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Topic Review
Mitochondrial Complex V Deficiency
Mitochondrial complex V deficiency is a shortage (deficiency) of a protein complex called complex V or a loss of its function. Complex V is found in cell structures called mitochondria, which convert the energy from food into a form that cells can use. Complex V is the last of five mitochondrial complexes that carry out a multistep process called oxidative phosphorylation, through which cells derive much of their energy.
  • 1.1K
  • 23 Dec 2020
Topic Review
Epidermal Nevus
An epidermal nevus (plural: nevi) is an abnormal, noncancerous (benign) patch of skin caused by an overgrowth of cells in the outermost layer of skin (epidermis). Epidermal nevi are typically seen at birth or develop in early childhood. Affected individuals have one or more nevi that vary in size.
  • 1.1K
  • 25 Dec 2020
Topic Review
Curcumin and Alzheimer’s Disease
Curcumin is a polyphenolic natural compound with diverse and attractive biological properties, which may prevent or ameliorate pathological processes underlying age-related cognitive decline, Alzheimer’s disease (AD), dementia, or mode disorders. AD is a chronic neurodegenerative disorder that is known as one of the rapidly growing diseases, especially in the elderly population. Moreover, being the eminent cause of dementia, posing problems for families, societies as well a severe burden on the economy. There are no effective drugs to cure AD. Although curcumin and its derivatives have shown properties that can be considered useful in inhibiting the hallmarks of AD, however, they have low bioavailability. Furthermore, to combat diagnostic and therapeutic limitations, various nanoformulations have also been recognized as theranostic agents that can also enhance the pharmacokinetic properties of curcumin and other bioactive compounds. Nanocarriers have shown beneficial properties to deliver curcumin and other nutritional compounds against the blood-brain barrier to efficiently distribute them in the brain. 
  • 1.1K
  • 06 Jan 2021
Topic Review
Galectin-3
Galectin-3 is a member of the galectins family of carbohydrate-binding proteins with specificity for N-acetyllactosamine (LacNAc)-containing glycoproteins, and the only known one with a single carbohydrate recognition domain and a unique N-terminus.
  • 1.1K
  • 16 Mar 2021
Topic Review
Rainwater Harvesting Systems
Rainwater harvesting (RWH) can be used to mitigate global water crises; however, they have been poorly received by communities because of the unsuitable quality of stored rainwater. Heterotrophic bacteria present in the water can degrade the water’s microbiological quality and create health issues. Moreover, exposure to visible light can affect both suspended and surface-attached heterotrophic bacteria, a phenomenon that is poorly investigated.
  • 1.1K
  • 29 Jul 2021
Topic Review
Sustainable Social and Economic Development of Russian Municipalities
Sustainable social and economic development of municipalities has been assessed in Russia. In Russia, the issue of improving socio-economic sustainability of municipalities in the region through the assessment of its indicators are particularly relevant. Regional policy measures to equalize the level of socio-economic development should be designed, taking into account the identified features of the territorial development of municipal districts.
  • 1.1K
  • 24 Nov 2021
Topic Review
Gasotransmitters in Hypertension/Kidney Disease
Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), three major gasotransmitters, are involved in pleiotropic biofunctions. Research on their roles in hypertension and kidney disease has greatly expanded recently. The developing kidney can be programmed by various adverse in utero conditions by so-called renal programming, giving rise to hypertension and kidney disease in adulthood. 
