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Topic Review
Sampling and Analysis of Airborne Pesticides
The escalating utilization of pesticides has led to pronounced environmental contamination, posing a significant threat to agroecosystems. The extensive and persistent global application of these chemicals has been linked to a spectrum of acute and chronic human health concerns.
  • 1.1K
  • 24 Nov 2023
Topic Review
Histoplasmosis in Solid Organ Transplantation
Histoplasma capsulatum, the etiological agent for histoplasmosis, is a dimorphic fungus that grows as a mold in the environment and as a yeast in human tissues. It has a broad global distribution with shifting epidemiology. While in immunocompetent individuals infection is usually self-resolving, solid organ transplant recipients are at increased risk of symptomatic disease with dissemination to extrapulmonary tissue. Diagnosis of histoplasmosis relies on direct observation of the pathogen (histopathology, cytopathology, and culture) or detection of antigens, antibodies, or nucleic acids. All transplant recipients with histoplasmosis warrant therapy, though the agent of choice and duration of therapy depends on the severity of disease.
  • 1.1K
  • 05 Mar 2024
Topic Review
Cellular Automata in Modeling and Predicting Urban Densification
The creation of an accurate simulation of future urban growth is considered to be one of the most important challenges of the last five decades that involves spatial modeling within a GIS environment. Even though built-up densification processes, or transitions from low to high density, are critical for policymakers concerned with limiting sprawl, the literature on models for urban study reveals that most of them focus solely on the expansion process. Although the majority of these models have similar goals, they differ in terms of implementation and theoretical assumptions. Cellular automata (CA) models have been proven to be successful at simulating urban growth dynamics and projecting future scenarios at multiple scales.
  • 1.1K
  • 05 Aug 2022
Topic Review
Collar
In finance, a collar is an option strategy that limits the range of possible positive or negative returns on an underlying to a specific range. A collar strategy is used as one of the ways to hedge against possible losses and it represents long put options financed with short call options. The collar combines the strategies of the protective put and the covered call.
  • 1.1K
  • 24 Nov 2022
Topic Review
Pesticide Residues and Bee Mortality
Honeybee health can be compromised not only by infectious and infesting diseases, but also by the acute or chronic action of certain pesticides. In recent years, there have been numerous reports of colony mortality by Italian beekeepers, and it was deemed necessary to draw up national guidelines with the aim of standardizing sampling active ties. In this paper, we present the results of a survey carried out in Italy from 2015 to 2019, following these guidelines. Residues of 150 pesticides in 696 samples were analyzed by LC-MS/MS and GC-MS/MS. On average, 50% of the honeybee samples were positive for one or more pesticides, insecticides being the most frequently detected, followed by organophosphates and neonicotinoids.
  • 1.1K
  • 30 Oct 2020
Topic Review
N2O Formation in Rice Plants
Rice plants in paddy emit a substantial amount of nitrous oxide (N2O), a potent greenhouse gas to the atmosphere. Field-based studies that report N2O fluxes from the paddy consider that the N2O emitted by rice plant is of microbial origin in the soil. Recent studies on other plants suggest that vegetation are also a natural source of N2O. However, the mechanisms of N2O formation in plants are unknown; consequently, the rice plant is regarded as a channel to transport soil micro-organisms produced N2O. The hypothesis that rice plants are a medium to transport soil produced N2O is based on flux measurement methods. However, more robust methods like 15N isotope analysis methods consider plants are a natural source of N2O. This led us to search for the possible pathway of N2O formation in rice plants cells.  Herein, we have proposed a potential pathway of N2O formation in rice plants.
  • 1.1K
  • 01 Nov 2020
Topic Review
Nutritional Strategies in Prediabetes
The risk of developing type 2 diabetes mellitus (T2DM) increases with existence of one of two precursor states—impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). IFG is defined as a fasting plasma glucose (FPG) concentration of ≥6.1 but <7.0 mmol/L, whereas IGT is defined as an FPG concentration of <7.0 mmol/L and a 2-h post-load plasma glucose concentration of ≥7.8 but <11.1 mmol/L following an oral glucose challenge . A glycated hemoglobin A1c (HbA1c) level of 5.7–6.4% has been included in the existing American Diabetes Association (ADA)’s criteria for high diabetes risk since 2010 .Prediabetes is broadly defined as blood glucose levels above normal but below that of diabetes . Prediabetes is typically an umbrella term encompassing IGT, IFG as well as elevated HbA1c levels—all of which are considered substantial risk factors for progression to overt diabetes.
