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Topic Review
Ergot Alkaloids on Cereals and Seeds
Ergot alkaloids are secondary metabolites resulting from fungi of the genus Claviceps that have proven to be highly toxic. These mycotoxins commonly infect cereal crops such as wheat, rye, barley, and oats. Due to the increase worldwide consumption of cereal and cereal-based products, the presence of ergot alkaloids in food presents a concern for human safety. For this reason, it is essential to develop several analytical methods that allow the detection of these toxic compounds. 
  • 1.3K
  • 04 Dec 2023
Topic Review
The Polarized Cardiac Arrest
The concept of “polarized arrest” is attractive because maintaining the membrane potential close to the resting potential value reduces the untoward effects of Ca2+ loading. A polarised tissue is also more resistant to ischemia and inflammations reported by several in vitro and animal studies. The future of polarized arrest is an exciting one and may play an important role in treating the next generation of patients who are older, sicker with multiple comorbidities and require more complex operations with prolonged cross-clamping times.
  • 1.3K
  • 26 Oct 2021
Topic Review
Marine Benthos and Corals
Researchers present thorough this review of the developments in the field, point out their current limitations and outline its timelines and unique potential. In order to do so, authors introduce the methods used in each of the advances in the application of deep learning (DL) to coral research that took place between the years: 2016–2018. DL has the unique capability of streamlining the description, analysis, and monitoring of coral reefs, saving time, and obtaining higher reliability and accuracy compared with error-prone human performance. Coral reefs are the most diverse and complex of marine ecosystems, undergoing a severe decline worldwide resulting from the adverse synergistic influences of global climate change, ocean acidification, and seawater warming, exacerbated by anthropogenic eutrophication and pollution. DL is an extension of some of the concepts originating from machine learning that join several multilayered neural networks. Machine learning refers to algorithms that automatically detect patterns in data. In the case of corals, these data are underwater photographic images. Based on “learned” patterns, such programs can recognize new images. The novelty of DL is in the use of state-of-art computerized image analyses technologies, and its fully automated methodology of dealing with large data sets of images. Automated Image recognition refers to technologies that identify and detect objects or attributes in a digital video or image automatically. Image recognition classifies data into selected categories out of many. Authors show that Neural Network methods are already reliable in distinguishing corals from other benthos and non-coral organisms. Automated recognition of live coral cover is a powerful indicator of reef response to slow and transient changes in the environment. Improving automated recognition of coral species, DL methods already recognize the decline of coral diversity due to natural and anthropogenic stressors. Diversity indicators can document the effectiveness of reef bioremediation initiatives. Authors explored the current applications of deep learning for corals and benthic image classification by discussing the most recent studies conducted by researchers. Authors review the developments in the field, point out their current limitations, and outline their timelines and unique potential. Authors also discussed a few future research directions in the fields of deep learning. Future needs are the age detection of single species, in order to track trends in their population recruitment, decline, and recovery. Fine resolution, at the polyp level, is still to be developed, in order to allow separation of species with similar macroscopic features. That refinement of DL will allow such comparisons and their analyses. Authors conclude that the usefulness of future, more refined automatic identification will allow reef comparison, and tracking long term changes in species diversity. The hitherto unused addition of intraspecific coral color parameters will add the inclusion of physiological coral responses to environmental conditions and change thereof. The core aim of this review was to underscore the strength and reliability of the DL approach for documenting coral reef features based on an evaluation of the currently available published uses of this method. Authors expect that this review will encourage researchers from computer vision and marine societies to collaborate on similar long-term joint ventures.
  • 1.3K
  • 30 Oct 2020
Topic Review
MAP-Kinases Interacting Kinases
The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are involved in oncogenic transformation and can promote metastasis and tumor progression, controlling the expression of specific proteins via eukaryotic initiation factor 4E (eIF4E) regulation, but also through other substrates. In hematological malignancies, which occupy the third place in the global cancer classification, MNK has been demonstrated to participate by regulating the transcription and expression of different proteins. Here is a short summary of the role of MNKs in hematological cancers based on studies conducted to elucidate the mechanism involved in their action, as well as the development of MNK inhibitors.
