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Topic Review
Applications of Graphene in Biosensors for Cancer Detection
Biosensors are a very promising tool for the possibility of sensitive, specific, and non-invasive diagnosis for early detection of cancer. Effective, accurate methods of cancer detection and clinical diagnosis are urgently needed. Biosensors are devices that are designed to detect a specific biological analyte by essentially converting a biological entity (i.e., protein, DNA, RNA) into an electrical signal that can be detected and analyzed. The ultimate goal of biosensors is to detect signals specific to each disease and cancer, and recently nanoparticles have been widely used in the design of biosensors. Graphene and its derivatives are nanoparticles with unique properties and have many applications in nanobiosensors.
  • 1.2K
  • 21 Jul 2022
Topic Review
Cryptococcus
Cryptococcosis is a disease caused by the pathogenic fungi Cryptococcus neoformans and Cryptococcus gattii, both environmental fungi that cause severe pneumonia and may even lead to cryptococcal meningoencephalitis. Although C. neoformans affects more fragile individuals, such as immunocompromised hosts through opportunistic infections, C. gattii causes a serious indiscriminate primary infection in immunocompetent individuals. Typically seen in tropical and subtropical environments, C. gattii has increased its endemic area, largely due to climatic factors that favor contagion in warmer climates. It is important to point out that not only C. gattii, but the Cryptococcus species complex produces a polysaccharidic capsule with immunomodulatory properties, enabling the pathogenic species of Cryptococccus to subvert the host immune response during the establishment of cryptococcosis, facilitating its dissemination in the infected organism. C. gattii causes a more severe and difficult-to-treat infection, with few antifungals eliciting an effective response during chronic treatment. 
  • 1.2K
  • 26 Jul 2022
Topic Review
Metallic/Metal Oxides Nanoparticles for Sensing Food Pathogens
Food quality currently creates significant problems for the industry and implicitly for consumers and society. The effects materialize in economic losses, alterations of the quality and organoleptic properties of the commercial products, and, last but not least, they constitute risk factors for the consumer’s health.
  • 1.2K
  • 23 Aug 2022
Topic Review
Measuring Network Throughput
Throughput of a network can be measured using various tools available on different platforms. This page explains the theory behind what these tools set out to measure and the issues regarding these measurements. Reasons for measuring throughput in networks. People are often concerned about measuring the maximum data throughput in bits per second of a communications link or network access. A typical method of performing a measurement is to transfer a 'large' file from one system to another system and measure the time required to complete the transfer or copy of the file. The throughput is then calculated by dividing the file size by the time to get the throughput in megabits, kilobits, or bits per second. Unfortunately, the results of such an exercise will often result in the goodput which is less than the maximum theoretical data throughput, leading to people believing that their communications link is not operating correctly. In fact, there are many overheads accounted for in throughput in addition to transmission overheads, including latency, TCP Receive Window size and system limitations, which means the calculated goodput does not reflect the maximum achievable throughput.
  • 1.2K
  • 17 Oct 2022
Topic Review
Personalized Marketing
Personalized marketing, or one-to-one marketing, individual marketing is a marketing strategy by which companies leverage data analysis and digital technology to deliver individualized messages and product offerings to current or prospective customers. Advancements in data collection methods, analytics, digital electronics, and digital economics, have enabled marketers to deploy more effective real-time and prolonged customer experience personalization tactics. Beginning in the early 1990s, web developers began tracking HTML calls that their websites were receiving from online visitors. This led to the 1993 founding of Webtrends, which is widely considered the first commercial web analytics solution. In 2012, the Web Analytics Association (WAA) officially changed its name to the Digital Analytics Association (DAA) in order to accommodate new and developing data streams that exist in addition to the web.
  • 1.2K
  • 26 Oct 2022
Topic Review
Neurofibromin Functions
Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 (NF1). Neurofibromatosis type 1 is an autosomal dominant disorder caused by inherited or de novo germline mutations in the NF1 tumor suppressor gene. It is the most common tumor-predisposing disease in humans. It affects approximately one in 3000 live births and patients present widely heterogeneous clinical manifestations, even within the same family.