  • 1.1K
  • 16 Oct 2020
Topic Review
Responsible Innovation in SMEs
SMEs, which represent 95% of the workforce, are considered responsible for approximately 60% of all greenhouse gas emissions and approximately 70% of global pollution [20, 98]. Thus, the concern for the care of natural resource degradation, climate change, economic progress, and societal well-being has promoted a scientific debate and social attention. In light of the current business situation, responsible innovation refers to a new approach to innovation governance that emphasizes the common and recurrent logic of sustainable development, adjusted to the needs of society [30]. However, its integration into industry is still in its infancy, and even more so when it comes to small and medium-sized enterprises (SMEs). The aim of this research is to use a systematic literature review to develop a conceptual model for responsible innovation and its relationship with SME performance, in connection with sustainable innovation and corporate social responsibility practices. A bibliometric analysis of 102 articles collected between 2000 and April 2020 from the Web of Science database was used, in addition to the systematic literature review using the Gephi and NVivo software. The study presents an overview of the articles, authors, and most influential journals and research clusters identified, and provides a solid conceptual framework to be applied in this field and in the context of SMEs.
  • 1.1K
  • 23 Dec 2020
Topic Review
Complement Factor I Deficiency
Complement factor I deficiency is a disorder that affects the immune system. People with this condition are prone to recurrent infections, including infections of the upper respiratory tract, ears, skin, and urinary tract. They may also contract more serious infections such as pneumonia, meningitis, and sepsis, which may be life-threatening.
  • 1.1K
  • 24 Dec 2020
Topic Review
Cement Substitute in Concrete Manufacturing
Striving for reduction of production costs and constraints on natural resources cause the use of waste materials as substitutes of traditional raw materials to become increasingly important. Dynamic development of sewerage systems and sewage treatment plants observed over the recent years leads to increase of mass of the produced sewage sludge. According to the Waste Law, the municipal sewage sludge can be used if it is properly stabilized, e.g., through thermal processing. This process results in significant quantities of fly ash which must be properly utilized. The description presents a brief highlight of solution of the abovementioned problem — the possibility of application of fly ash wastes as a cement substitute in the concrete manufacturing. If a predefined quantity of cement is replaced by the fly ash, then one can obtain cement composite with good strength parameters. This assumption is confirmed by the investigations.
  • 1.1K
  • 23 Apr 2021
Topic Review
Shear Energy on Harvesting Tools
Smart and precise agriculture has increasingly been developed in the last decade, and with that, the idea of optimizing the tools commonly used in this field for harvesting tasks. One way to improve these devices, particularly cutting tools conceived for harvesting purposes, is to measure the shear energy consumption required for a particular plant. The proposed methodology aims to establish both a design criterion for cutting grippers and a quantifiable way to evaluate and classify a harvesting tool for a specific crop.
  • 1.1K
  • 29 Apr 2021
Topic Review
MicroRNAs in Metastasis
Metastasis is the process whereby cancer cells migrate from the primary tumour site to colonise the surrounding or distant tissue or organ. Metastasis is the primary cause of cancer-related mortality and approximately half of all cancer patients present at diagnosis with some form of metastasis. MicroRNAs (miRNAs), a class of small (19-25 nucleotides) non-coding single-strand RNAs, regulate gene expression and play an important role in cancer development and progression including in the metastatic process. 
  • 1.1K
  • 19 Jul 2021
Topic Review
Cloning Coconut via Somatic Embryogenesis
Coconut [Cocos nucifera L.] is often called “the tree of life” because of its many uses in the food, beverage, medicinal, and cosmetic industries. Currently, more than 50% of the palms grown throughout the world are senile and need to be replanted immediately to ensure production levels meet the present and increasing demand for coconut products.
  • 1.1K
  • 19 Oct 2021
Topic Review
Framework of Efficient Energy Management System
The traditional power system is inefficient because it entirely depends on fossil fuels, and having centralized generation that is far away from consumers. In these circumstances, the generated electricity needs to be transmitted and distributed to consumers via transmission and distribution lines over long distances, spending many resources on construction, maintenance of all systems involved and high levels of technical losses. In smart grid, energy management is an indispensable for reducing energy cost of consumers while maximizing user comfort and alleviating the peak to average ratio and carbon emission under real time pricing approach.
  • 1.1K
  • 19 Apr 2022
Topic Review
Anti-Angiogenic Drugs
Angiogenesis can be revisited as a complex biological process with numerous compensatory pathways that can be activated, challenging the discovery of predictive biomarkers, since the cancer microenvironment and the complex milieu are difficult to classify and several actors are simultaneously shaping the key pro-angiogenic ecosystem. Bevacizumab represents the archetypic example of the various mechanisms of action, which may differ between cancer types and chemotherapy, unveiling the multifaceted functions in driving regression of existing tumor vasculature, halting new vessel growth, shaping the anti-permeability of surviving vasculature, and priming vessel normalization and co-option. Unfortunately, a poor correlation between response and survival exists, and the effects are mainly limited to PFS, and from a clinical trials standpoint, cross-over events at progression make identification of response criteria and biomarkers difficult.