  • 1.3K
  • 01 Nov 2020
Topic Review
TMEFF2
Transmembrane protein with an EGF-like and two follistatin-like domains 2 (TMEFF2) is a 374-residue long type-I transmembrane proteoglycan which is proteolytically shed from the cell surface. The protein is involved in a range of functions including metabolism, neuroprotection, apoptosis, embryonic development, onco-suppression and endocrine function. TMEFF2 is methylated in numerous cancers, and an inverse correlation with the stage, response to therapy and survival outcome has been observed. Moreover, TMEFF2 methylation increases with breast, colon and gastric cancer progression. TMEFF2 is methylated early during oncogenesis in breast and colorectal cancer, and the detection of methylated free-circulating TMEFF2 DNA has been suggested as a potential diagnostic tool. The TMEFF2 downregulation signature equals and sometimes outperforms the Gleason and pathological scores in prostate cancer. TMEFF2 is downregulated in glioma and cotricotropinomas, and it impairs the production of adrenocorticotropic hormone in glioma cells. Through binding the amyloid β protein, its precursor and derivatives, TMEFF2 provides neuroprotection in Alzheimer’s disease. Primary literature regarding TMEFF2 is incoherent and offers conflicting information, in particular, the oncogenic vs. onco-suppressive role of TMEFF2 in prostate cancer. 
  • 1.3K
  • 26 Jan 2021
Topic Review
Respiratory Distress and PCD
Primary ciliary dyskinesia (PCD) is inherited in a predominantly autosomal recessive manner with over 45 currently identified causative genes. It is a clinically heterogeneous disorder that results in a chronic wet cough and drainage from the paranasal sinuses, chronic otitis media with hearing impairment as well as male infertility. Approximately 50% of patients have situs inversus totalis. Prior to the development of chronic oto-sino-pulmonary symptoms, neonatal respiratory distress occurs in more than 80% of patients as a result of impaired mucociliary clearance and mucus impaction causing atelectasis and lobar collapse. Diagnosis is often delayed due to overlapping symptoms with other causes of neonatal respiratory distress. A work up for PCD should be initiated in the newborn with compatible clinical features, especially those with respiratory distress, consistent radiographic findings or persistent oxygen requirement and/or organ laterality defects
  • 1.3K
  • 10 Mar 2021
Topic Review
Phenolic Compounds in Fermented Quinoa
Quinoa (Chenopodium quinoa Willd.) is a pseudocereal crop, indigenous to the Andean region, increasingly singled out as a healthy food with an excellent nutritional profile. Fermentation can be used to increase phenolic compound content in quinoa seeds and flours. The use of fermented quinoa flours allows obtaining bread and pasta richer in phenolic compounds and with a greater antioxidant capacity. Fungi are the main starters used in quinoa seed fermentation, while Lactobacillus strains have been applied to produce sourdoughs. Quinoa has been also fermented to obtain yogurt-like beverages with a higher content in phenolic compounds and a greater antioxidant activity. Strains of Lactobacillus sp. and Bifidobacterium sp. have been used as starters.
  • 1.3K
  • 12 Jul 2021
Topic Review
Limosilactobacillus Reuteri in Diverticulitis
The microbiota is the set of commensal microorganisms, residing in the organism, helping proper functioning of organs and systems. The role that the microbiota plays in maintaining the health of vertebrates is widely accepted, particularly in the gastrointestinal system, where it is fundamental for immunity, development, and conversion of nutrients. Dysbiosis is an alteration of the microbiota which refers to a disturbed balance, which can cause a number of pathologies. Probiotics have proven to be effective in modulating the microbiota of the gastrointestinal system and, therefore, in promoting the health of the individual. In particular, Lactobacilli are a group of Gram-positive bacteria, which are able to produce lactic acid through glucose metabolism. They are present in different microenvironments, ranging from the vagina, to the mouth, to different tracts of the small intestine.
  • 1.3K
  • 20 Aug 2021
Topic Review
Resveratrol in Ovarian Cancer
Resveratrol, a natural polyphenolic stilbenoid, is a phytoestrogen. Most notably, accumulative evidence supports the notion that resveratrol has immunomodulatory and anticancer properties, and its antioxidant activity and ability to inhibit enzymes may contribute to its anti-inflammatory properties.
  • 1.3K
  • 12 Nov 2021
Topic Review
Bladder Ischemia
The concept of bladder ischemia as a contributing factor to detrusor overactivity and lower urinary tract symptoms (LUTS) is evolving. Bladder ischemia as a consequence of pelvic arterial atherosclerosis was first documented in experimental models and later in elderly patients with LUTS. It was shown that early-stage moderate ischemia produces detrusor overactivity, while prolonged severe ischemia provokes changes consistent with detrusor underactivity. Recent studies imply a central role of cellular energy sensors, cellular stress sensors, and stress response molecules in bladder responses to ischemia. The cellular energy sensor adenosine monophosphate-activated protein kinase was shown to play a role in detrusor overactivity and neurodegeneration in bladder ischemia.
