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Topic Review
Xylose Metabolism in Bacteria
Some wild-type and genetically modified bacteria can metabolize xylose through three different main pathways of metabolism: xylose isomerase pathway, oxidoreductase pathway, and non-phosphorylative pathway (including Weimberg and Dahms pathways). Two of the commercially interesting intermediates of these pathways are xylitol and xylonic acid, which can accumulate in the medium either through manipulation of the culture conditions or through genetic modification of the bacteria. 
  • 1.6K
  • 28 Sep 2021
Topic Review
Biological Synthesis of Nanocatalysts
Many well-established methods are extensively utilized for the synthesis of nanocatalysts. However, most conventional physical and chemical methods have some drawbacks, such as the toxicity of precursor materials, the requirement of high-temperature environments, and the high cost of synthesis, which ultimately hinder their fruitful applications in various fields. Bioinspired synthesis is eco-friendly, cost-effective, and requires a low energy/temperature ambient. Various microorganisms such as bacteria, fungi, and algae are used as nano-factories and can provide a novel method for the synthesis of different types of nanocatalysts. The synthesized nanocatalysts can be further utilized in various applications such as the removal of heavy metals, treatment of industrial effluents, fabrication of materials with unique properties, biomedical, and biosensors.
  • 1.6K
  • 04 Jan 2022
Topic Review
Decellularized Colorectal Cancer Matrices as Bioactive Scaffolds
More than a physical structure providing support to tissues, the extracellular matrix (ECM) is a complex and dynamic network of macromolecules that modulates the behavior of both cancer cells and associated stromal cells of the tumor microenvironment (TME). Over the last few years, several efforts have been made to develop new models that accurately mimic the interconnections within the TME and specifically the biomechanical and biomolecular complexity of the tumor ECM. Particularly in colorectal cancer, the ECM is highly remodeled and disorganized and constitutes a key component that affects cancer hallmarks, such as cell differentiation, proliferation, angiogenesis, invasion and metastasis. Therefore, several scaffolds produced from natural and/or synthetic polymers and ceramics have been used in 3D biomimetic strategies for colorectal cancer research. Nevertheless, decellularized ECM from colorectal tumors is a unique model that offers the maintenance of native ECM architecture and molecular composition.
  • 1.6K
  • 18 Jan 2022
Topic Review
Microalgal Genetic Engineering for Bioremediation of Heavy Metals
Molecular tools for genome editing, together with the advent of multi-omics technologies and computational approaches, have permitted the design of tailor-made microalgal cell factories with significantly improved heavy metal bioremediation capacity.
  • 1.6K
  • 15 Mar 2022
Topic Review
Bionanomaterials Based on Honey and Propolis for wounds
Wound healing is a public health concern worldwide, particularly in chronic wounds due to delayed healing and susceptibility to bacterial infection. Nanomaterials are widely used in wound healing treatments due to their unique properties associated with their size and very large surface-area-to-volume ratio compared to the same material in bulk. The properties of nanomaterials can be expanded and improved upon with the addition of honey and propolis, due to the presence of bioactive molecules such as polyphenols, flavonoids, peptides, and enzymes. These bionanomaterials can act at different stages of wound healing and through different mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulation, cell proliferation, and angiogenic effects.
  • 1.5K
  • 29 Jan 2023
Topic Review
Microparticles on Fungal Fermentation
Ranging from simple food ingredients to complex pharmaceuticals, value-added products via microbial fermentation have many advantages over their chemically synthesized alternatives. Some of such advantages are environment-friendly production pathways, more specificity in the case of enzymes as compared to the chemical catalysts and reduction of harmful chemicals, such as heavy metals or strong acids and bases. Fungal fermentation systems include yeast and filamentous fungal cells based on cell morphology and culture conditions.
  • 1.5K
  • 21 Dec 2022
Topic Review
Microbially Induced Carbonate Precipitation
 Microbially induced carbonate precipitation (MICP) is a promising technology for solidifying sandy soil, ground improvement, repairing concrete cracks, and remediation of polluted land. By solidifying sand into soil capable of growing shrubs, MICP can facilitate peak and neutralization of CO2 emissions because each square meter of shrub can absorb 253.1 grams of CO2 per year.
