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Topic Review
Zinc Transport
Zinc is a micronutrient involved in many fundamental roles that are vital for routine bodily functions. A tight control of its concentration, however, is necessary to ensure balance inside the cells. Zinc transporters are thus essential to maintain cellular homeostasis.
  • 1.2K
  • 25 Mar 2021
Topic Review
Beneficiation Methods of Borate Minerals
The modern boron applications have adsorbed the mineral processors’ attention to improve typical boron mineral’s (BM) beneficiation methods. In this regard, dry treatment and pretreatment processes—such as magnetic separation and calcination as environmentally friendly methods, due to their minimal or zero adverse effect on the environment—need more consideration. Over the years, anionic flotation has become the main technique for beneficiation of friable BMs; however, there is a gap in the investigation of cationic flotation separation since BMs’ surface negatively charges in a wide pH range. At present, enriching BMs’ flotation via surface modification is taking center stage, which can also be considered for reprocessing long-forgotten BM tailings.
  • 1.2K
  • 31 Mar 2021
Topic Review
Oxidized Albumin
Albumin is a major plasma protein, capable of partially crossing the glomerular filtration barrier, and reabsorbed mainly by the proximal tubule through different mechanisms. Among the different post-translational modifications that albumin can undergo, oxidation, cysteinylation, glycation, S-nitrilation, and S-guanylation appear as the most common. In particular, the oxidized form of albumin has been associated with obesity, being a risk factor in patients with chronic kidney disease, however, this relation remains to be clarify.
  • 1.2K
  • 29 Apr 2021
Topic Review
Natural Molecules and Neuroprotection
Some natural products and molecules are very promising neuroprotective agents because of their structural diversity and wide variety of biological activities. In addition to their neuroprotective effect, they are known for their antioxidant, anti-inflammatory and antiapoptotic effects and often serve as a starting point for drug discovery.
  • 1.2K
  • 27 May 2021
Topic Review
Patient-Derived Cancer Organoids
The emergence of three-dimensional human organoids has opened the door for the development of patient-derived cancer organoid (PDO) models, which closely recapitulate parental tumor tissue. 
  • 1.2K
  • 01 Jun 2021
Topic Review
Antigenic Essence
Antigenic essence – the part of a cell that is both available to the immune system and also highly specific to cell type on a molecular profile level. Antigenic essence can be collected from the cell surface by treating living cells with protease (trypsin) under mild conditions. Cells are a natural source for the entire diversity of native antigens including for anticancer vaccination. Antigenic essence takes advantage of this while also minimizing the limitations associated with the use of whole cells for anticancer vaccination.
  • 1.2K
  • 23 Jun 2021
Topic Review
Cleome droserifolia (Forssk.) Del.
The antioxidant, antimicrobial, and immunomodulatory activities of the Cleome droserifolia (Forssk.) Del. (Cd) shrub were investigated considering the biological activity of its phytogenic compounds.
  • 1.2K
  • 12 Jul 2021
Topic Review
Probiotic Endophytes for Banana
Endophytic bacteria reside in the internal tissues of the plant, establishing a strong symbiotic relationship that promotes plant growth and provides protection in exchange for a niche to carry out its life cycle. The nature of their mutualistic association depends on their location in the plant tissue, either intercellularly or intracellularly. Since they promote plant growth, increase crop yields, and afford disease resistance under harsh environmental conditions, endophytic bacteria are considered plant probiotics.
  • 1.2K
  • 22 Sep 2021
Topic Review
Systematic Review on Health Communication in China
Since the 1970s, health communication (HC) has attracted widespread attention from practitioners and researchers in various fields in China, leading to the production of a vast array of literature.
  • 1.2K
  • 24 Dec 2021
Topic Review
Sensors for Contaminants Detection in Hydrogen Fuel
Sensors can be used to prevent hydrogen from reaching flammable levels by triggering alarms and activating ventilation or shutdown of systems. Therefore, hydrogen sensors are an important enabling technology for the safe use of hydrogen. Sensors could even have other applications, such as contributing to ensure the lifetime of fuel cell electrical vehicles by warning if the hydrogen quality is not adequate. Here, chemical sensors that respond to a particular analyte in a selective and reversible way can be used in order to indicate the presence of impurities that may be harmful to the Fuel Cell Electrical Vehicle (FCEV). 
  • 1.2K
  • 19 Apr 2022
Topic Review
3-D structures of Potent Antimicrobial Peptides
Global rise of infections and deaths caused by drug-resistant bacterial pathogens are among the unmet medical needs. In an age of drying pipeline of novel antibiotics to treat bacterial infections, antimicrobial peptides (AMPs) are proven to be valid therapeutics modalities.  Direct in vivo applications of many AMPs could be challenging; however, works are demonstrating encouraging results for some of them.
  • 1.2K
  • 05 May 2022
Topic Review
Specific Bifunctionalization on the Phosphorus Dendrimers
Dendrimers are highly branched three-dimensional macromolecules, which properties are essentially dependent on the type of their terminal functions. Dendrimers are synthesized by iterative processes, which afford a new generation at the end of each sequence, characterized by a multiplication of the number of terminal functions. Such processes generate identical terminal functions on the surface of the dendrimers. However, it is sometimes desirable to have two types of surface functions in order to fulfil specific properties. Numerous properties have been explored already, most of them being related to catalysis, materials, or biology/nanomedicine. Strategies to get two types of terminal functions will be illustrated with polyphosphorhydrazone (PPH) dendrimers.