  • 1.3K
  • 15 Dec 2021
Topic Review
Precision Agroecology
Precision agroecology provides a unique opportunity to synthesize traditional knowledge and novel technology to transform food systems. Merging precision agriculture technology and agroecological principles offers a unique array of agricultural solutions driven by data collection, experimentation, and decision support tools. Precision agroecology can offer solutions to agriculture’s biggest challenges in achieving sustainability such as pollution, biodiversity loss, and climate change, as well as broader societal issues of rural depopulation and corporate consolidation of the agricultural sector.
  • 1.3K
  • 14 Jan 2022
Topic Review
Schwann Cell Involvement in Digestive System Disorders
Proper functioning of the digestive system is ensured by coordinated action of the central and peripheral nervous systems (PNS). Peripheral innervation of the digestive system can be viewed as intrinsic and extrinsic. The intrinsic portion is mainly composed of the neurons and glia of the enteric nervous system (ENS). The extrinsic part is formed by sympathetic, parasympathetic, and sensory branches of the PNS with Schwann cells (SCs) being the chef glial cells. SCs are a crucial component of digestive tract innervation, and a great deal of research evidence highlights the important status of these glial cells in health and disease.
  • 1.3K
  • 16 May 2022
Topic Review
Dietary Nitrate and the Maintenance of Oral Health
Nitrate (NO3) is the oxidative product of nitric oxide (NO) and nitrite (NO2). As soil content, NO3 is an essential substrate for all plant growth and provides, among other things, the nitrogen required for the synthesis of nitrogenous amino acids. It is taken up by the plant roots and originates either from the microbial decomposition of organic waste or from the activity of certain soil bacteria utilizing atmospheric nitrogen for the synthesis of ammonia, nitrite and nitrate. Since available nitrate is the limiting factor for plant growth, it is deliberately added to the soil in agricultural crop production in the form of nitrate-containing fertilizers. Although the role of the oral microbiota as a key element in the alternative formation of NO2 and NO from nitrate-rich foods has been known for many years, it is surprisingly only in recent years that the therapeutic and preventive prospects of a nitrate-rich diet have attracted the interest of dental researchers.
  • 1.3K
  • 10 Jun 2022
Topic Review
Manipulating Microbiota to Treat Atopic Dermatitis
Atopic dermatitis (AD) is a globally prevalent skin inflammation with a particular impact on children. Current therapies for AD are challenged by the limited armamentarium and the high heterogeneity of the disease. Thus, radically different approaches are needed to address a significant unmet need in AD patients. A novel promising therapeutic target for AD is the microbiota.
  • 1.3K
  • 13 Jun 2022
Topic Review
Pathogenesis of Choledochal Cyst
Choledochal cysts (CC) is characterized by extra- and/or intra-hepatic b\ile duct dilations. There are two main theories, “pancreaticobiliary maljunction” and “congenital stenosis of bile ducts” proposed for the pathogenesis of CC. Although family cases or CC associated with other anomalies have been reported, the molecular pathogenesis of CC is still poorly understood. Advances in transcriptomics and genomics analysis platforms have unveiled key expression signatures/genes/signaling pathways in the pathogenesis of human diseases including CC.
  • 1.3K
  • 24 Jun 2022
Topic Review
Electrochemical Biosensing of SARS-CoV-2 Virus for COVID-19 Management
Rapid and early diagnosis of lethal coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important issue considering global human health, economy, education, and other activities. The advancement of understanding of the chemistry/biochemistry and the structure of the SARS-CoV-2 virus has led to the development of low-cost, efficient, and reliable methods for COVID-19 diagnosis over “gold standard” real-time reverse transcription-polymerase chain reaction (RT-PCR) due to its several limitations. This led to the development of electrochemical sensors/biosensors for rapid, fast, and low-cost detection of the SARS-CoV-2 virus from the patient’s biological fluids by detecting the components of the virus, including structural proteins (antigens), nucleic acid, and antibodies created after COVID-19 infection. 