  • 1.5K
  • 01 Dec 2021
Topic Review
CRISPR-Based Genome Editing Tools
Genome-editing (GE) is having a tremendous influence around the globe in the life science community. Among its versatile uses, the desired modifications of genes, and more importantly the transgene (DNA)-free approach to develop genetically modified organism (GMO), are of special interest. The recent and rapid developments in genome-editing technology have given rise to hopes to achieve global food security in a sustainable manner. 
  • 1.5K
  • 23 Jun 2021
Topic Review
Potential Application of Fungal Pigments
Fungal pigments are produced as secondary metabolites when essential nutrients in the culture medium are depleted or the environment is unfavorable for growth. Since natural pigments have benefits over synthetic pigments, their popularity has grown considerably. It has been demonstrated that fungi are a reliable, accessible, alternative supply of natural pigments. Applications for fungal pigments include food coloring, antimicrobial defense, antioxidant agents, cancer prevention, and so on.
  • 1.5K
  • 11 Apr 2023
Topic Review
Syndecans and Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because pa-tients rarely express symptoms in initial stages, which prevents early detection and diagnosis. Syndecans, a subfamily of proteoglycans, are involved in many physiological processes includ-ing cell proliferation, adhesion, and migration. Syndecans are physiologically found in many cell types and their interactions with other macromolecules enhance many pathways. In particu-lar, extracellular matrix components, growth factors, and integrins collect the majority of syndecans associations acting as biochemical, physical, and mechanical transducers. Syndecans are transmembrane glycoproteins, but occasionally their extracellular domain can be released from the cell surface by the action of matrix metalloproteinases, converting them into soluble molecules that are capable of binding distant molecules such as extracellular matrix (ECM) components, growth factor receptors, and integrins from other cells.
  • 1.5K
  • 02 Mar 2021
Topic Review
Developments in FRET- and BRET-Based Biosensors
Resonance energy transfer technologies have achieved great success in the field of analysis. Particularly, fluorescence resonance energy transfer (FRET) and bioluminescence resonance energy transfer (BRET) provide strategies to design tools for sensing molecules and monitoring biological processes, which promote the development of biosensors.
  • 1.5K
  • 06 Jan 2023
Topic Review
Capillary-Driven Flow Device
The capillary flow device works on the principle of capillary-driven flow microfluidics and allows detection by multiple microchannels in a single microchip via smartphone imaging/portable detectors. Compared to other types of devices such as dipsticks and paper microfluidic devices, this device is fabricated with cheaper materials, coated with minute amounts of reagents and offers multiplexity on a single microchip. The sample is loaded into the microchannels via capillary force, which eliminates the requirement of external/internal fluidic mechanisms or controls. A capillary-driven flow device was developed in this study which is simple to operate and allows loading multiple samples in a single device.
  • 1.5K
  • 30 Oct 2020
Topic Review
Characteristics and Microbial Degradation of Preservatives in Cosmetics
Personal care products (PCPs) have surfaced as a novel class of pollutants due to their release into wastewater treatment plants (WWTPs) and receiving environments by sewage effluent and biosolid-augmentation soil, which poses potential risks to non-target organisms. Among PCPs, there are preservatives that are added to cosmetics for protection against microbial spoilage. 
  • 1.5K
  • 27 Dec 2022
Topic Review
Microbial Electrolysis Cell
Carbon constraints, as well as the growing hazard of greenhouse gas emissions, have accelerated research into all possible renewable energy and fuel sources. Microbial electrolysis cells (MECs), a novel technology able to convert soluble organic matter into energy such as hydrogen gas, represent the most recent breakthrough. 