  • 1.1K
  • 29 Nov 2021
Topic Review
Clonal Behavior of Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) are the only cell population that possesses both a self-renewing capacity and multipotency, and can give rise to all lineages of blood cells throughout an organism’s life. However, the self-renewal capacity of HSCs is not infinite, and cumulative evidence suggests that HSCs alter their function and become less active during organismal aging, leading ultimately to the disruption of hematopoietic homeostasis, such as anemia, perturbed immunity and increased propensity to hematological malignancies. Thus, understanding how HSCs alter their function during aging is a matter of critical importance to prevent or overcome these age-related changes in the blood system. Recent advances in clonal analysis have revealed the functional heterogeneity of murine HSC pools that is established upon development and skewed toward the clonal expansion of functionally poised HSCs during aging. In humans, next-generation sequencing has revealed age-related clonal hematopoiesis that originates from HSC subsets with acquired somatic mutations, and has highlighted it as a significant risk factor for hematological malignancies and cardiovascular diseases. 
  • 1.1K
  • 11 Mar 2022
Topic Review
Heat Tolerance in Common Wheat
Heat tolerance (HT) in plants is the capacity of plants to tolerate heat stress. It is a quantitative trait involving complex genetic, physiological, and biochemical controls and is affected by environmental factors. In response to heat stress, tolerant varieties generally activate an antioxidant defence system, express heat shock proteins (HSPs) and reduce senescence by staying green.
  • 1.1K
  • 25 Mar 2022
Topic Review
Portuguese Triticum aestivum
Bread wheat (Triticum aestivum) is a major crop worldwide, and it is highly susceptible to heat. Genetic diversity is scarce as regards heat tolerance, and remains a major concern for breeders in Mediterranean region. Grain traits were evaluated in Portuguese Triticum aestivum germplasm after plants exposure to heat during grain filling stage. Seven ancient landraces and traditional varieties from INIAV wheat collection, Gentil Rosso, Grécia, Mocho de Espiga Branca (MEB), Mocho de Espiga Quadrada (MEQ), Transmontano 94 (T94), Restauração and Ruivo, and two commercial varieties, Ardila and Nabão, were considered in the study. Plants were grown in a semi-controlled greenhouse. Heat increased test weight (TW), thousand-kernel weight (TKW), soluble sugars, protein and essential fatty acids (C18:1 and C18:2)  in some of the genotypes. From PCA analysis of traits, one commercial (Ardila) and two landraces (Restauração and Russo) showed clustering in approximate positions no matter the treatment and seem to be less susceptible to heat. In contrast, one landrace (MEQ) seems more differentially affected and hence less adapted to high temperatures during grain filling. Physiological responses to heat, particularly their impact on grain filling and quality, may assist breeding design of heat-adapted wheat in the scenario of predicted climate changes.
  • 1.1K
  • 24 Mar 2022
Topic Review
Computational Simulations of Heart Valves
Computational methods are a cost-effective tool that can be used to evaluate the flow parameters of heart valves. Valve repair and replacement have long-term stability and biocompatibility issues, highlighting the need for a more robust method for resolving valvular disease. For example, while fluid–structure interaction analyses are still scarcely utilized to study aortic valves, computational fluid dynamics is used to assess the effect of different aortic valve morphologies on velocity profiles, flow patterns, helicity, wall shear stress, and oscillatory shear index in the thoracic aorta. It has been analyzed that computational flow dynamic analyses can be integrated with other methods to create a superior, more compatible method of understanding risk and compatibility.
  • 1.1K
  • 10 May 2022
Topic Review
Current Trends in Skeletal Borderline Patients
Skeletal balance, functional occlusion, and facial harmony are common goals in orthodontics and orthognathic surgery. However, the boundary line for the decision between orthodontic and surgical treatment remains very controversial in adult borderline patients. Up to 10% of orthodontically treated patients are borderline and may have been treated either way (both with camouflage and orthognathic surgery). It is suggested that orthodontic camouflage of skeletal malocclusions would have acceptable results if there were an average or short facial pattern, mild anteroposterior jaw discrepancy, dental crowding lower than 4–6 mm, normal soft tissue features (nose, lips, chin), and no transverse skeletal problems. Poor results would be expected with the following: a long vertical facial pattern, moderate or severe antero-posterior jaw discrepancy, dental crowding greater than 4–6 mm, exaggerated facial features, and a transverse skeletal discrepancy.
  • 1.1K
  • 23 May 2022
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