Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Benzimidazole
Benzimidazole is an important heterocyclic fragment, present in many biologically active compounds with a great variety of therapeutic purposes. Most of the benzimidazole activities are explained through the existence of 1,3-tautomeric equilibrium. As the binding affinity of each tautomer to a protein target depends on an established bioactive conformation, the effect of tautomers on the ligand protein binding mechanism is determinant.
  • 5.0K
  • 27 Oct 2022
Topic Review
Xanthine Oxidoreductase Activities
Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid. XOR is widely distributed throughout living organisms and is highly conserved in prokaryotic, plant, and animal species. XOR activity is very versatile, generating both pro-oxidant (primarily within the cell) and anti-oxidant (primarily in plasma) products.
  • 5.0K
  • 21 Sep 2020
Topic Review
Sorbent-Based Microextraction of Natural Toxins from Food Samples
Natural toxins are chemical substances that are not toxic to the organisms that produce them, but which can be a potential risk to human health when ingested through food. Thus, it is of high interest to develop advanced analytical methodologies to control the occurrence of these compounds in food products. Current trends in sample preparation involve moving towards “greener” approaches by scaling down analytical operations, miniaturizing the instruments and integrating new advanced materials as sorbents. The combination of these new materials with sorbent-based microextraction technologies enables the development of high-throughput sample preparation methods, which improve conventional extraction and clean-up procedures.
  • 5.0K
  • 05 Nov 2021
Topic Review
WannaCry Ransomware Attack
The WannaCry ransomware attack was a worldwide cyberattack in May 2017 by the WannaCry ransomware cryptoworm, which targeted computers running the Microsoft Windows operating system by encrypting data and demanding ransom payments in the Bitcoin cryptocurrency. It propagated through EternalBlue, an exploit developed by the United States National Security Agency (NSA) for older Windows systems. EternalBlue was stolen and leaked by a group called The Shadow Brokers a month prior to the attack. While Microsoft had released patches previously to close the exploit, much of WannaCry's spread was from organizations that had not applied these, or were using older Windows systems that were past their end-of-life. These patches were imperative to organizations' cyber security but many were not implemented due to ignorance of their importance. Some have claimed a need for 24/7 operation, aversion to risking having formerly working applications breaking because of patch changes, lack of personnel or time to install them, or other reasons. The attack began at 07:44 UTC on 12 May 2017 and was halted a few hours later at 15:03 UTC by the registration of a kill switch discovered by Marcus Hutchins. The kill switch prevented already infected computers from being encrypted or further spreading WannaCry. The attack was estimated to have affected more than 200,000 computers across 150 countries, with total damages ranging from hundreds of millions to billions of United States dollar . Security experts believed from preliminary evaluation of the worm that the attack originated from North Korea or agencies working for the country. In December 2017, the United States and United Kingdom formally asserted that North Korea was behind the attack. A new variant of WannaCry forced Taiwan Semiconductor Manufacturing Company (TSMC) to temporarily shut down several of its chip-fabrication factories in August 2018. The virus spread to 10,000 machines in TSMC's most advanced facilities.
