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Topic Review
Potentially Toxic Elements
Potentially toxic element (PTE) pollution is a major abiotic stress, which reduces plant growth and affects food quality by entering the food chain, and ultimately poses hazards to human health.
  • 5.1K
  • 18 May 2021
Topic Review
Botulinum Toxin Therapy for Oromandibular Dystonia
Botulinum neurotoxin injection is effective and safe, with few side effects in most cases when properly administered by an experienced clinician. The diagnosis and treatment of oromandibular dystonia require both neurological and dental or oral surgical knowledge and skills, and well-designed multicenter trials with a multidisciplinary team approach must be necessary to ensure accurate diagnosis and proper treatment. 
  • 5.1K
  • 23 Jun 2022
Topic Review
Malayan Languages
The Malay or Malayan languages are a group of closely related languages spoken by Malays and related peoples across Brunei, Indonesia, Malaysia, Singapore, Southern Thailand and the far southern parts of the Philippines. They have traditionally been classified as Malay, Para-Malay, and Aboriginal Malay, but this reflects geography and ethnicity rather than a proper linguistic classification. The Malayan languages are mutually intelligible to varying extents, though the distinction between language and dialect is unclear in many cases. Para-Malay includes the Malayan languages of Sumatra. They are: Minangkabau, Central Malay (Bengkulu), Pekal, Musi (Palembang), Negeri Sembilan (Malaysia), and Duano’. Aboriginal Malay are the Malayan languages spoken by the Orang Asli (Proto-Malay) in Malaya. They are Jakun, Orang Kanaq, Orang Seletar, and Temuan. The other Malayan languages, included in neither of these groups, are associated with the expansion of the Malays across the archipelago. They include Malaccan Malay (Malaysian and Indonesian), Kedah Malay, Kedayan/Brunei Malay, Berau Malay, Bangka Malay, Jambi Malay, Kutai Malay, Loncong, Pattani Malay, and Banjarese. There are also several Malay-based creole languages, such as Betawi, Cocos Malay, Manado Malay and Sabah Malay, which may be more or less distinct from standard (Malaccan) Malay.
  • 5.1K
  • 13 Oct 2022
Topic Review
Sheep Meat Processed Products
A concise review of the origin and type of the most important sheep and goat processed meat products produced in different countries and world regions is made. The manuscript also summarizes the most recent studies on sheep and goat processed meats on the physicochemical characterizations, sensory quality, microbiological quality and safety. Some conclusions and future trends in production, processing and commercial potentiality for sheep and goat processed meat products are discussed.
  • 5.1K
  • 06 Dec 2023
Topic Review
Blading (Professional Wrestling)
In professional wrestling, blading is the practice of intentionally cutting oneself to provoke bleeding. It is also known as "juicing", "gigging", or "getting color". Similarly, a blade is an object used for blading and a bladejob is a specific act of blading. The act is usually done a good length into the match as the blood will mix with the flowing sweat to make it look like much more blood is flowing from the wound than there actually is. The preferred area for blading is usually the forehead, as scalp wounds bleed profusely and heal easily. Legitimate, unplanned bleeding which occurs outside the storyline is called "juicing the hard way".
  • 5.1K
  • 24 Oct 2022
Topic Review
Hole-Transporting Layer in Perovskite Solar Cells
Organic-inorganic halide perovskite solar cells (PSCs) have received particular attention because of the high-power conversion efficiencies (PCEs), facile fabrication route and low cost. The hole-transporting layer (HTL) play an important role in PSCs to effectively extract holes from the perovskite film and to transport holes to the metal electrode in normal PSCs. 
  • 5.1K
  • 09 Aug 2022
Topic Review
Closed Graph
In mathematics, particularly in functional analysis and topology, closed graph is a property of functions. A function f : X → Y between topological spaces has a closed graph if its graph is a closed subset of the product space X × Y. A related property is open graph. This property is studied because there are many theorems, known as closed graph theorems, giving conditions under which a function with a closed graph is necessarily continuous. One particularly well-known class of closed graph theorems are the closed graph theorems in functional analysis.