  • 1.1K
  • 03 Nov 2021
Topic Review
Growth of Biological Complexity from Prokaryotes to Hominids
The growth of complexity in evolution is a most intriguing phenomenon. Using gene phylostratigraphy, we showed this growth (as reflected in regulatory mechanisms) in the human genome, tracing the path from prokaryotes to hominids. Generally, the different regulatory gene families expanded at different times, yet only up to the Euteleostomi (bony vertebrates). The only exception was the expansion of transcription factors (TF) in placentals; however, we argue that this was not related to increase in general complexity. Surprisingly, although TF originated in the Prokaryota while chromatin appeared only in the Eukaryota, the expansion of epigenetic factors predated the expansion of TF. Signaling receptors, tumor suppressors, oncogenes, and aging- and disease-associated genes (indicating vulnerabilities in terms of complex organization and strongly enrichment in regulatory genes) also expanded only up to the Euteleostomi. The complexity-related gene properties (protein size, number of alternative splicing mRNA, length of untranslated mRNA, number of biological processes per gene, number of disordered regions in a protein, and density of TF–TF interactions) rose in multicellular organisms and declined after the Euteleostomi, and possibly earlier. At the same time, the speed of protein sequence evolution sharply increased in the genes that originated after the Euteleostomi. Thus, several lines of evidence indicate that molecular mechanisms of complexity growth were changing with time, and in the phyletic lineage leading to humans, the most salient shift occurred after the basic vertebrate body plan was fixed with bony skeleton. The obtained results can be useful for evolutionary medicine. 
  • 1.1K
  • 05 Nov 2021
Topic Review
Endogenous Metal Nanoparticles in Biological Systems
The blood and tissues of vertebrate animals and mammals contain small endogenous metal nanoparticles. These nanoparticles were observed to be composed of individual atoms of iron, copper, zinc, silver, gold, platinum, and other metals. Metal nanoparticles can bind proteins and produce proteinaceous particles called proteons. A small fraction of the entire pool of nanoparticles is usually linked with proteins to form proteons. These endogenous metal nanoparticles, along with engineered zinc and copper nanoparticles at subnanomolar levels, were shown to be lethal to cultured cancer cells. These nanoparticles appear to be elemental crystalline metal nanoparticles. It was discovered that zinc nanoparticles produce no odor response but increase the odor reaction if mixed with an odorant. Some other metal nanoparticles, including copper, silver, gold, and platinum nanoparticles, do not affect the responses to odorants. The sources of metal nanoparticles in animal blood and tissues may include dietary plants and gut microorganisms. The solid physiological and biochemical properties of metal nanoparticles reflect their importance in cell homeostasis and disease.
  • 1.1K
  • 05 Nov 2021
Topic Review
Neuroprotective Potentials of Marine Algae and Bioactive Metabolites
Marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. 
  • 1.1K
  • 26 Jan 2022
Topic Review
The Oil Palm Governance Policy in Indonesia
Indonesian palm oil encountered social-agrarian and environmental issues and has been subject to heavy criticism from the international community for years. The Indonesian government answered the very sharp international opinion by implementing standard certification to ensure the achievement of oil palm sustainability. This is especially applied for the small scale plantation at the upstream of the entire palm oil supply chain. Indonesian Sustainable Palm Oil (ISPO) certification has been applied as an instrument of guaranteeing sustainability principles for all business units with a particular attention on smallholders. The system is targeted to address land legality issues, business licensing, plant seedling certification, environmental management, as well as strengthening farmer organizations at the local level. The implementation of ISPO faced challenges and barriers that makes certification is not easy to achieved on the ground. 
  • 1.1K
  • 24 Apr 2022
Topic Review
Consumption of Dairy Foods and Cardiovascular Disease
A high intake of saturated fatty acids (SFAs) has been linked to an enhanced risk of cardiovascular diseases (CVD), and this effect is thought to be largely mediated by increased plasma LDL-cholesterol level and its proatherogenic effect. Within this context, dairy foods deserve consideration since they are largely consumed and contribute a relevant proportion to the global SFAs intake. A substantial reduction in the intake of dairy products and a preferential consumption of low-fat dairy products have been advocated as a strategy for CVD prevention, but evidence in this regard is scant and inconsistent. By reviewing the literature on the relationship of different dairy products (low/full-fat dairy, milk, cheese, yogurt) with CV events and major CV risk factors, this work provides consistent evidence that a moderate consumption of dairy foods is not associated with increased CV risk, independent of whether full-fat or low-fat products are considered. As for specific foods, fermented products and products added with probiotics are associated with a lower risk of CV events. Therefore, these results highlight the wide heterogeneity existing among dairy foods with regard to their association with CVD and expand current knowledge on the relevance of food choices with regard to cardiovascular health.