  • 1.2K
  • 28 Oct 2022
Topic Review
Westinghouse Lamp Plant
Coordinates: 40°46′53″N 74°11′45″W / 40.78137°N 74.19592°W / 40.78137; -74.19592 The Westinghouse Lamp Plant located in Bloomfield, New Jersey, was one of the lamp manufacturing plants of Westinghouse Electric Corporation. The plant had a major involvement in supplying uranium metal for the world's first self-sustaining chain reaction in Chicago (Chicago Pile-1) in the early phase of the Manhattan Project to create the first atomic bomb.
  • 1.2K
  • 24 Nov 2022
Topic Review
Risk Ratio
In epidemiology, risk ratio (RR) or relative risk is the ratio of the probability of an outcome in an exposed group to the probability of an outcome in an unexposed group. It is computed as [math]\displaystyle{ I_e / I_u }[/math], where [math]\displaystyle{ I_e }[/math] is the incidence in the exposed group, and [math]\displaystyle{ I_u }[/math] is the incidence in the unexposed group. Together with risk difference and odds ratio, risk ratio measures the association between the exposure and the outcome.
  • 1.2K
  • 01 Dec 2022
Topic Review
Heavy Metals in Agricultural Soils
Population growth and increasing food demand have led to an intensification of agricultural production systems, putting stress on soils and increasing soil contaminants. Some human-induced contaminants, such as heavy metals (HMs), are well-known and have been present in agricultural soils for a long time. In order to provide an overview of HMs in agricultural soils, it is important to investigate agriculturally related sources of contamination with HMs, behaviour of HMs in agricultural soils, as well as their interactions with soil microorganisms, fauna, and plants.
  • 1.2K
  • 08 Dec 2022
Topic Review
Human Milk Oligosaccharides as Potential Antibiofilm Agents
Bacteria possess a unique capability to form biofilms that are ubiquitous in nature. It is a multistage and elaborate process that begins with bacterial adhesion to surfaces, followed by the synthesis of extracellular polymeric substance (EPS) matrix, development of microcolonies, and finally concludes with the dispersion of the bacterial cells from the initial. The morphology of biofilms can be diverse and that mostly relies on the integral bacterial species and the circumstances under which the biofilm was originally formed. The development of biofilms protects the bacteria against enzymatic degradation, antimicrobials, and host defense systems. Population heterogeneity, slow metabolic activity, increased efflux pumps, and presence of persister subpopulations are some of the major factors that reduce antimicrobial susceptibility in biofilms. 
  • 1.2K
  • 08 Dec 2022
Topic Review
Biomimetic Approaches in Clinical Endodontics
Endodontics is an important sub-branch of dentistry which deals with the different conditions of pulp to prevent tooth loss. Traditionally, common procedures, namely pulp capping, root canal treatment, apexification, and apexigonesis, have been considered for the treatment of different pulp conditions using selected materials. However, clinically to regenerate dental pulp, tissue engineering has been advocated as a feasible approach. New trends are emerging in terms of regenerative endodontics which have led to the replacement of diseased and non-vital teeth into the functional and healthy dentine-pulp complex. Root- canal therapy is the standard management option when dental pulp is damaged irreversibly. This treatment modality involves soft-tissue removal and then filling that gap through the obturation technique with a synthetic material. The formation of tubular dentine and pulp-like tissue formation occurs when stem cells are transplanted into the root canal with an appropriate scaffold material. To sum up tissue engineering approach includes three components: (1) scaffold, (2) differentiation, growth, and factors, and (3) the recruitment of stem cells within the pulp or from the periapical region.
  • 1.2K
  • 31 Jan 2023
Topic Review
Functional Compounds and Ingredients from Soybean to Tofu
Soybean (Glycine max) is a soybean plant whose seeds are abounding in protein. In Asia, the soybean is a native plant with oval and spherical fruits. Due to different strains, the color of the seed coat is yellow, light green, brown, and black; they are also known as soy, green, and black beans. 