  • 1.5K
  • 09 Aug 2021
Topic Review
Evolution Road of Seaweed Aquaculture
Seaweeds (marine macroalgae) are autotrophic organisms capable of producing many compounds of interest. For a long time, seaweeds have been seen as a great nutritional resource, primarily in Asian countries to later gain importance in Europe and South America, as well as in North America and Australia. It has been reported that edible seaweeds have a nutritional value along with a low caloric input and with the presence of proteins, minerals (iron and calcium), vitamins, structural polysaccharides (fibers), omega-6 and omega-3 unsaturated fatty acids. Moreover, they have plenty of bioactive molecules that can be applied in nutraceutical, pharmaceutical and cosmetic areas. There are historical registers of harvest and cultivation of seaweeds but with the increment of the studies of seaweeds and their valuable compounds, their aquaculture has increased. The methodology of cultivation varies from onshore to offshore. Seaweeds can also be part of integrated multi-trophic aquaculture (IMTA), which has great opportunities but is also very challenging to the farmers. This multidisciplinary field applied to the seaweed aquaculture is very promising to improve the methods and techniques; this area is developed under the denominated industry 4.0.  Aquaculture consists in the creation or culture of aquatic organisms (in this case, Marine Macroalgae or Seaweeds), through the application of techniques designed to increase the production of these same organisms, in addition to the natural capabilities of the environment
  • 1.5K
  • 06 Apr 2021
Topic Review
Autophagy and Chronic Kidney Disease
Autophagy is a lysosomal protein degradation system that eliminates cytoplasmic components such as protein aggregates, damaged organelles, and even invading pathogens. Autophagy is an evolutionarily conserved homoeostatic strategy for cell survival in stressful conditions and has been linked to a variety of biological processes and disorders. It is vital for the homeostasis and survival of renal cells such as podocytes and tubular epithelial cells, as well as immune cells in the healthy kidney. Autophagy activation protects renal cells under stressed conditions, whereas autophagy deficiency increases the vulnerability of the kidney to injury, resulting in several aberrant processes that ultimately lead to renal failure.
  • 1.5K
  • 25 Apr 2023
Topic Review
Jackfruit Waste Utilizd in Sustainable Energy and Biochemicals
Jackfruit (Artocarpus heterophyllus L.) trees are known to produce huge fruits from their stems and are unique in terms of food utilization as vegetables and fruits. Jackfruit trees are cultivated throughout the lowlands in south and southeast Asian countries. In addition, it is found in east Africa, as well as throughout Brazil and Caribbean nations such as Jamaica.
  • 1.5K
  • 18 Sep 2023
Topic Review
Bionanotechnology in Food Packaging
Bionanotechnology, as a tool for incorporation of biological molecules into nanoartifacts, is gaining more and more importance in the field of food packaging. It offers an advanced expectation of food packaging that can ensure longer shelf life of products and safer packaging with improved food quality and traceability. 
  • 1.5K
  • 19 Feb 2021
Topic Review
Bioproducts from the Microalgae-Bacteria Interaction
In nature, interactions between bacteria and microalgae play an indispensable role in maintaining the integrity of the aquatic ecosystem through networks of interactions such as competition and mutualism. In fact, in the wild, the growth of algae is consistently associated with the growth of other microorganisms, especially bacteria. Axenic culture systems and sterilization of culture media in large-scale production of microalga are not economically feasible. Therefore, the characterization of associated heterotrophs in algae culture systems is an important step since bacteria may use compounds excreted by algae, increasing the availability of trace elements and solubility of nutrients, making them more bioavailable for microalgae. In addition, they can help to reduce the saturation of dissolved O2. In microalgae cultivation, it is well known that dissolved O2 can attain inhibitory levels.
  • 1.5K
  • 25 Nov 2022
Topic Review
Spirochetes as Causative Agents of Alzheimer’s Disease
Spirochetes are bacteria that can also form biofilms, and there is increasing evidence regarding infections with specific species. Borrelia burgdorferi, and several species of treponemes are some of the most studied spirochetes regarding Alzheimer’s Disease. Spirochetes were visualized in the neurofibrillary tangles and senile plaques in the brains of individuals with AD, and peptidoglycan was also located near Aβ deposits.
  • 1.5K
  • 06 Jan 2022
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