  • 5.1K
  • 18 Oct 2022
Topic Review
Identity
Identity refers to the distinct and unique set of characteristics, qualities, beliefs, and affiliations that define an individual or a group. It encompasses various aspects, including personal attributes, cultural heritage, social roles, and a sense of belonging. Identity is dynamic, shaped by personal experiences, societal influences, and the interactions between individuals and their broader cultural, social, and historical contexts. It plays a crucial role in shaping how individuals perceive themselves and how they are perceived by others. Additionally, identity can be expressed through factors such as ethnicity, nationality, gender, religion, and personal values, contributing to the richness and diversity of human experiences.
  • 5.1K
  • 25 Jan 2024
Topic Review
Types of Aluminium Matrix Composites
Al alloy has very attractive properties required in the production of aerospace, automotive, electrical and electronic, sports and recreational components/equipment. Its low strength and low wear resistance have challenged its applications in some other critical industrial utilities. Nonetheless, the invention of metal composites has removed such barriers. The addition of one or more reinforcements to Al has helped in the creation of aluminium matrix composites (AMCs), which has not only increased the global utilization of Al alloy, but has been a major source of global revenue and job. 
  • 5.1K
  • 20 Oct 2022
Topic Review
Fluid Catalytic Cracking
The fluid catalytic cracking (FCC) process is an alternative olefin production technology, with lower CO2 emission and higher energy-saving.
  • 5.1K
  • 23 Feb 2021
Topic Review
Ural–Altaic Languages
Ural–Altaic, Uralo-Altaic or Uraltaic is a linguistic convergence zone and former language-family proposal uniting the Uralic and the Altaic (in the narrow sense) languages. It is generally now agreed that even the Altaic languages most likely do not share a common descent: the similarities among Turkic, Mongolic and Tungusic are better explained by diffusion and borrowing. The term continues to be used for the central Eurasian typological, grammatical and lexical convergence zone. Indeed, "Ural-Altaic" may be preferable to "Altaic" in this sense. For example, J. Janhunen states that "speaking of 'Altaic' instead of 'Ural-Altaic' is a misconception, for there are no areal or typological features that are specific to 'Altaic' without Uralic." Originally suggested in the 18th century, the genealogical and racial hypotheses remained debated into the mid-20th century, often with disagreements exacerbated by pan-nationalist agendas. It had many proponents in Britain. Since the 1960s, the proposed language family has been widely rejected. A relationship between the Altaic, Indo-European and Uralic families was revived in the context of the Nostratic hypothesis, which was popular for a time, with for example Allan Bomhard treating Uralic, Altaic and Indo-European as coordinate branches. However, Nostratic too is now mostly rejected.
  • 5.1K
  • 31 Oct 2022
Topic Review
Targeted Therapy for NSCLC Patients with EGFR Mutations
Oncogenic mutations within the epidermal growth factor receptor (EGFR) kinase domain are well-established driver mutations in non–small cell lung cancer (NSCLC). Small-molecule tyrosine kinase inhibitors (TKIs) specifically targeting these mutations have improved treatment outcomes for patients with this subtype of NSCLC. Multiple targeted agents, including first-, second- and third-generation EGFR TKIs, have been approved or are under active investigation for patients with EGFR-mutant NSCLC. The first-generation TKIs, including erlotinib and gefitinib, are reversible inhibitors, binding both to mutant as well as wild-type (WT) EGFR. The second-generation TKIs, including afatinib and dacomitinib, are irreversible inhibitors that covalently bind to EGFR. The third-generation EGFR TKIs, including osimertinib (AZD9291), aumolertinib (HS-10296) and alflutinib (AST2818), are irreversible inhibitors that selectively bind to mutant EGFR and show greater efficacy than the first- and second-generation TKIs. Osimertinib has been approved by the FDA for both frontline and second-line treatment of NSCLC with EGFR-sensitizing mutations. Aumolertinib (HS-10296) and alflutinib (AST2818) have been approved for the treatment of EGFR-mutant NSCLC in China. Acquired resistance inevitably occurs, and a promising new generation of EGFR-targeting agents is under investigation.