  • 1.2K
  • 09 Mar 2023
Topic Review
Smart Transportation
As technology continues to evolve, our society is becoming enriched with more intelligent devices that help us perform our daily activities more efficiently and effectively. One of the most significant technological advancements of our time is the Internet of Things (IoT), which interconnects various smart devices (such as smart mobiles, intelligent refrigerators, smartwatches, smart fire alarms, smart door locks, and many more) allowing them to communicate with each other and exchange data seamlessly. 
  • 1.2K
  • 15 May 2023
Topic Review
Intranasal Drug Administration in Alzheimer-Type Dementia
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways. 
  • 1.2K
  • 22 May 2023
Topic Review
Segmental Switched Reluctance Motor
Due to the high robustness and control flexibility of switched reluctance motors (SRMs), segmented structures have been widely studied to expand its applications in aerospace and other industrial fields.
  • 1.2K
  • 04 Sep 2023
Topic Review
Mitochondrial Dynamics and Insulin Secretion
Mitochondria are involved in the regulation of cellular energy metabolism, calcium homeostasis, and apoptosis. For mitochondrial quality control, dynamic processes, such as mitochondrial fission and fusion, are necessary to maintain shape and function. Disturbances of mitochondrial dynamics lead to dysfunctional mitochondria, which contribute to the development and progression of numerous diseases, including Type 2 Diabetes (T2D). Compelling evidence has been put forward that mitochondrial dynamics play a significant role in the metabolism-secretion coupling of pancreatic β cells. The disruption of mitochondrial dynamics is linked to defects in energy production and increased apoptosis, ultimately impairing insulin secretion and β cell death. 
  • 1.2K
  • 10 Oct 2023
Topic Review
Factors Affecting Income of Flexible Workers in China
Numerous workers have adopted the flexible working approach due to its accommodating and job-sharing features, which play a key role in easing the employment pressure and maintaining socio-economic sustainability in China. It was found that, firstly, while the feature of flexible employment may be very different from formal employment, its relationship with work experience and income is as significantly correlated as it is for formal employment with a rise–fall, inverted U-shaped trend, but the return on work experience is lower than the employment level in the labor market. Secondly, there is an income gap between genders, especially in physical labor-intensive forms of flexible work; women can gradually narrow the gender income gap through continuous learning. Thirdly, the return on work experience in the older age group is lower than that in the youth group of flexible workers, and this may be due to the dynamic evolution of the elimination of existing work experience and the accumulation of new work experience. Fourthly, in contrast with the findings of the labor market as a whole, the trend of work experience return in flexible employment is reversed; the low-income group’s return rate of work experience is higher than that of the high-income group, and it can be seen that flexible employment is conducive to the development of new and young workers.
  • 1.2K
  • 07 Dec 2023
Topic Review
Giant Otter
The Giant Otter (Pteronura brasiliensis) stands as one of the largest and most charismatic members of the Mustelidae family, captivating observers with its sleek, streamlined physique and social behaviors. Endemic to the freshwater habitats of South America, particularly the Amazon Basin, this semi-aquatic carnivore is known for its intricate vocalizations and close-knit family groups. Despite facing threats from habitat loss, pollution, and illegal hunting, conservation efforts are underway to protect and preserve this iconic species and its vital role in maintaining the health of aquatic ecosystems.
  • 1.2K
  • 28 Feb 2024
Topic Review
Magnetic Nanoparticles for Diagnosis and Treatment of Cancer
Cancer is a disease that has resulted in millions of deaths worldwide. The current conventional therapies utilized for the treatment of cancer have detrimental side effects. This led scientific researchers to explore new therapeutic avenues with an improved benefit to risk profile. 
  • 1.2K
  • 10 Dec 2021
Topic Review
Wines Aging
Wine is perhaps the most ancient and popular alcoholic beverage worldwide. Winemaking practices involve careful vineyard management alongside controlled alcoholic fermentation and potential aging of the wine in barrels.
  • 1.2K
  • 02 Feb 2021
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