition and mutualism. In fact, in the wild, the growth of algae is consistently associated with the growth of other microorganisms, especially bacteria. Axenic culture systems and sterilization of culture media in large-scale production of microalga are not economically feasible. Therefore, the characterization of associated heterotrophs in algae culture systems is an important step since bacteria may use compounds excreted by algae, increasing the availability of trace elements and solubility of nutrients, making them more bioavailable for microalgae. In addition, they can help to reduce the saturation of dissolved O2. In microalgae cultivation, it is well known that dissolved O2 can attain inhibitory levels.
  • 1.6K
  • 25 Nov 2022
Topic Review
Evolution Road of Seaweed Aquaculture
Seaweeds (marine macroalgae) are autotrophic organisms capable of producing many compounds of interest. For a long time, seaweeds have been seen as a great nutritional resource, primarily in Asian countries to later gain importance in Europe and South America, as well as in North America and Australia. It has been reported that edible seaweeds have a nutritional value along with a low caloric input and with the presence of proteins, minerals (iron and calcium), vitamins, structural polysaccharides (fibers), omega-6 and omega-3 unsaturated fatty acids. Moreover, they have plenty of bioactive molecules that can be applied in nutraceutical, pharmaceutical and cosmetic areas. There are historical registers of harvest and cultivation of seaweeds but with the increment of the studies of seaweeds and their valuable compounds, their aquaculture has increased. The methodology of cultivation varies from onshore to offshore. Seaweeds can also be part of integrated multi-trophic aquaculture (IMTA), which has great opportunities but is also very challenging to the farmers. This multidisciplinary field applied to the seaweed aquaculture is very promising to improve the methods and techniques; this area is developed under the denominated industry 4.0.  Aquaculture consists in the creation or culture of aquatic organisms (in this case, Marine Macroalgae or Seaweeds), through the application of techniques designed to increase the production of these same organisms, in addition to the natural capabilities of the environment
  • 1.6K
  • 06 Apr 2021
Topic Review
Antioxidants and Human Oocyte Mitochondrial
Mitochondria produce adenosine triphosphate (ATP) while also generating high amounts of reactive oxygen species (ROS) derived from oxygen metabolism. ROS are small but highly reactive molecules that can be detrimental if unregulated. While normally functioning mitochondria produce molecules that counteract ROS production, an imbalance between the amount of ROS produced in the mitochondria and the capacity of the cell to counteract them leads to oxidative stress and ultimately to mitochondrial dysfunction. This dysfunction impairs cellular functions through reduced ATP output and/or increased oxidative stress. Mitochondrial dysfunction may also lead to poor oocyte quality and embryo development, ultimately affecting pregnancy outcomes. Improving mitochondrial function through antioxidant supplementation may enhance reproductive performance. Recent studies suggest that antioxidants may treat infertility by restoring mitochondrial function and promoting mitochondrial biogenesis. Antioxidant properties of coenzyme-Q10, resveratrol, melatonin and several vitamins have been evaluated in the human oocyte, although their direct action on mitochondrial function has yet to be elucidated.
  • 1.5K
  • 10 Jan 2021
Topic Review
Bionanotechnology in Food Packaging
Bionanotechnology, as a tool for incorporation of biological molecules into nanoartifacts, is gaining more and more importance in the field of food packaging. It offers an advanced expectation of food packaging that can ensure longer shelf life of products and safer packaging with improved food quality and traceability. 
  • 1.5K
  • 19 Feb 2021
Topic Review
Physical Methods for Biodegradable Polymers
Biodegradable polymers are materials that can decompose through the action of various environmental microorganisms, such as bacteria and fungi, to form water and carbon dioxide. The biodegradability characteristics have led to a growing demand for the accurate and precise determination of the degraded polymer composition. With the advancements in analytical product development, various analytical methods are available and touted as practical and preferable methods of bioanalytical techniques, which enable the understanding of the complex composition of biopolymers such as polyhydroxyalkanoates and poly(lactic acid).
  • 1.5K
  • 14 Dec 2022
Topic Review
Production and Application of Hyaluronic Acid
Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only in maintaining tissue hydration but also in cellular processes such as proliferation, differentiation, and the inflammatory response. HA has demonstrated its efficacy as a powerful bioactive molecule not only for skin antiaging but also in atherosclerosis, cancer, and other pathological conditions.
  • 1.5K
  • 25 Jun 2023
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