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Topic Review
Intestinal Homeostasis under Stress Siege
Intestinal homeostasis encompasses a complex and balanced interplay among a wide array of components that collaborate to maintain gut barrier integrity. The appropriate function of the gut barrier requires the mucus layer, a sticky cushion of mucopolysaccharides that overlays the epithelial cell surface. Mucus plays a critical anti-inflammatory role by preventing direct contact between luminal microbiota and the surface of the epithelial cell monolayer. Moreover, mucus is enriched with pivotal effectors of intestinal immunity, such as immunoglobulin A (IgA). A fragile and delicate equilibrium that supports proper barrier function can be disturbed by stress. The impact of stress upon intestinal homeostasis results from neuroendocrine mediators of the brain-gut axis (BGA), which comprises a nervous branch that includes the enteric nervous system (ENS) and the sympathetic and parasympathetic nervous systems, as well as an endocrine branch of the hypothalamic-pituitary-adrenal axis. 
  • 1.1K
  • 02 Jun 2021
Topic Review
Neurodevelopmental Consequences of Pediatric Cancer
Cognitive impairment is frequent in pediatric cancer, and behavioral and psychological disturbances often also affect children who have survived cancer problems. Furthermore, pediatric tumors are also often associated with sleep disorders. 
  • 1.1K
  • 23 Jun 2021
Topic Review
Silk Protein-Based Membrane for GBR
Silk derived from the silkworm is known for its excellent biological and mechanical properties. It has been used in various fields as a biomaterial, especially in bone tissue engineering scaffolding. Recently, silk protein-based biomaterial has been used as a barrier membrane scaffolding for guided bone regeneration (GBR). GBR promotes bone regeneration in bone defect areas using special barrier membranes. GBR membranes should have biocompatibility, biodegradability, cell occlusion, the mechanical properties of space-making, and easy clinical handling. Silk-based biomaterial has excellent biologic and mechanical properties that make it a good candidate to be used as GBR membranes. 
  • 1.1K
  • 24 Jun 2021
Topic Review
Insect Foods and Its Acceptance
Insects, especially mealworms, have a similar or higher nutritional value than many conventional food sources. For example, the protein content of mealworm larvae is reported to be almost 50% of dry weight, while the fat content is about 30% of larval dry weight. Mealworms can be cooked by different methods, such as hot air drying, oven broiling, roasting, pan frying, deep frying, boiling, steaming, and microwaving. Oven broiling in particular gives a desirable aroma of steamed corn for consumers. 
  • 1.1K
  • 05 Jul 2021
Topic Review
Herbal Extracts and Fish Gene
Herbal bioactive components can act as immunostimulants and influence several immune-related pathways. An immunostimulant is a component or action that elevates immune responses, especially innate immunity. Herbal bioactive components can have anti-bacterial, anti-viral, and anti-fungal functions and increase resistance against infectious microorganisms.
  • 1.1K
  • 06 Aug 2021
Topic Review
Melissa officinalis subsp. officinalis
The investigation aimed to study the in vitro and in silico antioxidant properties of Melissa officinalis subsp. officinalis essential oil (MOEO). The chemical composition of MOEO was determined using GC–MS analysis. Among 36 compounds identified in MOEO, the main were beta-cubebene (27.66%), beta-caryophyllene (27.41%), alpha-cadinene (4.72%), caryophyllene oxide (4.09%), and alpha-cadinol (4.07%), respectively. In vitro antioxidant properties of MOEO have been studied in 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging, and inhibition of β-carotene bleaching assays. The half-maximal inhibitory concentration (IC50) for the radical scavenging abilities of ABTS and DPPH were 1.225 ± 0.011 μg/mL and 14.015 ± 0.027 μg/mL, respectively, demonstrating good antioxidant activity. Moreover, MOEO exhibited a strong inhibitory effect (94.031 ± 0.082%) in the β-carotene bleaching assay by neutralizing hydroperoxides, responsible for the oxidation of highly unsaturated β-carotene. Furthermore, molecular docking showed that the MOEO components could exert an in vitro antioxidant activity through xanthine oxidoreductase inhibition. The most active structures are minor MOEO components (approximately 6%), among which the highest affinity for the target protein belongs to carvacrol.