  • 1.3K
  • 08 Aug 2022
Topic Review
Fossil Fuel Divestment
Fossil fuel divestment or fossil fuel divestment and investment in climate solutions is an attempt to reduce climate change by exerting social, political, and economic pressure for the institutional divestment of assets including stocks, bonds, and other financial instruments connected to companies involved in extracting fossil fuels. Fossil fuel divestment campaigns emerged on campuses in the United States in 2010 with students urging their administrations to turn endowment investments in the fossil fuel industry into investments in clean energy and communities most impacted by climate change. By 2015, fossil fuel divestment was reportedly the fastest growing divestment movement in history. In April 2020, a total of 1,192 institutions and over 58,000 individuals representing $14 trillion in assets worldwide had begun or committed to a divestment from fossil fuels.
  • 1.3K
  • 10 Oct 2022
Topic Review
Enzymes Related to Early Skin-Aging
Skin is the largest organ of the human body and is a great shield, as it protects it from external infections (environmental and chemical pollutants) as well as from UV irradiation. However, it is vulnerable since its degradation can occur both due to extrinsic and intrinsic factors, leading to early aging. Among all, extrinsic skin aging, called photoaging, is a remarkable result of oxidative stress caused by UV irradiation. In addition, reactive oxygen species (ROS) have also been found to contribute to skin aging, as they are produced in skin cells through UV irradiation, although at low concentrations they could be beneficial for some signaling pathways. Environmental and chemical pollutants also produce ROS, triggering a number of pathologies. Skin’s connective tissue includes a number of constituents, including collagen fibrils, elastic fibers, glycoproteins, and glycosaminoglycans. Among all, proteins like elastin, collagen, the glycosaminoglycan hyaluronic acid, and a polymeric pigment called melanin play pivotal roles in the regulation of skin’s elasticity as well as its protection against UV irradiation.
  • 1.3K
  • 28 Nov 2022
Topic Review Peer Reviewed
Primary Chondroprogenitors: Standardized & Versatile Allogeneic Cytotherapeutics
Primary chondroprogenitors obtained from standardized cell sources (e.g., FE002 clinical grade cell sources) may be cultured in vitro and may be cytotherapeutically applied in allogeneic musculoskeletal regenerative medicine. Multicentric translational research on FE002 human primary chondroprogenitors under the Swiss progenitor cell transplantation program has notably validated their robustness and high versatility for therapeutic formulation in clinically compatible prototypes, as well as a good safety profile in diverse in vivo preclinical models. Therein, stringently controlled primary cell source establishment and extensive cell manufacturing optimization have technically confirmed the adequation of FE002 primary chondroprogenitors with standard industrial biotechnology workflows for consistent diploid cell biobanking under GMP. Laboratory characterization studies and extensive qualification work on FE002 progenitor cell sources have elucidated the key and critical attributes of the cellular materials of interest for potential and diversified human cytotherapeutic uses. Multiple formulation studies (i.e., hydrogel-based standardized transplants, polymeric-scaffold-based tissue engineering products) have shown the high versatility of FE002 primary chondroprogenitors, for the obtention of functional allogeneic cytotherapeutics. Multiple in vivo preclinical studies (e.g., rodent models, GLP goat model) have robustly documented the safety of FE002 primary chondroprogenitors following implantation. Clinically, FE002 primary chondroprogenitors may potentially be used in various forms for volumetric tissue replacement (e.g., treatment of large chondral/osteochondral defects of the knee) or for the local management of chondral affections and pathologies (i.e., injection use in mild to moderate osteoarthritis cases). Overall, standardized FE002 primary chondroprogenitors as investigated under the Swiss progenitor cell transplantation program were shown to constitute tangible contenders in novel human musculoskeletal regenerative medicine approaches, for versatile and safe allogeneic clinical cytotherapeutic management. 
  • 1.3K
  • 22 May 2023
Topic Review
Denoising Techniques for High-Performance MEMS Microphones
The MEMS (Micro-Electro-Mechanical Systems) microphone is a representative device among the MEMS family, which has attracted substantial research interest, and those tailored for human voice have earned distinct success in commercialization. With the advancement of microphone technology and the market, microphones have become carriers for various intelligent applications, therefore demanding higher criteria in noise suppression. For instance, a hearing aid should suppress ambient noise while delivering relevant sounds to the user. Additionally, in specific environments, the noise performance of microphones is crucial for communication and intelligent voice-related needs such as voice activation and speech recognition.
  • 1.3K
  • 11 Mar 2024
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