  • 5.1K
  • 09 Feb 2023
Topic Review
Humic Substances
Humic substances are a very important part of our soil.  The topic is description of the structure of humic substances using NMR.  The NMR part is divided into two parts, liquid and solid state NMR.  The assignment of NMR spectra are discussed and the structural elements that can be deduced from the spectral information.  Principal Component Analysis is used as a tool to categorize the information.  Structural models are discussed.
  • 5.1K
  • 16 Jul 2024
Topic Review
Internal Monologue
An internal monologue, also called self-talk, inner speech, inner discourse or internal discourse, is a person's inner voice which provides a running verbal monologue of thoughts while they are conscious. It is usually tied to a person's sense of self. It is particularly important in planning, problem solving, self-reflection, self-image, critical thinking, emotions, and subvocalization (reading in one's head). As a result, it is relevant to a number of mental disorders, such as depression, and treatments like cognitive behavioural therapy which seek to alleviate symptoms by providing strategies to regulate cognitive behaviour. It may reflect both conscious and subconscious beliefs. In some cases people may think of inner speech as coming from an external source, as with schizophrenic auditory hallucinations. Additionally, not everyone has a verbal internal monologue (see § Absence of an internal monologue). The looser flow of thoughts and experiences, verbal or not, is called a stream of consciousness, which can also refer to a related technique in literature. In a theory of child development formulated by Lev Vygotsky, inner speech has a precursor in private speech (talking to oneself) at a young age.
  • 5.1K
  • 15 Nov 2022
Topic Review
Myeloid-Derived Suppressor Cells
Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells derived from bone marrow. They are precursors of dendritic cells, macrophages and/or granulocytes. They have the ability to significantly inhibit immune cell responses.
  • 5.1K
  • 27 Oct 2020
Topic Review
Effects of Creatine Supplementation on Brain Function
Creatine, a nitrogenous organic compound derived from reactions involving the amino acids arginine, glycine, and methionine, is important for resynthesizing ATP, particularly during times of increased metabolic demand (e.g., sleep deprivation, mental health conditions, or neurological diseases). Creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain creatine content in humans. Furthermore, creatine has shown some promise for attenuating symptoms of concussion, mild traumatic brain injury and depression but its effect on neurodegenerative diseases appears to be lacking. 
  • 5.1K
  • 09 Jun 2022
Topic Review
Tomato and Olive Oil in Prostate Health
Tomato, the fruit providing the most comprehensive complex of prostate-health-preserving micronutrients, has been shown to be superior to its single-nutrient counterparts in decreasing the incidence of age-related prostate diseases.
  • 5.1K
  • 30 Mar 2023
Topic Review
TCV and TGV Technology
Through ceramic via (TCV) technology expands the volume of high-precision and high-power thin-film circuits with 3D planar distribution, significantly improves the structural density and reduces the device size through via interconnection and circuit redistribution. Through glass via (TGV) technology has the advantages of high-density interconnection and low-loss transmission, which forms a highly reliable interconnection between the chip and the substrate, has higher I/O density and smaller spacing, and realizes passive on-chip devices, high-density copper interconnection and the heterogeneous integration of chips. Therefore, 3D integration and system-level packaging technology have developed rapidly.
  • 5.1K
  • 26 Jul 2023
Topic Review
Borderland
The word “borderland” has many meanings; however, it is most often considered from the geographical and sociological, or, in other words, spatial and cultural perspective. The borderland is an area or a territory located near the border or far away from the centre. Within the borderland, socio-cultural contact takes place between various nations or ethnic groups. This is where the “new people and their culture” are formed. A borderland is sometimes precisely delimited, e.g., based on natural objects such as rivers or mountain ranges, or on administrative attributes. It is, however, most frequently determined on the basis of settlement geography. Its actual area and range are determined by migrations, colonisation, and cultural diversity of its inhabitants .
  • 5.1K
  • 19 Jul 2021
Topic Review
Application of Analog-to-Digital Converter in Ultrasonic Imaging System
The ADC, a bridge between the analog world and the digital world, converts the analog signals to digital so that the analog signal in the baseband can be processed by the back-end computer or microprocessor.
  • 5.1K
  • 17 Jan 2022
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