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Topic Review
Total Polyphenol Content in Food Samples and Nutraceuticals
Total polyphenol content and antioxidant capacity were estimated in various food and nutraceutical samples. These were analyzed by using two antioxidant assays—ferric reducing antioxidant power (FRAP) and Folin–Ciocalteu (FC)—and a reversed-phase high performance liquid chromatography (HPLC), with a focus on providing compositional fingerprints dealing with polyphenolic compounds. A preliminary data exploration via principal component analysis (PCA) revealed that HPLC fingerprints were suitable chemical descriptors to classify the analyzed samples according to their nature. Moreover, chromatographic data were correlated with antioxidant data using partial least squares (PLS) regression.
  • 1.1K
  • 06 Apr 2022
Topic Review
Impact of Chemical Endocrine Disruptors on Endocrine System
Endocrine disruptors may be derived from natural animal, human, or plant (phytoestrogen) sources. However, the best-known are chemical endocrine disruptors (EDCs). EDCs include industrial ones (dioxins, polychlorinated biphenyls (PCBs) and alkyphenols), agricultural ones (pesticides, herbicides, fungicides, and insecticides), phthalates, bisphenol A (BPA), drugs (mitotane, ketoconazole, cardiac glycosides, nitrofurans, carbamazepine, and astazene), and heavy metals.
  • 1.1K
  • 27 May 2022
Topic Review
Dietary Application of Opuntia in Animal Nutrition
The cactus Opuntia ficus-indica (L.) Mill., commonly called prickly pear or cactus pear, is a tropical and subtropical plant belonging to the dicotyledonous angiosperm Cactaceae family, which comprises about 1500 species of cactus. Cactaceae have adaptive characteristics that ensure their development progress under drought conditions. The research provides information on the nutritive value of Opuntia in animal fodder production, its effects on animal performance, and the quality of the animal-derived products. 
  • 1.1K
  • 11 Jul 2022
Topic Review
Developing Microservice-Based Applications
Microservice Architecture (MSA) is a rising trend in software architecture design. Applications based on MSA are distributed applications whose components are microservices. MSA has already been adopted with great success by numerous companies, and a significant number of published papers discuss its advantages. However, there are several important challenges in the adoption of microservices such as finding the right decomposition approach, heterogeneous technology stacks, lack of relevant skills, out-of-date documentation, etc.
  • 1.1K
  • 15 Jul 2022
Topic Review
Cleaning in Times of Pandemic
Cleaning services are a transversal activity that guarantees the proper functioning and conditions of safety, hygiene, and health across all economic sectors. The COVID-19 pandemic increased the need for clean, sanitary spaces, particularly in health services and other areas with a large number of people. The workers in these services were often placed on the frontline without any specific training or information. 
  • 1.1K
  • 14 Jul 2022
Topic Review
Artisanal Beers
Beer is an alcoholic beverage frequently consumed globally. Special beers, known as artisanal, are progressively gaining consumer preference, opening up competition, and acquiring more space in the market.
  • 1.1K
  • 01 Aug 2022
Topic Review
Architecture of OkeyDoggy3D
The 2D pose is estimated from the multi-view RGB videos using the DeepLabCut model. Subsequently, the dog joint position-based dataset is prepared based on a camera calibration and triangulation using the Anipose algorithm by predicting the 3D pose from the 2D pose of the dog in a multi-view RGB video extracted using the DeepLabCut model.
  • 1.1K
  • 09 Sep 2022
Topic Review
Hypoxemia
Hypoxemia is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood. Hypoxemia has many causes, and often causes hypoxia as the blood is not supplying enough oxygen to the tissues of the body.
  • 1.1K
  • 17 Oct 2022
Topic Review
Human Cell and Organoid Models
Metabolic (dysfunction) associated fatty liver disease (MAFLD) is one of the most prevalent liver diseases and has no approved therapeutics. The high failure rates witnessed in late-phase MAFLD drug trials reflect the complexity of the disease, and how the disease develops and progresses remains to be fully understood. In vitro, human disease models play a pivotal role in mechanistic studies to unravel novel disease drivers and in drug testing studies to evaluate human-specific responses.
  • 1.1K
  • 25 Oct 2022
Topic Review
List of Sequenced Algae Genomes
This list of sequenced algae genomes contains algae species known to have publicly available complete genome sequences that have been assembled, annotated and published. Unassembled genomes are not included, nor are organelle-only sequences. For plant genomes see the list of sequenced plant genomes. For plastid sequences, see the list of sequenced plastomes. For all kingdoms, see the list of sequenced genomes.
  • 1.1K
  • 31 Oct 2022
Topic Review
Amnesty
Amnesty (from the Greek ἀμνηστία amnestia, "forgetfulness, passing over") is defined as: "A pardon extended by the government to a group or class of people, usually for a political offense; the act of a sovereign power officially forgiving certain classes of people who are subject to trial but have not yet been convicted." It includes more than pardon, inasmuch as it obliterates all legal remembrance of the offense. Amnesty is more and more used to express "freedom" and the time when prisoners can go free. Amnesties, which in the United Kingdom may be granted by the crown or by an act of Parliament, were formerly usual on coronations and similar occasions, but are chiefly exercised towards associations of political criminals, and are sometimes granted absolutely, though more frequently there are certain specified exceptions. Thus, in the case of the earliest recorded amnesty, that of Thrasybulus at Athens, the thirty tyrants and a few others were expressly excluded from its operation; and the amnesty proclaimed on the restoration of Charles II of England did not extend to those who had taken part in the execution of his father. Other famous amnesties include: Napoleon's amnesty of March 13, 1815 from which thirteen eminent persons, including Talleyrand, were exempt; the Prussian amnesty of August 10, 1840; the general amnesty proclaimed by the emperor Franz Josef I of Austria in 1857; the general amnesty granted by President of the United States, Andrew Johnson, after the American Civil War (1861–April 9, 1865), in 1868, and the French amnesty of 1905. Amnesty in U.S. politics in 1872 meant restoring the right to vote and hold office to ex-Confederates, which was achieved by act of Congress. Those were true amnesties, pardoning past violations without changing the laws violated. The Immigration Reform and Control Act of 1986—signed into law by President Ronald Reagan on November 6, 1986—granted amnesty to about 3 million undocumented immigrants in the United States.