  • 1.2K
  • 13 Sep 2022
Topic Review
Circular Economy Principles for Biobased Products
To support progress towards the transition to a circular economy, the ability to measure circularity is essential. The consideration of the role biobased products can play in this transition is however still largely lacking in the development of circularity monitoring approaches. The first step in coming to a suitable monitoring framework for biobased products is to define circular economy principles.
  • 1.2K
  • 27 Oct 2022
Topic Review
Uniaxial Load Specification for Vehicle Knuckle Part
Knuckle parts have a complex relationship with adjacent vehicle parts, making it difficult to determine the proper fatigue evaluation specification when considering vehicle operation. An accelerated triaxial load case for the knuckle part was derived using a combination of four event modules from the test code developed by the Korea Automotive Technology Institute. The fatigue damage analysis of the front and rear knuckle models was conducted with respect to the accelerated triaxial load case, and the maximum stress was measured at hotspots for the magnitude and orientation of the critical plane. The sensitivity analysis of the knuckle models was conducted for six directions of the unit force, and the proper uniaxial force orientations of the two knuckle models were determined for the maximum stress similarity in the triaxial load case in terms of the magnitude and orientation of the critical plane. 
  • 1.2K
  • 19 Dec 2022
Topic Review
The G-Protein-Coupled Estrogen Receptor System in Various Malignancies
The G-protein-coupled estrogen receptor (GPER) is receiving attention for its role in disease pathogenesis and treatment outcomes. GPER expression patterns in various cancers are highly complex and now debatable, with some cancers showing upregulated GPER expression patterns and others showing downregulated or even inconclusive GPER expression patterns. GPER, for example, is overexpressed in seminomas, melanomas, some ovarian cancers, lung cancers (NSCLC), insulin-resistant endometrial cancer models, and the vast majority of breast cancer models (particularly triple negative breast cancer, TNBC). 
  • 1.2K
  • 27 Dec 2022
Topic Review
Significance of microRNAs in Cardiovascular Diseases
The microRNAs (miRNAs), lncRNAs (long ncRNAs), and circRNAs (circular RNAs) with significant regulatory and structural roles make up approximately 99% of the human genome, which does not contain proteins. Non-coding RNAs (ncRNA) have been discovered to be essential novel regulators of cardiovascular risk factors and cellular processes, making them significant prospects for advanced diagnostics and prognosis evaluation. Cases of cardiovascular diseases (CVDs) are rising due to limitations in the existing therapeutic approach; most of the treatment options are based on the coding transcripts that encode proteins. Various investigations have shown the role of nc-RNA in the early diagnosis and treatment of CVDs. Furthermore, the development of novel diagnoses and treatments based on miRNAs, lncRNAs, and circRNAs could be more helpful in the clinical management of patients with CVDs. 
  • 1.2K
  • 21 Jun 2023
Topic Review
Limitations of Non-Invasive Prenatal Testing
Prenatal genetic screening tests are ”non-invasive” methods that include the maternal serum screening of markers related to aneuploidy with or without nuchal translucency ultrasonography, and cell-free DNA screening, known as non-invasive prenatal testing (NIPT). These tests are performed by drawing maternal peripheral blood sampling; therefore, there is no risk of procedure-related pregnancy complications.
  • 1.2K
  • 09 Aug 2023
Topic Review
Ruthenium(II)
The two Ru(III) and Ru(II) complexes, namely, BOLD-100 and RAPTA-C, are presently being studied in a clinical trial and preclinical studies evaluation, respectively, as anticancer agents. Ruthenium N-heterocyclic carbene (Ru-NHC) complexes show interesting properties in medicinal chemistry, exhibiting multiple biological activities, among them anticancer, antimicrobial, antioxidant, and anti-inflammatory. Among the newly synthesized complexes, RANHC-V and RANHC-VI are the most active against triple-negative human breast cancer cell lines MDA-MB-231. These compounds were selective in vitro inhibitors of the human topoisomerase I activity and triggered cell death by apoptosis. Furthermore, the Ru-NHC complexes’ antimicrobial activity was studied against Gram-positive and -negative bacteria, revealing that all the complexes possessed the best antibacterial activity against the Gram-positive Staphylococcus aureus, at a concentration of 0,025 mg/mL. Finally, the antioxidant effect was assessed by DPPH and ABTS radicals scavenging assays, resulting in a higher ability for inhibiting the ABTS+, with respect to the well-known antioxidant Trolox. Thus, this work provides encouraging insights for further development of novel Ru-NHC complexes as potent chemotherapeutic agents endowed with multiple biological properties.
  • 1.2K
  • 07 Mar 2024
Topic Review
Relations
Relations are ways in which things, the relata, stand to each other. Relations are in many ways similar to properties in that both characterize the things they apply to. Properties are sometimes treated as a special case of relations involving only one relatum. In philosophy (especially metaphysics), theories of relations are typically introduced to account for repetitions of how several things stand to each other.
  • 1.2K
  • 22 Nov 2022
Topic Review
Quality Control of the 26S Proteasome
The ubiquitin-26S proteasome system and autophagy are two major protein degradation machineries encoded in all eukaryotic organisms. While the ubiquitin-26S proteasome system (UPS) is responsible for the turnover of short-lived and/or soluble misfolded proteins under normal growth conditions, the autophagy-lysosomal/vacuolar protein degradation machinery is activated under stress conditions to remove long-lived proteins in the forms of aggregates, either soluble or insoluble, in the cytoplasm and damaged organelles. 
  • 1.2K
  • 31 Jan 2023
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