  • 5.0K
  • 14 Oct 2022
Topic Review
Restoration Movement
The Restoration Movement (also known as the American Restoration Movement or the Stone-Campbell Movement, and pejoratively as Campbellism) is a Christian movement that began on the United States frontier during the Second Great Awakening (1790–1840) of the early 19th century. The pioneers of this movement were seeking to reform the church from within and sought "the unification of all Christians in a single body patterned after the church of the New Testament.":54 Especially since the mid-20th century, members of these churches do not identify as Protestant but simply as Christian.:213 The Restoration Movement developed from several independent strands of religious revival that idealized early Christianity. Two groups, which independently developed similar approaches to the Christian faith, were particularly important. The first, led by Barton W. Stone, began at Cane Ridge, Kentucky, and identified as "Christians". The second began in western Pennsylvania and Virginia (now West Virginia) and was led by Thomas Campbell and his son, Alexander Campbell, both educated in Scotland; they eventually used the name "Disciples of Christ". Both groups sought to restore the whole Christian church on the pattern set forth in the New Testament, and both believed that creeds kept Christianity divided. In 1832 they joined in fellowship with a handshake. Among other things, they were united in the belief that Jesus is the Christ, the Son of God; that Christians should celebrate the Lord's Supper on the first day of each week; and that baptism of adult believers by immersion in water is a necessary condition for salvation. Because the founders wanted to abandon all denominational labels, they used the biblical names for the followers of Jesus.:27 Both groups promoted a return to the purposes of the 1st-century churches as described in the New Testament. One historian of the movement has argued that it was primarily a unity movement, with the restoration motif playing a subordinate role.:8 The Restoration Movement has since divided into multiple separate groups. There are three main branches in the U.S.: the Churches of Christ, the unaffiliated Christian Church/Church of Christ congregations, and the Christian Church (Disciples of Christ). Some characterize the divisions in the movement as the result of the tension between the goals of restoration and ecumenism: the Churches of Christ and unaffiliated Christian Church/Church of Christ congregations resolved the tension by stressing restoration, while the Christian Church (Disciples of Christ) resolved the tension by stressing ecumenism.:383 A number of groups outside the U.S. also have historical associations with this movement, such as the Evangelical Christian Church in Canada and the Churches of Christ in Australia. Because the Restoration Movement lacks any centralized structure, having originated in a variety of places with different leaders, there is no consistent nomenclature for the movement as a whole. The term "Restoration Movement" became popular during the 19th century; this appears to be due to the influence of Alexander Campbell's essays on "A Restoration of the Ancient Order of Things" in the Christian Baptist. The term "Stone-Campbell Movement" emerged towards the end of the 20th century as a way to avoid the difficulties associated with some of the other names that have been used, and to maintain a sense of the collective history of the movement.
  • 5.0K
  • 08 Dec 2022
Topic Review
Mental Chronometry
Mental chronometry is the study of reaction time (RT; also referred to as "response time") in perceptual-motor tasks to infer the content, duration, and temporal sequencing of mental operations. Mental chronometry is one of the core methodological paradigms of human experimental and cognitive psychology, but is also commonly analyzed in psychophysiology, cognitive neuroscience, and behavioral neuroscience to help elucidate the biological mechanisms underlying perception, attention, and decision-making across species. Mental chronometry uses measurements of elapsed time between sensory stimulus onsets and subsequent behavioral responses. It is considered an index of processing speed and efficiency indicating how fast an individual can execute task-relevant mental operations. Behavioral responses are typically button presses, but eye movements, vocal responses, and other observable behaviors can be used. RT is constrained by the speed of signal transmission in white matter as well as the processing efficiency of neocortical gray matter. Conclusions about information processing drawn from RT are often made with consideration of task experimental design, limitations in measurement technology, and mathematical modeling.
  • 5.0K
  • 10 Oct 2022
Topic Review
Daihatsu Rocky
The Daihatsu Rocky (Japanese: ダイハツ・ロッキー, Daihatsu Rokkī) is an automobile nameplate used by Daihatsu for their lineup of SUVs. The nameplate was originally used as a ladder frame-based mini SUV that was sold in Japan and some international markets between 1989 and 2002. It was gradually replaced by the introduction of Terios in 1997. Beginning in 2019, the Rocky nameplate returned to Japan as a subcompact crossover SUV that replaces the Be‣go and is also rebadged and sold under Toyota brand as the Toyota Raize (Japanese: トヨタ・ライズ, Toyota Raizu).
  • 5.0K
  • 27 Oct 2022
Topic Review
Botulinum Toxin Therapy for Oromandibular Dystonia
Botulinum neurotoxin injection is effective and safe, with few side effects in most cases when properly administered by an experienced clinician. The diagnosis and treatment of oromandibular dystonia require both neurological and dental or oral surgical knowledge and skills, and well-designed multicenter trials with a multidisciplinary team approach must be necessary to ensure accurate diagnosis and proper treatment. 
  • 5.0K
  • 23 Jun 2022
Topic Review
Porifera
Sponges, the members of the phylum Porifera (/pəˈrɪfərə/; meaning 'pore bearer'), are a basal animal clade as a sister of the Diploblasts. They are multicellular organisms that have bodies full of pores and channels allowing water to circulate through them, consisting of jelly-like mesohyl sandwiched between two thin layers of cells. Sponges have unspecialized cells that can transform into other types and that often migrate between the main cell layers and the mesohyl in the process. Sponges do not have nervous, digestive or circulatory systems. Instead, most rely on maintaining a constant water flow through their bodies to obtain food and oxygen and to remove wastes. Sponges were first to branch off the evolutionary tree from the last common ancestor of all animals, making them the sister group of all other animals.
