Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Hemochromatosis
Haemochromatosis, also spelled hemochromatosis, is a hereditary disease characterized by improper processing by the body of dietary iron which causes iron to accumulate in a number of body tissues, eventually causing organ dysfunction. It is the most common iron overload disorder.
  • 1.2K
  • 11 Nov 2022
Topic Review
Phosphatidylinositol Binding Clathrin-Assembly Protein and Alzheimer’s Disease
Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus after APOE and BIN1. PICALM is a clathrin-adaptor protein that plays a critical role in clathrin-mediated endocytosis and autophagy.
  • 1.2K
  • 22 Dec 2022
Topic Review
Natural Fiber in Frictional Material of Brake Pads
Research into the use of eco-friendly materials, such as natural fibers, in brake pads has gained momentum. This can be attributed to the potential of natural fibers to replace traditional materials in tribological applications such as braking pads. The harmful impact of commonly-used brake pad materials, such as metal and mineral fibers, on human health and the environment, necessitates the development of eco-friendly alternatives. Natural fibers, such as banana peels, palm kernels, and palm slag, have been shown to be viable replacements for traditional brake pad materials.
  • 1.2K
  • 23 Feb 2023
Topic Review
Roles of Cryogenic Cooling in Turning
Cryogenic machining is a recently developed technique used in various machining processes, including turning, milling, and drilling. Specifically, cryogenic turning is applied to three main groups of workpiece materials: superalloys, ferrous metals, and viscoelastic polymers/elastomers.
  • 1.2K
  • 23 Feb 2023
Topic Review
Isolated Marine Compounds with Antifungal Activity
The oceans represent the largest ecosystem on earth, with a high diversity of organisms. Oceans have received some attention, and promising compounds with antimicrobial activities were isolated from marine organisms such as bacteria, fungi, algae, sea cucumbers, sea sponges, etc. 
  • 1.2K
  • 02 Aug 2023
Topic Review
Functional Nanostructured Materials in the Cosmetics Industry
Cosmetics have always been in demand across the globe among people of all age groups. In the modern cosmetic world, nanostructured materials have proven hugely advantageous in producing cosmeceuticals or ‘nano-cosmeceuticals’ and various beauty products. The application of nanostructured materials in cosmetic products possesses some challenges in terms of short- and long-term safety and environmental issues, despite their growing popularity. The nanostructured particles in cosmeceuticals provide a targeted route of administration due to their high penetrability, site selectivity, high effectiveness, prolonged activity, and drug encapsulation potential. However, standard methods for toxicity evaluation may not be relevant for cosmeceuticals, leading to the need for an alternative methodology.
  • 1.2K
  • 21 Aug 2023
Topic Review
Preclinical Prostate Cancer Research
We address the challenges of using primary cultures and patient-derived xenografts to study prostate cancer. We describe emerging approaches using primary prostate epithelial cells and prostate organoids and their genetic manipulation for disease modelling. Furthermore, the use of human prostate-derived induced pluripotent stem cells (iPSCs) is highlighted as a promising complimentary approach. Finally, we discuss the manipulation of iPSCs to generate ‘avatars’ for drug disease testing. Specifically, we describe how a conceptual advance through the creation of living biobanks of "genetically engineered cancers" that contain patient-specific driver mutations hold promise for personalised medicine. 
  • 1.2K
  • 27 Oct 2020
Topic Review
Computational Methods in Drug Screening and Design
Drug development is one of the most significant processes in the pharmaceutical industry. Various computational methods have dramatically reduced the time and cost of drug discovery. 
  • 1.2K
  • 18 Nov 2021
Topic Review
Polycomb Repressive Complex 2
Polycomb repressive complex 2 (PRC2) represents a group of evolutionarily conserved multi-subunit complexes that repress gene transcription by introducing trimethylation of lysine 27 on histone 3 (H3K27me3). PRC2 activity is of key importance for cell identity specification and developmental phase transitions in animals and plants.