  • 1.1K
  • 14 Nov 2022
Topic Review
Bee Innate Immunity
As important pollinators, bees play a critical role in maintaining the balance of the ecosystem and improving the yield and quality of crops. However, in recent years, the bee population has significantly declined due to various pathogens and environmental stressors including viruses, bacteria, parasites, and increased pesticide application. The above threats trigger or suppress the innate immunity of bees, their only immune defense system, which is essential to maintaining individual health and that of the colony. In addition, bees can be divided into solitary and eusocial bees based on their life traits, and eusocial bees possess special social immunities, such as grooming behavior, which cooperate with innate immunity to maintain the health of the colony.
  • 1.1K
  • 29 Nov 2022
Topic Review
Sleep Apnea
Obstructive sleep apnea (OSA) is a common but largely undiagnosed clinical condition, which is turning into a serious public health issue. Of note is that its prevalence is gradually increasing in parallel with the obesity and type 2 diabetes mellitus (T2DM) epidemics.
  • 1.1K
  • 12 Jan 2023
Topic Review
Anticancer Effects of R-Loops
R-loops are three-stranded DNA/RNA hybrids that form by the annealing of the mRNA transcript to its coding template while displacing the non-coding strand. While R-loop formation regulates physiological genomic and mitochondrial transcription and DNA damage response, imbalanced R-loop formation can be a threat to the genomic integrity of the cell. As such, R-loop formation is a double-edged sword in cancer progression, and perturbed R-loop homeostasis is observed across various malignancies. 
  • 1.1K
  • 10 May 2023
Topic Review
Galectin-3 Targeting Drugs in Various Diseases
Galectin-3 (Gal3) is one of the most studied members of the galectin family that mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Since Gal3 is pro-inflammatory, it is involved in many diseases that are associated with chronic inflammation such as cancer, organ fibrosis, and type 2 diabetes.
  • 1.1K
  • 12 May 2023
Topic Review
Claudin-4 as Molecular Target for Epithelial Cancer Therapy
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors. Decreased expression of CLDN4 is a potential marker of epithelial-mesenchymal transition (EMT), and decreased epithelial differentiation due to reduced CLDN4 activity is involved in EMT induction. Non-TJ CLDN4 also activates integrin beta 1 and YAP to promote proliferation, EMT, and stemness. These roles in cancer have led to investigations of molecular therapies targeting CLDN4 using anti-CLDN4 extracellular domain antibodies, gene knockdown, clostridium perfringens enterotoxin (CPE), and C-terminus domain of CPE (C-CPE), which have demonstrated the experimental efficacy of this approach. 
  • 1.1K
  • 25 May 2023
Topic Review
Sustainable Food Waste Management Practices
Although food waste management has been significant for all stakeholders from all industries globally, research in hospitality food waste management and practices still needs to be further studied, especially in five-star hotels in developing countries. Using the Food Waste Hierarchy, this research proposes to contribute to the knowledge of sustainable food waste management and practices in five medium and large five-star hotels to promote the United Nations Sustainable Development Goals (SDGs).
  • 1.1K
  • 19 Sep 2023
Topic Review
Applications of Polymer Electrolytes in Lithium-Ion Batteries
Polymer electrolytes, a type of electrolyte used in lithium-ion batteries, combine polymers and ionic salts. Their integration into lithium-ion batteries has resulted in significant advancements in battery technology, including improved safety, increased capacity, and longer cycle life.
  • 1.1K
  • 12 Oct 2023
Topic Review
Gambling Addiction
Gambling addiction was the first addictive behavior not related to substance use that was recognized by the DSM-5. It shares diagnostics and comorbidity with other addictions.
  • 1.1K
  • 16 Oct 2023
Topic Review
Lactic Acid Bacteria in Dairy Foods
Lactic acid bacteria (LAB) are regarded as ‘Generally Recognized as Safe’ (GRAS) and are commonly used in the dairy industry and also form part of the microbiota of the human intestine. LAB play a significant role in biopreservation because they produce a variety of antimicrobial metabolites during the development and fermentation processes. The use of antimicrobial-producing LAB in the production of dairy products, which can be incorporated into fermented or nonfermented dairy products, implies a processing advantage to improve the safety and quality of dairy products, providing an additional barrier against foodborne diseases. Among the most common antimicrobials are bacteriocins, which are ribosomally produced antimicrobial peptides. They can kill or inhibit undesirable bacterial strains, whether closely related or not, without harming themselves. This ability is especially relevant in the food industry. Notably, many LAB bacteriocins, including those derived from such bacteria, have shown efficacy against Listeria monocytogenes, a significant concern in traditional cheeses made from raw milk.
  • 1.1K
  • 16 Nov 2023
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