  • 1.1K
  • 12 Aug 2021
Topic Review
Immune Resistance in Prostate Cancer
Utilizing the immune system to treat cancer has been a revolutionary development and has quickly become the standard treatment for many cancer types, superseding other targeted and systemic therapies. By targeting cancer cells and avoiding the toxicities of chemotherapy and radiation, immunotherapy offers a less toxic, yet, in many types of cancers, highly efficacious alternative. With regard to PCa, the interaction between prostatic epithelial cells and the immune and non-immune cells that make up the tumor microenvironment (TME) have been shown to have an important role in the complex changes that occur and ultimately result in disease progression, development of resistant metastases, and the overall resistance to both conventional and experimental therapies.
  • 1.1K
  • 09 Oct 2021
Topic Review
MiR in Major Depressive Disorder
Major depressive disorder (MDD) is a complex neuropsychiatric disorder with an increasing incidence and a 2–20% prevalence in the worldwide general population, being the leading cause of disability around the world. A significant decrease in life quality, functional impairment, and other psychosocial aspects, as well as comorbidities are associated with MDD, among others.
  • 1.1K
  • 03 Nov 2021
Topic Review
Skin Microbiota
Many relatively common chronic inflammatory skin diseases manifest on the face (seborrheic dermatitis, rosacea, acne, perioral/periorificial dermatitis, periocular dermatitis, etc.), thereby significantly imparing patient appearance and quality of life. Given the as yet unexplained pathogenesis and numerous factors involved, these diseases often present therapeutic challenges. Changes in human skin microbiota composition and/or functionality are believed to trigger immune dysregulation and, consequently, an inflammatory response, thereby playing a potentially significant role in the clinical manifestations and treatment of these diseases. Although cultivation methods have traditionally been used in studies of bacterial microbiome species, a large number of bacterial strains cannot be grown in the laboratory. Since standard culture-dependent methods detect fewer than 1% of all bacterial species, a metagenomic approach could be used to detect bacteria that cannot be cultivated. Studies on the possible association between changes in the microbiome and their association with skin diseases have improved understanding of disease development, diagnostics and therapeutics. Identification of the bacterial markers associated with particular inflammatory skin diseases would significantly accelerate the diagnostics and reduce treatment costs. Microbiota research and determination could facilitate the identification of potential causes of skin diseases that cannot be detected by simpler methods, thereby contributing to the design and development more effective therapies.
  • 1.1K
  • 01 Nov 2021
Topic Review
Sustainable Supply Chain Management for a Circular Economy
Sustainable supply chain management (SSCM) can implement ecological innovations that would collaborate to preserve the environment. Even more broadly, the circular economy (CE) emerges as a component for sustainable development, as it involves activities such as repair, reuse, refurbishment, and recycling. Thus, we conducted an integrative review of the international articles that relate the SSCM with CE.
  • 1.1K
  • 15 Dec 2021
Topic Review
The New Urban Profession: Entering Age of Uncertainty
The context of urbanism is changing rapidly. The context for working in the field of urban design and planning is influenced by the pace of change; uncertainty; and massive transitions. The urban professional, however, is still used to planning for small changes and repeating traditional approaches. 
  • 1.1K
  • 11 Feb 2022
Topic Review
Exosomes for Regulation of Immune Responses and Immunotherapy
Exosomes are membrane-enveloped nanosized (30–150 nm) extracellular vesicles of endosomal origin produced by almost all cell types and encompass a multitude of functioning biomolecules. Exosomes have been considered crucial players of cell-to-cell communication in physiological and pathological conditions. Accumulating evidence suggests that exosomes can modulate the immune system by delivering a plethora of signals that can either stimulate or suppress immune responses, which have potential applications as immunotherapies for cancer and autoimmune diseases.
  • 1.1K
  • 06 Apr 2022
Topic Review
Lycopene as Antioxidant for Type II Diabetes Mellitus
Nutrition is of utmost importance in chronic disease management and has often been described as the cornerstone of a variety of non-communicable diseases. In particular, type II diabetes mellitus (T2DM) represents a prevalent and global public health crisis. Lycopene, a bright red carotenoid hydrocarbon found in tomatoes and other red fruits and vegetables, has been extensively studied for its biological activities and treatment efficiency in diabetes care. Epidemiological investigations indicate that lycopene has potential antioxidant properties, is capable of scavenging reactive species, and alleviates oxidative stress in T2DM patients.
  • 1.1K
  • 01 Jun 2022
Topic Review
The Concept of Postbiotics
In 2021, the International Scientific Association for Probiotics and Prebiotics (ISAPP) defined a postbiotic as “a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”. This definition of postbiotic requires that the whole or components of inactivated microbes be present, with or without metabolic end products. The definition proposed by ISAPP is comprehensive enough to allow the development of postbiotics from different microorganisms, to be applied in different body sites, encouraging innovation in a promising area for any regulatory category and for companion or production animals, and plant or human health. From a technological perspective, probiotic products may contain inanimate microorganisms, which have the potential to impart a health benefit. However, their contribution to health in most cases has not been established, even if at least one probiotic has been shown to confer the same health benefit by live or inanimate cells.
  • 1.1K
  • 28 Jun 2022
Topic Review
The Dichotomy of Neural Networks and Cryptography
Neural networks and cryptographic schemes have come together in war and peace; a cross-impact that forms a dichotomy deserving a comprehensive review study. Neural networks can be used against cryptosystems; they can play roles in cryptanalysis and attacks against encryption algorithms and encrypted data. This side of the dichotomy can be interpreted as a war declared by neural networks. On the other hand, neural networks and cryptographic algorithms can mutually support each other. Neural networks can help improve the performance and the security of cryptosystems, and encryption techniques can support the confidentiality of neural networks. The latter side of the dichotomy can be referred to as the peace. 
  • 1.1K
  • 07 Jul 2022
Topic Review
The Concept of Green Marketing in Palm Oil
The term green marketing has been in use since the 1980s, following the shift of consumerism towards a cleaner and greener environment. There are many definitions of this term. Pride and Ferrell (1993) have tried to explain it as a way for a firm to design, distribute, market, and price a certain product without harming the environment. Polonsky (1994) has defined green marketing as all a firm’s activities to generate or facilitate services and/or products with minimal detrimental impact on the environment.
  • 1.1K
  • 22 Jul 2022
Topic Review
Pharmacokinetic Mechanisms of Transporter-Mediated Herb-Drug Interactions 
As the use of herbs has become more popular worldwide, there are increasing reports of herb-drug interactions (HDIs) following the combination of herbs and drugs. The active components of herbs are complex and have a variety of pharmacological activities, which inevitably affect changes in the pharmacokinetics of chemical drugs in vivo.
  • 1.1K
  • 20 Sep 2022
Topic Review
Revalorization of Microalgae Biomass for Synergistic Interaction
Microalgae and cyanobacteria are photosynthetic microorganisms’ sources of renewable biomass that can be used for bioplastic production. These microorganisms have high growth rates, and contrary to other feedstocks, such as land crops, they do not require arable land. In addition, they can be used as feedstock for bioplastic production while not competing with food sources (e.g., corn, wheat, and soy protein). 
  • 1.1K
  • 29 Sep 2022
Topic Review
Certain Novel Microorganisms for Fermentation Technology
Fermentation is one of the oldest biological food preservation methods, mainly known for enhancing the organoleptic properties of foods in the desired direction and extending food shelf life. The nutritional value of the food increases as essential amino acids, vitamins, and antimicrobial metabolites such as bacteriocin are synthesized during fermentation, which also breaks down fermentable carbohydrates into organic acids, carbon dioxide, and alcohol. These antimicrobial metabolites contribute to food safety by preventing the spoilage of foods by microorganisms. Moreover, fermentation reduces antinutritional factors, increases the digestibility of foods, and ultimately improves the sensory properties of foods.
  • 1.1K
  • 21 Oct 2022
Topic Review
CRISPR/Cas9 as a Promising Tool to Cure Blindness
CRISPR/Cas9 has been explored as an efficient therapeutic tool for the treatment of genetic diseases. It has been widely used in ophthalmology research by using mouse models to correct pathogenic mutations in the eye stem cells. CRISPR/Cas9 has been used to correct a large number of mutations related to inherited retinal disorders. In vivo therapeutic advantages for retinal diseases have been successfully achieved in some rodents. Advances in the CRISPR-based gene-editing domain, such as modified Cas variants and delivery approaches have optimized its application to treat blindness.
  • 1.1K
  • 20 Oct 2022
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