  • 1.2K
  • 08 Feb 2022
Topic Review
Caseinolytic Protease Protease Families
Bacterial proteases participate in the proteolytic elimination of misfolded or aggregated proteins, carried out by members of the AAA+ protein superfamily such as Hsp100/Clp (heat shock protein-100/caseinolytic protease), Lon, and FtsH. It is estimated that the Clp and Lon families perform around 80% of cellular proteolysis in bacteria. The HSP100/Clp family of ATPases plays crucial roles in the folding, assembly, and degradation of proteins during normal growth and, mainly, under stress-inducing conditions. This family is formed by several ATPase chaperones and the peptidase ClpP (caseinolytic protease proteolytic subunit).
  • 1.2K
  • 18 Jan 2023
Topic Review
Genetic Effects on Plant Immunity
An immune system is a protective mechanism that shields plants from environmental stresses. This primary function is to maintain optimal circumstances for the growth and development of plant tissues while avoiding harm from biotic and abiotic stress factors. Plants subjected to various stressors initiate stress signaling cascades that affect multiple gene expressions and induce adaptation. These signaling pathways are coordinated by transcription factors, non-coding RNAs, RNA-binding proteins, and protein-protein interaction networks.
  • 1.2K
  • 22 Nov 2022
Topic Review
Sociology of Culture
The sociology of culture is a subfield of sociology that examines how culture—defined as shared beliefs, values, norms, symbols, and practices—shapes and is shaped by social structures, power dynamics, and human interactions. It explores how cultural meanings are created, transmitted, and transformed across societies and historical periods. The field intersects with anthropology, media studies, political science, and philosophy, drawing upon both macro-sociological perspectives (structuralism, functionalism, Marxism) and micro-sociological approaches (symbolic interactionism, phenomenology). Cultural sociologists analyze topics such as ideology, mass media, identity formation, cultural consumption, globalization, and the role of institutions (such as religion, education, and the arts) in shaping cultural life. The field also investigates how culture influences social stratification, political ideologies, and economic systems.
  • 1.2K
  • 04 Mar 2025
Topic Review
MiRNA in Rhabdomyosarcoma
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood and adolescence, is a rare but aggressive malignancy that originates from immature mesenchymal cells committed to skeletal muscle differentiation. Although RMS is, generally, responsive to the modern multimodal therapeutic approaches, the prognosis of RMS depends on multiple variables and for some patients the outcome remains dismal. Further comprehension of the molecular and cellular biology of RMS would lead to identification of novel therapeutic targets. MicroRNAs (miRNAs) are small non-coding RNAs proved to function as key regulators of skeletal muscle cell fate determination and to play important roles in RMS pathogenesis. The purpose of this review is to better delineate the role of miRNAs as a biomarkers or functional leaders in RMS development, so to possibly elucidate some of RMS molecular mechanisms and potentially therapeutically target them to improve clinical management of pediatric RMS.
  • 1.2K
  • 30 Oct 2020
Topic Review
Greenhouse Gas Emissions from Shipping
Recent years have seen growing interest among governments, practitioners and researchers towards measures and initiatives aimed to increase the environmental performance of international shipping. Main drivers of this "green revolution" are identifiable in the need to meet internationally agreed emissions targets but also in financial issues and external pressures due to increasing awareness on climate change and environmental preservation. In April 2018, the International Maritime Organization (IMO) agreed on the Initial IMO Strategy to reduce greenhouse gas (GHG) emissions in the shipping sector. The Strategy includes a target to “reduce the total annual GHG emissions by at least 50 per cent by 2050 from 2008 levels whilst pursuing efforts towards phasing them out”. Being able to meet the ambitious decarbonization IMO’s targets is one of the major challenges the maritime industry has to face in decades. This contribution lists the most popular GHG emission reduction measures the shipping industry can adopt to try to cope with the new IMO's GHG requirements.