  • 5.0K
  • 18 Oct 2022
Topic Review
Bovine Colostrum in the Treatment of Cancer
Bovine colostrum (BC) has attracted the interest of numerous researchers investigating its anti-cancer potential in humans. Dressings loaded with BC are beneficial in treating chronic wounds and diabetic foot ulcers. Lactoferrin, a glycoprotein with potent anti-oxidant, anti-inflammatory, anti-cancer, and anti-microbial effects, is abundant in BC. The BC pills successfully promote the regression of low-grade cervical intraepithelial neoplasia when administered intravaginally. The biological, genetic, and molecular mechanisms driving BC remain to be determined. Oral BC supplements are generally well-tolerated, but some flatulence and nausea may happen. 
  • 5.0K
  • 21 Dec 2022
Topic Review
Sustainable Energy Consumption in Developing Country
Since energy consumption in developing countries has increased significantly, motivating energy-saving habits among citizens is an important issue both from the academic and industrial perspectives.
  • 5.0K
  • 09 Aug 2022
Topic Review Peer Reviewed
Age-Friendly Built Environment
Age-friendly built environments have been promoted by the World Health Organisation (WHO, Geneva, Switzerland) under the Global Age-friendly Cities (AFC) movement in which three domains are related to the built environment. These are: housing, transportation, outdoor spaces and public buildings. The aim is to foster active ageing by optimising opportunities for older adults to maximise their independent living ability and participate in their communities to enhance their quality of life and wellbeing. An age-friendly built environment is inclusive, accessible, respects individual needs and addresses the wide range of capacities across the course of life. Age-friendly housing promotes ageing in familiar surroundings and maintains social connections at the neighbourhood and community levels. Both age-friendly housing and buildings provide barrier-free provisions to minimise the needs for subsequent adaptations. Age-friendly public and outdoor spaces encourage older adults to spend time outside and engage with others against isolation and loneliness. Age-friendly public transport enables older adults to get around and enhances their mobility. For achieving an age-friendly living environment, a holistic approach is required to enable independent living, inclusion and active participation of older adults in society. The eight domains of the AFC movement are not mutually exclusive but overlap and support with one another.
  • 5.0K
  • 13 Apr 2022
Topic Review
Green Extraction Techniques for Active Ingredients in Tea
The so-called “Green Extraction”—which is based on the design of different extraction processes for the reduction in energy consumption, as well as the usage of alternative solvents and renewable natural materials —was developed.
  • 5.0K
  • 17 Feb 2023
Topic Review
Automotive Chassis Control Technology
Automotive chassis control technology plays a crucial role in ensuring the stability, performance, and safety of vehicles. This paper reviews and discusses automotive steering/braking/driving/suspension systems from perspectives of system composition, the state of the art, and key technologies. Detailed analysis is conducted on critical techniques related to system fault tolerance, road feel feedback, brake force distribution strategy, electric motors, and motor controllers.The development and application of automotive chassis control technology is in line with the goals and objectives for the advancement of the automotive industry in terms of innovation, safety, and environmental sustainability.
  • 5.0K
  • 29 Dec 2023
Topic Review
Outline of Transhumanism
The following outline provides an overview of and a topical guide to transhumanism, an international intellectual and cultural movement that affirms the possibility and desirability of fundamentally transforming the human condition by developing and making widely available technologies to eliminate aging and to greatly enhance human intellectual, physical and psychological capacities. Transhumanist thinkers study the potential benefits and dangers of emerging and hypothetical technologies that could overcome fundamental human limitations as well as study the ethical matters involved in developing and using such technologies. They predict that human beings may eventually be able to transform themselves into beings with such greatly expanded abilities as to merit the label posthuman.
  • 5.0K
  • 04 Nov 2022
Topic Review
Fountain (Duchamp)
Fountain is a readymade sculpture produced by Marcel Duchamp in 1917: a porcelain urinal signed "R.Mutt". In April 1917, an ordinary piece of plumbing chosen by Duchamp was rotated 90 degrees on its axis and submitted for an exhibition of the Society of Independent Artists, the first annual exhibition by the Society to be staged at The Grand Central Palace in New York. Fountain was not rejected by the committee but it was removed from the show area, since Society rules stated that all works would be accepted from artists who paid the fee. Following that removal, Fountain was photographed at Alfred Stieglitz's studio, and the photo published in The Blind Man. The original has been lost. The work is regarded by art historians and theorists of the avant-garde as a major landmark in 20th-century art. Sixteen replicas were commissioned by Duchamp in the 1950s and 1960s and made to his approval. Some scholars have suggested that the original work was by a female artist rather than Duchamp, but this is a minority view among historians.
  • 5.0K
  • 28 Nov 2022
Topic Review
Electrocardiogram Sensor
It is well-known that cardiovascular disease is one of the major causes of death worldwide nowadays. Electrocardiogram (ECG) sensor is one of the tools commonly used by cardiologists to diagnose and detect signs of heart disease with their patients. Since fast, prompt and accurate interpretation and decision is important in saving the life of patients from sudden heart attack or cardiac arrest, many innovations have been made to ECG sensors. However, the use of traditional ECG sensors is still prevalent in the clinical settings of many medical institutions.
  • 5.0K
  • 10 Feb 2021
Topic Review
Evolution of Digital Twins
A digital twin can be described as a digital replica of a real-world entity. It simulates the physical state and maybe the biological state and behavior of the real-world entity based on input data. It helps in predicting, optimizing, and improving decision making. It has revolutionized the industrial world, particularly the manufacturing industry, construction and healthcare sector, smart cities, and energy industry. 
  • 5.0K
  • 13 May 2021
Topic Review Peer Reviewed
Novel Bioactive Extraction and Nano-Encapsulation
An extraction technology works on the principle of two consecutive steps that involves mixture of solute with solvent and the movement of soluble compounds from the cell into the solvent and its consequent diffusion and extraction. The conventional extraction techniques are mostly based on the use of mild/high temperatures (50–90 °C) that can cause thermal degradation, are dependent on the mass transfer rate, being reflected on long extraction times, high costs, low extraction efficiency, with consequent low extraction yields. Due to these disadvantages, it is of interest to develop non-thermal extraction methods, such as microwave, ultrasounds, supercritical fluids (mostly using carbon dioxide, SC-CO2), and high hydrostatic pressure-assisted extractions which works on the phenomena of minimum heat exposure with reduced processing time, thereby minimizing the loss of bioactive compounds during extraction. Further, to improve the stability of these extracted compounds, nano-encapsulation is required. Nano-encapsulation is a process which forms a thin layer of protection against environmental degradation and retains the nutritional and functional qualities of bioactive compounds in nano-scale level capsules by employing fats, starches, dextrins, alginates, protein and lipid materials as encapsulation materials.
  • 5.0K
  • 13 Apr 2022
Topic Review
Pathophysiology and Classification of Disc Herniation
Low-back pain (LBP) is a broad category of musculoskeletal disorders regarded as one of the primary causes of disability in the general population, with a lifetime incidence of 65–85% of individuals worldwide. One of the specific causes of LBP is lumbar intervertebral disc disorders with nerve root irritation. Most individuals affected fall within the age range of 30 to 50 years, with a higher prevalence in men than in women. The intervertebral disc is formed by an inner nucleus pulposus (NP), an outer annulus fibrosus (AF), and the cartilaginous endplates that attach the disc to its vertebrae. The protrusion of disc material into the spinal canal from outside the annular lining is known as herniation. When compared to other regions, the lumbar region is where disc herniation is most commonly observed, especially at the L4-L5 and L5-S1 levels. Lumbar disc herniation associated with radiculopathy (LDHR) is the outcome of the extruded disc material pressing into or contacting the lumbar nerve roots.
  • 5.0K
  • 18 Feb 2024
  • Page
  • of
  • 2794
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback

Quick Survey

Encyclopedia MDPI is conducting a targeted survey to identify the specific barriers hindering efficient research. We invite you to spend 3 minutes defining the priorities for our next generation of structured knowledge tools.
Take Survey