  • 1.1K
  • 22 Mar 2022
Topic Review
Capture of Industrial CO2 by Algae
The importance of the cultivation of algae in various fields, including in the field of energy, is very high. Algae as a reserve type of renewable fuel are considered thanks to the rapid growth of algae and the ability of algae to store lipids. 
  • 1.1K
  • 06 Apr 2022
Topic Review
Genotoxic Effects of Lead
Lead (Pb) is one of the most widely used heavy metals in several industries for the manufacturing process of Pb-based products due to its physical and chemical properties, such as high density, softness, malleability, and poor conductibility. Thus, Pb can be found in workplaces and other contaminated environments. Pb toxicity can occur via both nonoccupational and occupational exposure through inhalation, ingestion, and dermal absorption.
  • 1.1K
  • 29 Apr 2022
Topic Review
MatriGrid® Based Biological Morphologies
A continuously rising number of literature sources claiming the similarities of 3D cell culturing to in vivo data shows the self-depicting importance of mimicking the three-dimensional microenvironment for cell culture. The MatriGrid®s, tools and techniques for the construction of a family of polycarbonate substrate scaffolds. These scaffolds are suitable not only for cell culturing but also for the manipulation and evolution of embroid bodies, for mimicking stem cell niches, or for control of the behavior of tissue slices. Some of these scaffold-based approaches use polymeric scaffolds for shaping the evolving oligocellular agglomerates. Scaffold-based approaches allow us not only to define the shape of the agglomerates but also to control biophysical and mechanical properties such as stiffness, shear stress, and nutritious flow if integrated into lab-on-a-chip devices or bioreactors.
  • 1.1K
  • 13 Jun 2022
Topic Review
Multiple Fuel Injection Strategies for Compression Ignition Engines
A significant volume of work is devoted to testing diesel fuel under a multiple fuel injection scenario whereas comparatively less is seen about neat biodiesel and biodiesel blends with diesel. Many mechanisms have been proposed to explain the reduction of exhaust emissions, combustion noise, and fuel consumption possible with multiple fuel injection events.
  • 1.1K
  • 27 Jul 2022
Topic Review
Mathematical Models of Apoptosis
Apoptosis is one of the most well-studied and characterized programmed cell death mechanisms. The detailed characterization of molecular interactions involved in apoptosis, and the growing amount of related quantitative data, has encouraged computational and systems biologists to develop mathematical models of apoptosis.
  • 1.1K
  • 20 Oct 2022
Topic Review
Viral Hepatitis
Viral hepatitis is liver inflammation due to a viral infection. It may present in acute form as a recent infection with relatively rapid onset, or in chronic form. The most common causes of viral hepatitis are the five unrelated hepatotropic viruses hepatitis A, B, C, D, and E. Other viruses can also cause liver inflammation, including cytomegalovirus, Epstein-Barr virus, and yellow fever. There also have been scores of recorded cases of viral hepatitis caused by herpes simplex virus.
  • 1.1K
  • 28 Oct 2022
Topic Review
Comparison of Notetaking Software
The tables below compare features of notable note-taking software.
  • 1.1K
  • 28 Nov 2022
Topic Review
Solar Thermal for Process Heating
To mitigate the consequences of climate change, there is an increasing need to minimize the usage of fossil fuels, especially in the industrial sector because the majority of the industrial sector primarily rely on fossil fuels to meet their needs for heat energy, and a practical strategy to reduce reliance on fossil fuels is to use energy from the sun.
  • 1.1K
  • 30 Nov 2022
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