  • 1.2K
  • 29 Oct 2020
Topic Review
Burn Injury and Skin Explants
Severe burn injuries remain a major health problem due to high rates of mortality, residual morbidity, and/or aesthetic damages. To find new therapies aimed at promoting a harmonious healing of skin burns, it is important to develop models which take into account the unique properties of the human skin. Based on previously described models of burn injury performed on human skin explants, we hypothesized that maintaining explants under constant tension forces would allow to more closely reproduce the pathophysiological processes of skin remodeling. We thus. Here, we set up and characterized an improved model of deep second-degree burn injury on ex vivo cultured human skin explants at air-liquid interface and maintained under conditions of constant tension forces. A spontaneous re-epithelialization of the lesion was observed 8 to 9 days post burn and was found to rely on the proliferation of basal keratinocytes at the wound edges. Collagen VII at the dermo-epidermal junction reformed along with the progression of re-epithelializatio and a synthesis of procollagen III was observed in the dermis at the wound site. These findings indicate that our model is suitable for the assessment of clinically-relevant therapies aimed at modulating the kinetics of re-epithelialization and/or the activation of fibroblasts following skin burn injuries. In this regard, we evaluated the use of a thermoreversible poloxamer hydrogel as a vehicle for topically-testable therapeutic molecules. Our data showed that, although useful for drug formulation, the p407/p188 poloxamer hydrogel induces a delay of skin re-epithelialization in humans skin explants submitted to experimental burn injury.
  • 1.2K
  • 09 Nov 2020
Topic Review
Shingles
Shingles (also known as herpes zoster) results from infection by the varicella zoster virus.
  • 1.2K
  • 25 Dec 2020
Topic Review
Carbapenemase-Producing Enterobacterales
Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins. CPEs have been classified by the WHO as high-priority pathogens given their association with morbidity and mortality and the scarce number of effective antibiotic treatments. In Spain, the frequency of OXA-48 CPE outbreaks is higher than in other European countries, representing the major resistance mechanism of CPEs. Horizontal transfer of plasmids and poor effective antibiotic treatment are additional threats to the correct prevention and control of these hospital outbreaks. One of the most important risk factors is antibiotic pressure, specifically carbapenem overuse.
  • 1.2K
  • 09 Feb 2021
Topic Review
Nature’s Role in Outdoor Therapies
Outdoor therapies are intentional therapeutic processes that are (1) place-based, (2) feature active bodily engagement, and (3) recognize nature-human kinship. Significant variety exists in practice, from walk and talk therapy, to expedition-based wilderness therapy, to garden and animal-assisted therapies. These approaches have shown improvement across a wide range of social, emotional, physical, physiological, and psychological outcomes and populations.
  • 1.2K
  • 20 May 2021
Topic Review
The Microbiota–Gut–Brain Axis
The microbiota–gut system can be thought of as a single unit that interacts with the brain via the “two-way” microbiota–gut–brain axis. Through this axis, a constant interplay mediated by the several products originating from the microbiota guarantees the physiological development and shaping of the gut and the brain. The modification of the composition of the microbiota destroys the bottom-to-top communication that ultimately influences brain motor, sensory, and cognitive functions, maintains brain homeostasis and/or contributes to the onset of pathological conditions. Elucidating the interplay between the gut microbiota and the central nervous system, and the role of microbiota in neuroinflammation, will lead to a better understanding of many neurodegenerative diseases pathogeneses, and, hopefully, to the development of new preventing or therapeutic strategies.
  • 1.2K
  • 11 Oct 2021
Topic Review
Myeloma Cell Death
Multiple myeloma (MM) is a neoplastic disease of plasma cells, characterized by a complex array of clinical manifestations. Despite extensive efforts and progress in the care of MM patients, the disease is still fatal because of de novo or acquired resistance of malignant cells to standard chemotherapies. In turn, new therapies and/or combination therapies are urgently needed. Reactive oxygen species (ROS) are unstable and highly reactive chemical molecules, able to alter the main structural components of cells, such as proteins and lipids, and thus, modifying cell fates. ROS levels are tightly controlled in normal cells both for their production and degradation. In turn, an unbalance of the redox status might be exploited to induce cell death. This is indeed the case for myeloma cells even those that are resistant, opening new perspectives for refractory or relapsed MM patients. 
  • 1.2K
  • 15 Jun 2021
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback